Incidental Mutation 'R5831:Or11g1'
| ID |
449333 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Or11g1
|
| Ensembl Gene |
ENSMUSG00000094692 |
| Gene Name |
olfactory receptor family 11 subfamily G member 1 |
| Synonyms |
GA_x6K02T2PMLR-6110726-6111661, Olfr738, MOR106-3 |
| MMRRC Submission |
043220-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.088)
|
| Stock # |
R5831 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
14 |
| Chromosomal Location |
50651003-50651938 bp(+) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
A to G
at 50651439 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000150559
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000058972]
[ENSMUST00000214320]
[ENSMUST00000214853]
[ENSMUST00000216949]
|
| AlphaFold |
L7N1X7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000058972
AA Change: N146S
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000059540
Gene: ENSMUSG00000094692
AA Change: N146S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_4
|
35 |
311 |
2.5e-50 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
39 |
309 |
1.3e-5 |
PFAM |
|
Pfam:7tm_1
|
45 |
294 |
6.9e-22 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000205382
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000214320
AA Change: N146S
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000214853
AA Change: N146S
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000216949
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 98.8%
- 20x: 96.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 41 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca13 |
A |
T |
11: 9,517,777 (GRCm39) |
K4460* |
probably null |
Het |
| Adam21 |
A |
G |
12: 81,605,875 (GRCm39) |
V629A |
probably benign |
Het |
| Adamts5 |
C |
T |
16: 85,665,006 (GRCm39) |
V653I |
probably damaging |
Het |
| Adarb2 |
G |
A |
13: 8,609,169 (GRCm39) |
A44T |
probably benign |
Het |
| Ank2 |
T |
C |
3: 127,132,808 (GRCm39) |
|
probably benign |
Het |
| Arhgap21 |
T |
C |
2: 20,868,024 (GRCm39) |
Y833C |
probably damaging |
Het |
| Brwd1 |
A |
G |
16: 95,820,636 (GRCm39) |
S1297P |
probably damaging |
Het |
| Cdc25b |
G |
T |
2: 131,029,301 (GRCm39) |
|
probably null |
Het |
| Ciart |
A |
T |
3: 95,786,214 (GRCm39) |
V287D |
probably damaging |
Het |
| Csf2ra |
A |
G |
19: 61,213,650 (GRCm39) |
F353S |
probably damaging |
Het |
| D630045J12Rik |
C |
T |
6: 38,119,592 (GRCm39) |
E1717K |
possibly damaging |
Het |
| Dhcr24 |
A |
G |
4: 106,421,611 (GRCm39) |
K82R |
probably benign |
Het |
| Dnah9 |
T |
A |
11: 65,998,947 (GRCm39) |
T1034S |
probably benign |
Het |
| Dock6 |
T |
C |
9: 21,714,332 (GRCm39) |
E1837G |
probably damaging |
Het |
| Eeig2 |
A |
T |
3: 108,900,019 (GRCm39) |
S110T |
possibly damaging |
Het |
| Flg2 |
G |
A |
3: 93,107,541 (GRCm39) |
V9I |
probably damaging |
Het |
| Hif1a |
A |
T |
12: 73,988,918 (GRCm39) |
T602S |
probably benign |
Het |
| Hip1 |
T |
C |
5: 135,440,117 (GRCm39) |
E1015G |
probably benign |
Het |
| Iqgap2 |
C |
T |
13: 95,811,880 (GRCm39) |
R707H |
probably damaging |
Het |
| Irgq |
C |
A |
7: 24,232,763 (GRCm39) |
F201L |
probably damaging |
Het |
| Isoc2b |
C |
A |
7: 4,854,023 (GRCm39) |
L116F |
probably null |
Het |
| Loxl3 |
A |
T |
6: 83,025,999 (GRCm39) |
T416S |
probably benign |
Het |
| Map3k13 |
A |
G |
16: 21,746,798 (GRCm39) |
*960W |
probably null |
Het |
| Morn1 |
A |
G |
4: 155,185,733 (GRCm39) |
H183R |
probably benign |
Het |
| Mrc1 |
A |
T |
2: 14,313,523 (GRCm39) |
N918I |
probably damaging |
Het |
| Nfxl1 |
A |
G |
5: 72,679,540 (GRCm39) |
V763A |
probably benign |
Het |
| Or4c100 |
G |
A |
2: 88,356,824 (GRCm39) |
W299* |
probably null |
Het |
| Papola |
A |
G |
12: 105,789,859 (GRCm39) |
K482E |
probably benign |
Het |
| Pck1 |
C |
T |
2: 172,998,792 (GRCm39) |
T350I |
probably damaging |
Het |
| Peli2 |
G |
A |
14: 48,405,727 (GRCm39) |
A51T |
probably damaging |
Het |
| Preb |
T |
C |
5: 31,116,208 (GRCm39) |
H133R |
probably benign |
Het |
| Rpl36-ps4 |
T |
C |
17: 88,228,685 (GRCm39) |
V73A |
probably benign |
Het |
| Scaf11 |
G |
A |
15: 96,314,962 (GRCm39) |
P1240L |
probably benign |
Het |
| Selenom |
G |
T |
11: 3,466,882 (GRCm39) |
E81* |
probably null |
Het |
| Serpinb1c |
T |
C |
13: 33,081,081 (GRCm39) |
M1V |
probably null |
Het |
| Tanc1 |
T |
C |
2: 59,615,685 (GRCm39) |
S231P |
possibly damaging |
Het |
| Trappc10 |
C |
T |
10: 78,045,260 (GRCm39) |
R476Q |
probably damaging |
Het |
| Twf2 |
T |
A |
9: 106,091,386 (GRCm39) |
D200E |
probably benign |
Het |
| Vmn1r17 |
T |
C |
6: 57,337,999 (GRCm39) |
Y122C |
probably benign |
Het |
| Vmn2r71 |
G |
A |
7: 85,272,922 (GRCm39) |
D579N |
probably benign |
Het |
| Vrtn |
A |
T |
12: 84,695,349 (GRCm39) |
E33V |
probably damaging |
Het |
|
| Other mutations in Or11g1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01608:Or11g1
|
APN |
14 |
50,651,910 (GRCm39) |
missense |
probably benign |
|
|
IGL01935:Or11g1
|
APN |
14 |
50,651,012 (GRCm39) |
missense |
probably benign |
|
|
IGL02431:Or11g1
|
APN |
14 |
50,651,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB008:Or11g1
|
UTSW |
14 |
50,651,786 (GRCm39) |
missense |
probably damaging |
0.96 |
|
BB018:Or11g1
|
UTSW |
14 |
50,651,786 (GRCm39) |
missense |
probably damaging |
0.96 |
|
PIT4480001:Or11g1
|
UTSW |
14 |
50,651,372 (GRCm39) |
missense |
probably benign |
0.14 |
|
R0620:Or11g1
|
UTSW |
14 |
50,651,154 (GRCm39) |
missense |
probably benign |
0.20 |
|
R1445:Or11g1
|
UTSW |
14 |
50,651,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1831:Or11g1
|
UTSW |
14 |
50,651,658 (GRCm39) |
splice site |
probably null |
|
|
R1915:Or11g1
|
UTSW |
14 |
50,651,798 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4748:Or11g1
|
UTSW |
14 |
50,651,333 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R5301:Or11g1
|
UTSW |
14 |
50,651,030 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5767:Or11g1
|
UTSW |
14 |
50,651,235 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R6173:Or11g1
|
UTSW |
14 |
50,651,654 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R6176:Or11g1
|
UTSW |
14 |
50,651,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7356:Or11g1
|
UTSW |
14 |
50,651,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7678:Or11g1
|
UTSW |
14 |
50,651,471 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7931:Or11g1
|
UTSW |
14 |
50,651,786 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8508:Or11g1
|
UTSW |
14 |
50,651,132 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8696:Or11g1
|
UTSW |
14 |
50,651,420 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9374:Or11g1
|
UTSW |
14 |
50,651,625 (GRCm39) |
missense |
probably benign |
0.38 |
|
R9470:Or11g1
|
UTSW |
14 |
50,651,235 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R9551:Or11g1
|
UTSW |
14 |
50,651,625 (GRCm39) |
missense |
probably benign |
0.38 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTCTGACACGAAGGTCATCTC -3'
(R):5'- AGCACAGCCCTCATTACTAGAG -3'
Sequencing Primer
(F):5'- ACGAAGGTCATCTCTTTCTCTGGATG -3'
(R):5'- AGCCCTCATTACTAGAGCATAAG -3'
|
| Posted On |
2016-12-20 |
Incidental Mutation