Mutagenetix > Incidental Mutation

Incidental Mutation 'R5746:Vmn2r11'

445780

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r11

Ensembl Gene

ENSMUSG00000091450

Gene Name

vomeronasal 2, receptor 11

Synonyms

EG384219

MMRRC Submission

043199-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.069) question?

Stock #

R5746 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

109194739-109207318 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 109201560 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 315 (T315S)

Ref Sequence

ENSEMBL: ENSMUSP00000133218 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164875]

AlphaFold

E9Q4X4

Predicted Effect

probably benign
Transcript: ENSMUST00000164875
AA Change: T315S

PolyPhen 2 Score 0.415 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000133218
Gene: ENSMUSG00000091450
AA Change: T315S

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	167	475	1.6e-29	PFAM
Pfam:NCD3G	520	574	9.1e-19	PFAM
Pfam:7tm_3	607	842	4.6e-55	PFAM

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.4%
20x: 95.6%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adora3	A	G	3: 105,815,126 (GRCm39)	E292G	possibly damaging	Het
Ank1	C	T	8: 23,606,612 (GRCm39)	T1187I	probably damaging	Het
Ankrd16	T	A	2: 11,789,178 (GRCm39)	I255K	probably damaging	Het
Atp6ap1l	T	C	13: 91,031,698 (GRCm39)	N328S	probably benign	Het
Cbln3	A	G	14: 56,120,601 (GRCm39)	S144P	probably damaging	Het
Cdh12	T	A	15: 21,358,810 (GRCm39)	L78Q	probably null	Het
Cpsf1	C	T	15: 76,484,037 (GRCm39)	R761H	probably benign	Het
Cyp2d10	T	G	15: 82,289,472 (GRCm39)	E213D	probably benign	Het
Gba2	T	C	4: 43,568,465 (GRCm39)		probably null	Het
Glb1l2	G	A	9: 26,708,086 (GRCm39)	A29V	probably benign	Het
Gm11149	C	T	9: 49,457,494 (GRCm39)	G393S	probably damaging	Het
Igkv6-29	C	A	6: 70,115,584 (GRCm39)	G70V	possibly damaging	Het
Kcnma1	T	C	14: 23,544,635 (GRCm39)	N574S	probably damaging	Het
Kdm2b	A	G	5: 123,017,427 (GRCm39)	V1099A	probably damaging	Het
Kel	C	T	6: 41,675,961 (GRCm39)	G243E	probably damaging	Het
Ly6g	A	T	15: 75,028,596 (GRCm39)	N19Y	possibly damaging	Het
Nexn	TCTTCCTTC	TCTTC	3: 151,948,513 (GRCm39)		probably benign	Het
Nod2	T	C	8: 89,390,970 (GRCm39)	S411P	probably damaging	Het
Plekha6	G	C	1: 133,200,045 (GRCm39)	R208P	possibly damaging	Het
Ptpn14	G	A	1: 189,578,610 (GRCm39)		probably null	Het
Smg6	G	A	11: 75,030,113 (GRCm39)	G211E	probably damaging	Het
Stx16	G	A	2: 173,935,292 (GRCm39)	G156R	probably damaging	Het
Tbc1d15	T	C	10: 115,046,184 (GRCm39)	S440G	probably damaging	Het
Tpm2	A	G	4: 43,519,731 (GRCm39)	V85A	possibly damaging	Het
Ttf1	G	T	2: 28,955,754 (GRCm39)	A373S	probably damaging	Het
Zcchc14	T	C	8: 122,331,378 (GRCm39)		probably benign	Het
Zfp146	T	C	7: 29,861,818 (GRCm39)	S75G	probably benign	Het
Zfp994	A	G	17: 22,420,254 (GRCm39)	Y232H	probably damaging	Het

Other mutations in Vmn2r11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00925:Vmn2r11	APN	5	109,194,885 (GRCm39)	missense	probably benign	0.00
IGL01677:Vmn2r11	APN	5	109,201,823 (GRCm39)	missense	possibly damaging	0.50
IGL02048:Vmn2r11	APN	5	109,202,658 (GRCm39)	missense	probably benign	0.00
IGL02559:Vmn2r11	APN	5	109,200,046 (GRCm39)	missense	probably damaging	0.98
IGL02879:Vmn2r11	APN	5	109,201,704 (GRCm39)	missense	possibly damaging	0.95
IGL03084:Vmn2r11	APN	5	109,207,209 (GRCm39)	missense	probably benign	0.00
IGL03163:Vmn2r11	APN	5	109,201,692 (GRCm39)	missense	probably benign	0.41
IGL03289:Vmn2r11	APN	5	109,196,788 (GRCm39)	splice site	probably benign
IGL03294:Vmn2r11	APN	5	109,201,935 (GRCm39)	missense	probably benign	0.22
R0233:Vmn2r11	UTSW	5	109,201,968 (GRCm39)	missense	probably benign	0.16
R0233:Vmn2r11	UTSW	5	109,201,968 (GRCm39)	missense	probably benign	0.16
R0421:Vmn2r11	UTSW	5	109,207,294 (GRCm39)	missense	probably benign	0.00
R0549:Vmn2r11	UTSW	5	109,199,963 (GRCm39)	missense	possibly damaging	0.80
R0628:Vmn2r11	UTSW	5	109,195,597 (GRCm39)	missense	possibly damaging	0.88
R1523:Vmn2r11	UTSW	5	109,201,707 (GRCm39)	missense	probably benign	0.25
R1660:Vmn2r11	UTSW	5	109,201,724 (GRCm39)	missense	possibly damaging	0.79
R1827:Vmn2r11	UTSW	5	109,199,938 (GRCm39)	missense	probably benign	0.01
R1913:Vmn2r11	UTSW	5	109,202,654 (GRCm39)	missense	probably benign
R2260:Vmn2r11	UTSW	5	109,201,657 (GRCm39)	nonsense	probably null
R2400:Vmn2r11	UTSW	5	109,199,928 (GRCm39)	missense	probably benign	0.03
R3933:Vmn2r11	UTSW	5	109,201,260 (GRCm39)	missense	probably damaging	0.97
R4091:Vmn2r11	UTSW	5	109,202,616 (GRCm39)	critical splice donor site	probably null
R4624:Vmn2r11	UTSW	5	109,200,101 (GRCm39)	missense	probably damaging	0.99
R4762:Vmn2r11	UTSW	5	109,195,436 (GRCm39)	missense	probably damaging	1.00
R5256:Vmn2r11	UTSW	5	109,202,658 (GRCm39)	missense	probably benign	0.26
R5370:Vmn2r11	UTSW	5	109,195,421 (GRCm39)	missense	probably damaging	1.00
R5419:Vmn2r11	UTSW	5	109,207,224 (GRCm39)	missense	possibly damaging	0.55
R5516:Vmn2r11	UTSW	5	109,195,032 (GRCm39)	missense	probably damaging	0.98
R5643:Vmn2r11	UTSW	5	109,194,869 (GRCm39)	missense	probably damaging	1.00
R5671:Vmn2r11	UTSW	5	109,202,772 (GRCm39)	missense	probably benign	0.03
R5679:Vmn2r11	UTSW	5	109,202,708 (GRCm39)	missense	probably benign	0.00
R5739:Vmn2r11	UTSW	5	109,207,114 (GRCm39)	critical splice donor site	probably null
R5995:Vmn2r11	UTSW	5	109,194,921 (GRCm39)	missense	probably damaging	1.00
R6147:Vmn2r11	UTSW	5	109,202,700 (GRCm39)	missense	probably benign	0.04
R6220:Vmn2r11	UTSW	5	109,201,434 (GRCm39)	missense	probably benign	0.09
R6374:Vmn2r11	UTSW	5	109,201,679 (GRCm39)	missense	possibly damaging	0.65
R6491:Vmn2r11	UTSW	5	109,196,800 (GRCm39)	missense	possibly damaging	0.95
R6804:Vmn2r11	UTSW	5	109,201,350 (GRCm39)	missense	probably damaging	1.00
R6814:Vmn2r11	UTSW	5	109,194,976 (GRCm39)	missense	possibly damaging	0.81
R6872:Vmn2r11	UTSW	5	109,194,976 (GRCm39)	missense	possibly damaging	0.81
R7014:Vmn2r11	UTSW	5	109,201,289 (GRCm39)	missense	probably damaging	1.00
R7041:Vmn2r11	UTSW	5	109,202,816 (GRCm39)	missense	probably damaging	1.00
R7043:Vmn2r11	UTSW	5	109,200,098 (GRCm39)	missense	probably benign	0.00
R7050:Vmn2r11	UTSW	5	109,202,657 (GRCm39)	missense	probably benign	0.05
R7184:Vmn2r11	UTSW	5	109,201,281 (GRCm39)	missense	probably damaging	1.00
R7388:Vmn2r11	UTSW	5	109,202,742 (GRCm39)	missense	probably benign	0.05
R7477:Vmn2r11	UTSW	5	109,207,214 (GRCm39)	missense	possibly damaging	0.67
R7524:Vmn2r11	UTSW	5	109,201,848 (GRCm39)	missense	probably benign	0.01
R7682:Vmn2r11	UTSW	5	109,195,481 (GRCm39)	missense	probably benign	0.02
R7715:Vmn2r11	UTSW	5	109,195,307 (GRCm39)	missense	probably damaging	0.99
R7869:Vmn2r11	UTSW	5	109,199,986 (GRCm39)	missense	probably damaging	1.00
R8094:Vmn2r11	UTSW	5	109,201,626 (GRCm39)	missense	probably damaging	1.00
R8277:Vmn2r11	UTSW	5	109,202,833 (GRCm39)	missense	probably benign	0.00
R8506:Vmn2r11	UTSW	5	109,207,270 (GRCm39)	missense	probably benign	0.00
R8676:Vmn2r11	UTSW	5	109,201,626 (GRCm39)	missense	probably damaging	1.00
R8701:Vmn2r11	UTSW	5	109,195,556 (GRCm39)	missense	probably damaging	1.00
R8749:Vmn2r11	UTSW	5	109,195,319 (GRCm39)	missense	probably damaging	0.97
R9046:Vmn2r11	UTSW	5	109,202,850 (GRCm39)	missense	probably benign	0.00
R9138:Vmn2r11	UTSW	5	109,201,904 (GRCm39)	missense	probably damaging	1.00
R9267:Vmn2r11	UTSW	5	109,199,929 (GRCm39)	missense	possibly damaging	0.93
R9306:Vmn2r11	UTSW	5	109,196,831 (GRCm39)	missense	probably damaging	1.00
R9384:Vmn2r11	UTSW	5	109,201,266 (GRCm39)	missense	probably damaging	1.00
R9443:Vmn2r11	UTSW	5	109,195,159 (GRCm39)	nonsense	probably null
R9520:Vmn2r11	UTSW	5	109,201,455 (GRCm39)	missense	probably benign	0.35
R9596:Vmn2r11	UTSW	5	109,201,563 (GRCm39)	missense	possibly damaging	0.67
R9677:Vmn2r11	UTSW	5	109,201,332 (GRCm39)	missense

Predicted Primers

PCR Primer
(F):5'- TGCTGTCCATTCCGATGTG -3'
(R):5'- CATGCAGATATACATGACAAGGGC -3'

Sequencing Primer
(F):5'- CCATTTTGCTATAGCTGTTCATTGAG -3'
(R):5'- CAGCTTTAGAAGGTGGGA -3'

Posted On

2016-11-21