Incidental Mutation 'R5817:Qars1'
ID 449110
Institutional Source Beutler Lab
Gene Symbol Qars1
Ensembl Gene ENSMUSG00000032604
Gene Name glutaminyl-tRNA synthetase 1
Synonyms 1200016L19Rik, Qars, 1110018N24Rik
MMRRC Submission 043397-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.962) question?
Stock # R5817 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 108385204-108393140 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) C to T at 108387441 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000006838] [ENSMUST00000134939] [ENSMUST00000194045] [ENSMUST00000208162] [ENSMUST00000207947] [ENSMUST00000208177] [ENSMUST00000208214] [ENSMUST00000207862] [ENSMUST00000208581] [ENSMUST00000207790] [ENSMUST00000207810]
AlphaFold Q8BML9
Predicted Effect probably benign
Transcript: ENSMUST00000006838
SMART Domains Protein: ENSMUSP00000006838
Gene: ENSMUSG00000032604

DomainStartEndE-ValueType
Pfam:tRNA_synt_1c_R1 4 162 1.2e-54 PFAM
Pfam:tRNA_synt_1c_R2 165 256 6.5e-31 PFAM
Pfam:tRNA-synt_1c 263 563 4.5e-119 PFAM
Pfam:tRNA-synt_1c_C 565 752 6.9e-48 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131005
Predicted Effect probably benign
Transcript: ENSMUST00000134939
SMART Domains Protein: ENSMUSP00000122918
Gene: ENSMUSG00000032604

DomainStartEndE-ValueType
Pfam:tRNA_synt_1c_R1 1 163 1.1e-55 PFAM
Pfam:tRNA_synt_1c_R2 164 256 6.9e-31 PFAM
Pfam:tRNA-synt_1c 263 563 2.5e-115 PFAM
Pfam:tRNA-synt_1c_C 565 720 5.7e-35 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136293
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137655
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137980
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144253
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141201
Predicted Effect noncoding transcript
Transcript: ENSMUST00000192627
Predicted Effect noncoding transcript
Transcript: ENSMUST00000192659
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154324
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154311
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207126
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207062
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141780
Predicted Effect noncoding transcript
Transcript: ENSMUST00000192065
Predicted Effect probably benign
Transcript: ENSMUST00000194045
Predicted Effect probably benign
Transcript: ENSMUST00000141903
SMART Domains Protein: ENSMUSP00000121146
Gene: ENSMUSG00000032604

DomainStartEndE-ValueType
Pfam:tRNA-synt_1c 2 148 2.1e-50 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000208162
Predicted Effect probably benign
Transcript: ENSMUST00000207947
Predicted Effect probably benign
Transcript: ENSMUST00000208074
Predicted Effect probably benign
Transcript: ENSMUST00000208177
Predicted Effect probably benign
Transcript: ENSMUST00000208962
Predicted Effect probably benign
Transcript: ENSMUST00000207180
Predicted Effect probably benign
Transcript: ENSMUST00000208214
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208102
Predicted Effect probably benign
Transcript: ENSMUST00000207713
Predicted Effect probably benign
Transcript: ENSMUST00000207862
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208069
Predicted Effect probably benign
Transcript: ENSMUST00000208581
Predicted Effect probably benign
Transcript: ENSMUST00000207734
Predicted Effect probably benign
Transcript: ENSMUST00000207790
Predicted Effect probably benign
Transcript: ENSMUST00000208506
Predicted Effect probably benign
Transcript: ENSMUST00000207810
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 95.8%
Validation Efficiency 100% (71/71)
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4 A G 4: 144,349,497 (GRCm39) I251M probably benign Het
Abcf3 T C 16: 20,367,833 (GRCm39) V63A possibly damaging Het
Agpat4 C T 17: 12,434,097 (GRCm39) probably benign Het
Ahcyl2 G A 6: 29,890,720 (GRCm39) V292M probably damaging Het
Ahnak2 A T 12: 112,740,437 (GRCm39) F406I probably damaging Het
Aqp7 G A 4: 41,035,510 (GRCm39) T115I probably benign Het
Arhgef5 G A 6: 43,252,038 (GRCm39) D930N probably benign Het
Cc2d2a G A 5: 43,869,760 (GRCm39) R887Q probably damaging Het
Ceacam18 A G 7: 43,291,265 (GRCm39) T236A probably benign Het
Chst15 A T 7: 131,870,873 (GRCm39) Y221N probably damaging Het
Chst15 G A 7: 131,870,876 (GRCm39) L220F probably damaging Het
Cntn2 G A 1: 132,446,486 (GRCm39) T784I probably benign Het
D630003M21Rik A G 2: 158,038,413 (GRCm39) L1011P probably damaging Het
Dync2h1 T A 9: 6,996,905 (GRCm39) D3894V probably damaging Het
Eif1ad19 G T 12: 87,740,201 (GRCm39) D119E probably benign Het
Fam13b T C 18: 34,590,850 (GRCm39) M443V possibly damaging Het
Fam20a T A 11: 109,564,244 (GRCm39) Q503L possibly damaging Het
Ftdc2 T C 16: 58,457,156 (GRCm39) I89V probably benign Het
Gm11677 C T 11: 111,615,537 (GRCm39) noncoding transcript Het
Gm5454 T A 13: 103,493,140 (GRCm39) noncoding transcript Het
Gm5581 A G 6: 131,144,132 (GRCm39) noncoding transcript Het
Gm6619 A G 6: 131,463,400 (GRCm39) I6V unknown Het
Gmcl1 A G 6: 86,691,230 (GRCm39) M255T probably damaging Het
Golm2 T A 2: 121,736,525 (GRCm39) S231T probably benign Het
Gprc5c T A 11: 114,754,450 (GRCm39) C42* probably null Het
Hmcn1 T A 1: 150,613,275 (GRCm39) E1384V possibly damaging Het
Il6 A G 5: 30,223,006 (GRCm39) I91V probably benign Het
Kmt2d A T 15: 98,760,244 (GRCm39) S1005T unknown Het
Map1a A T 2: 121,129,391 (GRCm39) H143L possibly damaging Het
Mical2 A T 7: 111,922,866 (GRCm39) T624S probably benign Het
Msh3 A T 13: 92,422,508 (GRCm39) N549K possibly damaging Het
Ncr1 T A 7: 4,343,894 (GRCm39) I164N possibly damaging Het
Or10ak11 T G 4: 118,687,296 (GRCm39) T115P probably damaging Het
Or51a5 A T 7: 102,771,115 (GRCm39) M292K possibly damaging Het
Or52m1 A G 7: 102,289,585 (GRCm39) N44S probably damaging Het
Or8d2b A G 9: 38,788,673 (GRCm39) D67G probably damaging Het
Palmd T C 3: 116,712,272 (GRCm39) I541M probably benign Het
Pcsk7 A T 9: 45,837,331 (GRCm39) M552L probably benign Het
Plekhh2 A G 17: 84,879,154 (GRCm39) E626G possibly damaging Het
Pole G A 5: 110,460,838 (GRCm39) D1176N probably damaging Het
Polr2f T C 15: 79,035,869 (GRCm39) I110T probably damaging Het
Pomt1 A T 2: 32,138,691 (GRCm39) I436F probably damaging Het
Prag1 A C 8: 36,570,857 (GRCm39) Q480P probably damaging Het
Ralgapa2 G A 2: 146,175,406 (GRCm39) S1797L probably damaging Het
Rbm26 T C 14: 105,366,039 (GRCm39) T832A probably damaging Het
Rnf169 A G 7: 99,574,976 (GRCm39) S540P probably benign Het
Serpini1 T A 3: 75,520,631 (GRCm39) M76K probably benign Het
Shq1 A G 6: 100,550,681 (GRCm39) L419S probably damaging Het
Slc25a17 G A 15: 81,211,261 (GRCm39) T225M probably damaging Het
Slc6a5 C A 7: 49,606,239 (GRCm39) L716I probably benign Het
Smc1b A G 15: 84,951,984 (GRCm39) V1149A probably damaging Het
Trappc1 A T 11: 69,215,060 (GRCm39) Q26L possibly damaging Het
Trpm2 C A 10: 77,801,814 (GRCm39) G84W probably damaging Het
Ttn G A 2: 76,573,010 (GRCm39) T24215M probably damaging Het
Ubn2 C A 6: 38,456,088 (GRCm39) T337K probably damaging Het
Ubr4 A G 4: 139,196,158 (GRCm39) K1265E probably damaging Het
Vmn1r214 T G 13: 23,219,491 (GRCm39) I328M probably damaging Het
Xcr1 C T 9: 123,684,922 (GRCm39) C280Y possibly damaging Het
Zc3h13 A G 14: 75,565,572 (GRCm39) E895G probably damaging Het
Other mutations in Qars1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01570:Qars1 APN 9 108,388,738 (GRCm39) missense probably damaging 1.00
IGL02336:Qars1 APN 9 108,392,185 (GRCm39) nonsense probably null
IGL02393:Qars1 APN 9 108,391,528 (GRCm39) missense probably benign 0.00
IGL03102:Qars1 APN 9 108,386,118 (GRCm39) missense probably benign 0.35
R0576:Qars1 UTSW 9 108,392,161 (GRCm39) intron probably benign
R1777:Qars1 UTSW 9 108,385,400 (GRCm39) critical splice donor site probably null
R1824:Qars1 UTSW 9 108,391,809 (GRCm39) missense probably damaging 1.00
R1871:Qars1 UTSW 9 108,391,315 (GRCm39) splice site probably null
R1897:Qars1 UTSW 9 108,391,282 (GRCm39) nonsense probably null
R1952:Qars1 UTSW 9 108,390,380 (GRCm39) missense probably benign 0.35
R1981:Qars1 UTSW 9 108,392,227 (GRCm39) missense probably damaging 1.00
R2172:Qars1 UTSW 9 108,386,399 (GRCm39) missense probably damaging 1.00
R2698:Qars1 UTSW 9 108,385,642 (GRCm39) missense possibly damaging 0.65
R4381:Qars1 UTSW 9 108,387,382 (GRCm39) unclassified probably benign
R4608:Qars1 UTSW 9 108,386,625 (GRCm39) splice site probably null
R4677:Qars1 UTSW 9 108,386,889 (GRCm39) unclassified probably benign
R4974:Qars1 UTSW 9 108,386,130 (GRCm39) missense probably damaging 1.00
R5234:Qars1 UTSW 9 108,391,364 (GRCm39) missense probably damaging 1.00
R5548:Qars1 UTSW 9 108,390,117 (GRCm39) missense possibly damaging 0.72
R6029:Qars1 UTSW 9 108,390,889 (GRCm39) missense probably damaging 1.00
R6110:Qars1 UTSW 9 108,385,297 (GRCm39) missense probably benign 0.02
R6889:Qars1 UTSW 9 108,390,382 (GRCm39) missense probably damaging 0.98
R7034:Qars1 UTSW 9 108,391,976 (GRCm39) missense probably damaging 1.00
R7036:Qars1 UTSW 9 108,391,976 (GRCm39) missense probably damaging 1.00
R7136:Qars1 UTSW 9 108,389,971 (GRCm39) missense probably damaging 1.00
R7178:Qars1 UTSW 9 108,392,322 (GRCm39) missense possibly damaging 0.50
R7192:Qars1 UTSW 9 108,388,760 (GRCm39) missense probably damaging 1.00
R7235:Qars1 UTSW 9 108,387,331 (GRCm39) missense probably damaging 1.00
R7813:Qars1 UTSW 9 108,386,670 (GRCm39) missense probably damaging 1.00
R8248:Qars1 UTSW 9 108,386,651 (GRCm39) missense probably benign 0.00
R8558:Qars1 UTSW 9 108,392,422 (GRCm39) missense probably benign
R9126:Qars1 UTSW 9 108,386,399 (GRCm39) missense probably damaging 1.00
R9245:Qars1 UTSW 9 108,386,132 (GRCm39) nonsense probably null
R9632:Qars1 UTSW 9 108,391,582 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- CTTGAGAGAGTACACCCTTGTCTG -3'
(R):5'- TCGCAGTCATGAGAATACGG -3'

Sequencing Primer
(F):5'- AGAGTACACCCTTGTCTGTATCTATC -3'
(R):5'- CCCGAGAAGTCTGTATGTAAGGTCC -3'
Posted On 2016-12-20