Incidental Mutation 'R5807:Wee1'
ID 448587
Institutional Source Beutler Lab
Gene Symbol Wee1
Ensembl Gene ENSMUSG00000031016
Gene Name WEE 1 homolog 1 (S. pombe)
Synonyms Wee1A
MMRRC Submission 043393-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R5807 (G1)
Quality Score 135
Status Validated
Chromosome 7
Chromosomal Location 109721266-109742506 bp(+) (GRCm39)
Type of Mutation frame shift
DNA Base Change (assembly) TCCCC to TCCC at 109723776 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000033326 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033326]
AlphaFold P47810
Predicted Effect probably null
Transcript: ENSMUST00000033326
SMART Domains Protein: ENSMUSP00000033326
Gene: ENSMUSG00000031016

DomainStartEndE-ValueType
low complexity region 62 112 N/A INTRINSIC
Pfam:Pkinase_Tyr 298 566 1.9e-26 PFAM
Pfam:Pkinase 298 568 1.7e-61 PFAM
low complexity region 620 631 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000185931
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210940
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency 98% (65/66)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a transgenic gene disruption may exhibit embryonic lethality at E7. Mice homozygous for a knock-out allele exhibit lethality between E3.5 and E7.5 with reduced proliferation, increased apoptosis and abnormal G2/M checkpoint function. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 A G 1: 71,342,651 (GRCm39) L943P probably damaging Het
Abcg5 C A 17: 84,979,719 (GRCm39) V214F probably damaging Het
Ang T A 14: 51,338,886 (GRCm39) probably benign Het
Arfgef3 A G 10: 18,523,546 (GRCm39) probably null Het
Arhgef4 A G 1: 34,846,696 (GRCm39) probably benign Het
Atp11b T C 3: 35,866,428 (GRCm39) I409T probably damaging Het
Atp5f1b G A 10: 127,924,431 (GRCm39) probably benign Het
Atp9a G A 2: 168,495,454 (GRCm39) A660V probably damaging Het
Avpr1a A G 10: 122,285,376 (GRCm39) T223A probably benign Het
Bmp2k T C 5: 97,211,353 (GRCm39) M507T unknown Het
Cep295 A G 9: 15,243,828 (GRCm39) S287P probably damaging Het
Chrna7 T A 7: 62,798,349 (GRCm39) D111V probably damaging Het
Clxn A T 16: 14,734,836 (GRCm39) I69F probably benign Het
Cnr2 A G 4: 135,644,747 (GRCm39) D275G probably benign Het
Col28a1 T A 6: 8,158,144 (GRCm39) M305L probably benign Het
Cpb1 T A 3: 20,317,906 (GRCm39) D206V probably damaging Het
Cyp2c50 T C 19: 40,101,944 (GRCm39) L453S probably damaging Het
Ddx52 T G 11: 83,840,508 (GRCm39) S284A probably benign Het
Eif2ak4 G T 2: 118,219,332 (GRCm39) R48L probably benign Het
Esrrb A G 12: 86,561,175 (GRCm39) E303G possibly damaging Het
Fbxo21 A G 5: 118,114,933 (GRCm39) E23G probably benign Het
Fcamr T C 1: 130,739,263 (GRCm39) S188P probably damaging Het
Fer1l6 C A 15: 58,462,399 (GRCm39) S818* probably null Het
Fn1 T C 1: 71,687,218 (GRCm39) D213G probably damaging Het
Gcg A G 2: 62,306,069 (GRCm39) I176T possibly damaging Het
Glis1 T A 4: 107,425,279 (GRCm39) S109T probably benign Het
Gm266 T C 12: 111,452,173 (GRCm39) D11G probably benign Het
Gm5070 C A 3: 95,317,965 (GRCm39) noncoding transcript Het
Gm8444 T C 15: 81,727,654 (GRCm39) probably benign Het
Golga4 A G 9: 118,356,198 (GRCm39) T117A probably damaging Het
Gpr132 G A 12: 112,816,416 (GRCm39) R137C probably damaging Het
Gvin-ps5 T A 7: 105,929,430 (GRCm39) noncoding transcript Het
Herc2 T A 7: 55,880,667 (GRCm39) F4766L probably damaging Het
Inhbc C A 10: 127,193,411 (GRCm39) E202* probably null Het
Kcnu1 C T 8: 26,339,742 (GRCm39) T20I possibly damaging Het
Klhdc3 T C 17: 46,988,391 (GRCm39) D161G probably damaging Het
Krt84 T A 15: 101,438,647 (GRCm39) K280M probably damaging Het
Krtap9-5 T A 11: 99,839,895 (GRCm39) C199S unknown Het
Mrgprb3 A G 7: 48,293,110 (GRCm39) V147A probably benign Het
Ndufs6 A T 13: 73,475,553 (GRCm39) F48L probably damaging Het
Obscn T C 11: 58,970,476 (GRCm39) S2586G probably damaging Het
Or10n1 A G 9: 39,525,759 (GRCm39) R299G probably benign Het
Or13c7b C A 4: 43,820,912 (GRCm39) V150L probably benign Het
Or51a25 C T 7: 102,373,409 (GRCm39) R96H possibly damaging Het
Osbpl6 A G 2: 76,414,857 (GRCm39) D416G probably damaging Het
Pdilt A G 7: 119,099,766 (GRCm39) probably benign Het
Phf12 C A 11: 77,913,252 (GRCm39) D401E probably benign Het
Pla2r1 C T 2: 60,259,065 (GRCm39) V1108M possibly damaging Het
Prim2 A G 1: 33,519,487 (GRCm39) probably benign Het
Ptpn6 T C 6: 124,701,947 (GRCm39) H406R probably benign Het
Qpctl G T 7: 18,877,132 (GRCm39) H329N probably damaging Het
Ripk3 T A 14: 56,022,755 (GRCm39) N390Y probably damaging Het
Rnase1 A G 14: 51,382,907 (GRCm39) V149A probably benign Het
Rtn3 T A 19: 7,434,192 (GRCm39) D581V probably damaging Het
Slamf1 A G 1: 171,602,630 (GRCm39) Y119C probably damaging Het
Slc25a34 A G 4: 141,350,973 (GRCm39) M12T probably benign Het
Tmem38a A G 8: 73,333,944 (GRCm39) Y141C probably damaging Het
Tnr C T 1: 159,714,500 (GRCm39) T793I possibly damaging Het
Tns3 T C 11: 8,443,211 (GRCm39) D384G probably damaging Het
Vmn2r116 T A 17: 23,606,281 (GRCm39) Y398N probably damaging Het
Other mutations in Wee1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00693:Wee1 APN 7 109,734,060 (GRCm39) splice site probably null
IGL00981:Wee1 APN 7 109,738,876 (GRCm39) missense probably damaging 1.00
IGL01017:Wee1 APN 7 109,725,055 (GRCm39) missense possibly damaging 0.93
IGL01357:Wee1 APN 7 109,741,242 (GRCm39) missense probably benign 0.39
IGL01838:Wee1 APN 7 109,723,744 (GRCm39) missense probably benign 0.01
IGL01970:Wee1 APN 7 109,738,457 (GRCm39) missense probably damaging 1.00
IGL02396:Wee1 APN 7 109,741,300 (GRCm39) missense probably damaging 1.00
IGL02511:Wee1 APN 7 109,738,483 (GRCm39) missense possibly damaging 0.55
IGL02884:Wee1 APN 7 109,725,269 (GRCm39) missense probably benign 0.02
IGL03085:Wee1 APN 7 109,723,805 (GRCm39) missense probably damaging 1.00
IGL03221:Wee1 APN 7 109,726,024 (GRCm39) missense probably damaging 1.00
IGL03383:Wee1 APN 7 109,738,899 (GRCm39) missense probably damaging 1.00
R0220:Wee1 UTSW 7 109,723,733 (GRCm39) missense probably benign 0.10
R1934:Wee1 UTSW 7 109,721,698 (GRCm39) missense probably benign 0.06
R3110:Wee1 UTSW 7 109,730,043 (GRCm39) missense probably damaging 1.00
R3112:Wee1 UTSW 7 109,730,043 (GRCm39) missense probably damaging 1.00
R3978:Wee1 UTSW 7 109,723,762 (GRCm39) missense probably damaging 1.00
R4348:Wee1 UTSW 7 109,730,165 (GRCm39) missense probably damaging 1.00
R5434:Wee1 UTSW 7 109,723,776 (GRCm39) frame shift probably null
R5435:Wee1 UTSW 7 109,723,776 (GRCm39) frame shift probably null
R5436:Wee1 UTSW 7 109,723,776 (GRCm39) frame shift probably null
R5449:Wee1 UTSW 7 109,723,776 (GRCm39) frame shift probably null
R5566:Wee1 UTSW 7 109,725,257 (GRCm39) nonsense probably null
R5630:Wee1 UTSW 7 109,723,776 (GRCm39) frame shift probably null
R5632:Wee1 UTSW 7 109,723,776 (GRCm39) frame shift probably null
R5685:Wee1 UTSW 7 109,723,776 (GRCm39) frame shift probably null
R5694:Wee1 UTSW 7 109,723,776 (GRCm39) frame shift probably null
R5941:Wee1 UTSW 7 109,723,776 (GRCm39) frame shift probably null
R6044:Wee1 UTSW 7 109,738,513 (GRCm39) missense probably benign 0.00
R6163:Wee1 UTSW 7 109,734,858 (GRCm39) missense probably damaging 1.00
R6826:Wee1 UTSW 7 109,723,870 (GRCm39) critical splice donor site probably null
R7203:Wee1 UTSW 7 109,734,001 (GRCm39) missense probably benign 0.00
R7835:Wee1 UTSW 7 109,730,085 (GRCm39) nonsense probably null
R8273:Wee1 UTSW 7 109,723,691 (GRCm39) missense probably benign 0.00
R8953:Wee1 UTSW 7 109,723,691 (GRCm39) missense probably benign 0.00
R9077:Wee1 UTSW 7 109,725,963 (GRCm39) missense probably damaging 1.00
R9336:Wee1 UTSW 7 109,721,689 (GRCm39) missense probably damaging 1.00
R9463:Wee1 UTSW 7 109,721,917 (GRCm39) missense probably damaging 1.00
R9673:Wee1 UTSW 7 109,725,210 (GRCm39) missense probably damaging 0.98
R9748:Wee1 UTSW 7 109,721,722 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TGGCCACTTAGGAAGGCAAG -3'
(R):5'- GACATTCATGCCATTCAGTAGAAAC -3'

Sequencing Primer
(F):5'- GTTGGAGGTTATATAGAGAAGACTCC -3'
(R):5'- AACCTAATTGTGTGCCAGGC -3'
Posted On 2016-12-15