Incidental Mutation 'R5799:Lipo3'
ID 447432
Institutional Source Beutler Lab
Gene Symbol Lipo3
Ensembl Gene ENSMUSG00000024766
Gene Name lipase, member O3
Synonyms Lipo1
MMRRC Submission 043388-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R5799 (G1)
Quality Score 86
Status Not validated
Chromosome 19
Chromosomal Location 33532560-33568069 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) T to C at 33755093 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000136249 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000178735]
AlphaFold Q3UT41
Predicted Effect unknown
Transcript: ENSMUST00000148137
AA Change: T230A
SMART Domains Protein: ENSMUSP00000118385
Gene: ENSMUSG00000079342
AA Change: T230A

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:Abhydro_lipase 37 99 2.8e-21 PFAM
Pfam:Hydrolase_4 76 239 4.3e-8 PFAM
Pfam:Abhydrolase_1 80 219 2.2e-17 PFAM
Pfam:Abhydrolase_5 80 233 8.7e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000178735
SMART Domains Protein: ENSMUSP00000136249
Gene: ENSMUSG00000079342

DomainStartEndE-ValueType
Pfam:Abhydro_lipase 33 95 1.3e-20 PFAM
Pfam:Hydrolase_4 72 231 3.5e-8 PFAM
Pfam:Abhydrolase_5 76 370 3.7e-10 PFAM
Pfam:Abhydrolase_1 76 376 6.8e-21 PFAM
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency 89% (51/57)
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AA986860 C T 1: 130,668,908 (GRCm39) Q92* probably null Het
Accsl T C 2: 93,694,748 (GRCm39) probably null Het
Ahnak2 T C 12: 112,745,365 (GRCm39) probably benign Het
Alcam T C 16: 52,130,212 (GRCm39) D46G probably benign Het
Asap2 T C 12: 21,218,247 (GRCm39) S57P probably damaging Het
Atg14 A T 14: 47,784,752 (GRCm39) V314D possibly damaging Het
C230029F24Rik C T 1: 49,377,307 (GRCm39) noncoding transcript Het
Calcr A T 6: 3,707,592 (GRCm39) I236N probably benign Het
Cass4 G A 2: 172,258,107 (GRCm39) G35E probably damaging Het
Chmp6 T C 11: 119,807,517 (GRCm39) I120T probably benign Het
Col13a1 A G 10: 61,684,919 (GRCm39) probably benign Het
Cstdc4 T A 16: 36,004,631 (GRCm39) M1K probably null Het
Ddhd2 T A 8: 26,238,629 (GRCm39) L328F probably damaging Het
Defa40 T A 8: 21,740,359 (GRCm39) probably null Het
Dnmt3l A G 10: 77,887,860 (GRCm39) D123G possibly damaging Het
Eea1 T A 10: 95,838,810 (GRCm39) V287E possibly damaging Het
Efcc1 A G 6: 87,708,164 (GRCm39) N97S probably benign Het
Exd1 A G 2: 119,369,262 (GRCm39) S118P probably benign Het
Ext2 G T 2: 93,642,317 (GRCm39) T184K probably benign Het
Fam186a G A 15: 99,864,705 (GRCm39) Q42* probably null Het
Gbp2 A T 3: 142,337,843 (GRCm39) I320L probably benign Het
Gramd2a G A 9: 59,615,299 (GRCm39) G13R probably benign Het
H2-Q5 T C 17: 35,613,115 (GRCm39) M5T unknown Het
Jak3 C T 8: 72,131,344 (GRCm39) L70F probably damaging Het
Lhpp G A 7: 132,307,364 (GRCm39) V254M probably damaging Het
Lig1 T A 7: 13,030,184 (GRCm39) V387E possibly damaging Het
Lrrc8b C T 5: 105,629,208 (GRCm39) S518L probably benign Het
Narf T C 11: 121,135,480 (GRCm39) Y111H probably damaging Het
Ncf4 A G 15: 78,135,177 (GRCm39) K78R probably benign Het
Nrap A T 19: 56,330,601 (GRCm39) C1118* probably null Het
Nubp2 A G 17: 25,104,772 (GRCm39) V23A probably damaging Het
Or4l1 A T 14: 50,166,497 (GRCm39) F168Y probably damaging Het
Or6c219 A T 10: 129,781,780 (GRCm39) D50E possibly damaging Het
Or8g55 T C 9: 39,785,392 (GRCm39) S274P possibly damaging Het
Pdzd7 G A 19: 45,025,428 (GRCm39) P356S probably benign Het
Rttn T C 18: 89,056,070 (GRCm39) V984A probably damaging Het
Ryr3 A G 2: 112,516,925 (GRCm39) S3334P probably damaging Het
Senp7 G A 16: 55,959,468 (GRCm39) probably null Het
Slc25a3 A C 10: 90,957,903 (GRCm39) Y50D probably benign Het
Slc35e2 C T 4: 155,694,483 (GRCm39) P10L probably benign Het
Slc38a2 A T 15: 96,592,970 (GRCm39) S163T probably benign Het
Sp110 A C 1: 85,505,050 (GRCm39) F434C probably benign Het
Stam2 A T 2: 52,610,922 (GRCm39) C4* probably null Het
Taf1a A G 1: 183,177,272 (GRCm39) D50G possibly damaging Het
Taf6l A T 19: 8,759,995 (GRCm39) Y106N possibly damaging Het
Taf7l2 T C 10: 115,948,674 (GRCm39) E284G probably damaging Het
Tbx20 G A 9: 24,636,816 (GRCm39) Q424* probably null Het
Tex10 A G 4: 48,433,295 (GRCm39) V829A possibly damaging Het
Tgfbr3 T C 5: 107,257,474 (GRCm39) probably benign Het
Tnfsf10 G T 3: 27,389,742 (GRCm39) V268F probably damaging Het
Trrap A G 5: 144,767,755 (GRCm39) T2571A probably benign Het
Other mutations in Lipo3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01521:Lipo3 APN 19 33,763,083 (GRCm39) missense probably damaging 1.00
IGL01697:Lipo3 APN 19 33,536,965 (GRCm39) missense probably damaging 1.00
IGL01916:Lipo3 APN 19 33,762,182 (GRCm39) missense probably damaging 1.00
IGL02027:Lipo3 APN 19 33,557,919 (GRCm39) nonsense probably null
IGL02047:Lipo3 APN 19 33,534,562 (GRCm39) missense probably benign 0.00
IGL02586:Lipo3 APN 19 33,559,539 (GRCm39) missense possibly damaging 0.95
IGL03005:Lipo3 APN 19 33,763,136 (GRCm39) missense possibly damaging 0.65
IGL03111:Lipo3 APN 19 33,559,637 (GRCm39) missense probably damaging 0.96
IGL03404:Lipo3 APN 19 33,560,440 (GRCm39) splice site probably benign
R0122:Lipo3 UTSW 19 33,600,086 (GRCm39) intron probably benign
R0128:Lipo3 UTSW 19 33,534,506 (GRCm39) critical splice donor site probably null
R0540:Lipo3 UTSW 19 33,536,967 (GRCm39) missense possibly damaging 0.62
R0551:Lipo3 UTSW 19 33,557,951 (GRCm39) missense probably damaging 1.00
R0568:Lipo3 UTSW 19 33,559,442 (GRCm39) splice site probably benign
R0646:Lipo3 UTSW 19 33,762,169 (GRCm39) nonsense probably null
R0669:Lipo3 UTSW 19 33,537,025 (GRCm39) missense probably benign 0.05
R1704:Lipo3 UTSW 19 33,757,743 (GRCm39) missense possibly damaging 0.87
R1772:Lipo3 UTSW 19 33,764,821 (GRCm39) missense probably benign 0.45
R1862:Lipo3 UTSW 19 33,762,092 (GRCm39) missense probably damaging 1.00
R1863:Lipo3 UTSW 19 33,762,092 (GRCm39) missense probably damaging 1.00
R2911:Lipo3 UTSW 19 33,556,767 (GRCm39) missense probably benign 0.00
R3801:Lipo3 UTSW 19 33,762,257 (GRCm39) missense probably damaging 0.99
R3802:Lipo3 UTSW 19 33,762,257 (GRCm39) missense probably damaging 0.99
R3803:Lipo3 UTSW 19 33,762,257 (GRCm39) missense probably damaging 0.99
R3973:Lipo3 UTSW 19 33,535,723 (GRCm39) missense probably damaging 1.00
R4020:Lipo3 UTSW 19 33,764,804 (GRCm39) missense probably benign 0.00
R4648:Lipo3 UTSW 19 33,760,860 (GRCm39) missense probably damaging 1.00
R4660:Lipo3 UTSW 19 33,598,360 (GRCm39) intron probably benign
R4775:Lipo3 UTSW 19 33,757,795 (GRCm39) missense probably damaging 1.00
R4787:Lipo3 UTSW 19 33,757,749 (GRCm39) missense probably benign 0.00
R4820:Lipo3 UTSW 19 33,560,497 (GRCm39) missense probably damaging 1.00
R4830:Lipo3 UTSW 19 33,753,987 (GRCm39) missense probably damaging 0.99
R4951:Lipo3 UTSW 19 33,759,621 (GRCm39) missense probably benign 0.01
R5117:Lipo3 UTSW 19 33,536,952 (GRCm39) missense probably benign
R5258:Lipo3 UTSW 19 33,591,243 (GRCm39) intron probably benign
R5853:Lipo3 UTSW 19 33,759,630 (GRCm39) missense probably benign 0.37
R6235:Lipo3 UTSW 19 33,760,963 (GRCm39) missense probably damaging 0.96
R6296:Lipo3 UTSW 19 33,757,737 (GRCm39) missense probably benign 0.10
R6383:Lipo3 UTSW 19 33,533,831 (GRCm39) missense probably benign 0.02
R6659:Lipo3 UTSW 19 33,533,828 (GRCm39) missense possibly damaging 0.55
R6913:Lipo3 UTSW 19 33,757,705 (GRCm39) missense probably benign 0.00
R6915:Lipo3 UTSW 19 33,562,293 (GRCm39) missense probably damaging 1.00
R7092:Lipo3 UTSW 19 33,591,092 (GRCm39) splice site probably null
R7444:Lipo3 UTSW 19 33,535,663 (GRCm39) critical splice donor site probably null
R7532:Lipo3 UTSW 19 33,560,464 (GRCm39) missense possibly damaging 0.90
R7672:Lipo3 UTSW 19 33,757,785 (GRCm39) missense probably benign 0.23
R7796:Lipo3 UTSW 19 33,759,634 (GRCm39) missense possibly damaging 0.75
R7945:Lipo3 UTSW 19 33,533,831 (GRCm39) missense probably benign 0.02
R8683:Lipo3 UTSW 19 33,759,604 (GRCm39) missense probably benign 0.04
R8936:Lipo3 UTSW 19 33,557,880 (GRCm39) missense probably damaging 1.00
R9062:Lipo3 UTSW 19 33,757,714 (GRCm39) missense probably damaging 1.00
R9086:Lipo3 UTSW 19 33,534,529 (GRCm39) missense probably benign 0.44
R9432:Lipo3 UTSW 19 33,533,864 (GRCm39) missense probably damaging 1.00
R9615:Lipo3 UTSW 19 33,754,047 (GRCm39) missense probably benign 0.02
R9620:Lipo3 UTSW 19 33,559,629 (GRCm39) nonsense probably null
Z1176:Lipo3 UTSW 19 33,562,328 (GRCm39) missense probably null 0.97
Predicted Primers PCR Primer
(F):5'- CCTGAAATACACCACTTCTAATTGC -3'
(R):5'- CTCCTGATCATTATAACCGCTTAAG -3'

Sequencing Primer
(F):5'- ACCACTTCTAATTGCCTAAAATACAG -3'
(R):5'- TCCAAAGAGCAACTAAATTACTCTG -3'
Posted On 2016-12-15