Incidental Mutation 'R5760:Or10j7'
ID 445223
Institutional Source Beutler Lab
Gene Symbol Or10j7
Ensembl Gene ENSMUSG00000058981
Gene Name olfactory receptor family 10 subfamily J member 7
Synonyms GA_x6K02T2R7CC-664297-665229, MOR267-5, Olfr1406
MMRRC Submission 043362-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.081) question?
Stock # R5760 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 173011009-173012071 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 173011318 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Serine at position 228 (A228S)
Ref Sequence ENSEMBL: ENSMUSP00000151023 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072395] [ENSMUST00000201132] [ENSMUST00000215878]
AlphaFold E9Q8X1
Predicted Effect probably benign
Transcript: ENSMUST00000072395
AA Change: A228S

PolyPhen 2 Score 0.048 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000072231
Gene: ENSMUSG00000058981
AA Change: A228S

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 3.9e-55 PFAM
Pfam:7tm_1 41 289 2.7e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000201132
AA Change: A228S

PolyPhen 2 Score 0.048 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000144530
Gene: ENSMUSG00000058981
AA Change: A228S

DomainStartEndE-ValueType
Pfam:7tm_4 31 88 5.4e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215878
AA Change: A228S

PolyPhen 2 Score 0.048 (Sensitivity: 0.94; Specificity: 0.83)
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 98.8%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930447A16Rik T C 15: 37,439,835 (GRCm39) probably benign Het
Abl2 C T 1: 156,469,427 (GRCm39) T793M probably benign Het
Accs A C 2: 93,676,105 (GRCm39) L90R probably damaging Het
Ahnak A T 19: 8,990,926 (GRCm39) D4070V probably damaging Het
Apbb2 A G 5: 66,520,100 (GRCm39) V475A probably benign Het
Atp10d T A 5: 72,418,280 (GRCm39) V602E probably benign Het
Cdh23 C T 10: 60,242,171 (GRCm39) V1088M probably damaging Het
Dennd6a A T 14: 26,333,195 (GRCm39) I144L probably damaging Het
Dnajc6 G A 4: 101,475,839 (GRCm39) A571T probably benign Het
Drap1 A G 19: 5,474,391 (GRCm39) I18T probably damaging Het
En2 C A 5: 28,371,997 (GRCm39) A158D probably benign Het
Fbn1 C T 2: 125,203,167 (GRCm39) G1219R probably damaging Het
Fkbpl G A 17: 34,864,303 (GRCm39) A24T probably benign Het
Gm7535 C T 17: 18,132,080 (GRCm39) probably benign Het
Hao2 A T 3: 98,787,748 (GRCm39) L227* probably null Het
Hdlbp C T 1: 93,368,499 (GRCm39) probably benign Het
Hivep3 A G 4: 119,952,208 (GRCm39) K175E possibly damaging Het
Hmcn2 G A 2: 31,304,580 (GRCm39) A3075T possibly damaging Het
Igkv6-15 A T 6: 70,383,516 (GRCm39) I95N probably damaging Het
Itgad A T 7: 127,802,537 (GRCm39) Q1001L probably benign Het
Jaml T A 9: 45,009,052 (GRCm39) M151K probably benign Het
Lix1 T A 17: 17,647,499 (GRCm39) V55D possibly damaging Het
Macf1 A G 4: 123,407,677 (GRCm39) S179P probably damaging Het
Matn2 T A 15: 34,355,753 (GRCm39) Q33L possibly damaging Het
Mcm3 CT CTT 1: 20,878,972 (GRCm39) probably null Het
Mroh5 A C 15: 73,693,356 (GRCm39) I28S probably damaging Het
Naip5 T G 13: 100,379,346 (GRCm39) K231N probably damaging Het
Neb A C 2: 52,073,830 (GRCm39) Y5683D probably damaging Het
Npc1l1 A T 11: 6,179,031 (GRCm39) H126Q probably benign Het
Npm2 A G 14: 70,886,935 (GRCm39) F110L probably damaging Het
Nsd3 A T 8: 26,149,772 (GRCm39) H319L probably damaging Het
Nup205 G A 6: 35,224,278 (GRCm39) R2039Q probably damaging Het
Or6b2b A G 1: 92,418,922 (GRCm39) L185P possibly damaging Het
Or7d10 A C 9: 19,832,050 (GRCm39) T182P probably benign Het
Pcdhac2 G A 18: 37,279,453 (GRCm39) G811E probably damaging Het
Pkhd1 T A 1: 20,143,778 (GRCm39) R3849S probably benign Het
Pmfbp1 A T 8: 110,247,655 (GRCm39) D317V probably damaging Het
Sall1 T C 8: 89,755,278 (GRCm39) N1234D possibly damaging Het
Slc12a7 T A 13: 73,961,741 (GRCm39) V1037D probably damaging Het
Slc12a8 G T 16: 33,445,155 (GRCm39) E404* probably null Het
Tchhl1 C G 3: 93,378,863 (GRCm39) S522R probably damaging Het
Tgif1 A G 17: 71,151,996 (GRCm39) V152A probably damaging Het
Tshz3 C A 7: 36,470,994 (GRCm39) H994Q probably damaging Het
Ubash3b T G 9: 40,988,719 (GRCm39) K62T probably benign Het
Ushbp1 G T 8: 71,840,012 (GRCm39) D546E probably damaging Het
Zfp458 A C 13: 67,405,853 (GRCm39) C192W probably damaging Het
Zfp808 A T 13: 62,319,740 (GRCm39) H323L probably damaging Het
Other mutations in Or10j7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00946:Or10j7 APN 1 173,011,190 (GRCm39) missense probably benign 0.45
IGL01609:Or10j7 APN 1 173,011,843 (GRCm39) missense probably benign 0.00
IGL01996:Or10j7 APN 1 173,011,294 (GRCm39) missense probably benign 0.00
F5770:Or10j7 UTSW 1 173,011,531 (GRCm39) missense probably benign 0.05
PIT4378001:Or10j7 UTSW 1 173,011,381 (GRCm39) missense probably benign 0.00
R0053:Or10j7 UTSW 1 173,011,845 (GRCm39) missense probably benign 0.35
R0800:Or10j7 UTSW 1 173,011,627 (GRCm39) missense probably damaging 1.00
R1793:Or10j7 UTSW 1 173,011,976 (GRCm39) missense probably benign
R2230:Or10j7 UTSW 1 173,011,182 (GRCm39) missense probably benign 0.04
R2232:Or10j7 UTSW 1 173,011,182 (GRCm39) missense probably benign 0.04
R5395:Or10j7 UTSW 1 173,011,247 (GRCm39) nonsense probably null
R5455:Or10j7 UTSW 1 173,011,818 (GRCm39) missense probably damaging 1.00
R5457:Or10j7 UTSW 1 173,011,180 (GRCm39) missense probably damaging 1.00
R5558:Or10j7 UTSW 1 173,011,585 (GRCm39) missense probably benign 0.01
R6285:Or10j7 UTSW 1 173,011,477 (GRCm39) missense probably damaging 1.00
R7159:Or10j7 UTSW 1 173,011,890 (GRCm39) missense possibly damaging 0.95
R7676:Or10j7 UTSW 1 173,011,120 (GRCm39) nonsense probably null
R8700:Or10j7 UTSW 1 173,011,429 (GRCm39) missense probably benign
R8829:Or10j7 UTSW 1 173,011,458 (GRCm39) missense probably benign 0.06
R9721:Or10j7 UTSW 1 173,011,915 (GRCm39) missense probably benign 0.07
R9785:Or10j7 UTSW 1 173,011,458 (GRCm39) missense probably benign 0.06
R9788:Or10j7 UTSW 1 173,011,458 (GRCm39) missense probably benign 0.06
R9789:Or10j7 UTSW 1 173,011,458 (GRCm39) missense probably benign 0.06
V7580:Or10j7 UTSW 1 173,011,531 (GRCm39) missense probably benign 0.05
V7581:Or10j7 UTSW 1 173,011,531 (GRCm39) missense probably benign 0.05
V7582:Or10j7 UTSW 1 173,011,531 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- CCCAACACTTTTCGCAGAGC -3'
(R):5'- CACACTGATTGAACATTTCTTCTGC -3'

Sequencing Primer
(F):5'- TTTCGCAGAGCATCCTGGAC -3'
(R):5'- GATTGAACATTTCTTCTGCGATGTC -3'
Posted On 2016-11-21