Incidental Mutation 'R5832:Galr2'
ID 449371
Institutional Source Beutler Lab
Gene Symbol Galr2
Ensembl Gene ENSMUSG00000020793
Gene Name galanin receptor 2
Synonyms GalR2, mGalR
MMRRC Submission 044054-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.075) question?
Stock # R5832 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 116171765-116174764 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 116172457 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 49 (L49Q)
Ref Sequence ENSEMBL: ENSMUSP00000054062 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055872]
AlphaFold O88854
Predicted Effect probably damaging
Transcript: ENSMUST00000055872
AA Change: L49Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000054062
Gene: ENSMUSG00000020793
AA Change: L49Q

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 35 306 4.1e-12 PFAM
Pfam:7tm_1 41 291 6.4e-52 PFAM
Pfam:7TM_GPCR_Srv 62 307 1.2e-7 PFAM
Pfam:7TM_GPCR_Srw 184 308 4.7e-8 PFAM
low complexity region 347 358 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154277
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.8%
  • 20x: 96.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this gene display a reduction in exploratory activity. There is also a modest shift in the distribution of different lymphocyte cell types. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930505A04Rik C T 11: 30,376,349 (GRCm39) V173M probably damaging Het
Adgrv1 G A 13: 81,251,421 (GRCm39) S6232F possibly damaging Het
Alox12 T C 11: 70,144,106 (GRCm39) E129G probably damaging Het
Anxa13 C A 15: 58,205,389 (GRCm39) noncoding transcript Het
Arfgef3 C T 10: 18,506,168 (GRCm39) G878D probably damaging Het
Asnsd1 T C 1: 53,386,634 (GRCm39) D331G probably damaging Het
Crisp1 A G 17: 40,612,208 (GRCm39) probably null Het
Eml5 T C 12: 98,842,447 (GRCm39) N217S probably benign Het
Fat1 A T 8: 45,470,460 (GRCm39) Y1463F possibly damaging Het
Fhod3 T C 18: 25,223,752 (GRCm39) W1033R probably damaging Het
Gstm5 T C 3: 107,804,853 (GRCm39) V115A probably benign Het
Gtpbp2 C T 17: 46,478,788 (GRCm39) T535I probably damaging Het
Hk1 T C 10: 62,128,144 (GRCm39) E326G probably benign Het
Igfn1 A G 1: 135,902,533 (GRCm39) V388A probably damaging Het
Iqgap2 C T 13: 95,811,880 (GRCm39) R707H probably damaging Het
Kitl C A 10: 99,915,882 (GRCm39) P137H probably damaging Het
Lamp3 A T 16: 19,520,070 (GRCm39) Y38N probably damaging Het
Lmo7 A T 14: 102,121,649 (GRCm39) N5I probably damaging Het
Mc3r T A 2: 172,091,350 (GRCm39) C191S probably benign Het
Mep1a G A 17: 43,789,055 (GRCm39) H574Y probably benign Het
Mybpc3 A G 2: 90,949,520 (GRCm39) probably null Het
Nav2 A T 7: 49,197,817 (GRCm39) probably null Het
Patz1 C T 11: 3,256,277 (GRCm39) P521L probably benign Het
Pramel14 A G 4: 143,718,532 (GRCm39) S304P probably damaging Het
Prkcd T C 14: 30,327,778 (GRCm39) T103A probably damaging Het
Pttg1ip T C 10: 77,419,859 (GRCm39) probably null Het
Rcbtb2 C A 14: 73,404,262 (GRCm39) Q85K possibly damaging Het
Rdh16f1 T A 10: 127,624,618 (GRCm39) V152E probably damaging Het
Rsph4a A G 10: 33,785,498 (GRCm39) I470V probably benign Het
Sarnp T C 10: 128,684,181 (GRCm39) probably null Het
Slc39a6 C A 18: 24,734,669 (GRCm39) V7L possibly damaging Het
Slco1a4 A G 6: 141,765,270 (GRCm39) I324T probably benign Het
Spata31d1a A T 13: 59,849,380 (GRCm39) V916E probably damaging Het
Srgap1 T G 10: 121,676,819 (GRCm39) T392P probably damaging Het
Tbc1d20 A T 2: 152,153,282 (GRCm39) M271L possibly damaging Het
Tbc1d22b T C 17: 29,789,621 (GRCm39) I161T possibly damaging Het
Tcof1 G T 18: 60,952,611 (GRCm39) N918K unknown Het
Tnr A G 1: 159,713,692 (GRCm39) T707A probably benign Het
Trim66 A G 7: 109,054,409 (GRCm39) F1267S probably damaging Het
Trpm6 A G 19: 18,764,183 (GRCm39) H263R possibly damaging Het
Tshz2 T A 2: 169,725,965 (GRCm39) V187D possibly damaging Het
Ube2f T G 1: 91,213,046 (GRCm39) V176G possibly damaging Het
Vmn2r109 C T 17: 20,761,318 (GRCm39) A680T probably benign Het
Vmn2r77 T A 7: 86,460,670 (GRCm39) C665* probably null Het
Zfp954 A G 7: 7,118,389 (GRCm39) V385A probably damaging Het
Other mutations in Galr2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01012:Galr2 APN 11 116,173,996 (GRCm39) missense probably damaging 1.00
PIT4418001:Galr2 UTSW 11 116,174,084 (GRCm39) missense probably benign 0.35
PIT4445001:Galr2 UTSW 11 116,172,474 (GRCm39) missense probably benign 0.13
R0426:Galr2 UTSW 11 116,172,517 (GRCm39) missense probably damaging 1.00
R1869:Galr2 UTSW 11 116,174,069 (GRCm39) missense possibly damaging 0.87
R2059:Galr2 UTSW 11 116,173,765 (GRCm39) missense probably damaging 1.00
R4579:Galr2 UTSW 11 116,172,325 (GRCm39) missense probably benign
R4666:Galr2 UTSW 11 116,174,455 (GRCm39) missense probably benign
R5974:Galr2 UTSW 11 116,173,852 (GRCm39) missense possibly damaging 0.62
R7081:Galr2 UTSW 11 116,173,874 (GRCm39) missense probably damaging 0.99
R7155:Galr2 UTSW 11 116,174,408 (GRCm39) missense possibly damaging 0.94
R7696:Galr2 UTSW 11 116,173,993 (GRCm39) missense probably damaging 1.00
R7810:Galr2 UTSW 11 116,173,946 (GRCm39) missense probably benign 0.23
R8921:Galr2 UTSW 11 116,173,973 (GRCm39) missense probably damaging 1.00
R9231:Galr2 UTSW 11 116,174,335 (GRCm39) missense probably benign
R9514:Galr2 UTSW 11 116,174,452 (GRCm39) missense probably benign
X0009:Galr2 UTSW 11 116,174,149 (GRCm39) missense probably benign 0.14
X0026:Galr2 UTSW 11 116,172,577 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TTGGAGCTCGACAGTCTTGC -3'
(R):5'- GAATGTTCACTCACCTGTCCAGC -3'

Sequencing Primer
(F):5'- GCTACGCGCTCACCAAG -3'
(R):5'- TCACCTGTCCAGCGAGACAG -3'
Posted On 2016-12-20