Incidental Mutation 'R5820:Oasl1'
ID 449851
Institutional Source Beutler Lab
Gene Symbol Oasl1
Ensembl Gene ENSMUSG00000041827
Gene Name 2'-5' oligoadenylate synthetase-like 1
Synonyms 7530414C13Rik
MMRRC Submission 043400-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5820 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 115061299-115075974 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 115075037 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 366 (V366M)
Ref Sequence ENSEMBL: ENSMUSP00000107771 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031540] [ENSMUST00000112143]
AlphaFold Q8VI94
Predicted Effect possibly damaging
Transcript: ENSMUST00000031540
AA Change: V366M

PolyPhen 2 Score 0.943 (Sensitivity: 0.80; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000031540
Gene: ENSMUSG00000041827
AA Change: V366M

DomainStartEndE-ValueType
low complexity region 31 42 N/A INTRINSIC
Pfam:OAS1_C 162 348 8e-76 PFAM
UBQ 350 425 1.58e0 SMART
UBQ 430 501 2.22e-11 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000112143
AA Change: V366M

PolyPhen 2 Score 0.943 (Sensitivity: 0.80; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000107771
Gene: ENSMUSG00000041827
AA Change: V366M

DomainStartEndE-ValueType
low complexity region 31 42 N/A INTRINSIC
Pfam:OAS1_C 163 346 1.9e-79 PFAM
UBQ 350 425 1.58e0 SMART
UBQ 430 501 2.22e-11 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140159
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152329
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155274
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155394
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 95.8%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice with a deletion of this gene have increased expression of type I interferon and show increased resistance to viral infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc4 A G 14: 118,841,607 (GRCm39) Y596H probably benign Het
Adgrg3 A T 8: 95,766,221 (GRCm39) M351L possibly damaging Het
Aqp7 G A 4: 41,035,510 (GRCm39) T115I probably benign Het
Arhgef38 A T 3: 132,866,560 (GRCm39) D192E probably benign Het
Arhgef40 T C 14: 52,224,953 (GRCm39) F33L possibly damaging Het
Arid1b A G 17: 5,046,529 (GRCm39) Y439C possibly damaging Het
Bltp1 T C 3: 37,093,675 (GRCm39) V875A probably benign Het
Bop1 G A 15: 76,339,041 (GRCm39) P386S probably damaging Het
Cacna1s A G 1: 136,007,342 (GRCm39) H453R probably damaging Het
Canx A G 11: 50,199,210 (GRCm39) V153A probably damaging Het
Chfr T A 5: 110,310,605 (GRCm39) D475E possibly damaging Het
Clcn7 A C 17: 25,368,026 (GRCm39) K208T probably damaging Het
Cmya5 G T 13: 93,229,288 (GRCm39) N1933K probably benign Het
CN725425 A G 15: 91,144,900 (GRCm39) T588A possibly damaging Het
Cwh43 G A 5: 73,585,975 (GRCm39) W358* probably null Het
Cyfip2 A T 11: 46,091,531 (GRCm39) W1130R probably damaging Het
Ddx60 A T 8: 62,409,155 (GRCm39) D397V possibly damaging Het
Disp1 T C 1: 182,917,151 (GRCm39) S92G probably benign Het
Dusp6 A G 10: 99,099,864 (GRCm39) D104G possibly damaging Het
Dzank1 C T 2: 144,355,408 (GRCm39) V96M probably damaging Het
Ecscr C A 18: 35,850,320 (GRCm39) V52F possibly damaging Het
Epha7 A T 4: 28,949,365 (GRCm39) N712I probably damaging Het
Eva1a C T 6: 82,048,154 (GRCm39) P11S probably benign Het
Fam187b T C 7: 30,676,577 (GRCm39) C29R probably damaging Het
Fau T C 19: 6,109,452 (GRCm39) V117A probably benign Het
Fbxw11 A G 11: 32,685,374 (GRCm39) D369G probably damaging Het
Fkbp15 A G 4: 62,263,783 (GRCm39) F95L probably benign Het
Fkbp6 A T 5: 135,368,774 (GRCm39) probably null Het
Fmo9 T C 1: 166,492,170 (GRCm39) K367E possibly damaging Het
Gad2 T C 2: 22,580,261 (GRCm39) V554A probably benign Het
Gm18025 T C 12: 34,340,631 (GRCm39) D154G probably benign Het
Gm4353 A G 7: 115,683,693 (GRCm39) F34S possibly damaging Het
Gucy2e A G 11: 69,123,522 (GRCm39) I459T probably benign Het
Hpx A G 7: 105,240,995 (GRCm39) I426T possibly damaging Het
Hspa9 T C 18: 35,076,227 (GRCm39) T362A possibly damaging Het
Insr G A 8: 3,205,976 (GRCm39) P1271L probably damaging Het
Jarid2 G A 13: 45,055,777 (GRCm39) V328I possibly damaging Het
Kat8 G A 7: 127,523,988 (GRCm39) E343K probably damaging Het
Kif18b A G 11: 102,803,874 (GRCm39) S429P probably benign Het
Lats1 A T 10: 7,581,672 (GRCm39) H819L probably damaging Het
Lmnb1 T A 18: 56,873,858 (GRCm39) D421E possibly damaging Het
Lrp4 T C 2: 91,322,960 (GRCm39) I1148T probably damaging Het
Map1b T A 13: 99,569,332 (GRCm39) M1130L unknown Het
Mlip G A 9: 77,137,764 (GRCm39) S381L probably damaging Het
Myh6 T C 14: 55,196,137 (GRCm39) Y554C probably damaging Het
Myl4 T C 11: 104,474,806 (GRCm39) F52L probably damaging Het
Nol12 C T 15: 78,824,680 (GRCm39) T169I probably benign Het
Nrde2 C T 12: 100,098,546 (GRCm39) R707H probably benign Het
Or8b47 T C 9: 38,435,895 (GRCm39) I289T possibly damaging Het
Otogl G A 10: 107,612,978 (GRCm39) silent Het
Polrmt C T 10: 79,574,157 (GRCm39) probably null Het
Ppil4 A G 10: 7,686,174 (GRCm39) D344G probably null Het
Ppp2r3d C T 9: 124,422,765 (GRCm38) A69T possibly damaging Het
Prmt3 C T 7: 49,498,554 (GRCm39) P487S probably damaging Het
Ptprm A T 17: 66,996,460 (GRCm39) L1209H probably damaging Het
Rnf115 G A 3: 96,635,164 (GRCm39) probably benign Het
Sec63 A G 10: 42,672,241 (GRCm39) D185G possibly damaging Het
Sema4b T C 7: 79,874,706 (GRCm39) S699P probably damaging Het
Serpinb3d T G 1: 107,006,089 (GRCm39) E333A probably damaging Het
Sh3rf2 T C 18: 42,274,112 (GRCm39) L426P possibly damaging Het
Slco6d1 A G 1: 98,427,503 (GRCm39) I611M probably damaging Het
Stk31 T A 6: 49,394,219 (GRCm39) Y194N probably damaging Het
Tlr9 G A 9: 106,099,906 (GRCm39) probably null Het
Ubqln3 G A 7: 103,790,674 (GRCm39) P472L probably benign Het
Vmn1r188 G A 13: 22,272,256 (GRCm39) G70D possibly damaging Het
Zfp318 A G 17: 46,723,699 (GRCm39) M1901V probably benign Het
Zfp407 A T 18: 84,578,649 (GRCm39) D821E probably benign Het
Other mutations in Oasl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01432:Oasl1 APN 5 115,075,466 (GRCm39) missense probably benign 0.01
IGL02061:Oasl1 APN 5 115,061,651 (GRCm39) missense probably damaging 0.97
IGL02888:Oasl1 APN 5 115,075,241 (GRCm39) missense probably damaging 1.00
IGL03230:Oasl1 APN 5 115,075,115 (GRCm39) missense probably damaging 1.00
ammonite UTSW 5 115,074,996 (GRCm39) missense probably damaging 1.00
dreadnaught UTSW 5 115,074,129 (GRCm39) critical splice donor site probably null
nautilus UTSW 5 115,075,242 (GRCm39) missense probably damaging 1.00
spirogyra UTSW 5 115,075,465 (GRCm39) missense probably benign 0.00
IGL03048:Oasl1 UTSW 5 115,075,400 (GRCm39) missense possibly damaging 0.56
R1510:Oasl1 UTSW 5 115,066,167 (GRCm39) missense probably benign 0.00
R1680:Oasl1 UTSW 5 115,074,003 (GRCm39) missense probably damaging 1.00
R1918:Oasl1 UTSW 5 115,061,528 (GRCm39) missense possibly damaging 0.84
R2090:Oasl1 UTSW 5 115,073,993 (GRCm39) missense probably damaging 1.00
R3977:Oasl1 UTSW 5 115,070,957 (GRCm39) missense probably damaging 1.00
R3978:Oasl1 UTSW 5 115,070,957 (GRCm39) missense probably damaging 1.00
R3980:Oasl1 UTSW 5 115,070,957 (GRCm39) missense probably damaging 1.00
R4158:Oasl1 UTSW 5 115,075,073 (GRCm39) missense possibly damaging 0.77
R4159:Oasl1 UTSW 5 115,075,073 (GRCm39) missense possibly damaging 0.77
R4160:Oasl1 UTSW 5 115,075,073 (GRCm39) missense possibly damaging 0.77
R4161:Oasl1 UTSW 5 115,075,073 (GRCm39) missense possibly damaging 0.77
R4797:Oasl1 UTSW 5 115,066,217 (GRCm39) missense probably benign 0.00
R5354:Oasl1 UTSW 5 115,075,055 (GRCm39) missense probably damaging 1.00
R5443:Oasl1 UTSW 5 115,074,129 (GRCm39) critical splice donor site probably null
R5919:Oasl1 UTSW 5 115,066,329 (GRCm39) missense probably damaging 1.00
R6746:Oasl1 UTSW 5 115,075,242 (GRCm39) missense probably damaging 1.00
R7471:Oasl1 UTSW 5 115,073,985 (GRCm39) missense probably damaging 1.00
R7720:Oasl1 UTSW 5 115,067,980 (GRCm39) missense probably damaging 1.00
R7766:Oasl1 UTSW 5 115,075,169 (GRCm39) missense probably damaging 1.00
R8115:Oasl1 UTSW 5 115,074,996 (GRCm39) missense probably damaging 1.00
R8243:Oasl1 UTSW 5 115,066,220 (GRCm39) missense probably benign 0.04
R8358:Oasl1 UTSW 5 115,075,465 (GRCm39) missense probably benign 0.00
R9566:Oasl1 UTSW 5 115,066,331 (GRCm39) missense probably benign 0.02
R9695:Oasl1 UTSW 5 115,074,054 (GRCm39) missense probably damaging 1.00
Z1177:Oasl1 UTSW 5 115,070,804 (GRCm39) missense possibly damaging 0.88
Predicted Primers PCR Primer
(F):5'- GGCGTTCCCTAAACATTTGCTG -3'
(R):5'- TCACAAAGACCTGGATCTCAG -3'

Sequencing Primer
(F):5'- CCTAAACATTTGCTGCGGAG -3'
(R):5'- ATGGTGTCCAGCAGGCAG -3'
Posted On 2016-12-20