Incidental Mutation 'R5777:Or7a36'
ID 446773
Institutional Source Beutler Lab
Gene Symbol Or7a36
Ensembl Gene ENSMUSG00000046493
Gene Name olfactory receptor family 7 subfamily A member 36
Synonyms GA_x6K02T2QGN0-2828447-2827518, MOR139-1, Olfr1352
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # R5777 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 78816884-78820555 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 78820512 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Alanine at position 296 (D296A)
Ref Sequence ENSEMBL: ENSMUSP00000054355 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058991] [ENSMUST00000203973]
AlphaFold Q8VGX5
Predicted Effect possibly damaging
Transcript: ENSMUST00000058991
AA Change: D296A

PolyPhen 2 Score 0.780 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000054355
Gene: ENSMUSG00000046493
AA Change: D296A

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.7e-52 PFAM
Pfam:7TM_GPCR_Srsx 35 305 9.1e-6 PFAM
Pfam:7tm_1 41 290 4.7e-28 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000203973
SMART Domains Protein: ENSMUSP00000144895
Gene: ENSMUSG00000046493

DomainStartEndE-ValueType
Pfam:7tm_4 1 122 6.1e-25 PFAM
Pfam:7TM_GPCR_Srx 1 123 7.5e-5 PFAM
Pfam:7TM_GPCR_Srsx 2 123 4.5e-8 PFAM
Pfam:7tm_1 8 123 2.1e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219714
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agrp T C 8: 106,294,000 (GRCm39) E41G probably benign Het
Amph A T 13: 19,230,186 (GRCm39) N45Y probably damaging Het
Atp11a T A 8: 12,882,522 (GRCm39) L470Q probably damaging Het
C130073F10Rik T A 4: 101,747,946 (GRCm39) Y76F possibly damaging Het
Casp12 A T 9: 5,354,548 (GRCm39) I306F probably benign Het
Cobll1 A T 2: 64,933,612 (GRCm39) M460K probably benign Het
Col6a4 A T 9: 105,890,895 (GRCm39) L1800I possibly damaging Het
Ctdsp1 T C 1: 74,433,227 (GRCm39) V131A probably damaging Het
Ctnna3 A G 10: 64,511,664 (GRCm39) H618R probably benign Het
Dhx38 C A 8: 110,283,534 (GRCm39) V538L possibly damaging Het
Dtwd1 A G 2: 126,001,733 (GRCm39) D151G probably damaging Het
Fbxw28 A G 9: 109,167,604 (GRCm39) L51P probably damaging Het
Gm4781 C T 10: 100,232,831 (GRCm39) noncoding transcript Het
Gm5134 C A 10: 75,840,594 (GRCm39) F479L probably benign Het
H2bc27 A G 11: 58,839,835 (GRCm39) K24E probably benign Het
Hexa T G 9: 59,468,243 (GRCm39) V290G probably damaging Het
Ifi206 C T 1: 173,308,928 (GRCm39) R356K possibly damaging Het
Kcnj12 G A 11: 60,961,277 (GRCm39) R525Q possibly damaging Het
Lrp2 A T 2: 69,285,869 (GRCm39) I3774N probably damaging Het
Msh4 C A 3: 153,569,076 (GRCm39) M832I probably benign Het
Myh10 A G 11: 68,676,685 (GRCm39) E852G probably damaging Het
Ndufaf1 A T 2: 119,490,963 (GRCm39) C32* probably null Het
Nos2 A G 11: 78,830,978 (GRCm39) E387G probably null Het
Or4f58 C T 2: 111,851,876 (GRCm39) G108R probably damaging Het
Or55b10 A G 7: 102,143,178 (GRCm39) V268A probably benign Het
Or5h27 T A 16: 59,006,266 (GRCm39) L193F unknown Het
Or7g29 A T 9: 19,287,014 (GRCm39) H54Q probably benign Het
Or8j3c A G 2: 86,253,669 (GRCm39) V117A probably benign Het
P3h3 T C 6: 124,832,921 (GRCm39) T211A probably benign Het
Pcdh7 A G 5: 57,876,856 (GRCm39) N137S probably damaging Het
Pgf T C 12: 85,216,148 (GRCm39) T157A possibly damaging Het
Prex1 T C 2: 166,428,579 (GRCm39) D714G probably damaging Het
Scn7a T C 2: 66,522,913 (GRCm39) I930M probably damaging Het
Siglecg T C 7: 43,058,837 (GRCm39) S197P possibly damaging Het
Skint7 T A 4: 111,845,289 (GRCm39) I367N probably benign Het
Slfn5 A T 11: 82,851,830 (GRCm39) D652V probably damaging Het
Stx1b G A 7: 127,410,090 (GRCm39) Q3* probably null Het
Tex35 T C 1: 156,934,777 (GRCm39) M46V probably benign Het
Tkt A C 14: 30,280,733 (GRCm39) T55P possibly damaging Het
Trim30c T C 7: 104,032,538 (GRCm39) R263G probably benign Het
U2af2 G A 7: 5,069,450 (GRCm39) R33Q probably benign Het
Washc4 T A 10: 83,391,469 (GRCm39) V182D probably damaging Het
Xirp2 T C 2: 67,340,348 (GRCm39) V863A possibly damaging Het
Zfp976 T G 7: 42,263,504 (GRCm39) H111P probably benign Het
Zfp982 A T 4: 147,595,321 (GRCm39) N48Y probably damaging Het
Other mutations in Or7a36
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01468:Or7a36 APN 10 78,819,696 (GRCm39) missense probably damaging 0.96
IGL01865:Or7a36 APN 10 78,820,512 (GRCm39) missense possibly damaging 0.94
R0196:Or7a36 UTSW 10 78,820,023 (GRCm39) missense possibly damaging 0.89
R0362:Or7a36 UTSW 10 78,820,220 (GRCm39) missense probably benign 0.00
R1574:Or7a36 UTSW 10 78,819,820 (GRCm39) missense probably damaging 1.00
R1574:Or7a36 UTSW 10 78,819,820 (GRCm39) missense probably damaging 1.00
R2982:Or7a36 UTSW 10 78,820,274 (GRCm39) missense probably damaging 1.00
R4724:Or7a36 UTSW 10 78,820,356 (GRCm39) missense probably damaging 1.00
R5000:Or7a36 UTSW 10 78,820,514 (GRCm39) missense probably benign 0.00
R5085:Or7a36 UTSW 10 78,819,928 (GRCm39) missense probably benign 0.03
R5145:Or7a36 UTSW 10 78,820,143 (GRCm39) missense probably benign 0.35
R5455:Or7a36 UTSW 10 78,820,371 (GRCm39) missense possibly damaging 0.59
R5822:Or7a36 UTSW 10 78,820,023 (GRCm39) missense possibly damaging 0.89
R6283:Or7a36 UTSW 10 78,820,113 (GRCm39) missense probably benign 0.01
R7242:Or7a36 UTSW 10 78,820,331 (GRCm39) nonsense probably null
R7504:Or7a36 UTSW 10 78,820,494 (GRCm39) missense possibly damaging 0.78
R8198:Or7a36 UTSW 10 78,820,443 (GRCm39) missense probably benign 0.03
R8268:Or7a36 UTSW 10 78,819,831 (GRCm39) missense probably damaging 0.98
R8684:Or7a36 UTSW 10 78,820,212 (GRCm39) missense probably benign 0.06
R8928:Or7a36 UTSW 10 78,820,547 (GRCm39) missense
R9408:Or7a36 UTSW 10 78,820,220 (GRCm39) missense probably benign 0.01
R9626:Or7a36 UTSW 10 78,820,213 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- CGAGCAATGTCCACAGTTCAG -3'
(R):5'- GGTTGGACTAAAGTAATGCATACTC -3'

Sequencing Primer
(F):5'- GGGGAAGTATAAAGCATTTTCCACC -3'
(R):5'- ACACTTTCAGCTTCTACCG -3'
Posted On 2016-12-15