Incidental Mutation 'R5790:Vmn2r24'
| ID |
448267 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r24
|
| Ensembl Gene |
ENSMUSG00000072780 |
| Gene Name |
vomeronasal 2, receptor 24 |
| Synonyms |
EG243628 |
| MMRRC Submission |
043384-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.055)
|
| Stock # |
R5790 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
123755930-123793239 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 123792499 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Leucine
at position 609
(M609L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000074602
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000075095]
|
| AlphaFold |
D3YUI0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000075095
AA Change: M609L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000074602
Gene: ENSMUSG00000072780
AA Change: M609L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
469 |
1.6e-32 |
PFAM |
|
Pfam:NCD3G
|
518 |
571 |
1.1e-22 |
PFAM |
|
Pfam:7tm_3
|
602 |
839 |
1.1e-54 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.4%
- 20x: 95.5%
|
| Validation Efficiency |
99% (73/74) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 70 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Agbl5 |
A |
T |
5: 31,051,702 (GRCm39) |
R633* |
probably null |
Het |
| Ahnak |
T |
C |
19: 8,992,612 (GRCm39) |
V4632A |
probably damaging |
Het |
| Asap1 |
T |
A |
15: 63,966,114 (GRCm39) |
D997V |
probably damaging |
Het |
| Atad2 |
T |
C |
15: 57,989,990 (GRCm39) |
Y162C |
probably damaging |
Het |
| Atp2b2 |
G |
T |
6: 113,736,270 (GRCm39) |
S936R |
probably damaging |
Het |
| Bcl11a |
T |
A |
11: 24,113,650 (GRCm39) |
L331Q |
probably damaging |
Het |
| C6 |
T |
A |
15: 4,792,968 (GRCm39) |
F358I |
probably damaging |
Het |
| Capn15 |
C |
T |
17: 26,183,521 (GRCm39) |
S386N |
probably benign |
Het |
| Ccdc66 |
G |
A |
14: 27,222,404 (GRCm39) |
T113I |
possibly damaging |
Het |
| Cd200 |
G |
T |
16: 45,217,621 (GRCm39) |
H23Q |
possibly damaging |
Het |
| Cdh17 |
A |
G |
4: 11,814,945 (GRCm39) |
|
probably null |
Het |
| Ces2b |
C |
T |
8: 105,560,568 (GRCm39) |
P128S |
probably damaging |
Het |
| Ces3b |
A |
T |
8: 105,819,270 (GRCm39) |
Q442L |
probably damaging |
Het |
| Chil4 |
T |
C |
3: 106,109,894 (GRCm39) |
H373R |
probably benign |
Het |
| Ciapin1 |
C |
A |
8: 95,551,811 (GRCm39) |
|
probably benign |
Het |
| Cnot10 |
A |
C |
9: 114,454,985 (GRCm39) |
|
probably null |
Het |
| Cpq |
A |
G |
15: 33,250,143 (GRCm39) |
K167E |
probably damaging |
Het |
| Dennd4b |
T |
A |
3: 90,184,757 (GRCm39) |
D1118E |
probably damaging |
Het |
| Dnah8 |
T |
A |
17: 31,093,978 (GRCm39) |
C4691S |
probably damaging |
Het |
| Dnajc1 |
A |
G |
2: 18,311,898 (GRCm39) |
|
probably benign |
Het |
| Dnhd1 |
G |
A |
7: 105,304,981 (GRCm39) |
R341H |
probably damaging |
Het |
| Dock10 |
G |
T |
1: 80,482,887 (GRCm39) |
T2145K |
probably benign |
Het |
| Eif3b |
T |
C |
5: 140,427,886 (GRCm39) |
V736A |
probably benign |
Het |
| Eno1 |
G |
T |
4: 150,329,710 (GRCm39) |
V195L |
probably benign |
Het |
| Ewsr1 |
C |
T |
11: 5,032,263 (GRCm39) |
|
probably benign |
Het |
| Fbn2 |
T |
C |
18: 58,209,768 (GRCm39) |
T1038A |
probably benign |
Het |
| Gabrb1 |
T |
C |
5: 72,293,827 (GRCm39) |
I367T |
possibly damaging |
Het |
| Gigyf1 |
C |
T |
5: 137,522,517 (GRCm39) |
|
probably benign |
Het |
| Glp2r |
T |
A |
11: 67,655,625 (GRCm39) |
Y39F |
probably damaging |
Het |
| Gm10036 |
T |
A |
18: 15,966,243 (GRCm39) |
Y131* |
probably null |
Het |
| Gm38706 |
T |
C |
6: 130,461,961 (GRCm39) |
|
noncoding transcript |
Het |
| Gna15 |
G |
A |
10: 81,345,218 (GRCm39) |
R216C |
probably damaging |
Het |
| Grin3a |
A |
G |
4: 49,792,717 (GRCm39) |
F339L |
probably damaging |
Het |
| Grk3 |
T |
G |
5: 113,114,842 (GRCm39) |
K126T |
possibly damaging |
Het |
| Hspa1l |
T |
C |
17: 35,196,216 (GRCm39) |
V85A |
probably benign |
Het |
| Iqsec1 |
A |
T |
6: 90,666,862 (GRCm39) |
L525* |
probably null |
Het |
| Irx3 |
T |
C |
8: 92,526,304 (GRCm39) |
T467A |
probably benign |
Het |
| Itga2 |
G |
A |
13: 115,004,742 (GRCm39) |
T530I |
probably benign |
Het |
| Lonp2 |
T |
C |
8: 87,358,118 (GRCm39) |
V113A |
probably benign |
Het |
| Msx3 |
C |
T |
7: 139,628,866 (GRCm39) |
R16H |
possibly damaging |
Het |
| Nek3 |
C |
A |
8: 22,621,313 (GRCm39) |
Q405H |
probably damaging |
Het |
| Nek3 |
T |
A |
8: 22,621,314 (GRCm39) |
Q403L |
probably damaging |
Het |
| Or2b6 |
T |
C |
13: 21,823,046 (GRCm39) |
T216A |
probably benign |
Het |
| Or6c66 |
A |
G |
10: 129,461,757 (GRCm39) |
Y58H |
probably damaging |
Het |
| P4ha1 |
A |
G |
10: 59,190,184 (GRCm39) |
N367S |
probably benign |
Het |
| Padi6 |
C |
A |
4: 140,459,569 (GRCm39) |
G429C |
probably damaging |
Het |
| Pidd1 |
T |
C |
7: 141,021,305 (GRCm39) |
|
probably benign |
Het |
| Plekhg5 |
T |
C |
4: 152,198,392 (GRCm39) |
V847A |
probably benign |
Het |
| Polr3e |
A |
G |
7: 120,527,190 (GRCm39) |
D56G |
probably damaging |
Het |
| Pomt2 |
T |
G |
12: 87,174,152 (GRCm39) |
N347T |
probably damaging |
Het |
| Ppp1r9a |
T |
C |
6: 5,134,363 (GRCm39) |
|
probably benign |
Het |
| Rbm33 |
A |
T |
5: 28,544,296 (GRCm39) |
D184V |
probably damaging |
Het |
| Rims2 |
A |
T |
15: 39,544,441 (GRCm39) |
T1431S |
probably damaging |
Het |
| Saal1 |
T |
C |
7: 46,351,352 (GRCm39) |
D208G |
probably damaging |
Het |
| Sis |
T |
C |
3: 72,835,507 (GRCm39) |
I952V |
probably benign |
Het |
| Slc30a1 |
T |
A |
1: 191,640,997 (GRCm39) |
D214E |
probably benign |
Het |
| Slc30a8 |
T |
C |
15: 52,197,043 (GRCm39) |
V318A |
possibly damaging |
Het |
| Smarca2 |
A |
G |
19: 26,654,124 (GRCm39) |
T770A |
probably damaging |
Het |
| Sptbn4 |
T |
A |
7: 27,065,853 (GRCm39) |
H2031L |
probably damaging |
Het |
| Ssbp1 |
A |
G |
6: 40,457,804 (GRCm39) |
S141G |
probably benign |
Het |
| Tgm4 |
A |
G |
9: 122,890,808 (GRCm39) |
E45G |
probably damaging |
Het |
| Thra |
T |
A |
11: 98,653,777 (GRCm39) |
S203T |
probably benign |
Het |
| Tle2 |
T |
C |
10: 81,426,149 (GRCm39) |
Y763H |
probably damaging |
Het |
| Tmem141 |
T |
A |
2: 25,511,087 (GRCm39) |
I102L |
probably benign |
Het |
| Tmem63c |
C |
T |
12: 87,104,410 (GRCm39) |
T77I |
probably benign |
Het |
| Tspo2 |
C |
A |
17: 48,756,047 (GRCm39) |
|
probably null |
Het |
| Ttc19 |
T |
A |
11: 62,172,340 (GRCm39) |
M1K |
probably null |
Het |
| Ucp1 |
A |
G |
8: 84,024,520 (GRCm39) |
N282D |
possibly damaging |
Het |
| Vmn1r33 |
A |
T |
6: 66,589,198 (GRCm39) |
F119I |
probably benign |
Het |
| Vwc2l |
A |
T |
1: 70,790,142 (GRCm39) |
H146L |
probably damaging |
Het |
|
| Other mutations in Vmn2r24 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00954:Vmn2r24
|
APN |
6 |
123,792,596 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01382:Vmn2r24
|
APN |
6 |
123,763,938 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
IGL01592:Vmn2r24
|
APN |
6 |
123,764,445 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL01754:Vmn2r24
|
APN |
6 |
123,781,120 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01939:Vmn2r24
|
APN |
6 |
123,764,404 (GRCm39) |
missense |
probably benign |
|
|
IGL02140:Vmn2r24
|
APN |
6 |
123,757,631 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02272:Vmn2r24
|
APN |
6 |
123,763,843 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02568:Vmn2r24
|
APN |
6 |
123,792,812 (GRCm39) |
missense |
probably benign |
0.36 |
|
IGL02748:Vmn2r24
|
APN |
6 |
123,793,057 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL03022:Vmn2r24
|
APN |
6 |
123,755,967 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03343:Vmn2r24
|
APN |
6 |
123,793,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0357:Vmn2r24
|
UTSW |
6 |
123,792,369 (GRCm39) |
frame shift |
probably null |
|
|
R0453:Vmn2r24
|
UTSW |
6 |
123,757,350 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R0538:Vmn2r24
|
UTSW |
6 |
123,793,012 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0607:Vmn2r24
|
UTSW |
6 |
123,763,893 (GRCm39) |
missense |
probably benign |
|
|
R1381:Vmn2r24
|
UTSW |
6 |
123,763,692 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1589:Vmn2r24
|
UTSW |
6 |
123,783,479 (GRCm39) |
splice site |
probably benign |
|
|
R1848:Vmn2r24
|
UTSW |
6 |
123,793,183 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2035:Vmn2r24
|
UTSW |
6 |
123,793,019 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2077:Vmn2r24
|
UTSW |
6 |
123,792,358 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2122:Vmn2r24
|
UTSW |
6 |
123,792,353 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R2145:Vmn2r24
|
UTSW |
6 |
123,755,972 (GRCm39) |
missense |
probably benign |
|
|
R2483:Vmn2r24
|
UTSW |
6 |
123,792,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2512:Vmn2r24
|
UTSW |
6 |
123,763,985 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3001:Vmn2r24
|
UTSW |
6 |
123,781,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3002:Vmn2r24
|
UTSW |
6 |
123,781,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3236:Vmn2r24
|
UTSW |
6 |
123,755,984 (GRCm39) |
nonsense |
probably null |
|
|
R3623:Vmn2r24
|
UTSW |
6 |
123,792,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3624:Vmn2r24
|
UTSW |
6 |
123,792,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3835:Vmn2r24
|
UTSW |
6 |
123,764,412 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4074:Vmn2r24
|
UTSW |
6 |
123,764,374 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4075:Vmn2r24
|
UTSW |
6 |
123,764,374 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4812:Vmn2r24
|
UTSW |
6 |
123,756,144 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4825:Vmn2r24
|
UTSW |
6 |
123,792,739 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5351:Vmn2r24
|
UTSW |
6 |
123,793,223 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5665:Vmn2r24
|
UTSW |
6 |
123,763,938 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R5808:Vmn2r24
|
UTSW |
6 |
123,792,597 (GRCm39) |
nonsense |
probably null |
|
|
R5879:Vmn2r24
|
UTSW |
6 |
123,764,226 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5923:Vmn2r24
|
UTSW |
6 |
123,792,751 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5969:Vmn2r24
|
UTSW |
6 |
123,755,981 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6050:Vmn2r24
|
UTSW |
6 |
123,792,691 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6171:Vmn2r24
|
UTSW |
6 |
123,764,205 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6174:Vmn2r24
|
UTSW |
6 |
123,793,236 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6356:Vmn2r24
|
UTSW |
6 |
123,783,368 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6562:Vmn2r24
|
UTSW |
6 |
123,757,386 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6563:Vmn2r24
|
UTSW |
6 |
123,781,137 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6584:Vmn2r24
|
UTSW |
6 |
123,792,764 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6630:Vmn2r24
|
UTSW |
6 |
123,763,981 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6803:Vmn2r24
|
UTSW |
6 |
123,755,960 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R6864:Vmn2r24
|
UTSW |
6 |
123,756,117 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7252:Vmn2r24
|
UTSW |
6 |
123,764,191 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7369:Vmn2r24
|
UTSW |
6 |
123,792,638 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7646:Vmn2r24
|
UTSW |
6 |
123,793,169 (GRCm39) |
missense |
probably benign |
0.20 |
|
R7799:Vmn2r24
|
UTSW |
6 |
123,757,422 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7803:Vmn2r24
|
UTSW |
6 |
123,757,438 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7959:Vmn2r24
|
UTSW |
6 |
123,755,949 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R8215:Vmn2r24
|
UTSW |
6 |
123,756,077 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8796:Vmn2r24
|
UTSW |
6 |
123,757,500 (GRCm39) |
missense |
probably benign |
|
|
R9172:Vmn2r24
|
UTSW |
6 |
123,783,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9300:Vmn2r24
|
UTSW |
6 |
123,793,030 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9369:Vmn2r24
|
UTSW |
6 |
123,792,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9375:Vmn2r24
|
UTSW |
6 |
123,792,542 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9523:Vmn2r24
|
UTSW |
6 |
123,763,950 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9546:Vmn2r24
|
UTSW |
6 |
123,764,266 (GRCm39) |
missense |
probably damaging |
0.98 |
|
RF006:Vmn2r24
|
UTSW |
6 |
123,783,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF016:Vmn2r24
|
UTSW |
6 |
123,781,174 (GRCm39) |
missense |
probably benign |
0.04 |
|
X0023:Vmn2r24
|
UTSW |
6 |
123,764,359 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Vmn2r24
|
UTSW |
6 |
123,781,155 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Vmn2r24
|
UTSW |
6 |
123,763,719 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCTCTGGCAAGATATACATCTC -3'
(R):5'- TTGCCAAGATAGCAGACACAG -3'
Sequencing Primer
(F):5'- GTCCTGAAGATCAGTATCCG -3'
(R):5'- AGATAGCAGACACAGCAACAG -3'
|
| Posted On |
2016-12-15 |
Incidental Mutation