Incidental Mutation 'R5751:Vmn2r90'
ID 446020
Institutional Source Beutler Lab
Gene Symbol Vmn2r90
Ensembl Gene ENSMUSG00000092120
Gene Name vomeronasal 2, receptor 90
Synonyms EG626942
MMRRC Submission 043201-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.139) question?
Stock # R5751 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 17924203-17954429 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 17954128 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 764 (Y764C)
Ref Sequence ENSEMBL: ENSMUSP00000126650 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000169805] [ENSMUST00000231659] [ENSMUST00000232078] [ENSMUST00000232113]
AlphaFold E9PXJ8
Predicted Effect probably damaging
Transcript: ENSMUST00000169805
AA Change: Y764C

PolyPhen 2 Score 0.965 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000126650
Gene: ENSMUSG00000092120
AA Change: Y764C

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 77 471 1.8e-43 PFAM
Pfam:NCD3G 514 567 3e-22 PFAM
Pfam:7tm_3 600 835 9.8e-54 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000231659
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231940
Predicted Effect probably benign
Transcript: ENSMUST00000232078
Predicted Effect probably benign
Transcript: ENSMUST00000232113
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acacb A G 5: 114,368,893 (GRCm39) T1704A possibly damaging Het
Adam6a T A 12: 113,508,447 (GRCm39) D273E possibly damaging Het
Adgrv1 T A 13: 81,670,355 (GRCm39) L1610F probably damaging Het
Ago2 C T 15: 73,000,172 (GRCm39) probably null Het
Apob T A 12: 8,062,619 (GRCm39) Y87* probably null Het
Aqp7 G A 4: 41,035,510 (GRCm39) T115I probably benign Het
Atp7b A G 8: 22,508,144 (GRCm39) V599A probably damaging Het
Dnah1 T A 14: 31,032,863 (GRCm39) I391F probably benign Het
Emc2 A G 15: 43,360,453 (GRCm39) probably null Het
Gbp9 G T 5: 105,229,124 (GRCm39) Q508K probably benign Het
Grpel1 C T 5: 36,626,811 (GRCm39) T31M probably benign Het
Gtf3c4 C T 2: 28,717,511 (GRCm39) A790T probably damaging Het
Hmcn1 A G 1: 150,449,305 (GRCm39) C115R probably damaging Het
Ik G A 18: 36,886,566 (GRCm39) R346H probably benign Het
Ldc1 A C 4: 130,114,234 (GRCm39) V61G probably benign Het
Lhx3 A G 2: 26,091,173 (GRCm39) S379P probably benign Het
Mocs1 A G 17: 49,756,766 (GRCm39) probably null Het
Mycbp2 C A 14: 103,385,986 (GRCm39) V3457F probably damaging Het
Or14j7 A T 17: 38,234,861 (GRCm39) I135L probably benign Het
Or4a2 A T 2: 89,248,031 (GRCm39) I242N probably damaging Het
Or5an6 G A 19: 12,371,780 (GRCm39) R51K probably benign Het
Orc5 C T 5: 22,704,969 (GRCm39) probably null Het
Phf20 T C 2: 156,109,261 (GRCm39) S203P probably benign Het
Pkd1l1 T C 11: 8,817,204 (GRCm39) S1815G possibly damaging Het
Pnpla7 T C 2: 24,871,790 (GRCm39) V11A probably damaging Het
Ranbp2 T C 10: 58,300,086 (GRCm39) probably null Het
Ranbp3l A G 15: 9,063,169 (GRCm39) D326G probably damaging Het
Rsph4a C T 10: 33,781,789 (GRCm39) A213V probably damaging Het
Sema3b A G 9: 107,476,913 (GRCm39) S570P probably benign Het
Spata31d1b T A 13: 59,866,787 (GRCm39) C1312S probably benign Het
Sphkap G T 1: 83,253,618 (GRCm39) T1377K probably benign Het
Stk32a A T 18: 43,438,085 (GRCm39) R195W possibly damaging Het
Tacr2 T C 10: 62,088,769 (GRCm39) I58T probably damaging Het
Tmem200c A T 17: 69,147,547 (GRCm39) K43N probably damaging Het
Tnik T C 3: 28,648,241 (GRCm39) M431T probably benign Het
Uckl1 A G 2: 181,216,245 (GRCm39) S167P possibly damaging Het
Zan C T 5: 137,408,423 (GRCm39) probably null Het
Other mutations in Vmn2r90
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00092:Vmn2r90 APN 17 17,953,758 (GRCm39) missense probably benign 0.00
IGL01330:Vmn2r90 APN 17 17,953,542 (GRCm39) missense probably benign 0.00
IGL01989:Vmn2r90 APN 17 17,933,494 (GRCm39) nonsense probably null
IGL02080:Vmn2r90 APN 17 17,933,120 (GRCm39) missense probably damaging 1.00
IGL02112:Vmn2r90 APN 17 17,932,465 (GRCm39) missense probably damaging 0.98
IGL02123:Vmn2r90 APN 17 17,953,744 (GRCm39) missense probably benign 0.01
IGL02749:Vmn2r90 APN 17 17,947,122 (GRCm39) makesense probably null
IGL03114:Vmn2r90 APN 17 17,953,771 (GRCm39) missense probably damaging 1.00
R0131:Vmn2r90 UTSW 17 17,932,511 (GRCm39) missense probably benign 0.00
R0131:Vmn2r90 UTSW 17 17,932,511 (GRCm39) missense probably benign 0.00
R0132:Vmn2r90 UTSW 17 17,932,511 (GRCm39) missense probably benign 0.00
R0184:Vmn2r90 UTSW 17 17,947,139 (GRCm39) nonsense probably null
R0379:Vmn2r90 UTSW 17 17,948,401 (GRCm39) missense probably damaging 1.00
R1022:Vmn2r90 UTSW 17 17,948,400 (GRCm39) missense probably damaging 1.00
R1024:Vmn2r90 UTSW 17 17,948,400 (GRCm39) missense probably damaging 1.00
R1897:Vmn2r90 UTSW 17 17,953,566 (GRCm39) missense probably damaging 1.00
R1993:Vmn2r90 UTSW 17 17,933,525 (GRCm39) missense probably damaging 1.00
R2472:Vmn2r90 UTSW 17 17,948,408 (GRCm39) missense probably damaging 1.00
R2508:Vmn2r90 UTSW 17 17,954,229 (GRCm39) missense probably damaging 1.00
R2679:Vmn2r90 UTSW 17 17,933,131 (GRCm39) missense possibly damaging 0.46
R3409:Vmn2r90 UTSW 17 17,953,638 (GRCm39) missense probably benign 0.00
R4693:Vmn2r90 UTSW 17 17,953,956 (GRCm39) missense possibly damaging 0.91
R4797:Vmn2r90 UTSW 17 17,932,567 (GRCm39) missense probably damaging 1.00
R5258:Vmn2r90 UTSW 17 17,933,114 (GRCm39) missense probably benign 0.12
R5358:Vmn2r90 UTSW 17 17,924,412 (GRCm39) critical splice donor site probably null
R5445:Vmn2r90 UTSW 17 17,954,386 (GRCm39) missense probably benign 0.04
R5446:Vmn2r90 UTSW 17 17,932,464 (GRCm39) missense probably damaging 0.99
R5567:Vmn2r90 UTSW 17 17,932,336 (GRCm39) missense probably damaging 1.00
R5680:Vmn2r90 UTSW 17 17,947,034 (GRCm39) missense possibly damaging 0.93
R5686:Vmn2r90 UTSW 17 17,933,712 (GRCm39) missense probably benign 0.02
R6156:Vmn2r90 UTSW 17 17,953,606 (GRCm39) missense probably benign 0.01
R6185:Vmn2r90 UTSW 17 17,953,644 (GRCm39) missense probably damaging 1.00
R6450:Vmn2r90 UTSW 17 17,953,498 (GRCm39) missense possibly damaging 0.47
R6707:Vmn2r90 UTSW 17 17,948,364 (GRCm39) missense probably damaging 1.00
R6802:Vmn2r90 UTSW 17 17,932,351 (GRCm39) missense probably damaging 1.00
R6913:Vmn2r90 UTSW 17 17,924,323 (GRCm39) missense probably damaging 1.00
R7070:Vmn2r90 UTSW 17 17,924,313 (GRCm39) missense probably damaging 0.98
R7237:Vmn2r90 UTSW 17 17,924,249 (GRCm39) missense possibly damaging 0.92
R7503:Vmn2r90 UTSW 17 17,933,510 (GRCm39) missense not run
R7698:Vmn2r90 UTSW 17 17,953,596 (GRCm39) missense probably benign
R7943:Vmn2r90 UTSW 17 17,932,566 (GRCm39) missense probably damaging 1.00
R8072:Vmn2r90 UTSW 17 17,947,142 (GRCm39) missense probably damaging 1.00
R8128:Vmn2r90 UTSW 17 17,954,155 (GRCm39) missense probably damaging 1.00
R8295:Vmn2r90 UTSW 17 17,948,358 (GRCm39) missense probably benign 0.03
R8345:Vmn2r90 UTSW 17 17,933,127 (GRCm39) nonsense probably null
R8682:Vmn2r90 UTSW 17 17,932,344 (GRCm39) missense possibly damaging 0.95
R8716:Vmn2r90 UTSW 17 17,924,343 (GRCm39) missense probably damaging 0.98
R9041:Vmn2r90 UTSW 17 17,954,286 (GRCm39) missense probably benign 0.00
R9412:Vmn2r90 UTSW 17 17,954,213 (GRCm39) missense probably damaging 1.00
R9607:Vmn2r90 UTSW 17 17,953,638 (GRCm39) missense possibly damaging 0.88
R9705:Vmn2r90 UTSW 17 17,933,039 (GRCm39) missense possibly damaging 0.91
Z1088:Vmn2r90 UTSW 17 17,953,879 (GRCm39) missense probably damaging 1.00
Z1176:Vmn2r90 UTSW 17 17,933,079 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGGCGCCTAATTTCATCATTC -3'
(R):5'- CTTGGGGCCAAAGATCAAGC -3'

Sequencing Primer
(F):5'- AATTTCATCATTCCCATCTGCACAC -3'
(R):5'- CTAAGGAGAGCTGTACTGGAAGCC -3'
Posted On 2016-11-21