Incidental Mutation 'R5744:Prdm16'
| ID |
445707 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Prdm16
|
| Ensembl Gene |
ENSMUSG00000039410 |
| Gene Name |
PR domain containing 16 |
| Synonyms |
line 27, Mel1, 5730557K01Rik, csp1 |
| MMRRC Submission |
043197-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.700)
|
| Stock # |
R5744 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
154400582-154721330 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 154613161 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 89
(S89P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000117598
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000030902]
[ENSMUST00000070313]
[ENSMUST00000097759]
[ENSMUST00000105636]
[ENSMUST00000105637]
[ENSMUST00000105638]
[ENSMUST00000124771]
|
| AlphaFold |
A2A935 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000030902
AA Change: S89P
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000030902
Gene: ENSMUSG00000039410
AA Change: S89P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
44 |
57 |
N/A |
INTRINSIC |
|
low complexity region
|
74 |
83 |
N/A |
INTRINSIC |
|
SET
|
84 |
217 |
8.75e-5 |
SMART |
|
ZnF_C2H2
|
230 |
250 |
2.82e1 |
SMART |
|
low complexity region
|
260 |
274 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
282 |
304 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
310 |
332 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
338 |
361 |
3.95e-4 |
SMART |
|
ZnF_C2H2
|
367 |
389 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
395 |
417 |
8.22e-2 |
SMART |
|
ZnF_C2H2
|
424 |
451 |
9.96e0 |
SMART |
|
low complexity region
|
496 |
517 |
N/A |
INTRINSIC |
|
low complexity region
|
520 |
540 |
N/A |
INTRINSIC |
|
low complexity region
|
610 |
641 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
951 |
973 |
5.29e-5 |
SMART |
|
ZnF_C2H2
|
979 |
1002 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
1008 |
1030 |
7.26e-3 |
SMART |
|
low complexity region
|
1116 |
1132 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000070313
AA Change: S89P
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000064546
Gene: ENSMUSG00000039410
AA Change: S89P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
44 |
57 |
N/A |
INTRINSIC |
|
low complexity region
|
74 |
83 |
N/A |
INTRINSIC |
|
SET
|
84 |
218 |
8.75e-5 |
SMART |
|
ZnF_C2H2
|
231 |
251 |
2.82e1 |
SMART |
|
low complexity region
|
261 |
275 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
283 |
305 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
311 |
333 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
339 |
362 |
3.95e-4 |
SMART |
|
ZnF_C2H2
|
368 |
390 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
396 |
418 |
8.22e-2 |
SMART |
|
ZnF_C2H2
|
425 |
452 |
9.96e0 |
SMART |
|
low complexity region
|
497 |
518 |
N/A |
INTRINSIC |
|
low complexity region
|
521 |
541 |
N/A |
INTRINSIC |
|
low complexity region
|
611 |
642 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
953 |
975 |
5.29e-5 |
SMART |
|
ZnF_C2H2
|
981 |
1004 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
1010 |
1032 |
7.26e-3 |
SMART |
|
low complexity region
|
1118 |
1134 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000097759
AA Change: S89P
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000095365
Gene: ENSMUSG00000039410
AA Change: S89P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
44 |
57 |
N/A |
INTRINSIC |
|
low complexity region
|
74 |
83 |
N/A |
INTRINSIC |
|
SET
|
84 |
217 |
8.75e-5 |
SMART |
|
ZnF_C2H2
|
230 |
250 |
2.82e1 |
SMART |
|
low complexity region
|
260 |
274 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
282 |
304 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
310 |
332 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
338 |
361 |
3.95e-4 |
SMART |
|
ZnF_C2H2
|
367 |
389 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
395 |
417 |
8.22e-2 |
SMART |
|
ZnF_C2H2
|
424 |
451 |
9.96e0 |
SMART |
|
low complexity region
|
496 |
517 |
N/A |
INTRINSIC |
|
low complexity region
|
520 |
540 |
N/A |
INTRINSIC |
|
low complexity region
|
610 |
641 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
952 |
974 |
5.29e-5 |
SMART |
|
ZnF_C2H2
|
980 |
1003 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
1009 |
1031 |
7.26e-3 |
SMART |
|
low complexity region
|
1117 |
1133 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000105636
AA Change: S89P
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000101261
Gene: ENSMUSG00000039410
AA Change: S89P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
44 |
57 |
N/A |
INTRINSIC |
|
low complexity region
|
74 |
83 |
N/A |
INTRINSIC |
|
SET
|
84 |
218 |
8.75e-5 |
SMART |
|
ZnF_C2H2
|
231 |
251 |
2.82e1 |
SMART |
|
low complexity region
|
261 |
275 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
283 |
305 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
311 |
333 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
339 |
362 |
3.95e-4 |
SMART |
|
ZnF_C2H2
|
368 |
390 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
396 |
418 |
8.22e-2 |
SMART |
|
ZnF_C2H2
|
425 |
452 |
9.96e0 |
SMART |
|
low complexity region
|
497 |
518 |
N/A |
INTRINSIC |
|
low complexity region
|
521 |
541 |
N/A |
INTRINSIC |
|
low complexity region
|
611 |
642 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
952 |
974 |
5.29e-5 |
SMART |
|
ZnF_C2H2
|
980 |
1003 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
1009 |
1031 |
7.26e-3 |
SMART |
|
low complexity region
|
1117 |
1133 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000105637
AA Change: S89P
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000101262
Gene: ENSMUSG00000039410
AA Change: S89P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
44 |
57 |
N/A |
INTRINSIC |
|
low complexity region
|
74 |
83 |
N/A |
INTRINSIC |
|
SET
|
84 |
216 |
8.75e-5 |
SMART |
|
ZnF_C2H2
|
229 |
249 |
2.82e1 |
SMART |
|
low complexity region
|
259 |
273 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
281 |
303 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
309 |
331 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
337 |
360 |
3.95e-4 |
SMART |
|
ZnF_C2H2
|
366 |
388 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
394 |
416 |
8.22e-2 |
SMART |
|
ZnF_C2H2
|
423 |
450 |
9.96e0 |
SMART |
|
low complexity region
|
495 |
516 |
N/A |
INTRINSIC |
|
low complexity region
|
519 |
539 |
N/A |
INTRINSIC |
|
low complexity region
|
609 |
640 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
950 |
972 |
5.29e-5 |
SMART |
|
ZnF_C2H2
|
978 |
1001 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
1007 |
1029 |
7.26e-3 |
SMART |
|
low complexity region
|
1115 |
1131 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000105638
AA Change: S89P
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000101263
Gene: ENSMUSG00000039410
AA Change: S89P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
44 |
57 |
N/A |
INTRINSIC |
|
low complexity region
|
74 |
83 |
N/A |
INTRINSIC |
|
SET
|
84 |
217 |
8.75e-5 |
SMART |
|
ZnF_C2H2
|
230 |
250 |
2.82e1 |
SMART |
|
low complexity region
|
260 |
274 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
282 |
304 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
310 |
332 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
338 |
361 |
3.95e-4 |
SMART |
|
ZnF_C2H2
|
367 |
389 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
395 |
417 |
8.22e-2 |
SMART |
|
ZnF_C2H2
|
424 |
451 |
9.96e0 |
SMART |
|
low complexity region
|
496 |
517 |
N/A |
INTRINSIC |
|
low complexity region
|
520 |
540 |
N/A |
INTRINSIC |
|
low complexity region
|
610 |
641 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
952 |
974 |
5.29e-5 |
SMART |
|
ZnF_C2H2
|
980 |
1003 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
1009 |
1031 |
7.26e-3 |
SMART |
|
low complexity region
|
1117 |
1133 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000124771
AA Change: S89P
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000117598
Gene: ENSMUSG00000039410
AA Change: S89P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
44 |
57 |
N/A |
INTRINSIC |
|
low complexity region
|
74 |
83 |
N/A |
INTRINSIC |
|
SET
|
84 |
213 |
8.04e-4 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000135064
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000141164
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000149605
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 95.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mutant mice exhibit a cleft secondary palate, whitening of brown adipose tissue in older or fed a high-fat diet, and impaired adaptive thermogenesis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 41 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aldoart2 |
A |
G |
12: 55,612,131 (GRCm39) |
I19V |
possibly damaging |
Het |
| Ascc3 |
T |
C |
10: 50,586,977 (GRCm39) |
I943T |
probably benign |
Het |
| Btaf1 |
T |
C |
19: 36,981,890 (GRCm39) |
V1640A |
probably benign |
Het |
| Cep250 |
T |
C |
2: 155,823,394 (GRCm39) |
F1015S |
possibly damaging |
Het |
| Cgnl1 |
G |
T |
9: 71,537,957 (GRCm39) |
|
probably null |
Het |
| Csgalnact2 |
C |
T |
6: 118,103,197 (GRCm39) |
G255E |
probably damaging |
Het |
| Ctla2a |
C |
T |
13: 61,083,767 (GRCm39) |
|
probably null |
Het |
| Dip2c |
A |
T |
13: 9,618,441 (GRCm39) |
I497F |
probably damaging |
Het |
| Eif3f |
C |
A |
7: 108,537,624 (GRCm39) |
T179K |
probably damaging |
Het |
| Frem2 |
A |
G |
3: 53,563,380 (GRCm39) |
F376L |
probably damaging |
Het |
| Gemin4 |
A |
T |
11: 76,102,991 (GRCm39) |
F590Y |
probably damaging |
Het |
| Gemin5 |
C |
A |
11: 58,046,009 (GRCm39) |
C433F |
possibly damaging |
Het |
| Gm7694 |
C |
T |
1: 170,130,075 (GRCm39) |
|
probably null |
Het |
| Gpr158 |
G |
A |
2: 21,373,331 (GRCm39) |
G89R |
probably damaging |
Het |
| Herc1 |
C |
T |
9: 66,415,475 (GRCm39) |
P4817S |
probably damaging |
Het |
| Hs6st3 |
T |
C |
14: 119,375,852 (GRCm39) |
L9P |
possibly damaging |
Het |
| Igdcc3 |
TGCCGCCGCCGCCGCCGCCGC |
TGCCGCCGCCGCCGCCGC |
9: 65,048,770 (GRCm39) |
|
probably benign |
Het |
| Il1rap |
A |
C |
16: 26,498,974 (GRCm39) |
I158L |
probably benign |
Het |
| Itpr2 |
A |
G |
6: 146,277,649 (GRCm39) |
S640P |
probably damaging |
Het |
| Metrn |
A |
G |
17: 26,014,211 (GRCm39) |
V205A |
probably damaging |
Het |
| Mfhas1 |
C |
A |
8: 36,056,636 (GRCm39) |
D370E |
probably damaging |
Het |
| Mn1 |
T |
C |
5: 111,568,402 (GRCm39) |
S791P |
possibly damaging |
Het |
| Mtmr3 |
A |
G |
11: 4,437,679 (GRCm39) |
V925A |
possibly damaging |
Het |
| Neil1 |
T |
C |
9: 57,051,485 (GRCm39) |
T278A |
probably damaging |
Het |
| Nol8 |
A |
G |
13: 49,815,802 (GRCm39) |
N619D |
possibly damaging |
Het |
| Nup214 |
T |
C |
2: 31,900,308 (GRCm39) |
L879P |
probably damaging |
Het |
| Or2l5 |
A |
G |
16: 19,334,086 (GRCm39) |
I100T |
probably benign |
Het |
| Or7a37 |
T |
C |
10: 78,806,017 (GRCm39) |
F178S |
probably damaging |
Het |
| Or9k2 |
T |
C |
10: 129,998,661 (GRCm39) |
D178G |
possibly damaging |
Het |
| Plxna1 |
C |
T |
6: 89,311,664 (GRCm39) |
R947Q |
possibly damaging |
Het |
| Reln |
A |
C |
5: 22,311,081 (GRCm39) |
S277R |
probably null |
Het |
| Sel1l |
A |
T |
12: 91,776,754 (GRCm39) |
I746N |
possibly damaging |
Het |
| Slc2a8 |
C |
T |
2: 32,866,040 (GRCm39) |
D291N |
probably benign |
Het |
| Slc7a5 |
T |
C |
8: 122,615,121 (GRCm39) |
N242S |
probably benign |
Het |
| Smco3 |
T |
C |
6: 136,808,763 (GRCm39) |
N37S |
probably damaging |
Het |
| Sult1c2 |
T |
A |
17: 54,280,990 (GRCm39) |
K38* |
probably null |
Het |
| Tfap2b |
T |
C |
1: 19,289,445 (GRCm39) |
M190T |
probably benign |
Het |
| Tnpo2 |
T |
A |
8: 85,778,523 (GRCm39) |
Y623* |
probably null |
Het |
| Tomm70a |
G |
T |
16: 56,942,202 (GRCm39) |
|
probably benign |
Het |
| Ttyh2 |
T |
C |
11: 114,593,136 (GRCm39) |
|
probably null |
Het |
| Zbtb10 |
A |
G |
3: 9,329,623 (GRCm39) |
Y327C |
probably damaging |
Het |
|
| Other mutations in Prdm16 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00987:Prdm16
|
APN |
4 |
154,426,426 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL01517:Prdm16
|
APN |
4 |
154,412,882 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01810:Prdm16
|
APN |
4 |
154,432,384 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL02260:Prdm16
|
APN |
4 |
154,412,744 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02623:Prdm16
|
APN |
4 |
154,425,334 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02744:Prdm16
|
APN |
4 |
154,429,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0126:Prdm16
|
UTSW |
4 |
154,413,295 (GRCm39) |
splice site |
probably benign |
|
|
R0345:Prdm16
|
UTSW |
4 |
154,425,568 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0365:Prdm16
|
UTSW |
4 |
154,426,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0440:Prdm16
|
UTSW |
4 |
154,561,084 (GRCm39) |
splice site |
probably benign |
|
|
R0899:Prdm16
|
UTSW |
4 |
154,613,366 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1127:Prdm16
|
UTSW |
4 |
154,613,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1546:Prdm16
|
UTSW |
4 |
154,613,117 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1803:Prdm16
|
UTSW |
4 |
154,419,718 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2117:Prdm16
|
UTSW |
4 |
154,432,382 (GRCm39) |
missense |
probably null |
0.99 |
|
R3814:Prdm16
|
UTSW |
4 |
154,412,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4348:Prdm16
|
UTSW |
4 |
154,561,124 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4458:Prdm16
|
UTSW |
4 |
154,406,765 (GRCm39) |
missense |
probably benign |
|
|
R4557:Prdm16
|
UTSW |
4 |
154,613,284 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4581:Prdm16
|
UTSW |
4 |
154,407,810 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4584:Prdm16
|
UTSW |
4 |
154,422,140 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4627:Prdm16
|
UTSW |
4 |
154,451,697 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4926:Prdm16
|
UTSW |
4 |
154,426,009 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R5055:Prdm16
|
UTSW |
4 |
154,419,719 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R5152:Prdm16
|
UTSW |
4 |
154,430,559 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5257:Prdm16
|
UTSW |
4 |
154,451,671 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5258:Prdm16
|
UTSW |
4 |
154,451,671 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5368:Prdm16
|
UTSW |
4 |
154,429,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5464:Prdm16
|
UTSW |
4 |
154,430,601 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5640:Prdm16
|
UTSW |
4 |
154,426,367 (GRCm39) |
missense |
probably benign |
|
|
R5892:Prdm16
|
UTSW |
4 |
154,407,716 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R5938:Prdm16
|
UTSW |
4 |
154,432,411 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6380:Prdm16
|
UTSW |
4 |
154,425,824 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6784:Prdm16
|
UTSW |
4 |
154,407,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7097:Prdm16
|
UTSW |
4 |
154,429,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7181:Prdm16
|
UTSW |
4 |
154,613,094 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7197:Prdm16
|
UTSW |
4 |
154,425,967 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7273:Prdm16
|
UTSW |
4 |
154,429,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7379:Prdm16
|
UTSW |
4 |
154,613,316 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7641:Prdm16
|
UTSW |
4 |
154,429,901 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7704:Prdm16
|
UTSW |
4 |
154,425,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7751:Prdm16
|
UTSW |
4 |
154,412,756 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8048:Prdm16
|
UTSW |
4 |
154,405,339 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8225:Prdm16
|
UTSW |
4 |
154,439,702 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8503:Prdm16
|
UTSW |
4 |
154,426,009 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8683:Prdm16
|
UTSW |
4 |
154,613,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8880:Prdm16
|
UTSW |
4 |
154,613,370 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9257:Prdm16
|
UTSW |
4 |
154,422,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9259:Prdm16
|
UTSW |
4 |
154,430,525 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
RF008:Prdm16
|
UTSW |
4 |
154,426,452 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0010:Prdm16
|
UTSW |
4 |
154,407,834 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Prdm16
|
UTSW |
4 |
154,426,243 (GRCm39) |
missense |
probably damaging |
0.97 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCCTGGGAAATGTGACATTCG -3'
(R):5'- ATGTATGAACCTGACCCGGAC -3'
Sequencing Primer
(F):5'- GGAAATGTGACATTCGAACGCTCTC -3'
(R):5'- CTGACCCGGACCTGCTG -3'
|
| Posted On |
2016-11-21 |
Incidental Mutation