Mutagenetix > Incidental Mutation

Incidental Mutation 'R5815:Gpr151'

449022

Institutional Source

Beutler Lab

Gene Symbol

Gpr151

Ensembl Gene

ENSMUSG00000042816

Gene Name

G protein-coupled receptor 151

Synonyms

GalRL, PGR7, C130082O03Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R5815 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

42710946-42712717 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 42712450 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Methionine at position 76 (T76M)

Ref Sequence

ENSEMBL: ENSMUSP00000058887 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000025375] [ENSMUST00000054738] [ENSMUST00000173642]

AlphaFold

Q7TSN6

Predicted Effect

probably benign
Transcript: ENSMUST00000025375

SMART Domains

Protein: ENSMUSP00000025375
Gene: ENSMUSG00000024498

Domain	Start	End	E-Value	Type
low complexity region	3	13	N/A	INTRINSIC
low complexity region	40	92	N/A	INTRINSIC
WW	132	164	8.27e-10	SMART
low complexity region	178	257	N/A	INTRINSIC
low complexity region	260	347	N/A	INTRINSIC
low complexity region	350	373	N/A	INTRINSIC
WW	432	464	2.65e-8	SMART
WW	531	563	1.2e-6	SMART
low complexity region	611	623	N/A	INTRINSIC
coiled coil region	629	654	N/A	INTRINSIC
FF	661	714	2.67e-13	SMART
FF	727	781	1.51e-12	SMART
FF	794	848	4.29e-17	SMART
FF	898	954	8.33e-15	SMART
FF	956	1012	1.47e-15	SMART
FF	1014	1079	1.3e-16	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000054738
AA Change: T76M

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000058887
Gene: ENSMUSG00000042816
AA Change: T76M

Domain	Start	End	E-Value	Type
Pfam:7tm_1	57	310	1.6e-18	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000173642

SMART Domains

Protein: ENSMUSP00000134458
Gene: ENSMUSG00000024498

Domain	Start	End	E-Value	Type
low complexity region	3	13	N/A	INTRINSIC
low complexity region	40	92	N/A	INTRINSIC
WW	132	164	8.27e-10	SMART
low complexity region	178	257	N/A	INTRINSIC
low complexity region	260	347	N/A	INTRINSIC
low complexity region	350	373	N/A	INTRINSIC
WW	432	464	2.65e-8	SMART
WW	531	563	1.2e-6	SMART
low complexity region	611	623	N/A	INTRINSIC
coiled coil region	629	654	N/A	INTRINSIC
FF	661	714	2.67e-13	SMART
FF	727	781	1.51e-12	SMART
FF	794	848	4.29e-17	SMART
FF	898	954	8.33e-15	SMART
FF	956	1012	1.47e-15	SMART

Coding Region Coverage

1x: 99.9%
3x: 99.5%
10x: 97.9%
20x: 93.8%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is similar to the galanin receptor subfamily of G protein-coupled receptors. The encoded protein is found predominantly in the central nervous system. [provided by RefSeq, Feb 2017]
PHENOTYPE: Homozygous mutation of this gene does not appear to result in a phenotype. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Afmid	A	G	11: 117,726,530 (GRCm39)	D226G	probably benign	Het
Ago2	T	C	15: 72,979,215 (GRCm39)		probably null	Het
Aldh1a1	C	A	19: 20,608,034 (GRCm39)	D285E	probably benign	Het
Alms1	T	C	6: 85,599,820 (GRCm39)	S1549P	probably damaging	Het
Apmap	T	C	2: 150,442,171 (GRCm39)	S68G	probably benign	Het
Atp8a1	A	T	5: 67,906,414 (GRCm39)	I500N	probably benign	Het
B3gnt7	A	C	1: 86,233,510 (GRCm39)	D135A	probably benign	Het
Bms1	A	T	6: 118,381,240 (GRCm39)	L692H	probably damaging	Het
Cdk17	T	A	10: 93,064,559 (GRCm39)	V276E	probably damaging	Het
Cep290	A	T	10: 100,393,970 (GRCm39)	E2059V	possibly damaging	Het
Cpxm2	C	A	7: 131,645,839 (GRCm39)	G693V	probably damaging	Het
Crocc	A	T	4: 140,762,507 (GRCm39)	V661E	probably damaging	Het
D1Pas1	A	T	1: 186,700,206 (GRCm39)	N45I	probably damaging	Het
Ddx19a	C	T	8: 111,705,781 (GRCm39)	W223*	probably null	Het
Ddx60	C	A	8: 62,416,756 (GRCm39)	S567Y	probably damaging	Het
Dhx36	A	T	3: 62,401,176 (GRCm39)	N363K	probably damaging	Het
Gm57859	C	A	11: 113,578,783 (GRCm39)		probably null	Het
Inhbc	C	T	10: 127,193,318 (GRCm39)	V233I	probably benign	Het
Ippk	C	T	13: 49,599,839 (GRCm39)	L233F	probably damaging	Het
Lama2	A	G	10: 26,862,847 (GRCm39)	V2972A	probably damaging	Het
Lrrc37a	T	C	11: 103,394,612 (GRCm39)	Q271R	probably benign	Het
Mia2	A	T	12: 59,220,892 (GRCm39)	K1083N	possibly damaging	Het
Mphosph9	A	C	5: 124,453,481 (GRCm39)	L277R	probably damaging	Het
Myo7b	A	T	18: 32,099,341 (GRCm39)	F1694I	probably damaging	Het
Obscn	T	C	11: 58,973,015 (GRCm39)		probably null	Het
Or1e16	AGCGGTCGTAGGC	AGC	11: 73,286,480 (GRCm39)		probably null	Het
Or2w6	T	C	13: 21,842,707 (GRCm39)	Y262C	probably damaging	Het
Pcdh10	A	G	3: 45,347,156 (GRCm39)	T984A	probably benign	Het
Pcdh20	T	C	14: 88,708,312 (GRCm39)	S39G	probably benign	Het
Pdia3	T	A	2: 121,266,892 (GRCm39)	Y467*	probably null	Het
Ptpn13	C	A	5: 103,745,556 (GRCm39)		probably null	Het
Reln	A	G	5: 22,152,431 (GRCm39)	M2345T	probably damaging	Het
Rnf126	A	T	10: 79,602,603 (GRCm39)	I20N	probably benign	Het
Satb1	A	G	17: 52,089,981 (GRCm39)	S289P	possibly damaging	Het
Scd4	A	T	19: 44,326,003 (GRCm39)	H119L	probably damaging	Het
Sco2	T	C	15: 89,256,574 (GRCm39)	T27A	probably benign	Het
Slc39a14	A	T	14: 70,544,194 (GRCm39)	I464N	probably damaging	Het
Slc4a8	T	A	15: 100,686,092 (GRCm39)	V220E	probably benign	Het
Themis3	C	T	17: 66,862,699 (GRCm39)	V420I	possibly damaging	Het
Tmf1	T	A	6: 97,150,364 (GRCm39)	T448S	probably benign	Het
Tspan33	G	A	6: 29,710,688 (GRCm39)	R87Q	probably damaging	Het
Vmn2r91	A	T	17: 18,326,464 (GRCm39)	M250L	probably benign	Het
Zc3h7a	A	T	16: 10,974,050 (GRCm39)	V245D	probably damaging	Het

Other mutations in Gpr151

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02631:Gpr151	APN	18	42,711,835 (GRCm39)	missense	probably benign	0.03
IGL03167:Gpr151	APN	18	42,711,439 (GRCm39)	missense	probably benign	0.06
R1561:Gpr151	UTSW	18	42,712,221 (GRCm39)	missense	probably benign	0.42
R3875:Gpr151	UTSW	18	42,711,661 (GRCm39)	missense	probably benign	0.02
R4294:Gpr151	UTSW	18	42,711,602 (GRCm39)	missense	probably benign	0.00
R5188:Gpr151	UTSW	18	42,711,820 (GRCm39)	missense	probably benign
R5431:Gpr151	UTSW	18	42,711,932 (GRCm39)	missense	probably damaging	1.00
R6199:Gpr151	UTSW	18	42,711,619 (GRCm39)	missense	probably benign	0.31
R6302:Gpr151	UTSW	18	42,712,459 (GRCm39)	missense	probably damaging	1.00
R6891:Gpr151	UTSW	18	42,711,985 (GRCm39)	missense	probably benign	0.15
R7180:Gpr151	UTSW	18	42,712,021 (GRCm39)	nonsense	probably null
R8262:Gpr151	UTSW	18	42,711,437 (GRCm39)	nonsense	probably null
R9328:Gpr151	UTSW	18	42,712,270 (GRCm39)	missense	probably damaging	0.98
R9421:Gpr151	UTSW	18	42,712,220 (GRCm39)	missense	probably benign	0.00
R9524:Gpr151	UTSW	18	42,712,710 (GRCm39)	unclassified	probably benign

Predicted Primers

PCR Primer
(F):5'- TGGCTGGGTCACTTGCATAC -3'
(R):5'- CCAGCAACATGAACGAGTCG -3'

Sequencing Primer
(F):5'- GAAGCATGCTTTGGCTACCAC -3'
(R):5'- ACGAGTCGTTTGCTCGC -3'

Posted On

2016-12-20