Mutagenetix > Incidental Mutation

Incidental Mutation 'R5749:Vmn2r93'

445940

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r93

Ensembl Gene

ENSMUSG00000079698

Gene Name

vomeronasal 2, receptor 93

Synonyms

EG627132

MMRRC Submission

043200-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.084) question?

Stock #

R5749 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

18518543-18546703 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 18518546 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Isoleucine at position 2 (F2I)

Ref Sequence

ENSEMBL: ENSMUSP00000156230 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079206] [ENSMUST00000231879] [ENSMUST00000231938]

AlphaFold

L7N1Z9

Predicted Effect

probably benign
Transcript: ENSMUST00000079206
AA Change: F2I

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000078200
Gene: ENSMUSG00000079698
AA Change: F2I

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	453	5.9e-40	PFAM
Pfam:NCD3G	509	562	2.6e-21	PFAM
Pfam:7tm_3	594	830	1.5e-50	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000231879
AA Change: F2I

PolyPhen 2 Score 0.062 (Sensitivity: 0.94; Specificity: 0.84)

Predicted Effect

probably benign
Transcript: ENSMUST00000231938
AA Change: F2I

PolyPhen 2 Score 0.046 (Sensitivity: 0.94; Specificity: 0.83)

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.3%
20x: 95.5%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsl6	G	A	11: 54,214,881 (GRCm39)		probably null	Het
Ankrd12	T	C	17: 66,293,091 (GRCm39)	S781G	probably benign	Het
Bicc1	A	G	10: 70,782,799 (GRCm39)	S523P	probably benign	Het
Ccdc163	T	A	4: 116,571,309 (GRCm39)	C44*	probably null	Het
Ccdc83	T	C	7: 89,873,156 (GRCm39)	T400A	probably damaging	Het
Cobl	A	G	11: 12,216,965 (GRCm39)	S426P	possibly damaging	Het
Cyp2b19	T	C	7: 26,462,844 (GRCm39)	I242T	possibly damaging	Het
Efnb2	A	C	8: 8,689,347 (GRCm39)	C92G	probably damaging	Het
Fam90a1a	T	A	8: 22,453,057 (GRCm39)	S137R	possibly damaging	Het
Fbxo17	G	A	7: 28,436,897 (GRCm39)	R284H	probably damaging	Het
Fem1b	A	G	9: 62,704,288 (GRCm39)	L324P	probably damaging	Het
Fsd1	T	A	17: 56,302,849 (GRCm39)		probably null	Het
Gtpbp4	A	G	13: 9,045,983 (GRCm39)		probably null	Het
Ifi209	A	C	1: 173,464,893 (GRCm39)	I8L	probably damaging	Het
Itga8	T	C	2: 12,266,889 (GRCm39)	E182G	probably damaging	Het
Itsn1	T	A	16: 91,703,743 (GRCm39)	L87H	probably damaging	Het
Klk1b16	T	C	7: 43,790,210 (GRCm39)	I160T	probably benign	Het
Lbp	T	A	2: 158,161,673 (GRCm39)	V52D	probably damaging	Het
Med23	T	C	10: 24,764,347 (GRCm39)	V318A	possibly damaging	Het
Myo16	C	T	8: 10,463,245 (GRCm39)	S604L	probably benign	Het
Or10ag52	C	T	2: 87,043,287 (GRCm39)	T17I	probably benign	Het
Or10g1	T	A	14: 52,647,961 (GRCm39)	M123L	probably damaging	Het
Or5b12	A	G	19: 12,897,589 (GRCm39)	V28A	probably benign	Het
Or6c38	A	T	10: 128,928,966 (GRCm39)	N292K	probably damaging	Het
Pcdh8	T	C	14: 80,007,525 (GRCm39)	D346G	probably damaging	Het
Ppara	A	T	15: 85,673,229 (GRCm39)	D140V	probably benign	Het
Prlr	T	A	15: 10,328,804 (GRCm39)	D426E	probably benign	Het
Prss36	T	A	7: 127,532,814 (GRCm39)	I192F	probably damaging	Het
Psg25	T	C	7: 18,258,776 (GRCm39)	E300G	probably damaging	Het
Pxylp1	A	G	9: 96,738,424 (GRCm39)	F26L	possibly damaging	Het
Rapgef4	A	T	2: 72,073,101 (GRCm39)	T796S	probably damaging	Het
Stard9	A	G	2: 120,534,267 (GRCm39)	H3508R	probably damaging	Het
Tep1	T	A	14: 51,081,529 (GRCm39)	D1282V	possibly damaging	Het
Tgfbr3l	A	G	8: 4,299,310 (GRCm39)	E59G	probably damaging	Het
Tnik	T	C	3: 28,648,241 (GRCm39)	M431T	probably benign	Het
Tns3	A	T	11: 8,401,177 (GRCm39)	H1040Q	probably benign	Het
Usp10	G	A	8: 120,667,872 (GRCm39)	E58K	probably damaging	Het
Vmn2r23	A	G	6: 123,710,232 (GRCm39)	T512A	probably benign	Het
Vmn2r52	C	T	7: 9,892,959 (GRCm39)	D727N	probably damaging	Het
Vmn2r66	T	A	7: 84,655,979 (GRCm39)	K346*	probably null	Het
Zfp697	T	C	3: 98,332,780 (GRCm39)	S69P	probably benign	Het
Zftraf1	A	C	15: 76,542,844 (GRCm39)		probably null	Het

Other mutations in Vmn2r93

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00743:Vmn2r93	APN	17	18,546,504 (GRCm39)	missense	probably damaging	1.00
IGL01326:Vmn2r93	APN	17	18,536,906 (GRCm39)	missense	possibly damaging	0.92
IGL01328:Vmn2r93	APN	17	18,545,819 (GRCm39)	missense	probably benign	0.00
IGL01360:Vmn2r93	APN	17	18,525,510 (GRCm39)	missense	possibly damaging	0.71
IGL01382:Vmn2r93	APN	17	18,533,578 (GRCm39)	nonsense	probably null
IGL01463:Vmn2r93	APN	17	18,525,150 (GRCm39)	missense	probably damaging	1.00
IGL02057:Vmn2r93	APN	17	18,546,032 (GRCm39)	missense	probably damaging	1.00
IGL02257:Vmn2r93	APN	17	18,545,770 (GRCm39)	unclassified	probably benign
IGL02686:Vmn2r93	APN	17	18,533,526 (GRCm39)	missense	possibly damaging	0.89
IGL02720:Vmn2r93	APN	17	18,525,296 (GRCm39)	missense	probably damaging	1.00
IGL03328:Vmn2r93	APN	17	18,525,220 (GRCm39)	missense	probably damaging	1.00
PIT4576001:Vmn2r93	UTSW	17	18,533,473 (GRCm39)	missense	probably benign
R0067:Vmn2r93	UTSW	17	18,546,672 (GRCm39)	missense	probably benign	0.00
R0067:Vmn2r93	UTSW	17	18,546,672 (GRCm39)	missense	probably benign	0.00
R0240:Vmn2r93	UTSW	17	18,525,061 (GRCm39)	missense	probably benign	0.00
R0240:Vmn2r93	UTSW	17	18,525,061 (GRCm39)	missense	probably benign	0.00
R0488:Vmn2r93	UTSW	17	18,546,311 (GRCm39)	missense	probably damaging	1.00
R0667:Vmn2r93	UTSW	17	18,546,503 (GRCm39)	missense	probably damaging	1.00
R0668:Vmn2r93	UTSW	17	18,518,667 (GRCm39)	missense	probably benign	0.00
R0850:Vmn2r93	UTSW	17	18,525,279 (GRCm39)	missense	possibly damaging	0.93
R0924:Vmn2r93	UTSW	17	18,524,443 (GRCm39)	missense	probably benign
R0947:Vmn2r93	UTSW	17	18,524,343 (GRCm39)	missense	probably benign	0.06
R1124:Vmn2r93	UTSW	17	18,518,710 (GRCm39)	missense	probably benign	0.00
R1584:Vmn2r93	UTSW	17	18,525,413 (GRCm39)	missense	possibly damaging	0.84
R1943:Vmn2r93	UTSW	17	18,546,063 (GRCm39)	missense	probably benign	0.04
R2012:Vmn2r93	UTSW	17	18,536,840 (GRCm39)	missense	probably benign	0.01
R2018:Vmn2r93	UTSW	17	18,546,324 (GRCm39)	missense	probably damaging	1.00
R2196:Vmn2r93	UTSW	17	18,525,428 (GRCm39)	missense	probably damaging	1.00
R2373:Vmn2r93	UTSW	17	18,518,665 (GRCm39)	missense	probably benign
R2864:Vmn2r93	UTSW	17	18,546,323 (GRCm39)	missense	probably damaging	1.00
R4276:Vmn2r93	UTSW	17	18,525,092 (GRCm39)	missense	possibly damaging	0.47
R4446:Vmn2r93	UTSW	17	18,524,312 (GRCm39)	missense	possibly damaging	0.93
R4537:Vmn2r93	UTSW	17	18,525,194 (GRCm39)	missense	possibly damaging	0.86
R4674:Vmn2r93	UTSW	17	18,525,255 (GRCm39)	missense	probably benign	0.34
R4726:Vmn2r93	UTSW	17	18,536,960 (GRCm39)	missense	probably damaging	1.00
R4936:Vmn2r93	UTSW	17	18,524,327 (GRCm39)	missense	possibly damaging	0.95
R4984:Vmn2r93	UTSW	17	18,533,389 (GRCm39)	splice site	probably null
R5111:Vmn2r93	UTSW	17	18,546,326 (GRCm39)	missense	probably damaging	0.99
R5918:Vmn2r93	UTSW	17	18,546,030 (GRCm39)	missense	probably damaging	1.00
R5921:Vmn2r93	UTSW	17	18,546,030 (GRCm39)	missense	probably damaging	1.00
R6091:Vmn2r93	UTSW	17	18,545,958 (GRCm39)	missense	probably benign	0.06
R6283:Vmn2r93	UTSW	17	18,524,366 (GRCm39)	missense	probably benign	0.02
R6680:Vmn2r93	UTSW	17	18,536,920 (GRCm39)	nonsense	probably null
R6876:Vmn2r93	UTSW	17	18,525,450 (GRCm39)	missense	probably benign	0.00
R6963:Vmn2r93	UTSW	17	18,536,849 (GRCm39)	missense	probably damaging	1.00
R6996:Vmn2r93	UTSW	17	18,524,903 (GRCm39)	missense	probably damaging	1.00
R7027:Vmn2r93	UTSW	17	18,533,548 (GRCm39)	missense	probably benign	0.01
R7034:Vmn2r93	UTSW	17	18,546,672 (GRCm39)	missense	probably benign	0.00
R7036:Vmn2r93	UTSW	17	18,546,672 (GRCm39)	missense	probably benign	0.00
R7246:Vmn2r93	UTSW	17	18,546,012 (GRCm39)	missense	possibly damaging	0.89
R7258:Vmn2r93	UTSW	17	18,525,403 (GRCm39)	missense	probably benign	0.32
R7323:Vmn2r93	UTSW	17	18,533,497 (GRCm39)	nonsense	probably null
R7325:Vmn2r93	UTSW	17	18,524,249 (GRCm39)	missense	probably benign	0.01
R7390:Vmn2r93	UTSW	17	18,525,329 (GRCm39)	missense	probably damaging	1.00
R7427:Vmn2r93	UTSW	17	18,546,672 (GRCm39)	missense	probably benign	0.00
R7428:Vmn2r93	UTSW	17	18,546,672 (GRCm39)	missense	probably benign	0.00
R7448:Vmn2r93	UTSW	17	18,546,248 (GRCm39)	missense	probably benign	0.19
R7453:Vmn2r93	UTSW	17	18,533,580 (GRCm39)	missense	probably benign	0.10
R7562:Vmn2r93	UTSW	17	18,518,731 (GRCm39)	missense	probably benign	0.01
R7662:Vmn2r93	UTSW	17	18,525,631 (GRCm39)	missense	probably benign	0.00
R7682:Vmn2r93	UTSW	17	18,525,583 (GRCm39)	missense	probably benign	0.03
R7704:Vmn2r93	UTSW	17	18,536,910 (GRCm39)	missense	probably benign	0.01
R7772:Vmn2r93	UTSW	17	18,533,482 (GRCm39)	missense	probably damaging	0.99
R7957:Vmn2r93	UTSW	17	18,545,954 (GRCm39)	nonsense	probably null
R8276:Vmn2r93	UTSW	17	18,525,649 (GRCm39)	critical splice donor site	probably null
R8290:Vmn2r93	UTSW	17	18,524,291 (GRCm39)	missense	probably damaging	1.00
R8362:Vmn2r93	UTSW	17	18,546,353 (GRCm39)	missense	probably benign	0.02
R8376:Vmn2r93	UTSW	17	18,525,230 (GRCm39)	missense	probably damaging	1.00
R8870:Vmn2r93	UTSW	17	18,525,320 (GRCm39)	missense	possibly damaging	0.91
R8925:Vmn2r93	UTSW	17	18,546,500 (GRCm39)	missense	probably damaging	0.99
R8927:Vmn2r93	UTSW	17	18,546,500 (GRCm39)	missense	probably damaging	0.99
R8954:Vmn2r93	UTSW	17	18,546,252 (GRCm39)	missense	probably damaging	0.99
R9038:Vmn2r93	UTSW	17	18,524,471 (GRCm39)	missense	probably benign
R9131:Vmn2r93	UTSW	17	18,546,143 (GRCm39)	missense	probably damaging	0.99
R9205:Vmn2r93	UTSW	17	18,524,281 (GRCm39)	missense	probably damaging	1.00
R9530:Vmn2r93	UTSW	17	18,518,562 (GRCm39)	missense	probably damaging	0.96
Z1088:Vmn2r93	UTSW	17	18,546,665 (GRCm39)	missense	probably damaging	1.00
Z1177:Vmn2r93	UTSW	17	18,525,600 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GGCCTCAGCACAAGAATCTAAG -3'
(R):5'- CGTAGCCATCCAAATATGTGTATGG -3'

Sequencing Primer
(F):5'- GGGAAAGGATAGCTTCAAAATTCCC -3'
(R):5'- GCCATCCAAATATGTGTATGGTATAG -3'

Posted On

2016-11-21