Incidental Mutation 'R5786:Fmo4'
ID 447990
Institutional Source Beutler Lab
Gene Symbol Fmo4
Ensembl Gene ENSMUSG00000026692
Gene Name flavin containing monooxygenase 4
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.093) question?
Stock # R5786 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 162620757-162641541 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 162631286 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Aspartic acid at position 227 (G227D)
Ref Sequence ENSEMBL: ENSMUSP00000107150 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028014] [ENSMUST00000111525] [ENSMUST00000140274] [ENSMUST00000144916]
AlphaFold Q8VHG0
Predicted Effect probably benign
Transcript: ENSMUST00000028014
AA Change: G227D

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000028014
Gene: ENSMUSG00000026692
AA Change: G227D

DomainStartEndE-ValueType
Pfam:FMO-like 2 531 9.4e-272 PFAM
Pfam:Pyr_redox_2 4 430 1e-8 PFAM
Pfam:Pyr_redox_3 6 220 5.1e-16 PFAM
Pfam:K_oxygenase 68 227 1.7e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111525
AA Change: G227D

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000107150
Gene: ENSMUSG00000026692
AA Change: G227D

DomainStartEndE-ValueType
Pfam:FMO-like 2 531 9.4e-272 PFAM
Pfam:Pyr_redox_2 3 225 1.7e-11 PFAM
Pfam:Pyr_redox_3 6 220 2.5e-9 PFAM
Pfam:K_oxygenase 67 227 6e-12 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140031
Predicted Effect probably benign
Transcript: ENSMUST00000140274
SMART Domains Protein: ENSMUSP00000118476
Gene: ENSMUSG00000026692

DomainStartEndE-ValueType
Pfam:FMO-like 2 99 1.5e-57 PFAM
Pfam:NAD_binding_8 7 94 1.6e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000144916
SMART Domains Protein: ENSMUSP00000119389
Gene: ENSMUSG00000026692

DomainStartEndE-ValueType
Pfam:FMO-like 1 114 2.6e-63 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000193508
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jan 2015]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810009J06Rik T A 6: 40,945,122 (GRCm39) D200E probably damaging Het
4930578I06Rik C A 14: 64,210,691 (GRCm39) R179L probably damaging Het
Abhd5 A G 9: 122,192,868 (GRCm39) probably null Het
Ankrd60 TGGCCACGCGG TGG 2: 173,419,882 (GRCm39) probably null Het
Ano5 G A 7: 51,216,066 (GRCm39) D348N possibly damaging Het
Apob C T 12: 8,065,304 (GRCm39) T4091I possibly damaging Het
Avil G A 10: 126,852,368 (GRCm39) probably null Het
Cacna1a T C 8: 85,142,350 (GRCm39) probably benign Het
Capn7 T C 14: 31,082,102 (GRCm39) L436P probably damaging Het
Ccdc33 A G 9: 57,937,235 (GRCm39) S655P possibly damaging Het
Ccr6 T C 17: 8,475,244 (GRCm39) S150P probably damaging Het
Cd1d1 T C 3: 86,906,095 (GRCm39) N60S probably benign Het
Ckap5 A G 2: 91,446,641 (GRCm39) probably null Het
Col15a1 A G 4: 47,280,865 (GRCm39) E753G possibly damaging Het
Col1a2 C T 6: 4,530,223 (GRCm39) R699W unknown Het
Cracd T C 5: 77,014,043 (GRCm39) probably null Het
Csf2rb T C 15: 78,233,155 (GRCm39) Y821H probably damaging Het
Cyp3a11 A G 5: 145,799,284 (GRCm39) I301T possibly damaging Het
Dpp3 C T 19: 4,968,350 (GRCm39) G241R possibly damaging Het
Dpyd G T 3: 119,220,886 (GRCm39) M952I probably damaging Het
Dsg3 A T 18: 20,654,628 (GRCm39) I111L possibly damaging Het
Ect2 A G 3: 27,201,102 (GRCm39) F123L probably damaging Het
Ehmt2 G C 17: 35,129,719 (GRCm39) D961H probably damaging Het
Esp1 A G 17: 41,041,809 (GRCm39) I34V probably benign Het
Fam171b G A 2: 83,708,580 (GRCm39) V361I probably benign Het
Flnc T A 6: 29,459,536 (GRCm39) Y2545* probably null Het
Grn C T 11: 102,324,869 (GRCm39) Q153* probably null Het
H2-DMb1 T G 17: 34,372,408 (GRCm39) S12R possibly damaging Het
Ica1 G T 6: 8,672,391 (GRCm39) N203K possibly damaging Het
Kdm4c C A 4: 74,277,722 (GRCm39) T792K probably damaging Het
Kif19a T A 11: 114,670,049 (GRCm39) Y81* probably null Het
Kifc2 G T 15: 76,548,578 (GRCm39) C440F probably damaging Het
Lpin2 A G 17: 71,537,268 (GRCm39) T234A probably benign Het
Lysmd2 C A 9: 75,542,885 (GRCm39) P164Q probably benign Het
Maea T A 5: 33,526,027 (GRCm39) D234E probably benign Het
Map4k1 T A 7: 28,699,445 (GRCm39) V572E probably damaging Het
Med6 C T 12: 81,620,733 (GRCm39) G166R probably null Het
Mtmr10 T C 7: 63,987,458 (GRCm39) I666T probably damaging Het
Myh14 T A 7: 44,262,887 (GRCm39) K1777M probably benign Het
Naip6 G T 13: 100,436,724 (GRCm39) Q600K probably benign Het
Obscn A G 11: 58,923,517 (GRCm39) S6461P probably damaging Het
Or1j4 T C 2: 36,740,061 (GRCm39) M1T probably null Het
Osbpl7 T A 11: 96,956,658 (GRCm39) V567E probably damaging Het
Rad51ap2 A T 12: 11,506,921 (GRCm39) D281V probably damaging Het
Rnd2 C T 11: 101,359,825 (GRCm39) L57F probably damaging Het
Rpl24 C A 16: 55,787,516 (GRCm39) H59N possibly damaging Het
Rtl1 G A 12: 109,559,053 (GRCm39) L929F possibly damaging Het
Runx3 C T 4: 134,890,575 (GRCm39) T159I probably damaging Het
Serpine2 T C 1: 79,794,637 (GRCm39) I99V probably benign Het
Slc12a6 C A 2: 112,115,067 (GRCm39) P12Q probably benign Het
Slc25a18 T C 6: 120,769,035 (GRCm39) L184P probably damaging Het
Smg1 T C 7: 117,812,120 (GRCm39) D57G probably benign Het
Spdye4c T A 2: 128,438,761 (GRCm39) *340K probably null Het
Srsf5 G A 12: 80,996,311 (GRCm39) E162K possibly damaging Het
Ssc5d T C 7: 4,939,817 (GRCm39) V751A probably benign Het
Tcf3 T C 10: 80,255,333 (GRCm39) N157S probably benign Het
Tdrd7 T C 4: 45,989,082 (GRCm39) V71A probably benign Het
Tex14 T C 11: 87,405,121 (GRCm39) C678R probably damaging Het
Tgm3 A T 2: 129,868,704 (GRCm39) K214* probably null Het
Vps53 A G 11: 75,953,833 (GRCm39) I659T probably benign Het
Zfp597 A T 16: 3,684,023 (GRCm39) C244* probably null Het
Zfp933 T A 4: 147,912,864 (GRCm39) probably null Het
Other mutations in Fmo4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00933:Fmo4 APN 1 162,621,592 (GRCm39) missense probably benign 0.00
IGL01090:Fmo4 APN 1 162,637,354 (GRCm39) splice site probably null
IGL01295:Fmo4 APN 1 162,626,693 (GRCm39) missense probably damaging 1.00
IGL02089:Fmo4 APN 1 162,626,649 (GRCm39) missense probably benign 0.04
IGL02483:Fmo4 APN 1 162,635,990 (GRCm39) missense possibly damaging 0.60
R0608:Fmo4 UTSW 1 162,631,220 (GRCm39) missense possibly damaging 0.95
R0660:Fmo4 UTSW 1 162,637,417 (GRCm39) missense probably benign 0.05
R0737:Fmo4 UTSW 1 162,635,961 (GRCm39) nonsense probably null
R1117:Fmo4 UTSW 1 162,631,232 (GRCm39) missense probably benign 0.03
R1464:Fmo4 UTSW 1 162,621,924 (GRCm39) missense possibly damaging 0.54
R1464:Fmo4 UTSW 1 162,621,924 (GRCm39) missense possibly damaging 0.54
R1577:Fmo4 UTSW 1 162,631,269 (GRCm39) missense possibly damaging 0.50
R1792:Fmo4 UTSW 1 162,621,859 (GRCm39) missense probably benign
R1875:Fmo4 UTSW 1 162,631,187 (GRCm39) missense possibly damaging 0.95
R1929:Fmo4 UTSW 1 162,626,616 (GRCm39) missense possibly damaging 0.95
R1956:Fmo4 UTSW 1 162,631,259 (GRCm39) missense probably benign 0.01
R1957:Fmo4 UTSW 1 162,631,259 (GRCm39) missense probably benign 0.01
R1958:Fmo4 UTSW 1 162,631,259 (GRCm39) missense probably benign 0.01
R2011:Fmo4 UTSW 1 162,626,458 (GRCm39) missense probably damaging 1.00
R2030:Fmo4 UTSW 1 162,621,741 (GRCm39) missense probably damaging 1.00
R2072:Fmo4 UTSW 1 162,637,456 (GRCm39) missense probably benign 0.20
R2272:Fmo4 UTSW 1 162,626,616 (GRCm39) missense possibly damaging 0.95
R3890:Fmo4 UTSW 1 162,621,624 (GRCm39) missense probably benign 0.39
R4255:Fmo4 UTSW 1 162,621,895 (GRCm39) missense probably benign 0.00
R4273:Fmo4 UTSW 1 162,632,748 (GRCm39) missense probably damaging 0.97
R4760:Fmo4 UTSW 1 162,637,396 (GRCm39) missense probably damaging 1.00
R5445:Fmo4 UTSW 1 162,632,842 (GRCm39) missense probably benign 0.24
R5726:Fmo4 UTSW 1 162,635,828 (GRCm39) critical splice donor site probably null
R6391:Fmo4 UTSW 1 162,621,538 (GRCm39) nonsense probably null
R6826:Fmo4 UTSW 1 162,631,338 (GRCm39) missense probably damaging 1.00
R7457:Fmo4 UTSW 1 162,621,672 (GRCm39) missense probably benign 0.00
R7913:Fmo4 UTSW 1 162,621,741 (GRCm39) missense possibly damaging 0.69
R8031:Fmo4 UTSW 1 162,626,421 (GRCm39) nonsense probably null
R8055:Fmo4 UTSW 1 162,636,015 (GRCm39) missense probably benign
R8234:Fmo4 UTSW 1 162,632,757 (GRCm39) missense probably damaging 1.00
R8346:Fmo4 UTSW 1 162,621,792 (GRCm39) missense probably benign 0.01
R8706:Fmo4 UTSW 1 162,621,592 (GRCm39) nonsense probably null
R9050:Fmo4 UTSW 1 162,635,099 (GRCm39) missense probably benign 0.15
R9467:Fmo4 UTSW 1 162,631,238 (GRCm39) missense probably benign
R9488:Fmo4 UTSW 1 162,631,337 (GRCm39) missense probably damaging 1.00
R9633:Fmo4 UTSW 1 162,631,191 (GRCm39) missense probably benign 0.00
X0020:Fmo4 UTSW 1 162,621,947 (GRCm39) missense probably benign 0.02
Z1177:Fmo4 UTSW 1 162,631,289 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TACATGCACATATAGAACTCCACTG -3'
(R):5'- TGCCAGACCAACATATTATAGCTAC -3'

Sequencing Primer
(F):5'- TGAACTGAAGTTTTTCCATGGAATG -3'
(R):5'- GGTCACACACAAGTCTATG -3'
Posted On 2016-12-15