Incidental Mutation 'R5661:Mocos'
ID 444110
Institutional Source Beutler Lab
Gene Symbol Mocos
Ensembl Gene ENSMUSG00000039616
Gene Name molybdenum cofactor sulfurase
Synonyms 1110018O12Rik
MMRRC Submission 043304-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.172) question?
Stock # R5661 (G1)
Quality Score 225
Status Validated
Chromosome 18
Chromosomal Location 24786748-24834632 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 24799052 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000063609 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068006]
AlphaFold Q14CH1
Predicted Effect probably null
Transcript: ENSMUST00000068006
SMART Domains Protein: ENSMUSP00000063609
Gene: ENSMUSG00000039616

DomainStartEndE-ValueType
Pfam:Aminotran_5 50 481 7.5e-29 PFAM
Pfam:MOSC_N 569 689 1.1e-32 PFAM
Pfam:MOSC 715 853 3.7e-21 PFAM
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency 97% (57/59)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] MOCOS sulfurates the molybdenum cofactor of xanthine dehydrogenase (XDH; MIM 607633) and aldehyde oxidase (AOX1; MIM 602841), which is required for their enzymatic activities (Ichida et al., 2001 [PubMed 11302742]).[supplied by OMIM, Feb 2010]
Allele List at MGI

All alleles(11) : Targeted(1) Gene trapped(10)

Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actg2 A G 6: 83,497,754 (GRCm39) I166T probably damaging Het
Actn1 T C 12: 80,231,618 (GRCm39) E273G probably benign Het
Arhgap15 G A 2: 44,212,739 (GRCm39) R403H possibly damaging Het
Arhgef26 T C 3: 62,285,075 (GRCm39) probably benign Het
Avl9 A T 6: 56,702,087 (GRCm39) R81* probably null Het
Brd3 G A 2: 27,351,584 (GRCm39) T223I possibly damaging Het
Cacna2d4 T C 6: 119,320,492 (GRCm39) M890T probably benign Het
Carm1 A G 9: 21,498,295 (GRCm39) D433G probably benign Het
Ccdc40 A G 11: 119,128,753 (GRCm39) K427E probably benign Het
Ccdc80 T C 16: 44,947,808 (GRCm39) Y929H probably damaging Het
Ccr9 A C 9: 123,609,164 (GRCm39) Y282S probably benign Het
Det1 C T 7: 78,492,958 (GRCm39) E349K probably damaging Het
Enpep T A 3: 129,070,406 (GRCm39) N834Y probably damaging Het
Epha7 A T 4: 28,946,217 (GRCm39) probably null Het
Fap A T 2: 62,367,307 (GRCm39) probably benign Het
Foxn4 A G 5: 114,411,053 (GRCm39) C23R probably benign Het
Gad1-ps T C 10: 99,280,901 (GRCm39) noncoding transcript Het
Gli2 C A 1: 118,781,032 (GRCm39) E238* probably null Het
Gm20939 C A 17: 95,183,207 (GRCm39) H148N probably damaging Het
Gnl1 T C 17: 36,293,447 (GRCm39) Y211H probably benign Het
Gpat3 A T 5: 101,033,808 (GRCm39) K221* probably null Het
Hjurp G C 1: 88,204,937 (GRCm39) probably benign Het
Hnrnph1 A T 11: 50,275,507 (GRCm39) Q415L probably benign Het
Kansl3 T C 1: 36,388,038 (GRCm39) E383G possibly damaging Het
Kdm5b T C 1: 134,526,811 (GRCm39) V311A probably benign Het
Lipk T A 19: 34,009,727 (GRCm39) M215K probably benign Het
Madd A G 2: 90,984,778 (GRCm39) probably null Het
Meltf A G 16: 31,700,744 (GRCm39) E88G possibly damaging Het
Mis18bp1 A T 12: 65,195,626 (GRCm39) S713T probably benign Het
Msto1 T A 3: 88,820,192 (GRCm39) D88V possibly damaging Het
Myo5a A G 9: 75,074,488 (GRCm39) Y799C probably benign Het
Nectin4 T A 1: 171,212,738 (GRCm39) L357H probably damaging Het
Or4p22 G A 2: 88,317,441 (GRCm39) V122M probably damaging Het
Or6c2 A T 10: 129,362,618 (GRCm39) H174L probably benign Het
Pax2 A G 19: 44,779,161 (GRCm39) N179S probably damaging Het
Pcdhac2 C A 18: 37,278,499 (GRCm39) T493K probably damaging Het
Pgk2 G T 17: 40,518,287 (GRCm39) C380* probably null Het
Pi4k2b G A 5: 52,900,906 (GRCm39) probably null Het
Plcb3 A G 19: 6,940,588 (GRCm39) V416A probably damaging Het
Pom121l2 G A 13: 22,168,425 (GRCm39) G899R possibly damaging Het
Ppp4r1 T C 17: 66,110,963 (GRCm39) probably null Het
Prkdc G A 16: 15,628,634 (GRCm39) E3460K possibly damaging Het
Psmb3 A G 11: 97,597,659 (GRCm39) E75G possibly damaging Het
Retnlb C T 16: 48,638,429 (GRCm39) T50I probably benign Het
Sec16a A G 2: 26,329,649 (GRCm39) S789P probably benign Het
Sec24d C T 3: 123,136,734 (GRCm39) T489I probably damaging Het
Sec24d T C 3: 123,136,791 (GRCm39) M508T possibly damaging Het
Slc5a8 C T 10: 88,755,290 (GRCm39) L466F possibly damaging Het
Terf1 T A 1: 15,889,888 (GRCm39) V221E probably damaging Het
Trak1 A G 9: 121,272,703 (GRCm39) N187S possibly damaging Het
Trappc11 T A 8: 47,965,642 (GRCm39) D528V probably damaging Het
Tut4 A G 4: 108,370,384 (GRCm39) D761G probably benign Het
Vmn1r170 A G 7: 23,306,231 (GRCm39) N211S possibly damaging Het
Zfpm2 G A 15: 40,959,467 (GRCm39) W50* probably null Het
Other mutations in Mocos
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00310:Mocos APN 18 24,793,101 (GRCm39) missense possibly damaging 0.88
IGL01859:Mocos APN 18 24,799,717 (GRCm39) splice site probably benign
IGL01884:Mocos APN 18 24,816,273 (GRCm39) missense probably damaging 1.00
IGL02174:Mocos APN 18 24,828,953 (GRCm39) missense probably benign 0.00
IGL02966:Mocos APN 18 24,809,668 (GRCm39) missense probably damaging 1.00
IGL02976:Mocos APN 18 24,799,626 (GRCm39) missense possibly damaging 0.92
buteo UTSW 18 24,799,467 (GRCm39) missense probably damaging 0.98
swainson UTSW 18 24,812,447 (GRCm39) missense probably damaging 1.00
P0008:Mocos UTSW 18 24,812,663 (GRCm39) missense probably benign 0.32
PIT4810001:Mocos UTSW 18 24,819,759 (GRCm39) missense probably damaging 1.00
R0131:Mocos UTSW 18 24,812,819 (GRCm39) missense probably benign 0.01
R0131:Mocos UTSW 18 24,812,819 (GRCm39) missense probably benign 0.01
R0132:Mocos UTSW 18 24,812,819 (GRCm39) missense probably benign 0.01
R0265:Mocos UTSW 18 24,799,333 (GRCm39) missense probably benign 0.01
R0737:Mocos UTSW 18 24,822,044 (GRCm39) missense probably damaging 0.98
R1231:Mocos UTSW 18 24,812,758 (GRCm39) missense probably benign 0.01
R1351:Mocos UTSW 18 24,793,107 (GRCm39) missense probably damaging 1.00
R1699:Mocos UTSW 18 24,816,273 (GRCm39) missense probably damaging 1.00
R1853:Mocos UTSW 18 24,829,026 (GRCm39) missense probably damaging 1.00
R2190:Mocos UTSW 18 24,797,114 (GRCm39) missense probably benign 0.01
R2350:Mocos UTSW 18 24,799,713 (GRCm39) splice site probably benign
R2680:Mocos UTSW 18 24,809,686 (GRCm39) missense probably damaging 1.00
R3840:Mocos UTSW 18 24,809,681 (GRCm39) missense probably damaging 1.00
R3841:Mocos UTSW 18 24,809,681 (GRCm39) missense probably damaging 1.00
R3847:Mocos UTSW 18 24,809,719 (GRCm39) missense probably damaging 0.99
R4059:Mocos UTSW 18 24,812,447 (GRCm39) missense probably damaging 1.00
R4158:Mocos UTSW 18 24,807,303 (GRCm39) missense probably damaging 0.99
R4205:Mocos UTSW 18 24,799,248 (GRCm39) missense possibly damaging 0.88
R4514:Mocos UTSW 18 24,816,269 (GRCm39) missense probably damaging 0.99
R4589:Mocos UTSW 18 24,787,095 (GRCm39) missense probably damaging 0.99
R4667:Mocos UTSW 18 24,799,491 (GRCm39) missense probably benign 0.11
R4668:Mocos UTSW 18 24,799,491 (GRCm39) missense probably benign 0.11
R5162:Mocos UTSW 18 24,787,109 (GRCm39) missense probably damaging 0.98
R5187:Mocos UTSW 18 24,825,611 (GRCm39) missense probably damaging 0.97
R5533:Mocos UTSW 18 24,807,357 (GRCm39) missense probably damaging 1.00
R5629:Mocos UTSW 18 24,797,142 (GRCm39) critical splice donor site probably null
R5952:Mocos UTSW 18 24,834,444 (GRCm39) missense possibly damaging 0.91
R5987:Mocos UTSW 18 24,819,750 (GRCm39) missense probably damaging 1.00
R6173:Mocos UTSW 18 24,809,639 (GRCm39) missense probably benign 0.03
R6209:Mocos UTSW 18 24,799,672 (GRCm39) missense probably benign 0.41
R6376:Mocos UTSW 18 24,834,542 (GRCm39) missense possibly damaging 0.50
R6416:Mocos UTSW 18 24,834,513 (GRCm39) missense probably damaging 0.99
R6452:Mocos UTSW 18 24,828,998 (GRCm39) missense probably benign 0.02
R6520:Mocos UTSW 18 24,799,447 (GRCm39) missense probably benign 0.01
R6631:Mocos UTSW 18 24,832,988 (GRCm39) missense probably benign 0.03
R6669:Mocos UTSW 18 24,799,467 (GRCm39) missense probably damaging 0.98
R7114:Mocos UTSW 18 24,799,572 (GRCm39) missense probably damaging 1.00
R7366:Mocos UTSW 18 24,809,673 (GRCm39) missense probably damaging 1.00
R7690:Mocos UTSW 18 24,797,082 (GRCm39) missense probably damaging 1.00
R7955:Mocos UTSW 18 24,799,216 (GRCm39) missense probably damaging 1.00
R8458:Mocos UTSW 18 24,799,314 (GRCm39) missense probably benign 0.00
R8762:Mocos UTSW 18 24,812,554 (GRCm39) missense probably damaging 0.99
R9072:Mocos UTSW 18 24,797,089 (GRCm39) missense probably damaging 0.98
R9073:Mocos UTSW 18 24,797,089 (GRCm39) missense probably damaging 0.98
R9192:Mocos UTSW 18 24,812,594 (GRCm39) missense probably benign 0.00
R9781:Mocos UTSW 18 24,828,939 (GRCm39) missense probably benign 0.02
Z1176:Mocos UTSW 18 24,803,690 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TGTGTCCAAGCAGAGATGGG -3'
(R):5'- ATGTGACACTCATGGCTGCAG -3'

Sequencing Primer
(F):5'- GCTCCAGAGGCAAGAAGTTTAAATTC -3'
(R):5'- TTCCTCATTCCCACCACAGAGG -3'
Posted On 2016-11-09