Incidental Mutation 'R5659:Or1j1'
ID 443960
Institutional Source Beutler Lab
Gene Symbol Or1j1
Ensembl Gene ENSMUSG00000075384
Gene Name olfactory receptor family 1 subfamily J member 1
Synonyms GA_x6K02T2NLDC-33507606-33506665, Olfr3, MOR136-14, Y71
MMRRC Submission 043303-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.255) question?
Stock # R5659 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 36702161-36703102 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 36702966 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 46 (I46N)
Ref Sequence ENSEMBL: ENSMUSP00000149118 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100151] [ENSMUST00000213988]
AlphaFold Q60879
Predicted Effect probably damaging
Transcript: ENSMUST00000100151
AA Change: I46N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000097728
Gene: ENSMUSG00000075384
AA Change: I46N

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.3e-61 PFAM
Pfam:7TM_GPCR_Srsx 35 220 2.9e-7 PFAM
Pfam:7tm_1 41 290 6.3e-25 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000120418
Predicted Effect probably damaging
Transcript: ENSMUST00000213988
AA Change: I46N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankhd1 T C 18: 36,694,103 (GRCm39) S105P probably damaging Het
Ano5 G A 7: 51,233,562 (GRCm39) R658H possibly damaging Het
Ap3b2 T A 7: 81,126,500 (GRCm39) I367F probably damaging Het
Apaf1 A T 10: 90,898,015 (GRCm39) C247* probably null Het
Aqp8 G A 7: 123,065,889 (GRCm39) W228* probably null Het
Arhgap32 T A 9: 32,093,256 (GRCm39) V178D probably damaging Het
Atp10b T A 11: 43,136,252 (GRCm39) W1127R probably damaging Het
Bcl6 A T 16: 23,787,159 (GRCm39) C580* probably null Het
Brd1 T C 15: 88,597,584 (GRCm39) T568A probably benign Het
Brsk1 C T 7: 4,718,371 (GRCm39) P665L possibly damaging Het
Cblc A G 7: 19,526,857 (GRCm39) L125P probably damaging Het
Ccdc87 T C 19: 4,890,878 (GRCm39) S457P probably damaging Het
Cxcr5 C T 9: 44,424,690 (GRCm39) M322I probably benign Het
Cyb5r4 T A 9: 86,937,881 (GRCm39) F300Y probably benign Het
Cyp3a25 T C 5: 145,928,356 (GRCm39) T230A possibly damaging Het
Dhx9 A G 1: 153,347,481 (GRCm39) V409A probably damaging Het
Dnah7b A G 1: 46,392,009 (GRCm39) D3790G probably damaging Het
Gin1 A G 1: 97,703,257 (GRCm39) T27A possibly damaging Het
Gipc1 A T 8: 84,390,755 (GRCm39) M287L probably benign Het
Kat6a T A 8: 23,428,176 (GRCm39) L1177* probably null Het
Klhl20 A G 1: 160,918,040 (GRCm39) V82A probably damaging Het
Kmt2e T C 5: 23,702,805 (GRCm39) I995T probably damaging Het
Lpin1 A T 12: 16,590,990 (GRCm39) V814E probably damaging Het
Luzp1 T A 4: 136,269,787 (GRCm39) V670D probably damaging Het
Lyst C A 13: 13,809,212 (GRCm39) A294E possibly damaging Het
Olr1 T A 6: 129,476,992 (GRCm39) E91V probably damaging Het
Or2k2 A T 4: 58,785,672 (GRCm39) F17I probably damaging Het
Or8b55 C T 9: 38,727,072 (GRCm39) T91I probably benign Het
Pam T C 1: 97,770,024 (GRCm39) Y476C probably damaging Het
Pcdhac1 T C 18: 37,225,470 (GRCm39) L761P probably damaging Het
Phf21b C T 15: 84,678,101 (GRCm39) W300* probably null Het
Pld2 T C 11: 70,448,387 (GRCm39) *945Q probably null Het
Ppp1r37 C T 7: 19,269,448 (GRCm39) V145M probably damaging Het
Rasgrf1 T A 9: 89,866,342 (GRCm39) N593K probably damaging Het
Rhot1 T G 11: 80,141,181 (GRCm39) probably null Het
Rmnd1 A T 10: 4,377,382 (GRCm39) M99K probably benign Het
Ros1 G A 10: 52,019,482 (GRCm39) T697I possibly damaging Het
Scgb1b10 G T 7: 31,800,303 (GRCm39) A4S probably benign Het
Shc3 T C 13: 51,670,630 (GRCm39) Y39C probably damaging Het
Slc25a23 A G 17: 57,352,500 (GRCm39) probably benign Het
Slc5a8 C T 10: 88,755,290 (GRCm39) L466F possibly damaging Het
Sqor G A 2: 122,629,523 (GRCm39) C127Y probably benign Het
Sv2a G C 3: 96,097,619 (GRCm39) W467S possibly damaging Het
Togaram2 G T 17: 71,994,667 (GRCm39) D39Y probably damaging Het
Tspan11 T A 6: 127,915,240 (GRCm39) probably null Het
Usp32 A G 11: 84,968,240 (GRCm39) V141A possibly damaging Het
Zbtb38 T C 9: 96,569,473 (GRCm39) H537R probably damaging Het
Zfat T C 15: 67,990,862 (GRCm39) Y1008C probably damaging Het
Zfp637 G A 6: 117,820,291 (GRCm39) G3E probably damaging Het
Zfp788 T A 7: 41,299,540 (GRCm39) Y673* probably null Het
Zhx2 T C 15: 57,685,704 (GRCm39) S358P probably benign Het
Other mutations in Or1j1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01523:Or1j1 APN 2 36,702,415 (GRCm39) missense probably benign
R0501:Or1j1 UTSW 2 36,702,492 (GRCm39) nonsense probably null
R0519:Or1j1 UTSW 2 36,702,627 (GRCm39) missense probably damaging 1.00
R0890:Or1j1 UTSW 2 36,702,586 (GRCm39) missense probably benign 0.06
R1353:Or1j1 UTSW 2 36,702,926 (GRCm39) missense possibly damaging 0.59
R1543:Or1j1 UTSW 2 36,703,069 (GRCm39) missense probably damaging 1.00
R3435:Or1j1 UTSW 2 36,702,690 (GRCm39) missense probably benign 0.06
R4378:Or1j1 UTSW 2 36,702,481 (GRCm39) missense probably benign
R4585:Or1j1 UTSW 2 36,702,537 (GRCm39) missense probably damaging 1.00
R4586:Or1j1 UTSW 2 36,702,537 (GRCm39) missense probably damaging 1.00
R4626:Or1j1 UTSW 2 36,702,271 (GRCm39) missense probably damaging 0.98
R4714:Or1j1 UTSW 2 36,703,047 (GRCm39) missense probably benign 0.37
R4720:Or1j1 UTSW 2 36,702,484 (GRCm39) missense probably benign 0.03
R5390:Or1j1 UTSW 2 36,702,444 (GRCm39) missense probably benign
R5681:Or1j1 UTSW 2 36,702,693 (GRCm39) missense probably benign 0.18
R6750:Or1j1 UTSW 2 36,702,954 (GRCm39) missense possibly damaging 0.90
R7003:Or1j1 UTSW 2 36,703,047 (GRCm39) missense possibly damaging 0.51
R7353:Or1j1 UTSW 2 36,702,915 (GRCm39) missense probably damaging 1.00
R7514:Or1j1 UTSW 2 36,702,651 (GRCm39) missense probably benign 0.03
R8094:Or1j1 UTSW 2 36,702,330 (GRCm39) missense probably damaging 1.00
R8298:Or1j1 UTSW 2 36,703,038 (GRCm39) missense probably benign 0.02
R9189:Or1j1 UTSW 2 36,702,214 (GRCm39) missense possibly damaging 0.79
R9577:Or1j1 UTSW 2 36,702,567 (GRCm39) missense probably damaging 1.00
R9622:Or1j1 UTSW 2 36,702,621 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTCATAGGCCATTGAAGTGATAAGG -3'
(R):5'- TTCCCCAGCAGTAGGTGTAC -3'

Sequencing Primer
(F):5'- CCATTGAAGTGATAAGGAAACTGTC -3'
(R):5'- GGTGTACCCAGCTGCTACATAAG -3'
Posted On 2016-11-09