Incidental Mutation 'R5794:Or5g27'
ID 447108
Institutional Source Beutler Lab
Gene Symbol Or5g27
Ensembl Gene ENSMUSG00000111179
Gene Name olfactory receptor family 5 subfamily G member 27
Synonyms MOR175-4, GA_x6K02T2Q125-47058060-47059004, Olfr996
MMRRC Submission 043385-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.116) question?
Stock # R5794 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 85409559-85410626 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 85409685 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 34 (V34A)
Ref Sequence ENSEMBL: ENSMUSP00000076330 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077075]
AlphaFold Q7TRA0
Predicted Effect probably benign
Transcript: ENSMUST00000077075
AA Change: V34A

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000076330
Gene: ENSMUSG00000111179
AA Change: V34A

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.2e-52 PFAM
Pfam:7tm_1 41 290 2.7e-16 PFAM
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 96.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aftph T C 11: 20,676,955 (GRCm39) probably null Het
Ank2 T C 3: 126,723,669 (GRCm39) N923S probably benign Het
Ano6 A T 15: 95,792,405 (GRCm39) T76S probably benign Het
Carmil1 G T 13: 24,276,533 (GRCm39) N204K probably damaging Het
Cep126 T G 9: 8,103,440 (GRCm39) N190T possibly damaging Het
Clasrp A T 7: 19,325,034 (GRCm39) D198E probably damaging Het
Cma1 T C 14: 56,181,977 (GRCm39) T18A probably benign Het
Ece1 A G 4: 137,683,844 (GRCm39) I565M probably damaging Het
Etl4 T A 2: 20,811,323 (GRCm39) F1135L probably damaging Het
Fbxw20 T C 9: 109,052,358 (GRCm39) N325S probably damaging Het
Fbxw20 A T 9: 109,062,668 (GRCm39) C53S possibly damaging Het
Gnb2 T C 5: 137,526,961 (GRCm39) D203G probably benign Het
Gprc5c G T 11: 114,755,093 (GRCm39) V257L possibly damaging Het
Hoxd9 T A 2: 74,529,617 (GRCm39) F291Y probably damaging Het
Igf2r T C 17: 12,928,332 (GRCm39) S1004G probably benign Het
Irgm1 T C 11: 48,757,064 (GRCm39) Y249C probably damaging Het
Kcnh3 A C 15: 99,130,855 (GRCm39) I491L probably benign Het
Kctd10 G A 5: 114,505,398 (GRCm39) R199W probably damaging Het
Klk1b4 A T 7: 43,859,069 (GRCm39) N29I probably damaging Het
Klrc1 C T 6: 129,652,317 (GRCm39) R188Q probably damaging Het
Krt32 C A 11: 99,975,812 (GRCm39) C275F probably damaging Het
Krt73 T A 15: 101,703,264 (GRCm39) T449S probably benign Het
Napepld T A 5: 21,888,429 (GRCm39) S7C possibly damaging Het
Nfia G T 4: 97,671,838 (GRCm39) V183L possibly damaging Het
Or6c3 A C 10: 129,309,295 (GRCm39) I245L possibly damaging Het
Psma3 A G 12: 71,037,271 (GRCm39) T111A probably benign Het
Psmd11 T A 11: 80,362,318 (GRCm39) D125E probably benign Het
Rabgap1 T A 2: 37,392,914 (GRCm39) D523E probably benign Het
Rttn G T 18: 89,013,693 (GRCm39) R454L probably benign Het
Serpine2 T C 1: 79,799,156 (GRCm39) N33D probably benign Het
Six4 A T 12: 73,159,124 (GRCm39) S271T possibly damaging Het
Smoc2 T A 17: 14,589,310 (GRCm39) C260S possibly damaging Het
Snai2 A T 16: 14,524,590 (GRCm39) Y32F probably benign Het
Tapt1 C T 5: 44,334,476 (GRCm39) G505D probably benign Het
Thap12 T A 7: 98,365,600 (GRCm39) D589E probably benign Het
Ttc23l G T 15: 10,551,636 (GRCm39) T30K possibly damaging Het
Vmn2r116 T C 17: 23,604,942 (GRCm39) I85T probably damaging Het
Zfp592 G T 7: 80,674,781 (GRCm39) V582L probably benign Het
Zfp827 T C 8: 79,797,071 (GRCm39) W386R probably damaging Het
Other mutations in Or5g27
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01550:Or5g27 APN 2 85,409,875 (GRCm39) nonsense probably null
IGL01972:Or5g27 APN 2 85,410,117 (GRCm39) missense probably damaging 1.00
IGL02102:Or5g27 APN 2 85,410,017 (GRCm39) missense probably damaging 0.98
IGL03159:Or5g27 APN 2 85,410,284 (GRCm39) missense probably damaging 0.99
R0539:Or5g27 UTSW 2 85,410,119 (GRCm39) missense probably damaging 0.99
R4275:Or5g27 UTSW 2 85,410,207 (GRCm39) missense probably benign 0.07
R4561:Or5g27 UTSW 2 85,409,964 (GRCm39) missense probably damaging 0.99
R4953:Or5g27 UTSW 2 85,410,069 (GRCm39) nonsense probably null
R6061:Or5g27 UTSW 2 85,409,886 (GRCm39) missense possibly damaging 0.48
R6695:Or5g27 UTSW 2 85,409,793 (GRCm39) missense probably damaging 1.00
R6981:Or5g27 UTSW 2 85,409,825 (GRCm39) missense probably benign 0.06
R7030:Or5g27 UTSW 2 85,409,746 (GRCm39) missense possibly damaging 0.56
R7399:Or5g27 UTSW 2 85,409,640 (GRCm39) missense probably benign 0.00
R8914:Or5g27 UTSW 2 85,410,056 (GRCm39) missense possibly damaging 0.72
R9594:Or5g27 UTSW 2 85,409,882 (GRCm39) nonsense probably null
R9686:Or5g27 UTSW 2 85,410,340 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TAGACCTACTGCCACTGATTTC -3'
(R):5'- CCAAAGAACCACATCTGTGCTG -3'

Sequencing Primer
(F):5'- GACCTACTGCCACTGATTTCATAATC -3'
(R):5'- CCCACAAAAGAGATGGCTTTGTTC -3'
Posted On 2016-12-15