Incidental Mutation 'R5759:Or7e175'
ID 445194
Institutional Source Beutler Lab
Gene Symbol Or7e175
Ensembl Gene ENSMUSG00000058491
Gene Name olfactory receptor family 7 subfamily E member 175
Synonyms Olfr869, MOR145-6, GA_x6K02T2PVTD-13878275-13879204
MMRRC Submission 043361-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # R5759 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 20040305-20050059 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 20049228 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 272 (V272E)
Ref Sequence ENSEMBL: ENSMUSP00000154723 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075717] [ENSMUST00000213024]
AlphaFold A0A2I3BRV7
Predicted Effect probably benign
Transcript: ENSMUST00000075717
AA Change: V272E

PolyPhen 2 Score 0.124 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000075135
Gene: ENSMUSG00000049028
AA Change: V272E

DomainStartEndE-ValueType
Pfam:7tm_4 45 321 6.2e-43 PFAM
Pfam:7TM_GPCR_Srsx 49 309 3e-8 PFAM
Pfam:7tm_1 55 304 1.5e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212969
Predicted Effect probably benign
Transcript: ENSMUST00000213024
AA Change: V272E

PolyPhen 2 Score 0.124 (Sensitivity: 0.93; Specificity: 0.86)
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 98.8%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik T C 3: 137,774,419 (GRCm39) S1203P probably benign Het
Adamts1 A G 16: 85,594,936 (GRCm39) V341A possibly damaging Het
Arf2 G A 11: 103,874,459 (GRCm39) G144S probably benign Het
Atr A G 9: 95,756,455 (GRCm39) N862D probably benign Het
Cep295nl T C 11: 118,224,472 (GRCm39) H124R possibly damaging Het
Chd6 C T 2: 160,825,682 (GRCm39) V1141I possibly damaging Het
Chst5 C A 8: 112,616,842 (GRCm39) K259N probably benign Het
Dchs1 T A 7: 105,413,383 (GRCm39) D1144V probably damaging Het
Dmxl2 T C 9: 54,282,792 (GRCm39) Y2795C probably damaging Het
Dnah7b A G 1: 46,316,280 (GRCm39) N3131S probably damaging Het
Dnah7c G A 1: 46,654,527 (GRCm39) G1436R probably damaging Het
Emp2 T A 16: 10,102,374 (GRCm39) Y146F probably damaging Het
Exoc6 C T 19: 37,562,189 (GRCm39) Q148* probably null Het
Fam13b T C 18: 34,630,488 (GRCm39) D90G probably damaging Het
Fam186b T G 15: 99,177,598 (GRCm39) Y576S probably benign Het
Fras1 T C 5: 96,857,775 (GRCm39) V2023A probably benign Het
Grm5 A C 7: 87,675,808 (GRCm39) M441L probably damaging Het
Hhatl A G 9: 121,617,343 (GRCm39) Y297H probably damaging Het
Ifi30 A G 8: 71,219,188 (GRCm39) probably benign Het
Ing2 G T 8: 48,122,040 (GRCm39) N169K possibly damaging Het
Kat6a T G 8: 23,428,028 (GRCm39) S1128A probably benign Het
Madd T C 2: 90,992,420 (GRCm39) E1041G possibly damaging Het
Mcm3 CT CTT 1: 20,878,972 (GRCm39) probably null Het
Mfsd5 G A 15: 102,189,513 (GRCm39) G295D possibly damaging Het
Minar1 A T 9: 89,483,125 (GRCm39) N757K probably benign Het
Mmp20 T A 9: 7,628,378 (GRCm39) probably null Het
Mybphl T C 3: 108,282,070 (GRCm39) V100A probably benign Het
Ndfip2 T A 14: 105,539,750 (GRCm39) probably null Het
Or7e170 A G 9: 19,795,484 (GRCm39) V39A probably benign Het
Or8b1c T A 9: 38,384,831 (GRCm39) S263T possibly damaging Het
Phf19 T G 2: 34,787,135 (GRCm39) D443A probably damaging Het
Piezo1 A G 8: 123,234,394 (GRCm39) V84A probably damaging Het
Septin9 A G 11: 117,243,094 (GRCm39) I94V probably benign Het
Slc35a1 C A 4: 34,675,032 (GRCm39) V132L probably benign Het
Sntg1 G A 1: 8,484,494 (GRCm39) S442L probably benign Het
Tcf25 A G 8: 124,108,196 (GRCm39) T84A probably benign Het
Tchhl1 C G 3: 93,378,863 (GRCm39) S522R probably damaging Het
Tmem106b A G 6: 13,075,041 (GRCm39) E76G probably damaging Het
Tnk2 C T 16: 32,499,482 (GRCm39) P932S probably benign Het
Trib1 G A 15: 59,526,350 (GRCm39) V307I probably benign Het
Trib3 A T 2: 152,185,215 (GRCm39) D11E probably benign Het
Trim34b T C 7: 103,980,640 (GRCm39) S243P possibly damaging Het
Vmn2r50 A G 7: 9,781,905 (GRCm39) I280T probably damaging Het
Zfp1010 A T 2: 176,956,765 (GRCm39) C244* probably null Het
Zfp445 G T 9: 122,682,211 (GRCm39) Q577K probably benign Het
Zfp599 T C 9: 22,160,957 (GRCm39) K403E probably damaging Het
Other mutations in Or7e175
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00966:Or7e175 APN 9 20,048,531 (GRCm39) missense probably benign
IGL01550:Or7e175 APN 9 20,048,750 (GRCm39) missense probably damaging 0.97
IGL02247:Or7e175 APN 9 20,048,516 (GRCm39) missense probably benign 0.01
IGL02448:Or7e175 APN 9 20,048,937 (GRCm39) nonsense probably null
IGL03076:Or7e175 APN 9 20,049,023 (GRCm39) missense probably benign 0.25
R0045:Or7e175 UTSW 9 20,048,487 (GRCm39) missense probably benign 0.25
R0962:Or7e175 UTSW 9 20,048,834 (GRCm39) missense probably damaging 1.00
R4588:Or7e175 UTSW 9 20,049,383 (GRCm39) makesense probably null
R4931:Or7e175 UTSW 9 20,048,858 (GRCm39) missense probably benign 0.19
R5030:Or7e175 UTSW 9 20,049,363 (GRCm39) missense probably benign 0.01
R5780:Or7e175 UTSW 9 20,048,793 (GRCm39) missense probably damaging 0.98
R6440:Or7e175 UTSW 9 20,048,490 (GRCm39) missense probably damaging 1.00
R6599:Or7e175 UTSW 9 20,049,239 (GRCm39) missense probably damaging 1.00
R6710:Or7e175 UTSW 9 20,049,378 (GRCm39) missense probably benign 0.01
R6953:Or7e175 UTSW 9 20,049,299 (GRCm39) missense probably benign 0.00
R7288:Or7e175 UTSW 9 20,048,737 (GRCm39) nonsense probably null
R7585:Or7e175 UTSW 9 20,040,307 (GRCm39)
R7860:Or7e175 UTSW 9 20,048,871 (GRCm39) missense probably benign 0.16
R8025:Or7e175 UTSW 9 20,048,928 (GRCm39) missense probably benign 0.01
R8178:Or7e175 UTSW 9 20,048,571 (GRCm39) missense possibly damaging 0.94
R8794:Or7e175 UTSW 9 20,048,630 (GRCm39) missense possibly damaging 0.94
R8954:Or7e175 UTSW 9 20,048,664 (GRCm39) missense probably damaging 1.00
R9116:Or7e175 UTSW 9 20,048,633 (GRCm39) missense probably damaging 1.00
R9162:Or7e175 UTSW 9 20,040,457 (GRCm39) missense probably benign 0.00
R9269:Or7e175 UTSW 9 20,048,757 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAGTGGCATGGAAATCTCTAAC -3'
(R):5'- GAAGGCTTTATGGAATTATATGGCCC -3'

Sequencing Primer
(F):5'- CTGTTCTGAAATGTTCACCAAAAGC -3'
(R):5'- GAATTATATGGCCCTTCGCTGCAG -3'
Posted On 2016-11-21