Incidental Mutation 'R5802:Hnrnpa3'
ID448764
Institutional Source Beutler Lab
Gene Symbol Hnrnpa3
Ensembl Gene ENSMUSG00000059005
Gene Nameheterogeneous nuclear ribonucleoprotein A3
SynonymsHnrpa3, 2610510D13Rik, 2410013L13Rik, 2610209F03Rik
MMRRC Submission 043391-MU
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.844) question?
Stock #R5802 (G1)
Quality Score225
Status Validated
Chromosome2
Chromosomal Location75659261-75669407 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 75665056 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Lysine at position 309 (N309K)
Ref Sequence ENSEMBL: ENSMUSP00000126069 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090792] [ENSMUST00000111961] [ENSMUST00000111962] [ENSMUST00000111964] [ENSMUST00000141974] [ENSMUST00000164947]
Predicted Effect unknown
Transcript: ENSMUST00000090792
AA Change: N331K
SMART Domains Protein: ENSMUSP00000088298
Gene: ENSMUSG00000059005
AA Change: N331K

DomainStartEndE-ValueType
low complexity region 5 22 N/A INTRINSIC
RRM 36 108 4.06e-24 SMART
RRM 127 199 1.94e-21 SMART
low complexity region 211 338 N/A INTRINSIC
low complexity region 349 378 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000111961
AA Change: N270K
SMART Domains Protein: ENSMUSP00000107592
Gene: ENSMUSG00000059005
AA Change: N270K

DomainStartEndE-ValueType
low complexity region 5 22 N/A INTRINSIC
RRM 36 108 4.06e-24 SMART
RRM 127 199 1.94e-21 SMART
Pfam:HnRNPA1 266 303 8.4e-18 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000111962
AA Change: N309K
SMART Domains Protein: ENSMUSP00000107593
Gene: ENSMUSG00000059005
AA Change: N309K

DomainStartEndE-ValueType
RRM 14 86 4.06e-24 SMART
RRM 105 177 1.94e-21 SMART
low complexity region 189 316 N/A INTRINSIC
low complexity region 327 356 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000111964
AA Change: N331K
SMART Domains Protein: ENSMUSP00000107595
Gene: ENSMUSG00000059005
AA Change: N331K

DomainStartEndE-ValueType
low complexity region 5 22 N/A INTRINSIC
RRM 36 108 4.06e-24 SMART
RRM 127 199 1.94e-21 SMART
low complexity region 211 338 N/A INTRINSIC
low complexity region 349 378 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132392
Predicted Effect unknown
Transcript: ENSMUST00000141974
AA Change: N146K
SMART Domains Protein: ENSMUSP00000116125
Gene: ENSMUSG00000059005
AA Change: N146K

DomainStartEndE-ValueType
PDB:2UP1|A 1 25 7e-8 PDB
low complexity region 26 153 N/A INTRINSIC
low complexity region 164 193 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000164947
AA Change: N309K
SMART Domains Protein: ENSMUSP00000126069
Gene: ENSMUSG00000059005
AA Change: N309K

DomainStartEndE-ValueType
RRM 14 86 4.06e-24 SMART
RRM 105 177 1.94e-21 SMART
low complexity region 189 316 N/A INTRINSIC
low complexity region 327 356 N/A INTRINSIC
Meta Mutation Damage Score 0.312 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency 97% (63/65)
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A830018L16Rik A T 1: 11,950,964 D383V probably damaging Het
Abca4 A T 3: 122,054,232 L67F probably damaging Het
Abcc9 C A 6: 142,656,676 probably null Het
Atp2a3 T C 11: 72,972,882 V175A probably damaging Het
B3galt4 T A 17: 33,950,757 D169V probably damaging Het
Bsn C T 9: 108,113,009 R1848Q possibly damaging Het
Camkk2 T C 5: 122,734,244 E90G probably damaging Het
Cdon T A 9: 35,454,420 I155N probably damaging Het
Cep70 A G 9: 99,296,405 N519D probably damaging Het
Clgn T C 8: 83,425,614 S582P probably damaging Het
Cnga3 T C 1: 37,260,925 F280S probably damaging Het
Dennd4c C T 4: 86,811,453 T764M probably benign Het
Dis3 A T 14: 99,099,664 S4T probably damaging Het
Dlgap1 T C 17: 70,766,091 probably null Het
Dnah17 C T 11: 118,036,446 V3839I possibly damaging Het
Dnajc1 A G 2: 18,284,739 Y286H probably benign Het
Dynap T A 18: 70,241,002 D151V unknown Het
Ednrb A G 14: 103,821,714 F292S probably damaging Het
Eef1a1 A G 9: 78,479,036 S396P probably damaging Het
Fancg A G 4: 43,006,582 F324S probably benign Het
Fbxw11 T A 11: 32,711,790 S56T probably benign Het
Gm13178 T A 4: 144,703,636 D261V probably damaging Het
Gm14409 T C 2: 177,265,256 T150A possibly damaging Het
Gm17535 G C 9: 3,035,758 V209L probably benign Homo
Gm20767 G A 13: 120,154,913 S96N possibly damaging Het
Gm5592 C T 7: 41,219,105 probably benign Het
Gm7030 A G 17: 36,111,287 probably benign Het
Gpr137 C T 19: 6,942,005 W51* probably null Het
Hbb-bs T C 7: 103,826,672 Y146C probably damaging Het
Herc1 G T 9: 66,462,878 C2982F probably damaging Het
Hydin A T 8: 110,452,060 I1096F possibly damaging Het
Klf12 A G 14: 100,022,894 V133A probably benign Het
Lats2 A T 14: 57,694,418 Y848N probably damaging Het
Loxl3 A G 6: 83,049,289 T453A possibly damaging Het
Ltn1 T G 16: 87,415,681 H664P probably benign Het
Lypd6 C T 2: 50,173,601 T40I probably benign Het
Nbeal1 A T 1: 60,272,221 T1817S probably benign Het
Nub1 A C 5: 24,702,441 Y350S possibly damaging Het
Pbp2 A G 6: 135,309,876 Y158H possibly damaging Het
Ptpru C T 4: 131,788,377 E827K possibly damaging Het
Rap1a A G 3: 105,745,936 Y32H probably damaging Het
Raph1 T C 1: 60,488,673 N1143S possibly damaging Het
Rbl1 T C 2: 157,161,433 T859A probably benign Het
Rom1 A G 19: 8,928,824 L117P probably damaging Het
Senp6 T C 9: 80,118,644 probably benign Het
Sirpb1c T C 3: 15,832,076 M379V probably benign Het
Slc6a4 C T 11: 77,019,236 T439M probably damaging Het
Srsf12 G T 4: 33,230,929 R141L probably damaging Het
Stk10 C T 11: 32,596,748 P335L probably benign Het
Tecpr1 A T 5: 144,206,546 N670K probably benign Het
Tgds T C 14: 118,132,707 E8G probably benign Het
Tmem129 A G 5: 33,657,716 S38P probably damaging Het
Trappc9 T C 15: 72,685,339 E812G probably damaging Het
Trmt10b T A 4: 45,314,236 probably benign Het
Wapl A G 14: 34,692,320 T380A probably damaging Het
Xylt1 A T 7: 117,656,691 T829S probably benign Het
Zc3h6 C T 2: 129,015,559 P666L possibly damaging Het
Zfp703 C T 8: 26,979,205 P299L probably damaging Het
Other mutations in Hnrnpa3
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0076:Hnrnpa3 UTSW 2 75661696 missense probably damaging 1.00
R0095:Hnrnpa3 UTSW 2 75661696 missense probably damaging 1.00
R4583:Hnrnpa3 UTSW 2 75663606 missense probably benign 0.23
R4762:Hnrnpa3 UTSW 2 75662007 missense possibly damaging 0.95
R5499:Hnrnpa3 UTSW 2 75665240 missense probably benign 0.23
R6253:Hnrnpa3 UTSW 2 75662570 missense possibly damaging 0.82
Predicted Primers PCR Primer
(F):5'- GATCACTTAGGCTTCTGATAAATGG -3'
(R):5'- ACACTCAGTGAACAGTTCCATATATTC -3'

Sequencing Primer
(F):5'- GCTTCTGATAAATGGAGTTTAGTACC -3'
(R):5'- TCCAGATCCATAGCCACCTGG -3'
Posted On2016-12-15