Incidental Mutation 'R5772:Or10ag60'
ID 445425
Institutional Source Beutler Lab
Gene Symbol Or10ag60
Ensembl Gene ENSMUSG00000059205
Gene Name olfactory receptor family 10 subfamily AG member 60
Synonyms GA_x6K02T2Q125-49112575-49113519, Olfr1130, MOR264-4
Accession Numbers
Essential gene? Probably non essential (E-score: 0.176) question?
Stock # R5772 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 87436556-87438678 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 87438517 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 262 (T262S)
Ref Sequence ENSEMBL: ENSMUSP00000078649 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079711] [ENSMUST00000213103] [ENSMUST00000216580]
AlphaFold A0A1L1SQT2
Predicted Effect probably benign
Transcript: ENSMUST00000079711
AA Change: T262S

PolyPhen 2 Score 0.115 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000078649
Gene: ENSMUSG00000068814
AA Change: T262S

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 3.4e-52 PFAM
Pfam:7tm_1 47 296 1.3e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213103
AA Change: T262S

PolyPhen 2 Score 0.095 (Sensitivity: 0.93; Specificity: 0.85)
Predicted Effect probably benign
Transcript: ENSMUST00000216580
AA Change: T262S

PolyPhen 2 Score 0.095 (Sensitivity: 0.93; Specificity: 0.85)
Meta Mutation Damage Score 0.0819 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency 98% (64/65)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932416K20Rik G A 8: 105,524,271 (GRCm39) noncoding transcript Het
Abcg8 A T 17: 84,994,127 (GRCm39) E48V probably damaging Het
Afap1l2 T C 19: 56,911,406 (GRCm39) T289A probably benign Het
Atf6 T A 1: 170,574,758 (GRCm39) D560V probably damaging Het
Bcl2l14 A T 6: 134,404,362 (GRCm39) K183N probably damaging Het
Carmil3 T C 14: 55,730,696 (GRCm39) L52P probably damaging Het
Cct3 T A 3: 88,208,274 (GRCm39) N61K probably damaging Het
Col18a1 A G 10: 77,002,177 (GRCm39) V10A unknown Het
Col26a1 G A 5: 136,876,420 (GRCm39) Q67* probably null Het
Cyp2d34 T C 15: 82,501,341 (GRCm39) D329G probably null Het
Dchs1 T A 7: 105,422,247 (GRCm39) I58F probably damaging Het
Ddx60 T C 8: 62,401,931 (GRCm39) L269P probably damaging Het
Dis3l2 G A 1: 86,806,154 (GRCm39) G325D probably damaging Het
Dync1h1 A T 12: 110,612,707 (GRCm39) K2861* probably null Het
Ednra A G 8: 78,401,696 (GRCm39) I198T possibly damaging Het
Ep300 T C 15: 81,524,115 (GRCm39) probably benign Het
Fam120a G A 13: 49,034,409 (GRCm39) P1068S probably benign Het
Fsip2 A T 2: 82,815,084 (GRCm39) M3606L probably benign Het
Garre1 A T 7: 33,953,413 (GRCm39) W238R probably damaging Het
Gm7713 T C 15: 59,866,492 (GRCm39) noncoding transcript Het
Gprin3 A T 6: 59,331,398 (GRCm39) V303D possibly damaging Het
Hmcn1 A T 1: 150,570,629 (GRCm39) V2178D possibly damaging Het
Hoxa11 A G 6: 52,222,380 (GRCm39) V107A possibly damaging Het
Iqub C A 6: 24,454,250 (GRCm39) M544I possibly damaging Het
Itgb4 A T 11: 115,879,258 (GRCm39) probably benign Het
Itpkb A G 1: 180,161,818 (GRCm39) probably benign Het
Kalrn A T 16: 33,796,190 (GRCm39) V1195E probably damaging Het
Kif12 C A 4: 63,084,178 (GRCm39) R608M probably damaging Het
Lcorl A T 5: 45,952,709 (GRCm39) probably null Het
Lrrc24 T C 15: 76,606,910 (GRCm39) E162G probably damaging Het
Med6 A G 12: 81,626,418 (GRCm39) S119P probably damaging Het
Mmab A C 5: 114,574,775 (GRCm39) L166R probably damaging Het
Myef2l A G 3: 10,153,566 (GRCm39) R112G probably damaging Het
Nom1 A G 5: 29,651,873 (GRCm39) K737R possibly damaging Het
Obscn T C 11: 58,946,970 (GRCm39) S4352G probably damaging Het
Or2w25 T A 11: 59,504,712 (GRCm39) D307E probably benign Het
Or4k35 A T 2: 111,100,057 (GRCm39) Y218* probably null Het
Or6d12 A C 6: 116,492,912 (GRCm39) D58A possibly damaging Het
Pdzrn3 G A 6: 101,149,275 (GRCm39) S351L probably benign Het
Pdzrn4 A T 15: 92,655,562 (GRCm39) E485V probably damaging Het
Prkdc T A 16: 15,597,252 (GRCm39) I2804K possibly damaging Het
Psg28 A G 7: 18,164,640 (GRCm39) L24P probably damaging Het
Resp18 A G 1: 75,250,644 (GRCm39) V145A possibly damaging Het
Rgl3 T C 9: 21,892,908 (GRCm39) M259V probably benign Het
Rhot2 A T 17: 26,058,781 (GRCm39) S540T probably benign Het
Ring1 T C 17: 34,241,282 (GRCm39) Y278C possibly damaging Het
Rpn2 A G 2: 157,137,265 (GRCm39) Y216C probably damaging Het
Scgb2b18 G A 7: 32,873,255 (GRCm39) L5F unknown Het
Slamf7 T C 1: 171,466,838 (GRCm39) probably null Het
Slc22a12 T C 19: 6,590,479 (GRCm39) N237S possibly damaging Het
Spen A T 4: 141,205,495 (GRCm39) V1044D unknown Het
Sqor A T 2: 122,651,261 (GRCm39) M175L probably benign Het
Stx16 G A 2: 173,935,292 (GRCm39) G156R probably damaging Het
Tars3 T G 7: 65,333,873 (GRCm39) F632V probably damaging Het
Tln1 A G 4: 43,545,191 (GRCm39) V1008A probably benign Het
Tmem145 A G 7: 25,015,039 (GRCm39) H554R probably benign Het
Trank1 A T 9: 111,195,744 (GRCm39) D1256V possibly damaging Het
Trbv19 A G 6: 41,155,794 (GRCm39) Y55C possibly damaging Het
Ttc23l C T 15: 10,551,555 (GRCm39) C57Y probably benign Het
Uap1 A T 1: 169,988,949 (GRCm39) C158S probably benign Het
Zfp353-ps T A 8: 42,535,647 (GRCm39) noncoding transcript Het
Zfp629 T A 7: 127,210,307 (GRCm39) I501F probably damaging Het
Zfp820 T C 17: 22,037,702 (GRCm39) Y542C probably damaging Het
Other mutations in Or10ag60
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01151:Or10ag60 APN 2 87,438,323 (GRCm39) missense probably damaging 1.00
IGL01310:Or10ag60 APN 2 87,437,852 (GRCm39) missense possibly damaging 0.68
IGL02558:Or10ag60 APN 2 87,437,903 (GRCm39) missense probably benign 0.00
R0323:Or10ag60 UTSW 2 87,437,841 (GRCm39) missense probably benign
R0590:Or10ag60 UTSW 2 87,438,338 (GRCm39) missense probably damaging 0.98
R0718:Or10ag60 UTSW 2 87,438,271 (GRCm39) missense probably benign 0.08
R2445:Or10ag60 UTSW 2 87,438,302 (GRCm39) missense probably damaging 0.99
R3408:Or10ag60 UTSW 2 87,438,220 (GRCm39) missense probably benign 0.03
R4280:Or10ag60 UTSW 2 87,438,595 (GRCm39) missense possibly damaging 0.90
R4491:Or10ag60 UTSW 2 87,437,736 (GRCm39) start codon destroyed probably null 0.84
R4928:Or10ag60 UTSW 2 87,438,487 (GRCm39) missense probably benign 0.06
R5033:Or10ag60 UTSW 2 87,438,055 (GRCm39) missense probably damaging 1.00
R5061:Or10ag60 UTSW 2 87,438,176 (GRCm39) missense probably benign 0.00
R5109:Or10ag60 UTSW 2 87,438,319 (GRCm39) missense possibly damaging 0.78
R5109:Or10ag60 UTSW 2 87,437,755 (GRCm39) missense possibly damaging 0.64
R6004:Or10ag60 UTSW 2 87,438,253 (GRCm39) missense probably damaging 1.00
R6005:Or10ag60 UTSW 2 87,438,424 (GRCm39) missense probably damaging 0.97
R6411:Or10ag60 UTSW 2 87,438,317 (GRCm39) missense probably damaging 1.00
R6964:Or10ag60 UTSW 2 87,437,957 (GRCm39) missense probably damaging 1.00
R7085:Or10ag60 UTSW 2 87,437,750 (GRCm39) missense probably benign 0.00
R7484:Or10ag60 UTSW 2 87,438,281 (GRCm39) missense probably damaging 1.00
R8429:Or10ag60 UTSW 2 87,437,868 (GRCm39) missense probably benign 0.06
R8471:Or10ag60 UTSW 2 87,437,989 (GRCm39) missense probably damaging 0.99
R8485:Or10ag60 UTSW 2 87,438,601 (GRCm39) missense probably benign 0.00
R8890:Or10ag60 UTSW 2 87,438,412 (GRCm39) missense probably damaging 1.00
R8935:Or10ag60 UTSW 2 87,438,421 (GRCm39) missense possibly damaging 0.72
X0060:Or10ag60 UTSW 2 87,438,386 (GRCm39) missense probably benign 0.11
Z1176:Or10ag60 UTSW 2 87,438,098 (GRCm39) missense probably benign 0.34
Predicted Primers PCR Primer
(F):5'- ACCACCCATTCTCAAGCTGG -3'
(R):5'- TCATCATTTGTTCCAGAGCTCTAAGC -3'

Sequencing Primer
(F):5'- ATTCTCAAGCTGGCCTGCG -3'
(R):5'- GCTCTAAGCACTACTTGATACGTAAC -3'
Posted On 2016-11-21