Incidental Mutation 'R5787:Ankrd60'
ID 448064
Institutional Source Beutler Lab
Gene Symbol Ankrd60
Ensembl Gene ENSMUSG00000027517
Gene Name ankyrin repeat domain 60
Synonyms 1700030G11Rik, 1700019A24Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5787 (G1)
Quality Score 217
Status Not validated
Chromosome 2
Chromosomal Location 173410451-173420066 bp(-) (GRCm39)
Type of Mutation frame shift
DNA Base Change (assembly) TGGCCACGCGG to TGG at 173419882 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000113291 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109112] [ENSMUST00000119453]
AlphaFold A2AMD2
Predicted Effect probably benign
Transcript: ENSMUST00000109112
SMART Domains Protein: ENSMUSP00000104740
Gene: ENSMUSG00000027517

DomainStartEndE-ValueType
ANK 73 102 2.83e0 SMART
ANK 106 135 2.13e-4 SMART
Predicted Effect probably null
Transcript: ENSMUST00000119453
SMART Domains Protein: ENSMUSP00000113291
Gene: ENSMUSG00000027517

DomainStartEndE-ValueType
low complexity region 1 21 N/A INTRINSIC
Blast:UBQ 70 142 5e-39 BLAST
ANK 193 222 2.83e0 SMART
ANK 226 255 2.13e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132669
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141051
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147693
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151763
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot11 C T 4: 106,617,327 (GRCm39) G240R probably damaging Het
Adam24 A G 8: 41,133,941 (GRCm39) N470D possibly damaging Het
Adcy8 T C 15: 64,576,067 (GRCm39) D1027G probably damaging Het
Amph A T 13: 19,132,624 (GRCm39) I8F possibly damaging Het
Ano5 G A 7: 51,216,066 (GRCm39) D348N possibly damaging Het
Atp6v0a1 A G 11: 100,909,400 (GRCm39) D43G probably benign Het
Bltp1 T C 3: 37,046,882 (GRCm39) probably null Het
Btnl10 T A 11: 58,811,169 (GRCm39) I164N probably damaging Het
Ccdc174 C T 6: 91,858,291 (GRCm39) Q71* probably null Het
Ceacam3 G A 7: 16,888,971 (GRCm39) E247K possibly damaging Het
Chrna2 A G 14: 66,386,457 (GRCm39) D201G probably benign Het
Clasp2 G A 9: 113,691,310 (GRCm39) D448N probably damaging Het
Clcn2 C A 16: 20,522,183 (GRCm39) R829L probably damaging Het
Clock A G 5: 76,384,898 (GRCm39) S440P probably damaging Het
Cntn2 T C 1: 132,450,797 (GRCm39) D29G probably damaging Het
Cpne4 A G 9: 104,899,600 (GRCm39) T428A probably benign Het
Cul3 T C 1: 80,260,438 (GRCm39) I304V probably benign Het
Cyp11a1 C A 9: 57,922,550 (GRCm39) Q77K probably benign Het
Cyp3a25 A G 5: 145,935,313 (GRCm39) V101A probably benign Het
Cyp4f15 T C 17: 32,921,782 (GRCm39) F485L probably damaging Het
Des T A 1: 75,340,290 (GRCm39) V399E probably damaging Het
Dhx58 T C 11: 100,592,145 (GRCm39) D301G possibly damaging Het
Ear6 A G 14: 52,091,855 (GRCm39) E134G probably benign Het
Eif2b3 A G 4: 116,901,637 (GRCm39) D100G probably damaging Het
Erich1 T C 8: 14,083,776 (GRCm39) probably null Het
Gm4787 G C 12: 81,424,604 (GRCm39) T518S probably benign Het
Htr4 T C 18: 62,546,693 (GRCm39) V82A probably damaging Het
Hydin A G 8: 111,052,985 (GRCm39) D219G probably damaging Het
Ifit1 T A 19: 34,624,975 (GRCm39) V37E probably benign Het
Isg20 T A 7: 78,569,558 (GRCm39) D176E probably benign Het
Islr2 A G 9: 58,105,637 (GRCm39) V585A probably damaging Het
Kat6a A G 8: 23,422,663 (GRCm39) E991G probably damaging Het
Kcnv1 T C 15: 44,977,726 (GRCm39) Y104C probably damaging Het
Lrtm1 G C 14: 28,743,947 (GRCm39) E138D possibly damaging Het
Mllt3 A T 4: 87,759,057 (GRCm39) D330E probably damaging Het
Mpp7 T C 18: 7,461,682 (GRCm39) N64D probably benign Het
Naip6 G T 13: 100,436,724 (GRCm39) Q600K probably benign Het
Nop9 T G 14: 55,983,791 (GRCm39) C141G possibly damaging Het
Nos1ap T C 1: 170,146,141 (GRCm39) E471G probably benign Het
Npr2 A G 4: 43,633,593 (GRCm39) T246A possibly damaging Het
Or2t1 A C 14: 14,328,725 (GRCm38) M205L probably damaging Het
Or4a76 T A 2: 89,461,018 (GRCm39) I75F probably benign Het
Or6z1 A T 7: 6,504,989 (GRCm39) S79T probably damaging Het
Pdlim4 T A 11: 53,946,042 (GRCm39) D271V probably damaging Het
Pik3r6 T C 11: 68,430,753 (GRCm39) V518A possibly damaging Het
Rab5a C T 17: 53,804,650 (GRCm39) P87S probably damaging Het
Rbsn C T 6: 92,176,797 (GRCm39) V239I possibly damaging Het
Rsph14 T A 10: 74,793,460 (GRCm39) I314F possibly damaging Het
S1pr2 A T 9: 20,879,232 (GRCm39) S199T probably benign Het
Scrib A G 15: 75,931,151 (GRCm39) L902P probably damaging Het
Slc25a23 T C 17: 57,360,825 (GRCm39) T200A probably damaging Het
Slc8a1 A T 17: 81,696,166 (GRCm39) I956N probably damaging Het
Spef2 A G 15: 9,748,812 (GRCm39) V15A possibly damaging Het
Stim1 T A 7: 102,084,647 (GRCm39) V533E possibly damaging Het
Tbck A T 3: 132,443,329 (GRCm39) D585V probably damaging Het
Tpr T A 1: 150,271,037 (GRCm39) L80Q probably benign Het
Trim67 C T 8: 125,521,051 (GRCm39) R138* probably null Het
Ttn T C 2: 76,580,627 (GRCm39) N23422S probably damaging Het
Uba6 A G 5: 86,260,511 (GRCm39) *1023Q probably null Het
Vmn1r208 T C 13: 22,956,841 (GRCm39) N219D possibly damaging Het
Vmn1r8 T A 6: 57,013,244 (GRCm39) S98R probably damaging Het
Other mutations in Ankrd60
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01980:Ankrd60 APN 2 173,412,996 (GRCm39) missense probably benign 0.33
R0060:Ankrd60 UTSW 2 173,414,406 (GRCm39) start codon destroyed probably null 1.00
R0060:Ankrd60 UTSW 2 173,414,406 (GRCm39) start codon destroyed probably null 1.00
R0569:Ankrd60 UTSW 2 173,412,859 (GRCm39) missense probably damaging 1.00
R0587:Ankrd60 UTSW 2 173,410,644 (GRCm39) missense possibly damaging 0.83
R2941:Ankrd60 UTSW 2 173,410,674 (GRCm39) missense probably damaging 1.00
R4549:Ankrd60 UTSW 2 173,414,395 (GRCm39) missense possibly damaging 0.89
R5322:Ankrd60 UTSW 2 173,410,610 (GRCm39) missense possibly damaging 0.76
R5763:Ankrd60 UTSW 2 173,419,882 (GRCm39) frame shift probably null
R5786:Ankrd60 UTSW 2 173,419,882 (GRCm39) frame shift probably null
R5788:Ankrd60 UTSW 2 173,419,882 (GRCm39) frame shift probably null
R7527:Ankrd60 UTSW 2 173,419,966 (GRCm39) missense probably benign 0.00
R7618:Ankrd60 UTSW 2 173,412,834 (GRCm39) splice site probably null
R7756:Ankrd60 UTSW 2 173,410,562 (GRCm39) makesense probably null
R7758:Ankrd60 UTSW 2 173,410,562 (GRCm39) makesense probably null
R8039:Ankrd60 UTSW 2 173,414,284 (GRCm39) critical splice donor site probably null
R9345:Ankrd60 UTSW 2 173,410,610 (GRCm39) missense possibly damaging 0.76
R9573:Ankrd60 UTSW 2 173,410,791 (GRCm39) missense possibly damaging 0.58
R9604:Ankrd60 UTSW 2 173,412,987 (GRCm39) missense probably benign 0.14
Predicted Primers PCR Primer
(F):5'- GCAGTTACGAGTGTCATGGG -3'
(R):5'- GAACAGACAAGAGGTTCCCC -3'

Sequencing Primer
(F):5'- ACCCAGGGCAGGAGTGG -3'
(R):5'- GACTCCTGACGTCTATGT -3'
Posted On 2016-12-15