Incidental Mutation 'R5665:Capn10'
ID 444306
Institutional Source Beutler Lab
Gene Symbol Capn10
Ensembl Gene ENSMUSG00000026270
Gene Name calpain 10
Synonyms Capn8
MMRRC Submission 043308-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.117) question?
Stock # R5665 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 92862130-92875670 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 92865653 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000112831 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027488] [ENSMUST00000117814] [ENSMUST00000152983]
AlphaFold Q9ESK3
Predicted Effect probably null
Transcript: ENSMUST00000027488
SMART Domains Protein: ENSMUSP00000027488
Gene: ENSMUSG00000026270

DomainStartEndE-ValueType
CysPc 2 329 1.75e-59 SMART
calpain_III 338 488 2.05e-60 SMART
calpain_III 507 645 1.3e-39 SMART
Predicted Effect probably null
Transcript: ENSMUST00000117814
SMART Domains Protein: ENSMUSP00000112831
Gene: ENSMUSG00000026270

DomainStartEndE-ValueType
CysPc 2 263 1.29e-16 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128429
Predicted Effect probably benign
Transcript: ENSMUST00000152983
SMART Domains Protein: ENSMUSP00000122158
Gene: ENSMUSG00000026270

DomainStartEndE-ValueType
CysPc 2 329 1.75e-59 SMART
calpain_III 338 488 2.71e-60 SMART
low complexity region 490 499 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000187342
Predicted Effect noncoding transcript
Transcript: ENSMUST00000191563
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit resistance to ryanodine- and palmitate-induced pancreatic apoptosis. Mice homozygous for a different knock-out allele exhibit increased adiposity, body and organ weights, and leptin serum levels on background containing LG/J. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930505A04Rik C T 11: 30,376,349 (GRCm39) V173M probably damaging Het
Acaca G T 11: 84,136,120 (GRCm39) E492* probably null Het
Acp7 T A 7: 28,315,968 (GRCm39) K206M probably benign Het
Agbl1 T A 7: 76,239,251 (GRCm39) F584I probably damaging Het
Ahi1 A G 10: 20,930,946 (GRCm39) I929V possibly damaging Het
Ank3 G A 10: 69,838,395 (GRCm39) R1566K possibly damaging Het
Arhgef40 A G 14: 52,238,357 (GRCm39) I1279V possibly damaging Het
Arl14 A C 3: 69,130,371 (GRCm39) T173P probably damaging Het
Asap1 A G 15: 64,184,302 (GRCm39) S44P probably damaging Het
Btbd7 C A 12: 102,751,456 (GRCm39) A1103S probably benign Het
Capn7 T C 14: 31,091,759 (GRCm39) F719L probably benign Het
Casp7 G A 19: 56,429,414 (GRCm39) D267N probably benign Het
Ccdc13 C A 9: 121,643,356 (GRCm39) K348N probably damaging Het
Chchd1 T C 14: 20,753,178 (GRCm39) F13L probably benign Het
Clcn6 T A 4: 148,099,018 (GRCm39) M442L possibly damaging Het
Col6a3 T C 1: 90,755,602 (GRCm39) E229G probably benign Het
Cyb5r3 A G 15: 83,038,755 (GRCm39) F278S probably damaging Het
Dhx16 C T 17: 36,201,978 (GRCm39) Q1002* probably null Het
Dppa4 T C 16: 48,111,378 (GRCm39) L121P probably benign Het
Dpyd A G 3: 118,710,741 (GRCm39) E383G probably damaging Het
Eif4g3 A G 4: 137,853,900 (GRCm39) T489A probably benign Het
Elovl1 G T 4: 118,288,832 (GRCm39) V174L probably damaging Het
Elp3 T C 14: 65,788,851 (GRCm39) K392E possibly damaging Het
Fancd2os C A 6: 113,574,985 (GRCm39) W7L probably damaging Het
Fchsd2 A G 7: 100,759,991 (GRCm39) T23A possibly damaging Het
Gabrp C G 11: 33,504,308 (GRCm39) A336P possibly damaging Het
Gcm2 T A 13: 41,263,387 (GRCm39) Y15F possibly damaging Het
Gpr132 G A 12: 112,816,416 (GRCm39) R137C probably damaging Het
Herc1 A G 9: 66,372,717 (GRCm39) E3091G probably damaging Het
Homer1 A T 13: 93,492,610 (GRCm39) M184L probably benign Het
Izumo1r T C 9: 14,812,145 (GRCm39) E117G probably damaging Het
Kcnt1 C T 2: 25,791,921 (GRCm39) Q590* probably null Het
Lama1 G T 17: 68,077,982 (GRCm39) C1139F probably damaging Het
Med29 C T 7: 28,086,239 (GRCm39) A190T probably benign Het
Muc4 T C 16: 32,569,600 (GRCm39) V220A probably benign Het
Mxra8 G T 4: 155,927,378 (GRCm39) V388L probably benign Het
Myo5a T C 9: 75,051,463 (GRCm39) probably null Het
Myrip A G 9: 120,290,499 (GRCm39) Y706C probably damaging Het
Nphp4 T C 4: 152,590,942 (GRCm39) V313A probably benign Het
Oga A C 19: 45,765,436 (GRCm39) S124A probably benign Het
Olfm2 T G 9: 20,579,840 (GRCm39) probably null Het
Or10ag52 T A 2: 87,044,072 (GRCm39) S279T probably benign Het
Or10x4 T C 1: 174,218,941 (GRCm39) F102S probably damaging Het
Pcdh15 C T 10: 74,462,620 (GRCm39) P1398L probably damaging Het
Pdpr A G 8: 111,841,443 (GRCm39) E225G possibly damaging Het
Pigs C A 11: 78,219,595 (GRCm39) probably null Het
Pkhd1 T A 1: 20,658,755 (GRCm39) T159S probably damaging Het
Plk4 A G 3: 40,768,021 (GRCm39) T87A possibly damaging Het
Plxna4 T C 6: 32,192,657 (GRCm39) Y768C probably damaging Het
Prl3d3 T A 13: 27,343,064 (GRCm39) probably null Het
Pygb T C 2: 150,662,808 (GRCm39) probably null Het
Rnf114 T C 2: 167,352,854 (GRCm39) I118T possibly damaging Het
Sbno2 A G 10: 79,894,287 (GRCm39) L1099P probably benign Het
Scaper T C 9: 55,714,916 (GRCm39) K791E probably damaging Het
Serping1 T C 2: 84,601,889 (GRCm39) T194A probably damaging Het
Slc12a9 A G 5: 137,319,665 (GRCm39) S617P possibly damaging Het
Slk G A 19: 47,624,896 (GRCm39) R1039H probably damaging Het
Sntb1 T A 15: 55,655,535 (GRCm39) E227V probably benign Het
Sostdc1 C A 12: 36,364,407 (GRCm39) P39T probably benign Het
Spred1 C T 2: 116,983,486 (GRCm39) R16* probably null Het
Srpk2 A G 5: 23,723,475 (GRCm39) I547T probably damaging Het
Stt3a A G 9: 36,670,610 (GRCm39) Y54H probably damaging Het
Stt3b A T 9: 115,095,215 (GRCm39) L272H probably damaging Het
Syne2 T A 12: 76,154,991 (GRCm39) probably null Het
Uso1 A T 5: 92,346,196 (GRCm39) E793V possibly damaging Het
Usp15 A T 10: 122,966,892 (GRCm39) L476* probably null Het
Vmn1r189 T C 13: 22,286,336 (GRCm39) Y167C probably damaging Het
Vmn2r24 A G 6: 123,763,938 (GRCm39) T272A possibly damaging Het
Vps13a A T 19: 16,646,054 (GRCm39) H1994Q probably damaging Het
Zbtb10 T C 3: 9,330,252 (GRCm39) S537P probably damaging Het
Zbtb12 T C 17: 35,114,859 (GRCm39) S215P possibly damaging Het
Zfp346 T C 13: 55,260,915 (GRCm39) M81T probably benign Het
Zfp800 T C 6: 28,244,512 (GRCm39) D151G probably null Het
Other mutations in Capn10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00902:Capn10 APN 1 92,870,281 (GRCm39) missense probably benign 0.00
IGL01071:Capn10 APN 1 92,872,797 (GRCm39) missense probably damaging 1.00
IGL01682:Capn10 APN 1 92,868,106 (GRCm39) missense probably benign 0.16
IGL01771:Capn10 APN 1 92,868,087 (GRCm39) missense probably damaging 1.00
IGL02952:Capn10 APN 1 92,872,896 (GRCm39) missense probably damaging 0.97
IGL03177:Capn10 APN 1 92,862,704 (GRCm39) missense probably benign 0.02
IGL03224:Capn10 APN 1 92,867,046 (GRCm39) missense probably damaging 1.00
P4717OSA:Capn10 UTSW 1 92,867,116 (GRCm39) missense probably damaging 1.00
R1256:Capn10 UTSW 1 92,874,668 (GRCm39) missense probably damaging 1.00
R1405:Capn10 UTSW 1 92,872,744 (GRCm39) missense probably benign 0.34
R1405:Capn10 UTSW 1 92,872,744 (GRCm39) missense probably benign 0.34
R1653:Capn10 UTSW 1 92,874,620 (GRCm39) missense probably damaging 1.00
R1737:Capn10 UTSW 1 92,862,677 (GRCm39) missense probably benign 0.10
R2127:Capn10 UTSW 1 92,865,756 (GRCm39) nonsense probably null
R2433:Capn10 UTSW 1 92,870,247 (GRCm39) missense probably benign 0.22
R2484:Capn10 UTSW 1 92,872,565 (GRCm39) missense probably damaging 0.97
R4004:Capn10 UTSW 1 92,868,313 (GRCm39) missense probably damaging 0.98
R4005:Capn10 UTSW 1 92,868,313 (GRCm39) missense probably damaging 0.98
R4560:Capn10 UTSW 1 92,867,084 (GRCm39) missense probably damaging 1.00
R4684:Capn10 UTSW 1 92,871,503 (GRCm39) missense probably damaging 1.00
R4766:Capn10 UTSW 1 92,871,141 (GRCm39) missense probably damaging 0.98
R4996:Capn10 UTSW 1 92,872,858 (GRCm39) missense probably damaging 1.00
R5733:Capn10 UTSW 1 92,871,635 (GRCm39) missense probably benign 0.03
R5937:Capn10 UTSW 1 92,867,105 (GRCm39) missense probably damaging 1.00
R6985:Capn10 UTSW 1 92,871,146 (GRCm39) missense probably damaging 1.00
R7140:Capn10 UTSW 1 92,872,993 (GRCm39) missense possibly damaging 0.85
R7495:Capn10 UTSW 1 92,871,092 (GRCm39) missense probably damaging 1.00
R8170:Capn10 UTSW 1 92,862,686 (GRCm39) missense probably damaging 0.98
R8393:Capn10 UTSW 1 92,871,130 (GRCm39) missense probably benign 0.09
R8943:Capn10 UTSW 1 92,871,454 (GRCm39) missense probably damaging 1.00
R9303:Capn10 UTSW 1 92,871,665 (GRCm39) critical splice donor site probably null
R9305:Capn10 UTSW 1 92,871,665 (GRCm39) critical splice donor site probably null
R9655:Capn10 UTSW 1 92,867,111 (GRCm39) missense probably damaging 1.00
R9776:Capn10 UTSW 1 92,871,586 (GRCm39) missense possibly damaging 0.67
Predicted Primers PCR Primer
(F):5'- TGCCATGGGAGAACTGTAGC -3'
(R):5'- AAGAATGTCCGGTGCTGTGC -3'

Sequencing Primer
(F):5'- CCATGGGAGAACTGTAGCAAAGG -3'
(R):5'- CTAGAAGTGACTGAGTGGGAAG -3'
Posted On 2016-11-09