Incidental Mutation 'R5759:Trim34b'
ID 445185
Institutional Source Beutler Lab
Gene Symbol Trim34b
Ensembl Gene ENSMUSG00000090215
Gene Name tripartite motif-containing 34B
Synonyms Trim34-2, Gm15134
MMRRC Submission 043361-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.180) question?
Stock # R5759 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 103978678-103986116 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 103980640 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 243 (S243P)
Ref Sequence ENSEMBL: ENSMUSP00000136926 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106847] [ENSMUST00000180136]
AlphaFold J3QNR8
Predicted Effect possibly damaging
Transcript: ENSMUST00000106847
AA Change: S243P

PolyPhen 2 Score 0.463 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000102460
Gene: ENSMUSG00000090215
AA Change: S243P

DomainStartEndE-ValueType
RING 15 58 7.8e-7 SMART
ZnF_RBZ 31 61 5.96e-1 SMART
BBOX 91 132 2.15e-9 SMART
low complexity region 195 209 N/A INTRINSIC
Blast:PRY 299 343 3e-21 BLAST
Pfam:SPRY 347 474 7.8e-12 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000178316
AA Change: S243P

PolyPhen 2 Score 0.463 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000136248
Gene: ENSMUSG00000090215
AA Change: S243P

DomainStartEndE-ValueType
RING 15 58 7.8e-7 SMART
ZnF_RBZ 31 61 5.96e-1 SMART
BBOX 91 132 2.15e-9 SMART
low complexity region 195 209 N/A INTRINSIC
Blast:PRY 299 343 3e-21 BLAST
Pfam:SPRY 345 484 3e-20 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000180136
AA Change: S243P

PolyPhen 2 Score 0.463 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000136926
Gene: ENSMUSG00000090215
AA Change: S243P

DomainStartEndE-ValueType
RING 15 58 7.8e-7 SMART
ZnF_RBZ 31 61 5.96e-1 SMART
BBOX 91 132 2.15e-9 SMART
low complexity region 195 209 N/A INTRINSIC
Blast:PRY 299 343 2e-21 BLAST
Pfam:SPRY 345 484 3e-20 PFAM
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 98.8%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik T C 3: 137,774,419 (GRCm39) S1203P probably benign Het
Adamts1 A G 16: 85,594,936 (GRCm39) V341A possibly damaging Het
Arf2 G A 11: 103,874,459 (GRCm39) G144S probably benign Het
Atr A G 9: 95,756,455 (GRCm39) N862D probably benign Het
Cep295nl T C 11: 118,224,472 (GRCm39) H124R possibly damaging Het
Chd6 C T 2: 160,825,682 (GRCm39) V1141I possibly damaging Het
Chst5 C A 8: 112,616,842 (GRCm39) K259N probably benign Het
Dchs1 T A 7: 105,413,383 (GRCm39) D1144V probably damaging Het
Dmxl2 T C 9: 54,282,792 (GRCm39) Y2795C probably damaging Het
Dnah7b A G 1: 46,316,280 (GRCm39) N3131S probably damaging Het
Dnah7c G A 1: 46,654,527 (GRCm39) G1436R probably damaging Het
Emp2 T A 16: 10,102,374 (GRCm39) Y146F probably damaging Het
Exoc6 C T 19: 37,562,189 (GRCm39) Q148* probably null Het
Fam13b T C 18: 34,630,488 (GRCm39) D90G probably damaging Het
Fam186b T G 15: 99,177,598 (GRCm39) Y576S probably benign Het
Fras1 T C 5: 96,857,775 (GRCm39) V2023A probably benign Het
Grm5 A C 7: 87,675,808 (GRCm39) M441L probably damaging Het
Hhatl A G 9: 121,617,343 (GRCm39) Y297H probably damaging Het
Ifi30 A G 8: 71,219,188 (GRCm39) probably benign Het
Ing2 G T 8: 48,122,040 (GRCm39) N169K possibly damaging Het
Kat6a T G 8: 23,428,028 (GRCm39) S1128A probably benign Het
Madd T C 2: 90,992,420 (GRCm39) E1041G possibly damaging Het
Mcm3 CT CTT 1: 20,878,972 (GRCm39) probably null Het
Mfsd5 G A 15: 102,189,513 (GRCm39) G295D possibly damaging Het
Minar1 A T 9: 89,483,125 (GRCm39) N757K probably benign Het
Mmp20 T A 9: 7,628,378 (GRCm39) probably null Het
Mybphl T C 3: 108,282,070 (GRCm39) V100A probably benign Het
Ndfip2 T A 14: 105,539,750 (GRCm39) probably null Het
Or7e170 A G 9: 19,795,484 (GRCm39) V39A probably benign Het
Or7e175 T A 9: 20,049,228 (GRCm39) V272E probably benign Het
Or8b1c T A 9: 38,384,831 (GRCm39) S263T possibly damaging Het
Phf19 T G 2: 34,787,135 (GRCm39) D443A probably damaging Het
Piezo1 A G 8: 123,234,394 (GRCm39) V84A probably damaging Het
Septin9 A G 11: 117,243,094 (GRCm39) I94V probably benign Het
Slc35a1 C A 4: 34,675,032 (GRCm39) V132L probably benign Het
Sntg1 G A 1: 8,484,494 (GRCm39) S442L probably benign Het
Tcf25 A G 8: 124,108,196 (GRCm39) T84A probably benign Het
Tchhl1 C G 3: 93,378,863 (GRCm39) S522R probably damaging Het
Tmem106b A G 6: 13,075,041 (GRCm39) E76G probably damaging Het
Tnk2 C T 16: 32,499,482 (GRCm39) P932S probably benign Het
Trib1 G A 15: 59,526,350 (GRCm39) V307I probably benign Het
Trib3 A T 2: 152,185,215 (GRCm39) D11E probably benign Het
Vmn2r50 A G 7: 9,781,905 (GRCm39) I280T probably damaging Het
Zfp1010 A T 2: 176,956,765 (GRCm39) C244* probably null Het
Zfp445 G T 9: 122,682,211 (GRCm39) Q577K probably benign Het
Zfp599 T C 9: 22,160,957 (GRCm39) K403E probably damaging Het
Other mutations in Trim34b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00975:Trim34b APN 7 103,978,859 (GRCm39) nonsense probably null
IGL01103:Trim34b APN 7 103,979,106 (GRCm39) missense probably damaging 1.00
IGL02252:Trim34b APN 7 103,979,139 (GRCm39) missense probably damaging 0.98
IGL03241:Trim34b APN 7 103,983,820 (GRCm39) intron probably benign
R0032:Trim34b UTSW 7 103,985,784 (GRCm39) missense possibly damaging 0.61
R0381:Trim34b UTSW 7 103,979,062 (GRCm39) missense probably damaging 1.00
R2403:Trim34b UTSW 7 103,978,876 (GRCm39) missense probably benign
R2520:Trim34b UTSW 7 103,980,446 (GRCm39) missense probably damaging 1.00
R2857:Trim34b UTSW 7 103,985,439 (GRCm39) missense probably benign 0.00
R2859:Trim34b UTSW 7 103,985,439 (GRCm39) missense probably benign 0.00
R3077:Trim34b UTSW 7 103,980,508 (GRCm39) missense possibly damaging 0.89
R4094:Trim34b UTSW 7 103,983,795 (GRCm39) missense probably benign
R4449:Trim34b UTSW 7 103,984,935 (GRCm39) missense probably benign 0.00
R5183:Trim34b UTSW 7 103,979,118 (GRCm39) missense possibly damaging 0.92
R5700:Trim34b UTSW 7 103,985,618 (GRCm39) missense probably damaging 1.00
R6236:Trim34b UTSW 7 103,985,525 (GRCm39) missense probably damaging 0.99
R6364:Trim34b UTSW 7 103,985,733 (GRCm39) missense probably damaging 0.99
R7034:Trim34b UTSW 7 103,978,743 (GRCm39) start gained probably benign
R7036:Trim34b UTSW 7 103,978,743 (GRCm39) start gained probably benign
R7237:Trim34b UTSW 7 103,978,794 (GRCm39) missense possibly damaging 0.80
R7392:Trim34b UTSW 7 103,985,604 (GRCm39) missense probably benign 0.00
R7405:Trim34b UTSW 7 103,985,690 (GRCm39) missense probably damaging 1.00
R7516:Trim34b UTSW 7 103,978,918 (GRCm39) missense probably damaging 1.00
R7646:Trim34b UTSW 7 103,984,559 (GRCm39) missense probably damaging 0.97
R7909:Trim34b UTSW 7 103,979,731 (GRCm39) missense probably benign 0.01
R8396:Trim34b UTSW 7 103,979,083 (GRCm39) missense probably damaging 1.00
R8472:Trim34b UTSW 7 103,980,545 (GRCm39) missense probably benign 0.00
R8806:Trim34b UTSW 7 103,985,319 (GRCm39) missense probably damaging 1.00
R9476:Trim34b UTSW 7 103,980,503 (GRCm39) missense probably damaging 1.00
R9510:Trim34b UTSW 7 103,980,503 (GRCm39) missense probably damaging 1.00
R9645:Trim34b UTSW 7 103,980,474 (GRCm39) missense probably benign 0.12
Z1176:Trim34b UTSW 7 103,984,521 (GRCm39) missense probably damaging 1.00
Z1177:Trim34b UTSW 7 103,980,560 (GRCm39) missense possibly damaging 0.79
Predicted Primers PCR Primer
(F):5'- GCTTTAATCAGCTTAGAAGAATCCTGG -3'
(R):5'- ACCCATGGCCATTATAGTCAGG -3'

Sequencing Primer
(F):5'- TCAGCTTAGAAGAATCCTGGACAAG -3'
(R):5'- TACCTTCTGCAGCCTGGGAAATG -3'
Posted On 2016-11-21