Incidental Mutation 'R5763:Vmn2r14'
| ID |
446106 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r14
|
| Ensembl Gene |
ENSMUSG00000091059 |
| Gene Name |
vomeronasal 2, receptor 14 |
| Synonyms |
EG231591 |
| MMRRC Submission |
043364-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.469)
|
| Stock # |
R5763 (G1)
|
| Quality Score |
121 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
109362822-109372488 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 109363724 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 731
(T731A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128015
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170341]
|
| AlphaFold |
E9Q759 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000170341
AA Change: T731A
PolyPhen 2
Score 0.487 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000128015
Gene: ENSMUSG00000091059
AA Change: T731A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
76 |
466 |
8.3e-31 |
PFAM |
|
Pfam:NCD3G
|
507 |
561 |
1.1e-17 |
PFAM |
|
Pfam:7tm_3
|
594 |
829 |
1.2e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.8%
- 10x: 97.5%
- 20x: 95.9%
|
| Validation Efficiency |
97% (70/72) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 65 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| AA986860 |
A |
G |
1: 130,670,768 (GRCm39) |
H330R |
possibly damaging |
Het |
| Acot11 |
C |
T |
4: 106,617,327 (GRCm39) |
G240R |
probably damaging |
Het |
| Actl6b |
T |
A |
5: 137,565,063 (GRCm39) |
L314Q |
possibly damaging |
Het |
| Adam22 |
A |
T |
5: 8,184,544 (GRCm39) |
C483S |
probably damaging |
Het |
| Adamts7 |
T |
A |
9: 90,070,462 (GRCm39) |
L601H |
probably damaging |
Het |
| Agl |
A |
T |
3: 116,547,009 (GRCm39) |
D1280E |
probably damaging |
Het |
| Ankrd60 |
TGGCCACGCGG |
TGG |
2: 173,419,882 (GRCm39) |
|
probably null |
Het |
| Astn2 |
T |
A |
4: 65,647,568 (GRCm39) |
M757L |
probably benign |
Het |
| Atr |
A |
G |
9: 95,827,176 (GRCm39) |
M2407V |
probably benign |
Het |
| Brca2 |
T |
C |
5: 150,471,471 (GRCm39) |
F2283L |
possibly damaging |
Het |
| Brwd1 |
A |
T |
16: 95,835,043 (GRCm39) |
Y940* |
probably null |
Het |
| Camk2g |
A |
T |
14: 20,789,415 (GRCm39) |
N218K |
probably damaging |
Het |
| Ces2a |
C |
T |
8: 105,462,756 (GRCm39) |
P115L |
probably benign |
Het |
| Col11a1 |
T |
C |
3: 113,888,245 (GRCm39) |
|
probably benign |
Het |
| Col1a2 |
T |
A |
6: 4,515,682 (GRCm39) |
D150E |
unknown |
Het |
| Crybg3 |
A |
G |
16: 59,374,973 (GRCm39) |
S2094P |
possibly damaging |
Het |
| Cttnbp2 |
T |
C |
6: 18,414,298 (GRCm39) |
N916D |
probably benign |
Het |
| Ddx24 |
A |
G |
12: 103,383,673 (GRCm39) |
F593L |
probably damaging |
Het |
| Dhx16 |
G |
A |
17: 36,192,580 (GRCm39) |
E171K |
possibly damaging |
Het |
| Dnah5 |
T |
C |
15: 28,311,298 (GRCm39) |
I1759T |
probably damaging |
Het |
| Dnah9 |
C |
A |
11: 65,846,065 (GRCm39) |
S2991I |
probably damaging |
Het |
| Entpd7 |
G |
T |
19: 43,692,705 (GRCm39) |
V87L |
probably damaging |
Het |
| Fam221a |
T |
G |
6: 49,355,518 (GRCm39) |
L207V |
probably damaging |
Het |
| Foxm1 |
T |
A |
6: 128,343,071 (GRCm39) |
I135N |
probably benign |
Het |
| Gabpa |
C |
A |
16: 84,657,297 (GRCm39) |
Q391K |
possibly damaging |
Het |
| Gipr |
T |
A |
7: 18,897,475 (GRCm39) |
H111L |
probably damaging |
Het |
| Gmip |
A |
G |
8: 70,270,501 (GRCm39) |
D737G |
probably damaging |
Het |
| Herc6 |
T |
A |
6: 57,639,872 (GRCm39) |
N995K |
probably damaging |
Het |
| Ldha |
G |
A |
7: 46,497,213 (GRCm39) |
|
probably benign |
Het |
| Lrrc37 |
G |
A |
11: 103,504,469 (GRCm39) |
P324S |
probably damaging |
Het |
| Masp1 |
T |
C |
16: 23,314,997 (GRCm39) |
E88G |
probably damaging |
Het |
| Mical2 |
G |
A |
7: 111,973,861 (GRCm39) |
|
probably null |
Het |
| Mill1 |
T |
A |
7: 17,979,587 (GRCm39) |
V18E |
probably benign |
Het |
| Mrgpra3 |
A |
T |
7: 47,239,355 (GRCm39) |
C190* |
probably null |
Het |
| Nog |
C |
T |
11: 89,192,291 (GRCm39) |
V186M |
probably damaging |
Het |
| Nrxn2 |
T |
C |
19: 6,581,369 (GRCm39) |
F392L |
probably benign |
Het |
| Or11h7 |
T |
C |
14: 50,891,525 (GRCm39) |
I277T |
possibly damaging |
Het |
| Or12j3 |
T |
A |
7: 139,953,568 (GRCm39) |
|
probably null |
Het |
| Or1e33 |
T |
A |
11: 73,738,693 (GRCm39) |
Q86L |
probably benign |
Het |
| Or4a79 |
T |
A |
2: 89,552,372 (GRCm39) |
M28L |
probably benign |
Het |
| Or7c74 |
T |
C |
2: 37,161,025 (GRCm39) |
|
noncoding transcript |
Het |
| Phyhd1 |
T |
A |
2: 30,169,983 (GRCm39) |
D158E |
probably damaging |
Het |
| Pik3r4 |
G |
T |
9: 105,546,974 (GRCm39) |
K917N |
probably benign |
Het |
| Pnma1 |
A |
G |
12: 84,194,124 (GRCm39) |
V193A |
possibly damaging |
Het |
| Podxl2 |
T |
C |
6: 88,826,805 (GRCm39) |
E167G |
probably damaging |
Het |
| Prss50 |
A |
T |
9: 110,691,517 (GRCm39) |
K82* |
probably null |
Het |
| Qsox1 |
A |
G |
1: 155,655,625 (GRCm39) |
S513P |
probably benign |
Het |
| Rheb |
A |
G |
5: 25,012,785 (GRCm39) |
V98A |
probably benign |
Het |
| Rhoj |
A |
G |
12: 75,438,606 (GRCm39) |
I131V |
probably benign |
Het |
| Rsph4a |
A |
T |
10: 33,781,684 (GRCm39) |
D178V |
probably damaging |
Het |
| Setd2 |
T |
G |
9: 110,385,343 (GRCm39) |
|
probably null |
Het |
| Siglecf |
A |
T |
7: 43,005,744 (GRCm39) |
K434* |
probably null |
Het |
| Slc14a1 |
T |
C |
18: 78,159,629 (GRCm39) |
Y88C |
probably benign |
Het |
| Snx15 |
T |
C |
19: 6,172,140 (GRCm39) |
E89G |
probably damaging |
Het |
| Son |
C |
T |
16: 91,454,378 (GRCm39) |
R1042C |
probably damaging |
Het |
| Srsf11 |
C |
T |
3: 157,728,981 (GRCm39) |
|
probably benign |
Het |
| Suz12 |
C |
A |
11: 79,916,134 (GRCm39) |
Y457* |
probably null |
Het |
| Tet1 |
T |
A |
10: 62,675,847 (GRCm39) |
N743I |
probably damaging |
Het |
| Tmc6 |
A |
G |
11: 117,660,259 (GRCm39) |
F660L |
possibly damaging |
Het |
| Tnpo1 |
A |
C |
13: 98,996,445 (GRCm39) |
I452S |
possibly damaging |
Het |
| Trav4-3 |
G |
T |
14: 53,836,844 (GRCm39) |
G103V |
probably damaging |
Het |
| Ubap2 |
T |
C |
4: 41,195,809 (GRCm39) |
K994E |
probably damaging |
Het |
| Vmn2r52 |
T |
A |
7: 9,905,231 (GRCm39) |
I203L |
probably benign |
Het |
| Zfp663 |
G |
T |
2: 165,200,355 (GRCm39) |
S75* |
probably null |
Het |
| Zik1 |
G |
T |
7: 10,226,293 (GRCm39) |
H25N |
probably benign |
Het |
|
| Other mutations in Vmn2r14 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01472:Vmn2r14
|
APN |
5 |
109,364,180 (GRCm39) |
nonsense |
probably null |
|
|
IGL01504:Vmn2r14
|
APN |
5 |
109,369,285 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01828:Vmn2r14
|
APN |
5 |
109,372,443 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02093:Vmn2r14
|
APN |
5 |
109,368,275 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02103:Vmn2r14
|
APN |
5 |
109,372,349 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02123:Vmn2r14
|
APN |
5 |
109,367,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02145:Vmn2r14
|
APN |
5 |
109,368,454 (GRCm39) |
nonsense |
probably null |
|
|
IGL02676:Vmn2r14
|
APN |
5 |
109,367,882 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02720:Vmn2r14
|
APN |
5 |
109,369,305 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02877:Vmn2r14
|
APN |
5 |
109,368,054 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02974:Vmn2r14
|
APN |
5 |
109,369,292 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL03151:Vmn2r14
|
APN |
5 |
109,364,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03297:Vmn2r14
|
APN |
5 |
109,363,973 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03386:Vmn2r14
|
APN |
5 |
109,368,350 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL03394:Vmn2r14
|
APN |
5 |
109,367,702 (GRCm39) |
missense |
probably null |
0.83 |
|
ANU74:Vmn2r14
|
UTSW |
5 |
109,366,910 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0316:Vmn2r14
|
UTSW |
5 |
109,366,762 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0755:Vmn2r14
|
UTSW |
5 |
109,364,226 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1219:Vmn2r14
|
UTSW |
5 |
109,372,440 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1321:Vmn2r14
|
UTSW |
5 |
109,364,117 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1465:Vmn2r14
|
UTSW |
5 |
109,368,195 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R1465:Vmn2r14
|
UTSW |
5 |
109,368,195 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R1509:Vmn2r14
|
UTSW |
5 |
109,363,862 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1551:Vmn2r14
|
UTSW |
5 |
109,369,283 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1628:Vmn2r14
|
UTSW |
5 |
109,367,838 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1668:Vmn2r14
|
UTSW |
5 |
109,366,913 (GRCm39) |
nonsense |
probably null |
|
|
R2013:Vmn2r14
|
UTSW |
5 |
109,369,109 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2201:Vmn2r14
|
UTSW |
5 |
109,366,698 (GRCm39) |
splice site |
probably null |
|
|
R2417:Vmn2r14
|
UTSW |
5 |
109,372,329 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3029:Vmn2r14
|
UTSW |
5 |
109,363,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3120:Vmn2r14
|
UTSW |
5 |
109,372,431 (GRCm39) |
missense |
probably null |
0.00 |
|
R3729:Vmn2r14
|
UTSW |
5 |
109,364,095 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3762:Vmn2r14
|
UTSW |
5 |
109,368,033 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3943:Vmn2r14
|
UTSW |
5 |
109,363,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3944:Vmn2r14
|
UTSW |
5 |
109,363,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4222:Vmn2r14
|
UTSW |
5 |
109,364,149 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4224:Vmn2r14
|
UTSW |
5 |
109,364,149 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4239:Vmn2r14
|
UTSW |
5 |
109,364,277 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4240:Vmn2r14
|
UTSW |
5 |
109,364,277 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4782:Vmn2r14
|
UTSW |
5 |
109,369,370 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4832:Vmn2r14
|
UTSW |
5 |
109,363,976 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4884:Vmn2r14
|
UTSW |
5 |
109,369,384 (GRCm39) |
splice site |
probably null |
|
|
R4896:Vmn2r14
|
UTSW |
5 |
109,368,246 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5004:Vmn2r14
|
UTSW |
5 |
109,368,246 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5117:Vmn2r14
|
UTSW |
5 |
109,363,961 (GRCm39) |
missense |
probably benign |
0.16 |
|
R5285:Vmn2r14
|
UTSW |
5 |
109,365,442 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5413:Vmn2r14
|
UTSW |
5 |
109,369,154 (GRCm39) |
missense |
probably benign |
0.29 |
|
R5569:Vmn2r14
|
UTSW |
5 |
109,368,261 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5701:Vmn2r14
|
UTSW |
5 |
109,367,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5726:Vmn2r14
|
UTSW |
5 |
109,365,486 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5872:Vmn2r14
|
UTSW |
5 |
109,369,222 (GRCm39) |
missense |
probably benign |
|
|
R5985:Vmn2r14
|
UTSW |
5 |
109,368,082 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6268:Vmn2r14
|
UTSW |
5 |
109,369,283 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6273:Vmn2r14
|
UTSW |
5 |
109,369,133 (GRCm39) |
missense |
probably benign |
0.44 |
|
R6409:Vmn2r14
|
UTSW |
5 |
109,364,096 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6944:Vmn2r14
|
UTSW |
5 |
109,364,140 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6944:Vmn2r14
|
UTSW |
5 |
109,363,925 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7608:Vmn2r14
|
UTSW |
5 |
109,369,276 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7740:Vmn2r14
|
UTSW |
5 |
109,368,324 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7768:Vmn2r14
|
UTSW |
5 |
109,368,086 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7804:Vmn2r14
|
UTSW |
5 |
109,368,324 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7872:Vmn2r14
|
UTSW |
5 |
109,369,219 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7993:Vmn2r14
|
UTSW |
5 |
109,363,862 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8006:Vmn2r14
|
UTSW |
5 |
109,368,324 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8007:Vmn2r14
|
UTSW |
5 |
109,368,324 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8187:Vmn2r14
|
UTSW |
5 |
109,368,420 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8369:Vmn2r14
|
UTSW |
5 |
109,369,342 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8463:Vmn2r14
|
UTSW |
5 |
109,369,340 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8968:Vmn2r14
|
UTSW |
5 |
109,365,533 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9008:Vmn2r14
|
UTSW |
5 |
109,367,893 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9030:Vmn2r14
|
UTSW |
5 |
109,368,054 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9039:Vmn2r14
|
UTSW |
5 |
109,367,902 (GRCm39) |
nonsense |
probably null |
|
|
R9150:Vmn2r14
|
UTSW |
5 |
109,367,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9164:Vmn2r14
|
UTSW |
5 |
109,364,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9216:Vmn2r14
|
UTSW |
5 |
109,369,112 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9225:Vmn2r14
|
UTSW |
5 |
109,369,288 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9245:Vmn2r14
|
UTSW |
5 |
109,368,176 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9342:Vmn2r14
|
UTSW |
5 |
109,368,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9472:Vmn2r14
|
UTSW |
5 |
109,367,962 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9678:Vmn2r14
|
UTSW |
5 |
109,364,041 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9774:Vmn2r14
|
UTSW |
5 |
109,369,126 (GRCm39) |
missense |
probably benign |
0.07 |
|
Z1177:Vmn2r14
|
UTSW |
5 |
109,367,741 (GRCm39) |
missense |
probably benign |
0.33 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAGGTGATCCAGACACTGCAG -3'
(R):5'- TTCACAGTGGCTATTTCTACAGTG -3'
Sequencing Primer
(F):5'- TGCAGAATACCAGCATGCTG -3'
(R):5'- AACTGTGCTCATGGCTTTCAAG -3'
|
| Posted On |
2016-11-21 |
Incidental Mutation