Incidental Mutation 'R5694:Epha10'
ID 443812
Institutional Source Beutler Lab
Gene Symbol Epha10
Ensembl Gene ENSMUSG00000028876
Gene Name Eph receptor A10
Synonyms
MMRRC Submission 043325-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5694 (G1)
Quality Score 192
Status Not validated
Chromosome 4
Chromosomal Location 124775408-124811594 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 124796446 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Valine at position 385 (A385V)
Gene Model predicted gene model for transcript(s):
AlphaFold no structure available at present
Predicted Effect unknown
Transcript: ENSMUST00000149146
AA Change: A385V
SMART Domains Protein: ENSMUSP00000118801
Gene: ENSMUSG00000028876
AA Change: A385V

DomainStartEndE-ValueType
Pfam:Ephrin_lbd 1 66 2.2e-25 PFAM
low complexity region 74 87 N/A INTRINSIC
FN3 193 290 6.54e-6 SMART
FN3 306 392 1.66e-7 SMART
Pfam:EphA2_TM 421 496 2.4e-15 PFAM
TyrKc 499 754 5.17e-90 SMART
SAM 784 851 1.2e-15 SMART
low complexity region 852 862 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151791
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells (Aasheim et al., 2005 [PubMed 15777695]). See MIM 179610 for additional background on Eph receptors and ephrins.[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc9 A T 6: 142,546,673 (GRCm39) I1353N probably damaging Het
Actr1a C A 19: 46,384,157 (GRCm39) probably benign Het
Adamts14 A T 10: 61,065,431 (GRCm39) M356K probably benign Het
Adamtsl2 A G 2: 26,971,736 (GRCm39) H7R probably benign Het
Angptl2 T C 2: 33,118,628 (GRCm39) V134A probably damaging Het
Armc8 A G 9: 99,378,202 (GRCm39) probably null Het
Astn2 T C 4: 65,868,375 (GRCm39) D488G probably damaging Het
Cat A T 2: 103,303,339 (GRCm39) V146E probably damaging Het
Dmxl1 T C 18: 50,027,324 (GRCm39) V2144A probably damaging Het
Efcab5 T G 11: 77,079,701 (GRCm39) D15A probably benign Het
Erg C A 16: 95,161,890 (GRCm39) E388D probably benign Het
Fbxo10 T A 4: 45,035,970 (GRCm39) I931F probably damaging Het
Frem1 A G 4: 82,912,353 (GRCm39) L673P probably damaging Het
Gm4922 A C 10: 18,660,035 (GRCm39) I229S possibly damaging Het
Gnptab T A 10: 88,250,348 (GRCm39) D153E probably benign Het
Htr7 T C 19: 36,034,521 (GRCm39) M45V probably benign Het
Hycc1 C A 5: 24,196,794 (GRCm39) L31F probably damaging Het
Igkv4-51 C T 6: 69,658,911 (GRCm39) V5M probably damaging Het
Ints7 G A 1: 191,318,730 (GRCm39) E156K probably damaging Het
Map3k21 A G 8: 126,671,507 (GRCm39) T932A probably benign Het
Mapk1 T G 16: 16,836,333 (GRCm39) D160E probably benign Het
Mast4 A T 13: 102,910,701 (GRCm39) Y479* probably null Het
Meig1 T A 2: 3,412,999 (GRCm39) K7N probably damaging Het
Mthfd1l T A 10: 3,985,239 (GRCm39) D548E possibly damaging Het
Myo16 A G 8: 10,619,606 (GRCm39) R1386G probably benign Het
Nphs2 T C 1: 156,153,607 (GRCm39) S353P probably benign Het
Or12j4 T C 7: 140,046,644 (GRCm39) F177L probably benign Het
Or8b1 T A 9: 38,399,532 (GRCm39) I69K probably damaging Het
Pcdha9 G T 18: 37,131,425 (GRCm39) V165L probably benign Het
Pde3a T A 6: 141,196,228 (GRCm39) S305T possibly damaging Het
Phf14 C A 6: 11,990,124 (GRCm39) L718I possibly damaging Het
Plscr5 A T 9: 92,087,564 (GRCm39) K178* probably null Het
Rab44 T A 17: 29,364,940 (GRCm39) M645K unknown Het
Rab44 T C 17: 29,359,474 (GRCm39) L554P probably damaging Het
Rnf222 A G 11: 68,783,723 (GRCm39) T97A probably benign Het
Rnpepl1 T C 1: 92,846,663 (GRCm39) S522P probably benign Het
Serinc5 A G 13: 92,825,302 (GRCm39) I244V probably benign Het
Serpinb10 A T 1: 107,463,187 (GRCm39) probably null Het
Siglech T A 7: 55,418,404 (GRCm39) F124Y probably damaging Het
Smarcc2 A T 10: 128,319,996 (GRCm39) I790L probably benign Het
Sos2 C A 12: 69,637,689 (GRCm39) R1007S probably damaging Het
Stk4 C T 2: 163,942,484 (GRCm39) T372M possibly damaging Het
Tbc1d10c A T 19: 4,234,963 (GRCm39) L366H probably damaging Het
Tor4a T C 2: 25,084,932 (GRCm39) T324A probably benign Het
Trim12a C A 7: 103,956,450 (GRCm39) C30F probably damaging Het
Ttll3 G A 6: 113,376,669 (GRCm39) V350M probably damaging Het
Uggt1 A T 1: 36,218,737 (GRCm39) D63E probably damaging Het
Unc5b G A 10: 60,609,526 (GRCm39) T590I probably benign Het
Wee1 TCCCC TCCC 7: 109,723,776 (GRCm39) probably null Het
Wls A C 3: 159,545,624 (GRCm39) I16L probably benign Het
Zfp101 T C 17: 33,599,919 (GRCm39) I612M probably benign Het
Zfp677 C A 17: 21,618,021 (GRCm39) D359E probably damaging Het
Other mutations in Epha10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01969:Epha10 APN 4 124,779,670 (GRCm39) missense probably damaging 1.00
R1319:Epha10 UTSW 4 124,775,707 (GRCm39) missense probably benign
R1544:Epha10 UTSW 4 124,779,389 (GRCm39) missense probably damaging 1.00
R4504:Epha10 UTSW 4 124,809,480 (GRCm39) unclassified probably benign
R4505:Epha10 UTSW 4 124,809,480 (GRCm39) unclassified probably benign
R4507:Epha10 UTSW 4 124,809,480 (GRCm39) unclassified probably benign
R4572:Epha10 UTSW 4 124,796,361 (GRCm39) missense unknown
R4605:Epha10 UTSW 4 124,779,550 (GRCm39) missense probably damaging 1.00
R4818:Epha10 UTSW 4 124,780,007 (GRCm39) critical splice donor site probably null
R5037:Epha10 UTSW 4 124,809,178 (GRCm39) unclassified probably benign
R5281:Epha10 UTSW 4 124,807,781 (GRCm39) unclassified probably benign
R5319:Epha10 UTSW 4 124,807,793 (GRCm39) unclassified probably benign
R5322:Epha10 UTSW 4 124,779,541 (GRCm39) missense probably damaging 1.00
R5400:Epha10 UTSW 4 124,807,914 (GRCm39) unclassified probably benign
R5681:Epha10 UTSW 4 124,796,359 (GRCm39) missense unknown
R6813:Epha10 UTSW 4 124,796,486 (GRCm39) missense
R7471:Epha10 UTSW 4 124,796,365 (GRCm39) missense
R7699:Epha10 UTSW 4 124,796,440 (GRCm39) missense
R7732:Epha10 UTSW 4 124,809,092 (GRCm39) missense
R7735:Epha10 UTSW 4 124,807,472 (GRCm39) missense
R7793:Epha10 UTSW 4 124,808,246 (GRCm39) missense probably benign 0.00
R7899:Epha10 UTSW 4 124,808,628 (GRCm39) missense
R8057:Epha10 UTSW 4 124,796,476 (GRCm39) missense
R8142:Epha10 UTSW 4 124,779,639 (GRCm39) missense probably damaging 0.99
R8558:Epha10 UTSW 4 124,788,777 (GRCm39) missense
R9136:Epha10 UTSW 4 124,796,427 (GRCm39) missense
R9494:Epha10 UTSW 4 124,808,649 (GRCm39) missense
R9515:Epha10 UTSW 4 124,775,704 (GRCm39) missense probably benign
R9540:Epha10 UTSW 4 124,779,751 (GRCm39) missense probably damaging 0.98
X0026:Epha10 UTSW 4 124,779,340 (GRCm39) missense probably damaging 1.00
Z1176:Epha10 UTSW 4 124,779,568 (GRCm39) missense probably damaging 1.00
Z1176:Epha10 UTSW 4 124,777,735 (GRCm39) missense probably damaging 1.00
Z1177:Epha10 UTSW 4 124,775,753 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- CCCCAATTTCAGGGTAGTCC -3'
(R):5'- AAGATGTGAAGTGCTTCCCC -3'

Sequencing Primer
(F):5'- GGTAGTCCCTTGCGTCTCC -3'
(R):5'- AAAGGCCTGAAGCTCTTCTG -3'
Posted On 2016-11-09