Incidental Mutation 'R0544:Adgrb2'
| ID |
44667 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adgrb2
|
| Ensembl Gene |
ENSMUSG00000028782 |
| Gene Name |
adhesion G protein-coupled receptor B2 |
| Synonyms |
Bai2 |
| MMRRC Submission |
038736-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0544 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
129878663-129916426 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 129911335 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 1207
(V1207A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000101636
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000030571]
[ENSMUST00000097868]
[ENSMUST00000106015]
[ENSMUST00000106017]
[ENSMUST00000106018]
[ENSMUST00000120204]
[ENSMUST00000121049]
|
| AlphaFold |
Q8CGM1 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000030571
AA Change: V1207A
PolyPhen 2
Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000030571
Gene: ENSMUSG00000028782
AA Change: V1207A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
1.86e-13 |
SMART |
|
TSP1
|
413 |
463 |
9.89e-9 |
SMART |
|
TSP1
|
469 |
519 |
3.09e-10 |
SMART |
|
HormR
|
521 |
587 |
3.27e-18 |
SMART |
|
Pfam:GAIN
|
600 |
842 |
1.6e-41 |
PFAM |
|
GPS
|
864 |
917 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
923 |
1192 |
1.7e-67 |
PFAM |
|
low complexity region
|
1357 |
1371 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000097868
AA Change: V1174A
PolyPhen 2
Score 0.904 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000095480
Gene: ENSMUSG00000028782
AA Change: V1174A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
1.86e-13 |
SMART |
|
TSP1
|
413 |
463 |
9.89e-9 |
SMART |
|
TSP1
|
469 |
519 |
3.09e-10 |
SMART |
|
HormR
|
521 |
587 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
597 |
859 |
1.2e-54 |
PFAM |
|
GPS
|
864 |
917 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
923 |
1159 |
2.6e-69 |
PFAM |
|
low complexity region
|
1324 |
1338 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000106012
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000106015
AA Change: V1207A
PolyPhen 2
Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000101636
Gene: ENSMUSG00000028782
AA Change: V1207A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
1.86e-13 |
SMART |
|
TSP1
|
413 |
463 |
9.89e-9 |
SMART |
|
TSP1
|
469 |
519 |
3.09e-10 |
SMART |
|
HormR
|
521 |
587 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
597 |
859 |
6.4e-55 |
PFAM |
|
GPS
|
864 |
917 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
923 |
1192 |
4.1e-68 |
PFAM |
|
low complexity region
|
1357 |
1371 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000106017
AA Change: V1195A
PolyPhen 2
Score 0.887 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000101638
Gene: ENSMUSG00000028782
AA Change: V1195A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
1.86e-13 |
SMART |
|
TSP1
|
413 |
463 |
9.89e-9 |
SMART |
|
TSP1
|
469 |
519 |
3.09e-10 |
SMART |
|
HormR
|
521 |
587 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
597 |
859 |
6.3e-55 |
PFAM |
|
GPS
|
864 |
917 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
923 |
1180 |
4.6e-68 |
PFAM |
|
low complexity region
|
1345 |
1359 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000106018
AA Change: V1119A
PolyPhen 2
Score 0.904 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000101639
Gene: ENSMUSG00000028782
AA Change: V1119A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
1.86e-13 |
SMART |
|
TSP1
|
358 |
408 |
9.89e-9 |
SMART |
|
TSP1
|
414 |
464 |
3.09e-10 |
SMART |
|
HormR
|
466 |
532 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
542 |
804 |
1.1e-54 |
PFAM |
|
GPS
|
809 |
862 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
868 |
1104 |
2.4e-69 |
PFAM |
|
low complexity region
|
1269 |
1283 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000120204
AA Change: V1119A
PolyPhen 2
Score 0.904 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000112524
Gene: ENSMUSG00000028782
AA Change: V1119A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
9.89e-9 |
SMART |
|
TSP1
|
414 |
464 |
3.09e-10 |
SMART |
|
HormR
|
466 |
532 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
542 |
804 |
8.2e-55 |
PFAM |
|
GPS
|
809 |
862 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
868 |
1104 |
9.6e-70 |
PFAM |
|
low complexity region
|
1269 |
1283 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000121049
AA Change: V1152A
PolyPhen 2
Score 0.942 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000112869
Gene: ENSMUSG00000028782
AA Change: V1152A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
1.86e-13 |
SMART |
|
TSP1
|
358 |
408 |
9.89e-9 |
SMART |
|
TSP1
|
414 |
464 |
3.09e-10 |
SMART |
|
HormR
|
466 |
532 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
542 |
804 |
6.1e-55 |
PFAM |
|
GPS
|
809 |
862 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
868 |
1137 |
3.8e-68 |
PFAM |
|
low complexity region
|
1302 |
1316 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000136416
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000163625
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000166118
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000136787
|
| Meta Mutation Damage Score |
0.3905 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.0%
- 20x: 94.6%
|
| Validation Efficiency |
98% (97/99) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
PHENOTYPE: Mice homozygous for disruptions in this gene show a lessening of depression like behavior. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 97 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9930012K11Rik |
A |
T |
14: 70,394,763 (GRCm39) |
F130L |
probably benign |
Het |
| Aatf |
C |
T |
11: 84,313,831 (GRCm39) |
R511Q |
probably benign |
Het |
| Acot12 |
A |
T |
13: 91,932,775 (GRCm39) |
D516V |
probably benign |
Het |
| Akap9 |
A |
G |
5: 4,119,185 (GRCm39) |
D3564G |
probably benign |
Het |
| Arl8b |
C |
T |
6: 108,760,189 (GRCm39) |
|
probably benign |
Het |
| Atf6b |
T |
C |
17: 34,867,273 (GRCm39) |
|
probably null |
Het |
| Atrn |
G |
A |
2: 130,828,746 (GRCm39) |
G1097D |
probably damaging |
Het |
| Btbd6 |
A |
G |
12: 112,940,702 (GRCm39) |
E61G |
probably damaging |
Het |
| Car15 |
A |
G |
16: 17,653,680 (GRCm39) |
|
probably benign |
Het |
| Car5b |
G |
A |
X: 162,762,297 (GRCm39) |
R282C |
probably damaging |
Het |
| Carmil2 |
C |
T |
8: 106,417,867 (GRCm39) |
A654V |
probably damaging |
Het |
| Ccdc88b |
A |
G |
19: 6,834,634 (GRCm39) |
L124P |
probably damaging |
Het |
| Ccnd1 |
A |
G |
7: 144,491,023 (GRCm39) |
|
probably benign |
Het |
| Cenph |
A |
G |
13: 100,909,249 (GRCm39) |
S53P |
probably damaging |
Het |
| Chrm3 |
T |
A |
13: 9,927,615 (GRCm39) |
I474F |
probably damaging |
Het |
| Cln8 |
T |
A |
8: 14,946,769 (GRCm39) |
V261E |
probably benign |
Het |
| Coa6 |
A |
G |
8: 127,149,499 (GRCm39) |
D25G |
probably benign |
Het |
| Col4a1 |
T |
G |
8: 11,276,487 (GRCm39) |
|
probably benign |
Het |
| Cpxm1 |
T |
C |
2: 130,235,055 (GRCm39) |
H588R |
probably damaging |
Het |
| Cul7 |
T |
C |
17: 46,974,470 (GRCm39) |
L1516P |
possibly damaging |
Het |
| Dcdc5 |
A |
G |
2: 106,181,909 (GRCm39) |
|
noncoding transcript |
Het |
| Ddx5 |
T |
C |
11: 106,673,288 (GRCm39) |
|
probably benign |
Het |
| Dhx16 |
C |
A |
17: 36,192,551 (GRCm39) |
P161Q |
probably benign |
Het |
| Dpy19l1 |
A |
T |
9: 24,396,406 (GRCm39) |
|
probably benign |
Het |
| Fastkd5 |
A |
G |
2: 130,457,216 (GRCm39) |
V458A |
probably damaging |
Het |
| Fhit |
A |
G |
14: 9,870,172 (GRCm38) |
V99A |
probably damaging |
Het |
| Fndc3a |
A |
T |
14: 72,795,062 (GRCm39) |
|
probably benign |
Het |
| Foxd4 |
A |
T |
19: 24,877,182 (GRCm39) |
S339R |
possibly damaging |
Het |
| Gm10842 |
T |
A |
11: 105,037,880 (GRCm39) |
D54E |
unknown |
Het |
| Gns |
T |
A |
10: 121,212,172 (GRCm39) |
Y94* |
probably null |
Het |
| Gp2 |
A |
G |
7: 119,053,719 (GRCm39) |
W81R |
probably benign |
Het |
| Hdac5 |
T |
G |
11: 102,086,922 (GRCm39) |
Q46P |
probably damaging |
Het |
| Homer2 |
A |
C |
7: 81,299,426 (GRCm39) |
V13G |
probably damaging |
Het |
| Irs3 |
A |
G |
5: 137,642,101 (GRCm39) |
S446P |
probably benign |
Het |
| Ism2 |
G |
T |
12: 87,332,113 (GRCm39) |
D141E |
probably damaging |
Het |
| Jak1 |
T |
A |
4: 101,048,822 (GRCm39) |
M19L |
probably benign |
Het |
| Kcnd3 |
C |
A |
3: 105,566,075 (GRCm39) |
R419S |
probably damaging |
Het |
| Lamb1 |
T |
C |
12: 31,332,694 (GRCm39) |
F272S |
probably damaging |
Het |
| Ldlrad2 |
T |
G |
4: 137,299,579 (GRCm39) |
T82P |
possibly damaging |
Het |
| Lrp2 |
T |
C |
2: 69,322,275 (GRCm39) |
K1885E |
probably benign |
Het |
| Mbd5 |
T |
C |
2: 49,147,221 (GRCm39) |
V477A |
possibly damaging |
Het |
| Mrps33 |
A |
T |
6: 39,782,488 (GRCm39) |
M11K |
possibly damaging |
Het |
| Mylk |
G |
C |
16: 34,699,845 (GRCm39) |
E403Q |
possibly damaging |
Het |
| Myom2 |
T |
A |
8: 15,119,796 (GRCm39) |
V184E |
probably damaging |
Het |
| Ncor1 |
C |
A |
11: 62,224,602 (GRCm39) |
G1210V |
probably damaging |
Het |
| Ncor1 |
C |
T |
11: 62,224,603 (GRCm39) |
G1210R |
probably damaging |
Het |
| Nlrp4a |
A |
G |
7: 26,156,555 (GRCm39) |
D760G |
probably benign |
Het |
| Noc4l |
A |
G |
5: 110,798,989 (GRCm39) |
V231A |
possibly damaging |
Het |
| Or2at1 |
T |
C |
7: 99,416,867 (GRCm39) |
I166T |
probably benign |
Het |
| Or4c112 |
T |
C |
2: 88,854,170 (GRCm39) |
Y59C |
probably damaging |
Het |
| Or4f14 |
A |
T |
2: 111,742,905 (GRCm39) |
Y123* |
probably null |
Het |
| Or4n4b |
A |
T |
14: 50,536,139 (GRCm39) |
V209E |
probably benign |
Het |
| Or52ab7 |
T |
A |
7: 102,977,858 (GRCm39) |
I55N |
probably damaging |
Het |
| Or5b98 |
A |
G |
19: 12,931,066 (GRCm39) |
T38A |
possibly damaging |
Het |
| Or5h25 |
T |
A |
16: 58,930,588 (GRCm39) |
K128N |
probably benign |
Het |
| Or8k23 |
T |
C |
2: 86,186,007 (GRCm39) |
T240A |
probably damaging |
Het |
| Padi4 |
GCTGCGTACCTCCAC |
GC |
4: 140,475,760 (GRCm39) |
|
probably benign |
Het |
| Patj |
T |
A |
4: 98,457,347 (GRCm39) |
M1283K |
probably damaging |
Het |
| Pkd1 |
C |
T |
17: 24,804,657 (GRCm39) |
T790I |
probably damaging |
Het |
| Plod3 |
C |
A |
5: 137,020,465 (GRCm39) |
T526K |
probably benign |
Het |
| Plxnb2 |
C |
A |
15: 89,042,816 (GRCm39) |
|
probably benign |
Het |
| Polr1g |
G |
T |
7: 19,093,066 (GRCm39) |
P38Q |
probably damaging |
Het |
| Pramel1 |
T |
A |
4: 143,124,175 (GRCm39) |
D283E |
possibly damaging |
Het |
| Prpf40a |
T |
C |
2: 53,031,663 (GRCm39) |
|
probably benign |
Het |
| Psg23 |
A |
T |
7: 18,348,607 (GRCm39) |
Y67N |
probably damaging |
Het |
| Rftn1 |
T |
A |
17: 50,301,289 (GRCm39) |
Q242L |
possibly damaging |
Het |
| Rp1l1 |
A |
T |
14: 64,269,515 (GRCm39) |
E1700D |
probably benign |
Het |
| Scube3 |
T |
C |
17: 28,383,127 (GRCm39) |
F435S |
probably damaging |
Het |
| Sdk2 |
T |
C |
11: 113,671,836 (GRCm39) |
Y2104C |
probably damaging |
Het |
| Septin11 |
A |
G |
5: 93,313,227 (GRCm39) |
E358G |
possibly damaging |
Het |
| Sh3bp1 |
T |
C |
15: 78,789,975 (GRCm39) |
L246P |
probably damaging |
Het |
| Sis |
T |
C |
3: 72,858,975 (GRCm39) |
Y352C |
probably damaging |
Het |
| Skint1 |
T |
C |
4: 111,878,562 (GRCm39) |
S165P |
probably damaging |
Het |
| Skint10 |
C |
T |
4: 112,586,008 (GRCm39) |
|
probably benign |
Het |
| Slc1a2 |
A |
T |
2: 102,586,417 (GRCm39) |
R340S |
probably damaging |
Het |
| Slc26a3 |
C |
A |
12: 31,497,739 (GRCm39) |
Q48K |
probably benign |
Het |
| Slc5a2 |
A |
T |
7: 127,869,171 (GRCm39) |
Y317F |
probably damaging |
Het |
| Sorbs3 |
T |
A |
14: 70,431,375 (GRCm39) |
T262S |
probably benign |
Het |
| Tas2r118 |
G |
T |
6: 23,969,400 (GRCm39) |
S220R |
probably damaging |
Het |
| Terf2ip |
C |
A |
8: 112,741,974 (GRCm39) |
Q223K |
possibly damaging |
Het |
| Tespa1 |
A |
G |
10: 130,196,680 (GRCm39) |
Q206R |
probably damaging |
Het |
| Tex10 |
T |
C |
4: 48,462,766 (GRCm39) |
|
probably null |
Het |
| Tle1 |
T |
A |
4: 72,043,227 (GRCm39) |
K547N |
probably damaging |
Het |
| Tmem131l |
T |
A |
3: 83,805,853 (GRCm39) |
Q1530L |
probably damaging |
Het |
| Tomm20l |
A |
G |
12: 71,169,851 (GRCm39) |
E145G |
possibly damaging |
Het |
| Tra2a |
C |
T |
6: 49,227,885 (GRCm39) |
|
probably benign |
Het |
| Trim32 |
G |
A |
4: 65,531,491 (GRCm39) |
R16Q |
probably damaging |
Het |
| Trim37 |
T |
A |
11: 87,036,328 (GRCm39) |
Y121* |
probably null |
Het |
| Tube1 |
C |
T |
10: 39,016,941 (GRCm39) |
|
probably null |
Het |
| Usp6nl |
T |
A |
2: 6,425,820 (GRCm39) |
V187D |
probably damaging |
Het |
| Vmn1r13 |
T |
C |
6: 57,187,248 (GRCm39) |
F136L |
probably benign |
Het |
| Vmn1r201 |
A |
T |
13: 22,659,316 (GRCm39) |
I177F |
probably benign |
Het |
| Vmn1r203 |
A |
T |
13: 22,708,443 (GRCm39) |
T75S |
possibly damaging |
Het |
| Vmn1r225 |
C |
T |
17: 20,722,718 (GRCm39) |
S53L |
probably benign |
Het |
| Xab2 |
A |
T |
8: 3,660,994 (GRCm39) |
W707R |
probably damaging |
Het |
| Zfp808 |
T |
C |
13: 62,317,248 (GRCm39) |
|
probably benign |
Het |
| Zng1 |
A |
G |
19: 24,926,575 (GRCm39) |
Y159H |
possibly damaging |
Het |
|
| Other mutations in Adgrb2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00309:Adgrb2
|
APN |
4 |
129,912,598 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00425:Adgrb2
|
APN |
4 |
129,912,865 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL00490:Adgrb2
|
APN |
4 |
129,905,665 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL00928:Adgrb2
|
APN |
4 |
129,886,096 (GRCm39) |
missense |
probably benign |
|
|
IGL01353:Adgrb2
|
APN |
4 |
129,906,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01521:Adgrb2
|
APN |
4 |
129,886,085 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01590:Adgrb2
|
APN |
4 |
129,907,606 (GRCm39) |
splice site |
probably benign |
|
|
IGL01813:Adgrb2
|
APN |
4 |
129,906,359 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01831:Adgrb2
|
APN |
4 |
129,903,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01939:Adgrb2
|
APN |
4 |
129,885,925 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01960:Adgrb2
|
APN |
4 |
129,906,177 (GRCm39) |
splice site |
probably benign |
|
|
IGL01993:Adgrb2
|
APN |
4 |
129,912,635 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02646:Adgrb2
|
APN |
4 |
129,913,075 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02655:Adgrb2
|
APN |
4 |
129,885,972 (GRCm39) |
nonsense |
probably null |
|
|
IGL02695:Adgrb2
|
APN |
4 |
129,912,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02998:Adgrb2
|
APN |
4 |
129,912,862 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL03372:Adgrb2
|
APN |
4 |
129,911,362 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0098:Adgrb2
|
UTSW |
4 |
129,901,624 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0206:Adgrb2
|
UTSW |
4 |
129,886,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0311:Adgrb2
|
UTSW |
4 |
129,910,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0380:Adgrb2
|
UTSW |
4 |
129,901,624 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0382:Adgrb2
|
UTSW |
4 |
129,901,624 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0492:Adgrb2
|
UTSW |
4 |
129,901,624 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0965:Adgrb2
|
UTSW |
4 |
129,886,209 (GRCm39) |
small deletion |
probably benign |
|
|
R1458:Adgrb2
|
UTSW |
4 |
129,908,384 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R1601:Adgrb2
|
UTSW |
4 |
129,886,630 (GRCm39) |
missense |
probably benign |
0.43 |
|
R1711:Adgrb2
|
UTSW |
4 |
129,886,417 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1758:Adgrb2
|
UTSW |
4 |
129,905,668 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1783:Adgrb2
|
UTSW |
4 |
129,903,098 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R1827:Adgrb2
|
UTSW |
4 |
129,906,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1838:Adgrb2
|
UTSW |
4 |
129,904,024 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1881:Adgrb2
|
UTSW |
4 |
129,904,078 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1888:Adgrb2
|
UTSW |
4 |
129,907,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1888:Adgrb2
|
UTSW |
4 |
129,907,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1894:Adgrb2
|
UTSW |
4 |
129,907,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2275:Adgrb2
|
UTSW |
4 |
129,900,647 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2926:Adgrb2
|
UTSW |
4 |
129,902,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4472:Adgrb2
|
UTSW |
4 |
129,902,146 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4490:Adgrb2
|
UTSW |
4 |
129,906,121 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4499:Adgrb2
|
UTSW |
4 |
129,886,454 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4758:Adgrb2
|
UTSW |
4 |
129,903,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4900:Adgrb2
|
UTSW |
4 |
129,907,668 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4904:Adgrb2
|
UTSW |
4 |
129,906,332 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R4922:Adgrb2
|
UTSW |
4 |
129,901,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5330:Adgrb2
|
UTSW |
4 |
129,915,995 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5331:Adgrb2
|
UTSW |
4 |
129,915,995 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5550:Adgrb2
|
UTSW |
4 |
129,908,727 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5995:Adgrb2
|
UTSW |
4 |
129,910,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6047:Adgrb2
|
UTSW |
4 |
129,912,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6534:Adgrb2
|
UTSW |
4 |
129,916,012 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6565:Adgrb2
|
UTSW |
4 |
129,913,069 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6813:Adgrb2
|
UTSW |
4 |
129,903,284 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6963:Adgrb2
|
UTSW |
4 |
129,908,155 (GRCm39) |
frame shift |
probably null |
|
|
R6966:Adgrb2
|
UTSW |
4 |
129,908,155 (GRCm39) |
frame shift |
probably null |
|
|
R7197:Adgrb2
|
UTSW |
4 |
129,903,315 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7409:Adgrb2
|
UTSW |
4 |
129,912,862 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7451:Adgrb2
|
UTSW |
4 |
129,908,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7453:Adgrb2
|
UTSW |
4 |
129,908,430 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7461:Adgrb2
|
UTSW |
4 |
129,915,006 (GRCm39) |
critical splice acceptor site |
probably benign |
|
|
R7511:Adgrb2
|
UTSW |
4 |
129,915,904 (GRCm39) |
missense |
probably benign |
|
|
R7613:Adgrb2
|
UTSW |
4 |
129,915,006 (GRCm39) |
critical splice acceptor site |
probably benign |
|
|
R7729:Adgrb2
|
UTSW |
4 |
129,885,917 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7818:Adgrb2
|
UTSW |
4 |
129,908,762 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R7818:Adgrb2
|
UTSW |
4 |
129,908,353 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8033:Adgrb2
|
UTSW |
4 |
129,912,805 (GRCm39) |
missense |
probably benign |
|
|
R8039:Adgrb2
|
UTSW |
4 |
129,916,061 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8097:Adgrb2
|
UTSW |
4 |
129,901,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8256:Adgrb2
|
UTSW |
4 |
129,901,921 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8425:Adgrb2
|
UTSW |
4 |
129,898,850 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R8804:Adgrb2
|
UTSW |
4 |
129,899,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9011:Adgrb2
|
UTSW |
4 |
129,916,111 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9018:Adgrb2
|
UTSW |
4 |
129,907,659 (GRCm39) |
missense |
probably benign |
0.34 |
|
R9102:Adgrb2
|
UTSW |
4 |
129,912,802 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9113:Adgrb2
|
UTSW |
4 |
129,910,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9120:Adgrb2
|
UTSW |
4 |
129,906,302 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R9211:Adgrb2
|
UTSW |
4 |
129,886,199 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9267:Adgrb2
|
UTSW |
4 |
129,885,901 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9328:Adgrb2
|
UTSW |
4 |
129,915,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9470:Adgrb2
|
UTSW |
4 |
129,903,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9608:Adgrb2
|
UTSW |
4 |
129,907,352 (GRCm39) |
missense |
probably damaging |
0.98 |
|
RF020:Adgrb2
|
UTSW |
4 |
129,903,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Adgrb2
|
UTSW |
4 |
129,911,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Adgrb2
|
UTSW |
4 |
129,912,912 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1177:Adgrb2
|
UTSW |
4 |
129,905,619 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCCGTTTTCAACTCTGCACAAGG -3'
(R):5'- GCGTAACTTGAACCCAGTCTCTGTC -3'
Sequencing Primer
(F):5'- GCGCTTATAGCTCAGATAGCC -3'
(R):5'- gtctcAGATGGGATGGGGAAG -3'
|
| Posted On |
2013-06-11 |
Incidental Mutation