Incidental Mutation 'R5782:Zzz3'
ID 447781
Institutional Source Beutler Lab
Gene Symbol Zzz3
Ensembl Gene ENSMUSG00000039068
Gene Name zinc finger, ZZ domain containing 3
Synonyms 6430567E01Rik, 3110065C23Rik
MMRRC Submission 043379-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R5782 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 152101110-152168463 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 152133737 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 265 (E265G)
Ref Sequence ENSEMBL: ENSMUSP00000101707 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089982] [ENSMUST00000106100] [ENSMUST00000106101] [ENSMUST00000106103] [ENSMUST00000200570]
AlphaFold Q6KAQ7
Predicted Effect possibly damaging
Transcript: ENSMUST00000089982
AA Change: E265G

PolyPhen 2 Score 0.689 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000087428
Gene: ENSMUSG00000039068
AA Change: E265G

DomainStartEndE-ValueType
SANT 657 711 1.42e-9 SMART
low complexity region 776 787 N/A INTRINSIC
low complexity region 799 814 N/A INTRINSIC
ZnF_ZZ 823 871 6.46e-3 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000106100
AA Change: E265G

PolyPhen 2 Score 0.689 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000101706
Gene: ENSMUSG00000039068
AA Change: E265G

DomainStartEndE-ValueType
SANT 658 712 1.42e-9 SMART
low complexity region 777 788 N/A INTRINSIC
low complexity region 800 815 N/A INTRINSIC
ZnF_ZZ 824 872 6.46e-3 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000106101
AA Change: E265G

PolyPhen 2 Score 0.689 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000101707
Gene: ENSMUSG00000039068
AA Change: E265G

DomainStartEndE-ValueType
SANT 658 712 1.42e-9 SMART
low complexity region 777 788 N/A INTRINSIC
low complexity region 800 815 N/A INTRINSIC
ZnF_ZZ 824 872 6.46e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000106103
SMART Domains Protein: ENSMUSP00000101709
Gene: ENSMUSG00000039068

DomainStartEndE-ValueType
SANT 157 211 1.42e-9 SMART
low complexity region 276 287 N/A INTRINSIC
low complexity region 299 314 N/A INTRINSIC
ZnF_ZZ 323 371 6.46e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138115
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150802
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197987
Predicted Effect probably benign
Transcript: ENSMUST00000200570
SMART Domains Protein: ENSMUSP00000143693
Gene: ENSMUSG00000039068

DomainStartEndE-ValueType
SANT 161 215 1.42e-9 SMART
low complexity region 280 291 N/A INTRINSIC
low complexity region 303 318 N/A INTRINSIC
ZnF_ZZ 327 375 6.46e-3 SMART
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actl9 A T 17: 33,652,735 (GRCm39) Q265L probably benign Het
Adamtsl3 T A 7: 82,189,494 (GRCm39) probably null Het
Agt A T 8: 125,283,870 (GRCm39) probably null Het
Ankrd11 A G 8: 123,626,756 (GRCm39) L142P probably damaging Het
Arhgef19 C A 4: 140,983,623 (GRCm39) Q719K probably damaging Het
Armh3 A G 19: 45,874,466 (GRCm39) V569A probably benign Het
Atrnl1 G T 19: 57,741,718 (GRCm39) W1159L possibly damaging Het
Atxn2 T C 5: 121,935,373 (GRCm39) Y325H probably damaging Het
Brwd1 A T 16: 95,844,243 (GRCm39) Y770* probably null Het
Cdc20 T C 4: 118,290,239 (GRCm39) E474G probably benign Het
Cdk5rap3 A G 11: 96,802,412 (GRCm39) L254P probably benign Het
Cep83 A T 10: 94,584,894 (GRCm39) N333I probably damaging Het
Cox4i2 A C 2: 152,606,731 (GRCm39) D150A probably damaging Het
Cse1l A G 2: 166,770,921 (GRCm39) I314M probably damaging Het
Cuedc1 A G 11: 88,060,858 (GRCm39) Y67C probably damaging Het
Cyp2j9 C T 4: 96,462,142 (GRCm39) V380I probably benign Het
Fancd2 A G 6: 113,525,833 (GRCm39) N302S probably benign Het
Foxa1 T A 12: 57,589,302 (GRCm39) H306L probably benign Het
Gse1 T C 8: 121,293,260 (GRCm39) S204P probably damaging Het
Hspa13 C A 16: 75,554,985 (GRCm39) R367L probably damaging Het
Kcnk2 T G 1: 188,988,776 (GRCm39) D267A probably damaging Het
Kctd18 A G 1: 57,998,396 (GRCm39) Y68H probably damaging Het
Khdc4 T G 3: 88,618,985 (GRCm39) V563G probably damaging Het
Klf7 C T 1: 64,081,570 (GRCm39) E253K possibly damaging Het
Lcn12 A T 2: 25,383,769 (GRCm39) F34I probably damaging Het
Lrrk2 A T 15: 91,586,386 (GRCm39) R401W probably damaging Het
Lzts1 A T 8: 69,593,350 (GRCm39) S86T probably benign Het
Mtres1 T C 10: 43,408,899 (GRCm39) I81M probably benign Het
Mtus1 T A 8: 41,535,764 (GRCm39) I651F probably damaging Het
Myl2 T A 5: 122,242,933 (GRCm39) F106L probably damaging Het
Neb T A 2: 52,154,059 (GRCm39) K2351* probably null Het
Or14c45 T A 7: 86,176,421 (GRCm39) I152N probably damaging Het
Or52e5 T C 7: 104,718,956 (GRCm39) I94T probably damaging Het
Otogl G A 10: 107,612,978 (GRCm39) silent Het
Parg A T 14: 31,996,862 (GRCm39) R318* probably null Het
Pcdhga3 C T 18: 37,809,353 (GRCm39) S602F possibly damaging Het
Pcnx2 A G 8: 126,480,223 (GRCm39) V2028A probably damaging Het
Pkhd1 T C 1: 20,128,824 (GRCm39) T3960A probably benign Het
Psen1 T A 12: 83,759,233 (GRCm39) H81Q possibly damaging Het
Psma6 A G 12: 55,457,041 (GRCm39) N109S possibly damaging Het
Ptpro A T 6: 137,376,496 (GRCm39) I659F possibly damaging Het
Rap1gds1 C G 3: 138,664,840 (GRCm39) E288D possibly damaging Het
Reln C T 5: 22,223,054 (GRCm39) R993K probably benign Het
Saxo1 T A 4: 86,364,044 (GRCm39) L146F probably damaging Het
Six4 A G 12: 73,150,832 (GRCm39) V571A probably benign Het
Slc2a10 C A 2: 165,356,758 (GRCm39) Y139* probably null Het
Slc34a1 A G 13: 55,550,501 (GRCm39) I66V possibly damaging Het
Slfn8 G T 11: 82,907,867 (GRCm39) N46K probably damaging Het
Smc6 G C 12: 11,340,835 (GRCm39) A496P probably damaging Het
Stk31 T G 6: 49,446,070 (GRCm39) N902K probably benign Het
Stk36 T A 1: 74,644,584 (GRCm39) Y114N possibly damaging Het
Sult2b1 C T 7: 45,380,770 (GRCm39) V271M probably damaging Het
Tenm4 A G 7: 96,542,246 (GRCm39) I1920V probably benign Het
Trbc2 A G 6: 41,523,871 (GRCm39) probably benign Het
Trpc2 A G 7: 101,733,186 (GRCm39) D419G possibly damaging Het
Trpm7 T C 2: 126,639,634 (GRCm39) N1654S probably benign Het
Tsku A T 7: 98,002,057 (GRCm39) D91E probably damaging Het
Ttn T A 2: 76,606,355 (GRCm39) R18151S probably damaging Het
Tyr C T 7: 87,142,224 (GRCm39) C112Y probably damaging Het
Ubash3a G A 17: 31,454,477 (GRCm39) G435S probably benign Het
Vav1 T C 17: 57,603,001 (GRCm39) I51T probably damaging Het
Vmn2r61 T A 7: 41,949,253 (GRCm39) C558S probably damaging Het
Zan C T 5: 137,418,269 (GRCm39) C2943Y unknown Het
Zfp1002 T C 2: 150,097,438 (GRCm39) E25G probably benign Het
Zfp267 T C 3: 36,219,128 (GRCm39) S384P possibly damaging Het
Zfp318 TGAAGAAGAAGAAGAAGAAGAAGAAGAAG TGAAGAAGAAGAAGAAGAAGAAG 17: 46,723,440 (GRCm39) probably benign Het
Zfp575 C A 7: 24,285,027 (GRCm39) G205C possibly damaging Het
Zfp740 G T 15: 102,116,801 (GRCm39) probably benign Het
Other mutations in Zzz3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00691:Zzz3 APN 3 152,134,151 (GRCm39) missense probably benign 0.16
IGL00707:Zzz3 APN 3 152,154,680 (GRCm39) nonsense probably null
IGL00983:Zzz3 APN 3 152,161,447 (GRCm39) splice site probably benign
IGL01586:Zzz3 APN 3 152,161,476 (GRCm39) missense possibly damaging 0.80
IGL01973:Zzz3 APN 3 152,134,007 (GRCm39) missense probably benign 0.00
IGL02002:Zzz3 APN 3 152,157,006 (GRCm39) missense probably damaging 0.98
IGL02009:Zzz3 APN 3 152,133,752 (GRCm39) missense possibly damaging 0.80
IGL02260:Zzz3 APN 3 152,157,720 (GRCm39) missense probably benign 0.04
IGL02336:Zzz3 APN 3 152,133,696 (GRCm39) missense possibly damaging 0.74
IGL02454:Zzz3 APN 3 152,134,211 (GRCm39) missense probably benign 0.03
IGL02519:Zzz3 APN 3 152,133,027 (GRCm39) missense probably damaging 1.00
R0067:Zzz3 UTSW 3 152,134,040 (GRCm39) missense possibly damaging 0.88
R0067:Zzz3 UTSW 3 152,134,040 (GRCm39) missense possibly damaging 0.88
R0314:Zzz3 UTSW 3 152,133,085 (GRCm39) missense probably benign 0.00
R0536:Zzz3 UTSW 3 152,154,465 (GRCm39) missense probably damaging 1.00
R1706:Zzz3 UTSW 3 152,154,735 (GRCm39) missense probably damaging 1.00
R2869:Zzz3 UTSW 3 152,152,481 (GRCm39) synonymous silent
R2870:Zzz3 UTSW 3 152,152,481 (GRCm39) synonymous silent
R2871:Zzz3 UTSW 3 152,152,481 (GRCm39) synonymous silent
R2872:Zzz3 UTSW 3 152,152,481 (GRCm39) synonymous silent
R3927:Zzz3 UTSW 3 152,161,499 (GRCm39) missense probably damaging 1.00
R4195:Zzz3 UTSW 3 152,134,102 (GRCm39) missense probably benign 0.02
R4768:Zzz3 UTSW 3 152,154,420 (GRCm39) missense probably damaging 1.00
R5248:Zzz3 UTSW 3 152,133,182 (GRCm39) missense probably damaging 0.99
R5566:Zzz3 UTSW 3 152,161,461 (GRCm39) missense probably damaging 1.00
R5752:Zzz3 UTSW 3 152,157,759 (GRCm39) missense possibly damaging 0.48
R5884:Zzz3 UTSW 3 152,156,295 (GRCm39) missense probably damaging 1.00
R6008:Zzz3 UTSW 3 152,133,788 (GRCm39) missense probably benign 0.01
R6155:Zzz3 UTSW 3 152,133,319 (GRCm39) missense possibly damaging 0.57
R6557:Zzz3 UTSW 3 152,134,097 (GRCm39) missense probably damaging 1.00
R6865:Zzz3 UTSW 3 152,133,690 (GRCm39) missense probably benign 0.01
R7344:Zzz3 UTSW 3 152,157,736 (GRCm39) missense probably damaging 0.98
R7588:Zzz3 UTSW 3 152,128,405 (GRCm39) missense possibly damaging 0.85
R7636:Zzz3 UTSW 3 152,133,289 (GRCm39) missense probably benign
R7732:Zzz3 UTSW 3 152,154,479 (GRCm39) missense probably damaging 1.00
R8157:Zzz3 UTSW 3 152,155,285 (GRCm39) missense probably null 0.71
R8490:Zzz3 UTSW 3 152,134,290 (GRCm39) nonsense probably null
R8926:Zzz3 UTSW 3 152,133,529 (GRCm39) missense possibly damaging 0.76
R9143:Zzz3 UTSW 3 152,163,908 (GRCm39) missense probably benign 0.04
R9243:Zzz3 UTSW 3 152,133,920 (GRCm39) missense probably damaging 1.00
R9494:Zzz3 UTSW 3 152,133,468 (GRCm39) missense possibly damaging 0.88
R9540:Zzz3 UTSW 3 152,156,306 (GRCm39) nonsense probably null
X0018:Zzz3 UTSW 3 152,134,370 (GRCm39) missense possibly damaging 0.88
Z1176:Zzz3 UTSW 3 152,154,734 (GRCm39) missense possibly damaging 0.94
Predicted Primers PCR Primer
(F):5'- GGGCCACTTAATGCTGCAGTAG -3'
(R):5'- ACTGCTCTTTGGAGGCACTG -3'

Sequencing Primer
(F):5'- CCACTTAATGCTGCAGTAGTAGAAG -3'
(R):5'- GAGGCACTGCTATCTCCCAC -3'
Posted On 2016-12-15