Incidental Mutation 'R5749:Or6c38'
ID 445930
Institutional Source Beutler Lab
Gene Symbol Or6c38
Ensembl Gene ENSMUSG00000050198
Gene Name olfactory receptor family 6 subfamily C member 38
Synonyms MOR114-4, Olfr768, GA_x6K02T2PULF-10779441-10778503
MMRRC Submission 043200-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R5749 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 128928903-128929841 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 128928966 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 292 (N292K)
Ref Sequence ENSEMBL: ENSMUSP00000089619 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063031]
AlphaFold Q8VGC4
Predicted Effect probably damaging
Transcript: ENSMUST00000063031
AA Change: N292K

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000089619
Gene: ENSMUSG00000050198
AA Change: N292K

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 5.7e-50 PFAM
Pfam:7tm_1 39 288 5e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216212
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216681
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsl6 G A 11: 54,214,881 (GRCm39) probably null Het
Ankrd12 T C 17: 66,293,091 (GRCm39) S781G probably benign Het
Bicc1 A G 10: 70,782,799 (GRCm39) S523P probably benign Het
Ccdc163 T A 4: 116,571,309 (GRCm39) C44* probably null Het
Ccdc83 T C 7: 89,873,156 (GRCm39) T400A probably damaging Het
Cobl A G 11: 12,216,965 (GRCm39) S426P possibly damaging Het
Cyp2b19 T C 7: 26,462,844 (GRCm39) I242T possibly damaging Het
Efnb2 A C 8: 8,689,347 (GRCm39) C92G probably damaging Het
Fam90a1a T A 8: 22,453,057 (GRCm39) S137R possibly damaging Het
Fbxo17 G A 7: 28,436,897 (GRCm39) R284H probably damaging Het
Fem1b A G 9: 62,704,288 (GRCm39) L324P probably damaging Het
Fsd1 T A 17: 56,302,849 (GRCm39) probably null Het
Gtpbp4 A G 13: 9,045,983 (GRCm39) probably null Het
Ifi209 A C 1: 173,464,893 (GRCm39) I8L probably damaging Het
Itga8 T C 2: 12,266,889 (GRCm39) E182G probably damaging Het
Itsn1 T A 16: 91,703,743 (GRCm39) L87H probably damaging Het
Klk1b16 T C 7: 43,790,210 (GRCm39) I160T probably benign Het
Lbp T A 2: 158,161,673 (GRCm39) V52D probably damaging Het
Med23 T C 10: 24,764,347 (GRCm39) V318A possibly damaging Het
Myo16 C T 8: 10,463,245 (GRCm39) S604L probably benign Het
Or10ag52 C T 2: 87,043,287 (GRCm39) T17I probably benign Het
Or10g1 T A 14: 52,647,961 (GRCm39) M123L probably damaging Het
Or5b12 A G 19: 12,897,589 (GRCm39) V28A probably benign Het
Pcdh8 T C 14: 80,007,525 (GRCm39) D346G probably damaging Het
Ppara A T 15: 85,673,229 (GRCm39) D140V probably benign Het
Prlr T A 15: 10,328,804 (GRCm39) D426E probably benign Het
Prss36 T A 7: 127,532,814 (GRCm39) I192F probably damaging Het
Psg25 T C 7: 18,258,776 (GRCm39) E300G probably damaging Het
Pxylp1 A G 9: 96,738,424 (GRCm39) F26L possibly damaging Het
Rapgef4 A T 2: 72,073,101 (GRCm39) T796S probably damaging Het
Stard9 A G 2: 120,534,267 (GRCm39) H3508R probably damaging Het
Tep1 T A 14: 51,081,529 (GRCm39) D1282V possibly damaging Het
Tgfbr3l A G 8: 4,299,310 (GRCm39) E59G probably damaging Het
Tnik T C 3: 28,648,241 (GRCm39) M431T probably benign Het
Tns3 A T 11: 8,401,177 (GRCm39) H1040Q probably benign Het
Usp10 G A 8: 120,667,872 (GRCm39) E58K probably damaging Het
Vmn2r23 A G 6: 123,710,232 (GRCm39) T512A probably benign Het
Vmn2r52 C T 7: 9,892,959 (GRCm39) D727N probably damaging Het
Vmn2r66 T A 7: 84,655,979 (GRCm39) K346* probably null Het
Vmn2r93 T A 17: 18,518,546 (GRCm39) F2I probably benign Het
Zfp697 T C 3: 98,332,780 (GRCm39) S69P probably benign Het
Zftraf1 A C 15: 76,542,844 (GRCm39) probably null Het
Other mutations in Or6c38
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00902:Or6c38 APN 10 128,929,265 (GRCm39) missense probably benign 0.08
IGL01947:Or6c38 APN 10 128,929,747 (GRCm39) missense possibly damaging 0.52
IGL03026:Or6c38 APN 10 128,929,057 (GRCm39) missense possibly damaging 0.60
R1353:Or6c38 UTSW 10 128,929,733 (GRCm39) missense probably benign 0.14
R1426:Or6c38 UTSW 10 128,929,559 (GRCm39) missense probably damaging 1.00
R1766:Or6c38 UTSW 10 128,929,616 (GRCm39) missense probably benign 0.24
R2356:Or6c38 UTSW 10 128,929,761 (GRCm39) missense probably benign 0.40
R3522:Or6c38 UTSW 10 128,929,711 (GRCm39) missense possibly damaging 0.93
R3751:Or6c38 UTSW 10 128,929,175 (GRCm39) missense probably damaging 1.00
R3779:Or6c38 UTSW 10 128,929,165 (GRCm39) missense possibly damaging 0.94
R4582:Or6c38 UTSW 10 128,929,027 (GRCm39) missense possibly damaging 0.93
R4772:Or6c38 UTSW 10 128,929,537 (GRCm39) missense possibly damaging 0.92
R4792:Or6c38 UTSW 10 128,929,489 (GRCm39) missense probably damaging 1.00
R6571:Or6c38 UTSW 10 128,928,990 (GRCm39) missense probably damaging 0.98
R6619:Or6c38 UTSW 10 128,929,323 (GRCm39) missense possibly damaging 0.95
R7052:Or6c38 UTSW 10 128,929,744 (GRCm39) missense probably damaging 0.98
R7096:Or6c38 UTSW 10 128,929,715 (GRCm39) missense probably damaging 0.97
R7409:Or6c38 UTSW 10 128,929,081 (GRCm39) missense probably damaging 1.00
R7852:Or6c38 UTSW 10 128,929,385 (GRCm39) missense probably benign 0.45
R8332:Or6c38 UTSW 10 128,929,174 (GRCm39) missense possibly damaging 0.95
R9183:Or6c38 UTSW 10 128,929,201 (GRCm39) missense probably benign 0.06
R9245:Or6c38 UTSW 10 128,929,472 (GRCm39) missense probably damaging 1.00
X0024:Or6c38 UTSW 10 128,929,216 (GRCm39) missense probably damaging 1.00
X0024:Or6c38 UTSW 10 128,928,984 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- AAGGTGTGTTTTCCCACCTC -3'
(R):5'- TTATCAGAACCATCCTCAGATTCCC -3'

Sequencing Primer
(F):5'- CTGTTAACCTATAATCCCTCACAATC -3'
(R):5'- TCAGATTCCCATCAGCCCAG -3'
Posted On 2016-11-21