Mutagenetix > Incidental Mutation

Incidental Mutation 'R5752:Ncoa4-ps'

444861

Institutional Source

Beutler Lab

Gene Symbol

Ncoa4-ps

Ensembl Gene

ENSMUSG00000021908

Gene Name

nuclear receptor coactivator 4, pseudogene

Synonyms

Gm6768

MMRRC Submission

043357-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.281) question?

Stock #

R5752 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

119224713-119226590 bp(+) (GRCm39)

Type of Mutation

exon

DNA Base Change (assembly)

A to G at 119226349 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000022467

SMART Domains

Protein: ENSMUSP00000136708
Gene: ENSMUSG00000021908

Domain	Start	End	E-Value	Type
Pfam:ARA70	33	169	2.4e-28	PFAM
Pfam:ARA70	199	334	4.7e-51	PFAM

Meta Mutation Damage Score

0.0869

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.6%
20x: 96.1%

Validation Efficiency

98% (58/59)

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A330017A19Rik	C	A	17: 47,200,966 (GRCm39)		probably benign	Het
Aldh1l2	C	A	10: 83,356,244 (GRCm39)	G49C	probably damaging	Het
Arhgap26	G	A	18: 39,419,725 (GRCm39)	E11K	probably damaging	Het
Asns	C	T	6: 7,689,365 (GRCm39)	G46S	probably damaging	Het
Atrn	G	T	2: 130,748,464 (GRCm39)		probably benign	Het
Cep126	A	C	9: 8,120,746 (GRCm39)	Y92*	probably null	Het
Cfap69	T	C	5: 5,639,204 (GRCm39)	T567A	probably damaging	Het
Clgn	T	A	8: 84,123,670 (GRCm39)	Y61N	probably damaging	Het
Col28a1	T	G	6: 8,015,025 (GRCm39)	K793N	possibly damaging	Het
Cxcl9	C	A	5: 92,471,715 (GRCm39)	M108I	probably benign	Het
Cyp4f37	A	T	17: 32,850,306 (GRCm39)	I318F	probably damaging	Het
Daam1	T	C	12: 71,993,320 (GRCm39)	M363T	unknown	Het
Dnajc13	A	C	9: 104,069,973 (GRCm39)		probably null	Het
Entpd2	G	A	2: 25,289,781 (GRCm39)		probably benign	Het
F3	T	A	3: 121,526,053 (GRCm39)	N205K	probably damaging	Het
Fat2	A	T	11: 55,180,063 (GRCm39)	F1426Y	possibly damaging	Het
Galnt6	A	T	15: 100,602,007 (GRCm39)	F267I	probably damaging	Het
Gm1322	G	A	2: 67,014,979 (GRCm39)		noncoding transcript	Het
Hdgfl3	A	C	7: 81,549,451 (GRCm39)	S143A	possibly damaging	Het
Ints7	T	A	1: 191,308,005 (GRCm39)	D12E	probably benign	Het
Kank3	A	G	17: 34,037,037 (GRCm39)	T114A	probably benign	Het
Lrp1b	A	G	2: 41,185,624 (GRCm39)	Y1364H	probably damaging	Het
Mef2b	A	G	8: 70,618,267 (GRCm39)	T116A	possibly damaging	Het
Megf8	C	T	7: 25,054,539 (GRCm39)	T1885I	probably damaging	Het
Mrps11	A	G	7: 78,433,343 (GRCm39)	K30E	probably benign	Het
Naca	T	A	10: 127,877,797 (GRCm39)		probably benign	Het
Nhsl3	GGTG	GGTGTG	4: 129,117,773 (GRCm39)		probably null	Het
Or2at1	T	C	7: 99,417,155 (GRCm39)	I262T	probably benign	Het
Paip2b	C	T	6: 83,808,252 (GRCm39)		probably null	Het
Plcb2	G	T	2: 118,541,532 (GRCm39)		probably benign	Het
Plcd4	A	G	1: 74,587,131 (GRCm39)		probably null	Het
Pnpla8	A	G	12: 44,329,670 (GRCm39)	N74S	probably benign	Het
Pot1b	A	T	17: 55,994,834 (GRCm39)	I276N	probably damaging	Het
Qprt	C	T	7: 126,708,416 (GRCm39)	G5D	probably benign	Het
Rab11fip1	T	C	8: 27,646,614 (GRCm39)	N154S	probably damaging	Het
Rin3	G	A	12: 102,279,378 (GRCm39)		probably benign	Het
Sdf4	C	T	4: 156,080,761 (GRCm39)	P37S	probably damaging	Het
Selp	A	T	1: 163,964,811 (GRCm39)	D491V	probably damaging	Het
Sh3gl3	A	G	7: 81,824,696 (GRCm39)		probably benign	Het
Sp110	G	C	1: 85,504,923 (GRCm39)		probably benign	Het
Spata31d1e	T	C	13: 59,891,016 (GRCm39)	Y268C	probably damaging	Het
Tas2r134	A	G	2: 51,517,880 (GRCm39)	R120G	probably damaging	Het
Tgfbr3	T	C	5: 107,287,673 (GRCm39)	R509G	probably benign	Het
Tle3	T	A	9: 61,314,753 (GRCm39)	Y231N	probably damaging	Het
Top6bl	C	A	19: 4,676,048 (GRCm39)	A695S	probably benign	Het
Ttc41	C	T	10: 86,594,210 (GRCm39)	T881I	probably benign	Het
Ttll8	T	C	15: 88,816,931 (GRCm39)	Y271C	probably benign	Het
Ttn	A	T	2: 76,778,328 (GRCm39)	I1307K	possibly damaging	Het
Ube2k	A	G	5: 65,723,411 (GRCm39)	D48G	probably damaging	Het
Vcan	T	C	13: 89,828,069 (GRCm39)	T3126A	probably damaging	Het
Vps13d	T	C	4: 144,875,540 (GRCm39)	T1656A	probably benign	Het
Zzz3	C	A	3: 152,157,759 (GRCm39)	S777R	possibly damaging	Het

Other mutations in Ncoa4-ps

Allele	Source	Chr	Coord	Type	Predicted Effect
IGL01778:Ncoa4-ps	APN	12	119,226,231 (GRCm39)	exon	noncoding transcript
R0683:Ncoa4-ps	UTSW	12	119,224,813 (GRCm39)	exon	noncoding transcript
R1186:Ncoa4-ps	UTSW	12	119,225,206 (GRCm39)	exon	noncoding transcript
R1485:Ncoa4-ps	UTSW	12	119,224,785 (GRCm39)	exon	noncoding transcript
R1708:Ncoa4-ps	UTSW	12	119,225,968 (GRCm39)	exon	noncoding transcript
R1800:Ncoa4-ps	UTSW	12	119,225,506 (GRCm39)	exon	noncoding transcript
R2280:Ncoa4-ps	UTSW	12	119,226,573 (GRCm39)	exon	noncoding transcript
R4827:Ncoa4-ps	UTSW	12	119,225,529 (GRCm39)	exon	noncoding transcript
R4922:Ncoa4-ps	UTSW	12	119,226,252 (GRCm39)	exon	noncoding transcript
R5183:Ncoa4-ps	UTSW	12	119,225,023 (GRCm39)	exon	noncoding transcript
R5562:Ncoa4-ps	UTSW	12	119,225,957 (GRCm39)	exon	noncoding transcript
R6033:Ncoa4-ps	UTSW	12	119,225,475 (GRCm39)	exon	noncoding transcript
R6033:Ncoa4-ps	UTSW	12	119,225,475 (GRCm39)	exon	noncoding transcript
R6084:Ncoa4-ps	UTSW	12	119,225,386 (GRCm39)	exon	noncoding transcript
R6151:Ncoa4-ps	UTSW	12	119,224,841 (GRCm39)	exon	noncoding transcript
X0024:Ncoa4-ps	UTSW	12	119,225,419 (GRCm39)	exon	noncoding transcript

Predicted Primers

PCR Primer
(F):5'- CTCTGCCCTTCCAGAAATGAGC -3'
(R):5'- AGAGATCACAAACTGCTGGG -3'

Sequencing Primer
(F):5'- CTAAGGCACCCAAGGCTATGG -3'
(R):5'- ATCACAAACTGCTGGGAGGCC -3'

Posted On

2016-11-21