Incidental Mutation 'R5755:Syngr3'
ID 445015
Institutional Source Beutler Lab
Gene Symbol Syngr3
Ensembl Gene ENSMUSG00000007021
Gene Name synaptogyrin 3
Synonyms
MMRRC Submission 043202-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5755 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 24904066-24908923 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 24905509 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 155 (F155S)
Ref Sequence ENSEMBL: ENSMUSP00000007236 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000007236] [ENSMUST00000047179]
AlphaFold Q8R191
Predicted Effect probably damaging
Transcript: ENSMUST00000007236
AA Change: F155S

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000007236
Gene: ENSMUSG00000007021
AA Change: F155S

DomainStartEndE-ValueType
low complexity region 3 15 N/A INTRINSIC
Pfam:MARVEL 20 166 4.1e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000047179
SMART Domains Protein: ENSMUSP00000038367
Gene: ENSMUSG00000041130

DomainStartEndE-ValueType
low complexity region 2 23 N/A INTRINSIC
RING 27 66 4.73e-1 SMART
ZnF_C2H2 115 140 9.46e0 SMART
low complexity region 144 153 N/A INTRINSIC
ZnF_C2H2 185 208 5.2e0 SMART
ZnF_C2H2 209 237 7.11e0 SMART
ZnF_C2H2 238 268 6.47e1 SMART
low complexity region 311 331 N/A INTRINSIC
low complexity region 344 356 N/A INTRINSIC
low complexity region 371 385 N/A INTRINSIC
low complexity region 445 454 N/A INTRINSIC
low complexity region 482 501 N/A INTRINSIC
low complexity region 526 544 N/A INTRINSIC
low complexity region 581 589 N/A INTRINSIC
low complexity region 645 663 N/A INTRINSIC
low complexity region 668 683 N/A INTRINSIC
low complexity region 694 748 N/A INTRINSIC
ZnF_C2H2 869 890 8.84e1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130936
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an integral membrane protein. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it is a synaptic vesicle protein that also interacts with the dopamine transporter. The gene product belongs to the synaptogyrin gene family. [provided by RefSeq, Dec 2010]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca3 T A 17: 24,617,428 (GRCm39) F1042I probably damaging Het
Ahnak A G 19: 8,979,096 (GRCm39) T127A probably benign Het
Aloxe3 A G 11: 69,023,575 (GRCm39) I233V probably benign Het
Ambn T A 5: 88,612,350 (GRCm39) probably null Het
Atp2b1 A G 10: 98,839,032 (GRCm39) E39G probably damaging Het
Atp2b1 T C 10: 98,830,671 (GRCm39) probably null Het
Camsap2 C T 1: 136,210,065 (GRCm39) G476R probably damaging Het
Cdk4 T A 10: 126,900,591 (GRCm39) probably null Het
Dcaf12 T C 4: 41,313,356 (GRCm39) Y63C probably damaging Het
Dtna T A 18: 23,754,520 (GRCm39) S445T probably benign Het
Ehmt2 T C 17: 35,127,214 (GRCm39) M109T probably benign Het
Erbb4 T C 1: 68,599,678 (GRCm39) E133G possibly damaging Het
F830016B08Rik T A 18: 60,433,878 (GRCm39) F320L probably damaging Het
Fyco1 A G 9: 123,657,773 (GRCm39) V801A possibly damaging Het
Gm57858 A T 3: 36,071,842 (GRCm39) M501K probably benign Het
Jag1 T A 2: 136,930,610 (GRCm39) N674Y probably damaging Het
Kcnj10 A G 1: 172,197,161 (GRCm39) E225G possibly damaging Het
Klhl11 T A 11: 100,355,177 (GRCm39) M215L probably benign Het
Kmt2d G T 15: 98,761,527 (GRCm39) P608T unknown Het
Map3k19 T C 1: 127,750,118 (GRCm39) M1078V probably benign Het
Neto1 T C 18: 86,517,219 (GRCm39) V512A probably damaging Het
Notch1 T C 2: 26,363,704 (GRCm39) D910G probably benign Het
Or1e19 T A 11: 73,316,557 (GRCm39) N84I probably benign Het
Or2w1 T A 13: 21,317,695 (GRCm39) I250K probably damaging Het
Parvg T C 15: 84,215,297 (GRCm39) probably null Het
Pi4kb A T 3: 94,901,608 (GRCm39) probably null Het
Plag1 T C 4: 3,904,492 (GRCm39) K233R possibly damaging Het
Polr1h T A 17: 37,269,049 (GRCm39) D43V probably benign Het
Rasgrp3 A C 17: 75,831,940 (GRCm39) D587A probably benign Het
Slc7a10 A T 7: 34,898,336 (GRCm39) I336F probably damaging Het
Snx8 T G 5: 140,338,796 (GRCm39) E254A possibly damaging Het
Sp3 A T 2: 72,768,725 (GRCm39) silent Het
Sp8 G T 12: 118,812,822 (GRCm39) A226S probably damaging Het
Spata31d1c C A 13: 65,184,341 (GRCm39) Q628K probably benign Het
Styx C A 14: 45,605,910 (GRCm39) T138K probably benign Het
Trip11 C T 12: 101,851,924 (GRCm39) W428* probably null Het
Ubr4 A G 4: 139,187,406 (GRCm39) T3825A possibly damaging Het
Vmn2r113 A T 17: 23,176,955 (GRCm39) T580S probably benign Het
Zbtb11 T A 16: 55,821,076 (GRCm39) S724R probably benign Het
Zcchc4 T C 5: 52,973,511 (GRCm39) S379P probably benign Het
Other mutations in Syngr3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02554:Syngr3 APN 17 24,905,302 (GRCm39) missense probably benign 0.00
IGL02739:Syngr3 APN 17 24,905,372 (GRCm39) missense probably damaging 0.99
R0568:Syngr3 UTSW 17 24,905,555 (GRCm39) missense probably benign 0.00
R1019:Syngr3 UTSW 17 24,906,534 (GRCm39) missense possibly damaging 0.88
R1398:Syngr3 UTSW 17 24,905,414 (GRCm39) missense probably benign 0.00
R1547:Syngr3 UTSW 17 24,906,698 (GRCm39) missense probably damaging 0.98
R1564:Syngr3 UTSW 17 24,905,642 (GRCm39) splice site probably null
R1819:Syngr3 UTSW 17 24,906,696 (GRCm39) missense possibly damaging 0.85
R1946:Syngr3 UTSW 17 24,906,680 (GRCm39) missense probably benign 0.26
R4094:Syngr3 UTSW 17 24,908,817 (GRCm39) unclassified probably benign
R8033:Syngr3 UTSW 17 24,905,579 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TAGCTGATCTGTGGCAAAGAG -3'
(R):5'- AATGGCAATTTGCTGGTGAAC -3'

Sequencing Primer
(F):5'- GAGACATATCGGTGCCTAGGC -3'
(R):5'- GAACCTAAGGGACATTGCACTTTCTC -3'
Posted On 2016-11-21