Incidental Mutation 'R5794:Zfp827'
ID 447122
Institutional Source Beutler Lab
Gene Symbol Zfp827
Ensembl Gene ENSMUSG00000071064
Gene Name zinc finger protein 827
Synonyms D630040G17Rik, 2810449M09Rik
MMRRC Submission 043385-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.920) question?
Stock # R5794 (G1)
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 79755066-79920395 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 79797071 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Arginine at position 386 (W386R)
Ref Sequence ENSEMBL: ENSMUSP00000096214 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087927] [ENSMUST00000098614] [ENSMUST00000119254]
AlphaFold Q505G8
Predicted Effect probably damaging
Transcript: ENSMUST00000087927
AA Change: W386R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000085238
Gene: ENSMUSG00000071064
AA Change: W386R

DomainStartEndE-ValueType
low complexity region 102 128 N/A INTRINSIC
low complexity region 226 256 N/A INTRINSIC
low complexity region 271 298 N/A INTRINSIC
low complexity region 306 342 N/A INTRINSIC
low complexity region 343 348 N/A INTRINSIC
ZnF_C2H2 371 393 6.78e-3 SMART
ZnF_C2H2 399 422 5.59e-4 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000098614
AA Change: W386R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000096214
Gene: ENSMUSG00000071064
AA Change: W386R

DomainStartEndE-ValueType
low complexity region 102 128 N/A INTRINSIC
low complexity region 226 256 N/A INTRINSIC
low complexity region 271 298 N/A INTRINSIC
low complexity region 306 342 N/A INTRINSIC
low complexity region 343 348 N/A INTRINSIC
ZnF_C2H2 371 393 6.78e-3 SMART
ZnF_C2H2 399 421 2.99e-4 SMART
ZnF_C2H2 430 452 5.42e-2 SMART
internal_repeat_2 561 585 3.31e-7 PROSPERO
low complexity region 613 627 N/A INTRINSIC
internal_repeat_2 719 743 3.31e-7 PROSPERO
ZnF_C2H2 814 836 2.4e-3 SMART
ZnF_C2H2 842 864 4.72e-2 SMART
ZnF_C2H2 894 916 1.64e-1 SMART
ZnF_C2H2 926 949 7.89e0 SMART
low complexity region 956 974 N/A INTRINSIC
ZnF_C2H2 1016 1038 1.26e-2 SMART
ZnF_C2H2 1044 1066 3.07e-1 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000119254
AA Change: W386R

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000113199
Gene: ENSMUSG00000071064
AA Change: W386R

DomainStartEndE-ValueType
low complexity region 102 128 N/A INTRINSIC
low complexity region 226 256 N/A INTRINSIC
low complexity region 271 298 N/A INTRINSIC
low complexity region 306 342 N/A INTRINSIC
low complexity region 343 348 N/A INTRINSIC
ZnF_C2H2 371 393 6.78e-3 SMART
ZnF_C2H2 399 421 2.99e-4 SMART
ZnF_C2H2 430 452 5.42e-2 SMART
internal_repeat_2 561 585 3.25e-7 PROSPERO
low complexity region 613 627 N/A INTRINSIC
internal_repeat_2 719 743 3.25e-7 PROSPERO
ZnF_C2H2 814 836 2.4e-3 SMART
ZnF_C2H2 842 864 4.72e-2 SMART
ZnF_C2H2 894 916 1.64e-1 SMART
ZnF_C2H2 926 949 7.89e0 SMART
low complexity region 956 974 N/A INTRINSIC
ZnF_C2H2 1016 1038 1.26e-2 SMART
ZnF_C2H2 1044 1066 3.07e-1 SMART
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 96.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aftph T C 11: 20,676,955 (GRCm39) probably null Het
Ank2 T C 3: 126,723,669 (GRCm39) N923S probably benign Het
Ano6 A T 15: 95,792,405 (GRCm39) T76S probably benign Het
Carmil1 G T 13: 24,276,533 (GRCm39) N204K probably damaging Het
Cep126 T G 9: 8,103,440 (GRCm39) N190T possibly damaging Het
Clasrp A T 7: 19,325,034 (GRCm39) D198E probably damaging Het
Cma1 T C 14: 56,181,977 (GRCm39) T18A probably benign Het
Ece1 A G 4: 137,683,844 (GRCm39) I565M probably damaging Het
Etl4 T A 2: 20,811,323 (GRCm39) F1135L probably damaging Het
Fbxw20 T C 9: 109,052,358 (GRCm39) N325S probably damaging Het
Fbxw20 A T 9: 109,062,668 (GRCm39) C53S possibly damaging Het
Gnb2 T C 5: 137,526,961 (GRCm39) D203G probably benign Het
Gprc5c G T 11: 114,755,093 (GRCm39) V257L possibly damaging Het
Hoxd9 T A 2: 74,529,617 (GRCm39) F291Y probably damaging Het
Igf2r T C 17: 12,928,332 (GRCm39) S1004G probably benign Het
Irgm1 T C 11: 48,757,064 (GRCm39) Y249C probably damaging Het
Kcnh3 A C 15: 99,130,855 (GRCm39) I491L probably benign Het
Kctd10 G A 5: 114,505,398 (GRCm39) R199W probably damaging Het
Klk1b4 A T 7: 43,859,069 (GRCm39) N29I probably damaging Het
Klrc1 C T 6: 129,652,317 (GRCm39) R188Q probably damaging Het
Krt32 C A 11: 99,975,812 (GRCm39) C275F probably damaging Het
Krt73 T A 15: 101,703,264 (GRCm39) T449S probably benign Het
Napepld T A 5: 21,888,429 (GRCm39) S7C possibly damaging Het
Nfia G T 4: 97,671,838 (GRCm39) V183L possibly damaging Het
Or5g27 T C 2: 85,409,685 (GRCm39) V34A probably benign Het
Or6c3 A C 10: 129,309,295 (GRCm39) I245L possibly damaging Het
Psma3 A G 12: 71,037,271 (GRCm39) T111A probably benign Het
Psmd11 T A 11: 80,362,318 (GRCm39) D125E probably benign Het
Rabgap1 T A 2: 37,392,914 (GRCm39) D523E probably benign Het
Rttn G T 18: 89,013,693 (GRCm39) R454L probably benign Het
Serpine2 T C 1: 79,799,156 (GRCm39) N33D probably benign Het
Six4 A T 12: 73,159,124 (GRCm39) S271T possibly damaging Het
Smoc2 T A 17: 14,589,310 (GRCm39) C260S possibly damaging Het
Snai2 A T 16: 14,524,590 (GRCm39) Y32F probably benign Het
Tapt1 C T 5: 44,334,476 (GRCm39) G505D probably benign Het
Thap12 T A 7: 98,365,600 (GRCm39) D589E probably benign Het
Ttc23l G T 15: 10,551,636 (GRCm39) T30K possibly damaging Het
Vmn2r116 T C 17: 23,604,942 (GRCm39) I85T probably damaging Het
Zfp592 G T 7: 80,674,781 (GRCm39) V582L probably benign Het
Other mutations in Zfp827
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01448:Zfp827 APN 8 79,787,362 (GRCm39) missense possibly damaging 0.82
IGL01545:Zfp827 APN 8 79,797,063 (GRCm39) missense probably damaging 1.00
IGL01552:Zfp827 APN 8 79,802,820 (GRCm39) missense probably damaging 1.00
IGL02261:Zfp827 APN 8 79,906,708 (GRCm39) missense probably damaging 0.97
IGL02451:Zfp827 APN 8 79,787,601 (GRCm39) missense probably damaging 1.00
IGL03130:Zfp827 APN 8 79,787,586 (GRCm39) missense probably damaging 1.00
IGL03411:Zfp827 APN 8 79,803,116 (GRCm39) missense probably damaging 0.99
E0354:Zfp827 UTSW 8 79,863,206 (GRCm39) missense probably damaging 1.00
R0502:Zfp827 UTSW 8 79,905,706 (GRCm39) splice site probably null
R0547:Zfp827 UTSW 8 79,786,939 (GRCm39) missense probably damaging 1.00
R0926:Zfp827 UTSW 8 79,844,821 (GRCm39) missense probably benign 0.00
R0975:Zfp827 UTSW 8 79,787,814 (GRCm39) missense probably benign 0.00
R1305:Zfp827 UTSW 8 79,787,523 (GRCm39) missense possibly damaging 0.95
R1462:Zfp827 UTSW 8 79,803,108 (GRCm39) missense probably benign
R1462:Zfp827 UTSW 8 79,803,108 (GRCm39) missense probably benign
R1638:Zfp827 UTSW 8 79,802,975 (GRCm39) missense possibly damaging 0.94
R1714:Zfp827 UTSW 8 79,787,202 (GRCm39) missense probably damaging 1.00
R2044:Zfp827 UTSW 8 79,802,865 (GRCm39) missense probably benign
R2132:Zfp827 UTSW 8 79,912,350 (GRCm39) missense possibly damaging 0.53
R3844:Zfp827 UTSW 8 79,863,248 (GRCm39) missense probably damaging 0.99
R4329:Zfp827 UTSW 8 79,916,463 (GRCm39) utr 3 prime probably benign
R4629:Zfp827 UTSW 8 79,787,011 (GRCm39) missense probably damaging 0.99
R4873:Zfp827 UTSW 8 79,787,403 (GRCm39) missense probably damaging 1.00
R4875:Zfp827 UTSW 8 79,787,403 (GRCm39) missense probably damaging 1.00
R4936:Zfp827 UTSW 8 79,787,812 (GRCm39) missense probably benign
R4965:Zfp827 UTSW 8 79,787,910 (GRCm39) missense probably benign
R5103:Zfp827 UTSW 8 79,797,032 (GRCm39) missense probably damaging 1.00
R5366:Zfp827 UTSW 8 79,912,333 (GRCm39) missense possibly damaging 0.94
R5825:Zfp827 UTSW 8 79,905,645 (GRCm39) missense probably damaging 1.00
R6118:Zfp827 UTSW 8 79,803,067 (GRCm39) missense possibly damaging 0.75
R6236:Zfp827 UTSW 8 79,797,105 (GRCm39) missense probably damaging 1.00
R6263:Zfp827 UTSW 8 79,905,702 (GRCm39) missense probably damaging 1.00
R6306:Zfp827 UTSW 8 79,787,324 (GRCm39) missense probably damaging 1.00
R6490:Zfp827 UTSW 8 79,916,606 (GRCm39) utr 3 prime probably benign
R6497:Zfp827 UTSW 8 79,906,757 (GRCm39) missense probably damaging 1.00
R7250:Zfp827 UTSW 8 79,916,721 (GRCm39) missense
R7290:Zfp827 UTSW 8 79,916,442 (GRCm39) missense possibly damaging 0.86
R7443:Zfp827 UTSW 8 79,917,047 (GRCm39) missense
R7708:Zfp827 UTSW 8 79,902,591 (GRCm39) missense probably damaging 1.00
R7754:Zfp827 UTSW 8 79,916,958 (GRCm39) missense
R7836:Zfp827 UTSW 8 79,912,979 (GRCm39) missense probably damaging 1.00
R7995:Zfp827 UTSW 8 79,844,887 (GRCm39) missense possibly damaging 0.86
R8162:Zfp827 UTSW 8 79,787,206 (GRCm39) nonsense probably null
R8747:Zfp827 UTSW 8 79,755,316 (GRCm39) start codon destroyed probably null
R8798:Zfp827 UTSW 8 79,916,463 (GRCm39) utr 3 prime probably benign
R8980:Zfp827 UTSW 8 79,803,092 (GRCm39) missense probably benign 0.00
R9099:Zfp827 UTSW 8 79,917,107 (GRCm39) missense
R9178:Zfp827 UTSW 8 79,818,564 (GRCm39) missense probably damaging 1.00
R9246:Zfp827 UTSW 8 79,803,132 (GRCm39) missense possibly damaging 0.75
R9277:Zfp827 UTSW 8 79,787,029 (GRCm39) missense probably damaging 0.97
R9318:Zfp827 UTSW 8 79,844,982 (GRCm39) missense possibly damaging 0.75
R9339:Zfp827 UTSW 8 79,844,887 (GRCm39) missense probably benign 0.00
R9425:Zfp827 UTSW 8 79,905,588 (GRCm39) missense probably damaging 1.00
R9499:Zfp827 UTSW 8 79,787,403 (GRCm39) missense probably damaging 1.00
R9544:Zfp827 UTSW 8 79,905,604 (GRCm39) missense probably damaging 1.00
R9551:Zfp827 UTSW 8 79,787,403 (GRCm39) missense probably damaging 1.00
R9552:Zfp827 UTSW 8 79,787,403 (GRCm39) missense probably damaging 1.00
R9588:Zfp827 UTSW 8 79,905,604 (GRCm39) missense probably damaging 1.00
R9665:Zfp827 UTSW 8 79,906,756 (GRCm39) missense possibly damaging 0.89
Predicted Primers PCR Primer
(F):5'- TCCTTAAAGGAAAGCAGCCG -3'
(R):5'- TACTCACAACCCAGTGTTAGC -3'

Sequencing Primer
(F):5'- GCAGCCGTAAGAGTTTCCTCATAG -3'
(R):5'- ACAACCCAGTGTTAGCTTTCTCAGG -3'
Posted On 2016-12-15