Incidental Mutation 'R5815:Or2w6'
ID 449010
Institutional Source Beutler Lab
Gene Symbol Or2w6
Ensembl Gene ENSMUSG00000049737
Gene Name olfactory receptor family 2 subfamily W member 6
Synonyms GA_x6K02T2QHY8-11577590-11578528, MOR256-12, Olfr1361
Accession Numbers
Essential gene? Probably non essential (E-score: 0.149) question?
Stock # R5815 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 21842538-21848693 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 21842707 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 262 (Y262C)
Ref Sequence ENSEMBL: ENSMUSP00000150315 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055615] [ENSMUST00000214321]
AlphaFold Q8VFH0
Predicted Effect probably damaging
Transcript: ENSMUST00000055615
AA Change: Y262C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000062356
Gene: ENSMUSG00000049737
AA Change: Y262C

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srv 30 312 4.2e-10 PFAM
Pfam:7tm_4 36 313 7.7e-52 PFAM
Pfam:7tm_1 46 295 1.5e-25 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214321
AA Change: Y262C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.9%
  • 20x: 93.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afmid A G 11: 117,726,530 (GRCm39) D226G probably benign Het
Ago2 T C 15: 72,979,215 (GRCm39) probably null Het
Aldh1a1 C A 19: 20,608,034 (GRCm39) D285E probably benign Het
Alms1 T C 6: 85,599,820 (GRCm39) S1549P probably damaging Het
Apmap T C 2: 150,442,171 (GRCm39) S68G probably benign Het
Atp8a1 A T 5: 67,906,414 (GRCm39) I500N probably benign Het
B3gnt7 A C 1: 86,233,510 (GRCm39) D135A probably benign Het
Bms1 A T 6: 118,381,240 (GRCm39) L692H probably damaging Het
Cdk17 T A 10: 93,064,559 (GRCm39) V276E probably damaging Het
Cep290 A T 10: 100,393,970 (GRCm39) E2059V possibly damaging Het
Cpxm2 C A 7: 131,645,839 (GRCm39) G693V probably damaging Het
Crocc A T 4: 140,762,507 (GRCm39) V661E probably damaging Het
D1Pas1 A T 1: 186,700,206 (GRCm39) N45I probably damaging Het
Ddx19a C T 8: 111,705,781 (GRCm39) W223* probably null Het
Ddx60 C A 8: 62,416,756 (GRCm39) S567Y probably damaging Het
Dhx36 A T 3: 62,401,176 (GRCm39) N363K probably damaging Het
Gm57859 C A 11: 113,578,783 (GRCm39) probably null Het
Gpr151 G A 18: 42,712,450 (GRCm39) T76M probably benign Het
Inhbc C T 10: 127,193,318 (GRCm39) V233I probably benign Het
Ippk C T 13: 49,599,839 (GRCm39) L233F probably damaging Het
Lama2 A G 10: 26,862,847 (GRCm39) V2972A probably damaging Het
Lrrc37a T C 11: 103,394,612 (GRCm39) Q271R probably benign Het
Mia2 A T 12: 59,220,892 (GRCm39) K1083N possibly damaging Het
Mphosph9 A C 5: 124,453,481 (GRCm39) L277R probably damaging Het
Myo7b A T 18: 32,099,341 (GRCm39) F1694I probably damaging Het
Obscn T C 11: 58,973,015 (GRCm39) probably null Het
Or1e16 AGCGGTCGTAGGC AGC 11: 73,286,480 (GRCm39) probably null Het
Pcdh10 A G 3: 45,347,156 (GRCm39) T984A probably benign Het
Pcdh20 T C 14: 88,708,312 (GRCm39) S39G probably benign Het
Pdia3 T A 2: 121,266,892 (GRCm39) Y467* probably null Het
Ptpn13 C A 5: 103,745,556 (GRCm39) probably null Het
Reln A G 5: 22,152,431 (GRCm39) M2345T probably damaging Het
Rnf126 A T 10: 79,602,603 (GRCm39) I20N probably benign Het
Satb1 A G 17: 52,089,981 (GRCm39) S289P possibly damaging Het
Scd4 A T 19: 44,326,003 (GRCm39) H119L probably damaging Het
Sco2 T C 15: 89,256,574 (GRCm39) T27A probably benign Het
Slc39a14 A T 14: 70,544,194 (GRCm39) I464N probably damaging Het
Slc4a8 T A 15: 100,686,092 (GRCm39) V220E probably benign Het
Themis3 C T 17: 66,862,699 (GRCm39) V420I possibly damaging Het
Tmf1 T A 6: 97,150,364 (GRCm39) T448S probably benign Het
Tspan33 G A 6: 29,710,688 (GRCm39) R87Q probably damaging Het
Vmn2r91 A T 17: 18,326,464 (GRCm39) M250L probably benign Het
Zc3h7a A T 16: 10,974,050 (GRCm39) V245D probably damaging Het
Other mutations in Or2w6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01878:Or2w6 APN 13 21,842,953 (GRCm39) missense possibly damaging 0.63
IGL02025:Or2w6 APN 13 21,843,433 (GRCm39) missense possibly damaging 0.92
IGL02275:Or2w6 APN 13 21,843,170 (GRCm39) missense probably benign 0.01
IGL02831:Or2w6 APN 13 21,843,074 (GRCm39) missense probably benign
IGL02932:Or2w6 APN 13 21,843,001 (GRCm39) missense probably damaging 1.00
R0102:Or2w6 UTSW 13 21,842,905 (GRCm39) missense probably damaging 1.00
R0597:Or2w6 UTSW 13 21,843,316 (GRCm39) missense probably damaging 0.96
R1669:Or2w6 UTSW 13 21,843,456 (GRCm39) missense possibly damaging 0.91
R2006:Or2w6 UTSW 13 21,842,642 (GRCm39) missense possibly damaging 0.94
R2292:Or2w6 UTSW 13 21,843,001 (GRCm39) missense probably damaging 1.00
R4894:Or2w6 UTSW 13 21,843,352 (GRCm39) missense probably damaging 1.00
R4919:Or2w6 UTSW 13 21,842,794 (GRCm39) missense possibly damaging 0.59
R5339:Or2w6 UTSW 13 21,843,404 (GRCm39) missense probably benign 0.37
R6248:Or2w6 UTSW 13 21,843,244 (GRCm39) missense possibly damaging 0.72
R8273:Or2w6 UTSW 13 21,843,377 (GRCm39) missense probably damaging 1.00
R8323:Or2w6 UTSW 13 21,843,302 (GRCm39) missense possibly damaging 0.95
R8913:Or2w6 UTSW 13 21,843,274 (GRCm39) missense probably damaging 1.00
R9010:Or2w6 UTSW 13 21,842,681 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GACCATTCCTAGGTCTGATAGC -3'
(R):5'- TATGGCCTTGGAAGCACTGG -3'

Sequencing Primer
(F):5'- AATACCCAAATGTGTTCATCCCTTG -3'
(R):5'- GCTTTTGCGTTGGCGATTTTTATC -3'
Posted On 2016-12-20