Incidental Mutation 'R5659:Togaram2'
ID 444009
Institutional Source Beutler Lab
Gene Symbol Togaram2
Ensembl Gene ENSMUSG00000045761
Gene Name TOG array regulator of axonemal microtubules 2
Synonyms Fam179a, 4632412N22Rik
MMRRC Submission 043303-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.071) question?
Stock # R5659 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 71980256-72036664 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 71994667 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Tyrosine at position 39 (D39Y)
Ref Sequence ENSEMBL: ENSMUSP00000122691 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000097284] [ENSMUST00000144479] [ENSMUST00000153445]
AlphaFold Q3TYG6
Predicted Effect probably damaging
Transcript: ENSMUST00000097284
AA Change: D39Y

PolyPhen 2 Score 0.960 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000094886
Gene: ENSMUSG00000045761
AA Change: D39Y

DomainStartEndE-ValueType
low complexity region 49 60 N/A INTRINSIC
low complexity region 94 105 N/A INTRINSIC
low complexity region 467 474 N/A INTRINSIC
Pfam:CLASP_N 492 705 2.3e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000122869
Predicted Effect probably damaging
Transcript: ENSMUST00000144479
AA Change: D40Y

PolyPhen 2 Score 0.960 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000114359
Gene: ENSMUSG00000045761
AA Change: D40Y

DomainStartEndE-ValueType
low complexity region 50 61 N/A INTRINSIC
low complexity region 95 106 N/A INTRINSIC
low complexity region 468 475 N/A INTRINSIC
Pfam:CLASP_N 493 706 2.4e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000153445
AA Change: D39Y

PolyPhen 2 Score 0.960 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000122691
Gene: ENSMUSG00000045761
AA Change: D39Y

DomainStartEndE-ValueType
low complexity region 49 60 N/A INTRINSIC
low complexity region 94 105 N/A INTRINSIC
low complexity region 467 474 N/A INTRINSIC
Pfam:CLASP_N 492 705 2.3e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156665
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankhd1 T C 18: 36,694,103 (GRCm39) S105P probably damaging Het
Ano5 G A 7: 51,233,562 (GRCm39) R658H possibly damaging Het
Ap3b2 T A 7: 81,126,500 (GRCm39) I367F probably damaging Het
Apaf1 A T 10: 90,898,015 (GRCm39) C247* probably null Het
Aqp8 G A 7: 123,065,889 (GRCm39) W228* probably null Het
Arhgap32 T A 9: 32,093,256 (GRCm39) V178D probably damaging Het
Atp10b T A 11: 43,136,252 (GRCm39) W1127R probably damaging Het
Bcl6 A T 16: 23,787,159 (GRCm39) C580* probably null Het
Brd1 T C 15: 88,597,584 (GRCm39) T568A probably benign Het
Brsk1 C T 7: 4,718,371 (GRCm39) P665L possibly damaging Het
Cblc A G 7: 19,526,857 (GRCm39) L125P probably damaging Het
Ccdc87 T C 19: 4,890,878 (GRCm39) S457P probably damaging Het
Cxcr5 C T 9: 44,424,690 (GRCm39) M322I probably benign Het
Cyb5r4 T A 9: 86,937,881 (GRCm39) F300Y probably benign Het
Cyp3a25 T C 5: 145,928,356 (GRCm39) T230A possibly damaging Het
Dhx9 A G 1: 153,347,481 (GRCm39) V409A probably damaging Het
Dnah7b A G 1: 46,392,009 (GRCm39) D3790G probably damaging Het
Gin1 A G 1: 97,703,257 (GRCm39) T27A possibly damaging Het
Gipc1 A T 8: 84,390,755 (GRCm39) M287L probably benign Het
Kat6a T A 8: 23,428,176 (GRCm39) L1177* probably null Het
Klhl20 A G 1: 160,918,040 (GRCm39) V82A probably damaging Het
Kmt2e T C 5: 23,702,805 (GRCm39) I995T probably damaging Het
Lpin1 A T 12: 16,590,990 (GRCm39) V814E probably damaging Het
Luzp1 T A 4: 136,269,787 (GRCm39) V670D probably damaging Het
Lyst C A 13: 13,809,212 (GRCm39) A294E possibly damaging Het
Olr1 T A 6: 129,476,992 (GRCm39) E91V probably damaging Het
Or1j1 A T 2: 36,702,966 (GRCm39) I46N probably damaging Het
Or2k2 A T 4: 58,785,672 (GRCm39) F17I probably damaging Het
Or8b55 C T 9: 38,727,072 (GRCm39) T91I probably benign Het
Pam T C 1: 97,770,024 (GRCm39) Y476C probably damaging Het
Pcdhac1 T C 18: 37,225,470 (GRCm39) L761P probably damaging Het
Phf21b C T 15: 84,678,101 (GRCm39) W300* probably null Het
Pld2 T C 11: 70,448,387 (GRCm39) *945Q probably null Het
Ppp1r37 C T 7: 19,269,448 (GRCm39) V145M probably damaging Het
Rasgrf1 T A 9: 89,866,342 (GRCm39) N593K probably damaging Het
Rhot1 T G 11: 80,141,181 (GRCm39) probably null Het
Rmnd1 A T 10: 4,377,382 (GRCm39) M99K probably benign Het
Ros1 G A 10: 52,019,482 (GRCm39) T697I possibly damaging Het
Scgb1b10 G T 7: 31,800,303 (GRCm39) A4S probably benign Het
Shc3 T C 13: 51,670,630 (GRCm39) Y39C probably damaging Het
Slc25a23 A G 17: 57,352,500 (GRCm39) probably benign Het
Slc5a8 C T 10: 88,755,290 (GRCm39) L466F possibly damaging Het
Sqor G A 2: 122,629,523 (GRCm39) C127Y probably benign Het
Sv2a G C 3: 96,097,619 (GRCm39) W467S possibly damaging Het
Tspan11 T A 6: 127,915,240 (GRCm39) probably null Het
Usp32 A G 11: 84,968,240 (GRCm39) V141A possibly damaging Het
Zbtb38 T C 9: 96,569,473 (GRCm39) H537R probably damaging Het
Zfat T C 15: 67,990,862 (GRCm39) Y1008C probably damaging Het
Zfp637 G A 6: 117,820,291 (GRCm39) G3E probably damaging Het
Zfp788 T A 7: 41,299,540 (GRCm39) Y673* probably null Het
Zhx2 T C 15: 57,685,704 (GRCm39) S358P probably benign Het
Other mutations in Togaram2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00943:Togaram2 APN 17 72,031,999 (GRCm39) missense probably damaging 1.00
IGL01298:Togaram2 APN 17 72,023,508 (GRCm39) missense possibly damaging 0.71
IGL01625:Togaram2 APN 17 72,021,693 (GRCm39) missense probably benign 0.06
IGL01691:Togaram2 APN 17 72,036,485 (GRCm39) missense probably null 0.02
IGL02165:Togaram2 APN 17 72,004,861 (GRCm39) missense probably benign 0.00
IGL02186:Togaram2 APN 17 71,992,166 (GRCm39) missense possibly damaging 0.64
IGL02664:Togaram2 APN 17 72,036,234 (GRCm39) missense probably damaging 0.97
IGL02712:Togaram2 APN 17 72,011,749 (GRCm39) missense probably benign 0.04
IGL03000:Togaram2 APN 17 72,024,365 (GRCm39) missense probably benign 0.08
IGL03209:Togaram2 APN 17 72,002,740 (GRCm39) critical splice donor site probably null
R0211:Togaram2 UTSW 17 72,036,243 (GRCm39) missense probably damaging 1.00
R0212:Togaram2 UTSW 17 72,031,978 (GRCm39) missense probably damaging 1.00
R0219:Togaram2 UTSW 17 72,021,225 (GRCm39) splice site probably benign
R0268:Togaram2 UTSW 17 72,004,993 (GRCm39) critical splice donor site probably null
R0617:Togaram2 UTSW 17 72,007,504 (GRCm39) missense possibly damaging 0.87
R0831:Togaram2 UTSW 17 72,023,439 (GRCm39) missense probably damaging 1.00
R0972:Togaram2 UTSW 17 72,014,309 (GRCm39) missense probably damaging 1.00
R1635:Togaram2 UTSW 17 72,004,846 (GRCm39) missense probably benign 0.05
R1799:Togaram2 UTSW 17 71,998,450 (GRCm39) missense probably damaging 1.00
R2062:Togaram2 UTSW 17 72,023,360 (GRCm39) missense probably benign 0.26
R2414:Togaram2 UTSW 17 72,023,304 (GRCm39) intron probably benign
R2866:Togaram2 UTSW 17 72,016,592 (GRCm39) missense probably benign 0.00
R2867:Togaram2 UTSW 17 72,016,592 (GRCm39) missense probably benign 0.00
R2867:Togaram2 UTSW 17 72,016,592 (GRCm39) missense probably benign 0.00
R4066:Togaram2 UTSW 17 72,023,233 (GRCm39) intron probably benign
R4807:Togaram2 UTSW 17 72,004,918 (GRCm39) missense probably damaging 1.00
R5680:Togaram2 UTSW 17 71,996,204 (GRCm39) missense probably benign 0.00
R5975:Togaram2 UTSW 17 72,036,200 (GRCm39) missense probably damaging 1.00
R5996:Togaram2 UTSW 17 72,011,778 (GRCm39) missense probably damaging 0.99
R6619:Togaram2 UTSW 17 71,996,266 (GRCm39) missense probably damaging 0.99
R6682:Togaram2 UTSW 17 72,011,749 (GRCm39) missense probably benign 0.04
R6922:Togaram2 UTSW 17 72,014,129 (GRCm39) missense probably damaging 1.00
R6956:Togaram2 UTSW 17 72,036,183 (GRCm39) missense probably benign 0.00
R6968:Togaram2 UTSW 17 72,016,608 (GRCm39) missense probably damaging 1.00
R7007:Togaram2 UTSW 17 72,016,638 (GRCm39) missense probably damaging 0.99
R7015:Togaram2 UTSW 17 72,016,563 (GRCm39) missense possibly damaging 0.62
R7140:Togaram2 UTSW 17 72,021,761 (GRCm39) missense probably benign 0.00
R7383:Togaram2 UTSW 17 72,007,512 (GRCm39) missense probably damaging 1.00
R7691:Togaram2 UTSW 17 72,023,405 (GRCm39) missense probably benign 0.16
R7778:Togaram2 UTSW 17 72,011,746 (GRCm39) missense probably benign 0.00
R7824:Togaram2 UTSW 17 72,011,746 (GRCm39) missense probably benign 0.00
R7862:Togaram2 UTSW 17 71,996,168 (GRCm39) missense probably benign 0.00
R7864:Togaram2 UTSW 17 72,007,935 (GRCm39) missense probably damaging 0.96
R7968:Togaram2 UTSW 17 72,024,428 (GRCm39) missense probably benign 0.18
R8125:Togaram2 UTSW 17 72,023,489 (GRCm39) missense probably benign 0.16
R8227:Togaram2 UTSW 17 72,021,237 (GRCm39) nonsense probably null
R8331:Togaram2 UTSW 17 72,036,221 (GRCm39) missense probably damaging 1.00
R8354:Togaram2 UTSW 17 72,004,873 (GRCm39) missense probably benign 0.00
R8454:Togaram2 UTSW 17 72,004,873 (GRCm39) missense probably benign 0.00
R9043:Togaram2 UTSW 17 71,993,699 (GRCm39) missense probably benign 0.00
R9050:Togaram2 UTSW 17 72,007,878 (GRCm39) missense probably damaging 1.00
R9303:Togaram2 UTSW 17 71,996,408 (GRCm39) missense probably damaging 0.97
R9305:Togaram2 UTSW 17 71,996,408 (GRCm39) missense probably damaging 0.97
R9458:Togaram2 UTSW 17 72,024,246 (GRCm39) missense possibly damaging 0.93
R9660:Togaram2 UTSW 17 72,024,365 (GRCm39) missense probably damaging 0.98
R9776:Togaram2 UTSW 17 72,023,508 (GRCm39) missense possibly damaging 0.94
X0063:Togaram2 UTSW 17 72,014,192 (GRCm39) missense possibly damaging 0.91
Z1088:Togaram2 UTSW 17 72,021,275 (GRCm39) missense possibly damaging 0.87
Z1177:Togaram2 UTSW 17 72,007,997 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TGTAGCAGAGAGATGGTCGT -3'
(R):5'- GGAGAATGTCCAAACATCCAGA -3'

Sequencing Primer
(F):5'- CAGAGAGATGGTCGTGGGGTATG -3'
(R):5'- AGACACCATCATTTCCTCCTCTGG -3'
Posted On 2016-11-09