Incidental Mutation 'R5821:Cped1'
ID 449935
Institutional Source Beutler Lab
Gene Symbol Cped1
Ensembl Gene ENSMUSG00000062980
Gene Name cadherin-like and PC-esterase domain containing 1
Synonyms A430107O13Rik
MMRRC Submission 043401-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R5821 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 21985915-22256403 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 22138681 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 415 (F415L)
Gene Model predicted gene model for transcript(s): [ENSMUST00000115383]
AlphaFold B2RX70
Predicted Effect probably benign
Transcript: ENSMUST00000115383
AA Change: F553L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000111041
Gene: ENSMUSG00000062980
AA Change: F553L

DomainStartEndE-ValueType
transmembrane domain 13 35 N/A INTRINSIC
low complexity region 110 122 N/A INTRINSIC
low complexity region 133 147 N/A INTRINSIC
Pfam:Cadherin-like 574 663 1e-9 PFAM
Pfam:PC-Esterase 753 1018 2e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000137437
AA Change: F415L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000119808
Gene: ENSMUSG00000062980
AA Change: F415L

DomainStartEndE-ValueType
transmembrane domain 13 35 N/A INTRINSIC
low complexity region 110 122 N/A INTRINSIC
low complexity region 133 147 N/A INTRINSIC
Pfam:Cadherin-like 570 663 6.2e-12 PFAM
Pfam:PC-Esterase 753 963 1.6e-33 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154734
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.1%
Validation Efficiency 100% (55/55)
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700001O22Rik A T 2: 30,686,458 (GRCm39) V278D possibly damaging Het
Acacb A G 5: 114,322,167 (GRCm39) D227G possibly damaging Het
Akap9 A G 5: 4,096,064 (GRCm39) E2313G probably benign Het
Cchcr1 A T 17: 35,839,745 (GRCm39) E564D probably damaging Het
Cers2 G A 3: 95,229,008 (GRCm39) probably benign Het
Cfap161 A G 7: 83,425,188 (GRCm39) I301T probably benign Het
Ciita A T 16: 10,329,669 (GRCm39) E648V possibly damaging Het
Cir1 C T 2: 73,142,804 (GRCm39) C10Y probably damaging Het
Clasp1 T A 1: 118,518,214 (GRCm39) F1087I probably damaging Het
Dnah7b A G 1: 46,181,292 (GRCm39) T1060A possibly damaging Het
Epha5 G T 5: 84,232,587 (GRCm39) P809H probably damaging Het
Fuca1 T A 4: 135,650,273 (GRCm39) probably null Het
Galnt2l A T 8: 123,627,372 (GRCm39) *98R probably null Het
Gm26796 G A 12: 80,805,564 (GRCm39) R237C unknown Het
Idua A G 5: 108,827,600 (GRCm39) Y138C probably benign Het
Ighd A T 12: 113,373,253 (GRCm39) L240H probably benign Het
Ing2 C G 8: 48,121,861 (GRCm39) C229S probably benign Het
Kat8 G A 7: 127,523,988 (GRCm39) E343K probably damaging Het
Kctd8 A T 5: 69,267,828 (GRCm39) N427K probably benign Het
Kif16b T C 2: 142,544,586 (GRCm39) E1147G probably damaging Het
Kif18a G A 2: 109,120,190 (GRCm39) probably benign Het
Krt82 T A 15: 101,456,820 (GRCm39) R187* probably null Het
Lrrk2 T C 15: 91,593,593 (GRCm39) probably null Het
M1ap T C 6: 82,945,083 (GRCm39) Y126H probably benign Het
Mmel1 A G 4: 154,970,044 (GRCm39) N226D possibly damaging Het
Mtmr11 A G 3: 96,075,185 (GRCm39) D353G possibly damaging Het
Nfkbia A T 12: 55,538,005 (GRCm39) H149Q probably damaging Het
Nr5a1 A T 2: 38,598,511 (GRCm39) F95L probably damaging Het
Nutm2 A G 13: 50,623,891 (GRCm39) Y196C probably benign Het
Oxtr A G 6: 112,466,457 (GRCm39) I101T probably damaging Het
Pcsk2 T A 2: 143,591,035 (GRCm39) probably null Het
Pde5a T C 3: 122,611,604 (GRCm39) I514T probably benign Het
Pign A G 1: 105,516,788 (GRCm39) W585R possibly damaging Het
Pomgnt1 A G 4: 116,012,933 (GRCm39) S407G probably benign Het
Ppfia3 G A 7: 45,003,040 (GRCm39) T372I probably damaging Het
Prrc2b A T 2: 32,102,144 (GRCm39) E739V probably damaging Het
Ro60 A G 1: 143,642,503 (GRCm39) V209A probably benign Het
Scn7a T C 2: 66,574,047 (GRCm39) E192G probably damaging Het
Slmap T C 14: 26,183,435 (GRCm39) D316G probably damaging Het
Smim8 GGTTTAATGAAGAG GG 4: 34,771,259 (GRCm39) probably benign Het
Smim8 TTTAATGAAGAGCT TT 4: 34,771,261 (GRCm39) probably benign Het
Tgm2 T A 2: 157,984,974 (GRCm39) Y44F possibly damaging Het
Tmc8 C A 11: 117,683,455 (GRCm39) S670* probably null Het
Tmem145 A G 7: 25,014,946 (GRCm39) D523G probably benign Het
Vmn2r115 G A 17: 23,566,937 (GRCm39) G483E probably damaging Het
Other mutations in Cped1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00509:Cped1 APN 6 22,215,522 (GRCm39) missense probably damaging 1.00
IGL00909:Cped1 APN 6 22,122,426 (GRCm39) splice site probably benign
IGL01434:Cped1 APN 6 22,017,004 (GRCm39) missense probably damaging 0.99
IGL01572:Cped1 APN 6 22,051,300 (GRCm39) missense probably benign 0.00
IGL02063:Cped1 APN 6 22,138,701 (GRCm39) missense probably damaging 0.98
IGL02216:Cped1 APN 6 22,059,944 (GRCm39) missense probably damaging 1.00
IGL02257:Cped1 APN 6 22,145,606 (GRCm39) missense possibly damaging 0.86
IGL02541:Cped1 APN 6 22,120,988 (GRCm39) missense probably benign 0.00
IGL03008:Cped1 APN 6 22,233,601 (GRCm39) missense probably benign 0.01
IGL03237:Cped1 APN 6 22,233,595 (GRCm39) missense probably damaging 1.00
PIT4382001:Cped1 UTSW 6 22,222,449 (GRCm39) nonsense probably null
PIT4812001:Cped1 UTSW 6 22,122,293 (GRCm39) missense probably benign 0.02
R0048:Cped1 UTSW 6 22,119,601 (GRCm39) missense probably benign 0.08
R0128:Cped1 UTSW 6 22,121,038 (GRCm39) missense probably benign 0.00
R0130:Cped1 UTSW 6 22,121,038 (GRCm39) missense probably benign 0.00
R0267:Cped1 UTSW 6 22,119,475 (GRCm39) missense probably damaging 0.99
R0374:Cped1 UTSW 6 22,222,545 (GRCm39) splice site probably benign
R0482:Cped1 UTSW 6 22,016,957 (GRCm39) missense probably benign 0.32
R0734:Cped1 UTSW 6 22,085,040 (GRCm39) missense probably damaging 1.00
R1033:Cped1 UTSW 6 22,016,950 (GRCm39) missense probably damaging 0.99
R1118:Cped1 UTSW 6 22,237,698 (GRCm39) missense probably benign 0.19
R1181:Cped1 UTSW 6 22,215,561 (GRCm39) missense probably damaging 0.99
R1300:Cped1 UTSW 6 22,119,552 (GRCm39) missense probably benign 0.00
R1485:Cped1 UTSW 6 22,132,387 (GRCm39) critical splice donor site probably null
R1507:Cped1 UTSW 6 22,122,260 (GRCm39) missense probably damaging 1.00
R1830:Cped1 UTSW 6 22,237,727 (GRCm39) missense probably damaging 1.00
R1879:Cped1 UTSW 6 22,085,014 (GRCm39) splice site probably null
R1902:Cped1 UTSW 6 22,120,980 (GRCm39) splice site probably null
R1991:Cped1 UTSW 6 22,233,926 (GRCm39) missense probably damaging 1.00
R2020:Cped1 UTSW 6 22,143,963 (GRCm39) missense probably benign 0.38
R2883:Cped1 UTSW 6 22,143,978 (GRCm39) missense probably damaging 1.00
R3011:Cped1 UTSW 6 22,088,695 (GRCm39) missense probably damaging 1.00
R4466:Cped1 UTSW 6 22,123,651 (GRCm39) missense probably benign 0.29
R4668:Cped1 UTSW 6 22,237,652 (GRCm39) missense probably benign 0.06
R4808:Cped1 UTSW 6 22,088,756 (GRCm39) missense probably damaging 1.00
R5402:Cped1 UTSW 6 22,143,951 (GRCm39) missense probably benign 0.05
R5417:Cped1 UTSW 6 22,233,579 (GRCm39) missense probably null 0.01
R5741:Cped1 UTSW 6 22,123,620 (GRCm39) missense probably benign 0.02
R5977:Cped1 UTSW 6 22,254,607 (GRCm39) missense probably damaging 1.00
R6255:Cped1 UTSW 6 22,138,714 (GRCm39) splice site probably null
R6304:Cped1 UTSW 6 22,016,922 (GRCm39) missense probably benign 0.14
R6416:Cped1 UTSW 6 22,123,648 (GRCm39) missense probably damaging 1.00
R6444:Cped1 UTSW 6 21,986,930 (GRCm39) missense probably benign 0.00
R6617:Cped1 UTSW 6 22,215,546 (GRCm39) nonsense probably null
R6650:Cped1 UTSW 6 22,233,975 (GRCm39) missense probably damaging 1.00
R7048:Cped1 UTSW 6 22,119,469 (GRCm39) missense probably benign 0.36
R7083:Cped1 UTSW 6 22,123,579 (GRCm39) missense probably benign 0.01
R7234:Cped1 UTSW 6 22,254,625 (GRCm39) missense probably damaging 0.99
R7387:Cped1 UTSW 6 22,059,933 (GRCm39) missense probably benign 0.01
R7493:Cped1 UTSW 6 22,215,512 (GRCm39) missense probably damaging 1.00
R7720:Cped1 UTSW 6 22,222,430 (GRCm39) missense probably damaging 1.00
R7747:Cped1 UTSW 6 22,143,973 (GRCm39) missense probably damaging 1.00
R7966:Cped1 UTSW 6 22,059,953 (GRCm39) critical splice donor site probably null
R8113:Cped1 UTSW 6 22,233,480 (GRCm39) missense possibly damaging 0.89
R8186:Cped1 UTSW 6 22,123,587 (GRCm39) missense probably benign 0.01
R8215:Cped1 UTSW 6 22,132,277 (GRCm39) missense probably damaging 1.00
R8265:Cped1 UTSW 6 22,222,426 (GRCm39) missense probably benign 0.04
R8280:Cped1 UTSW 6 21,986,820 (GRCm39) missense unknown
R8286:Cped1 UTSW 6 22,254,601 (GRCm39) missense probably benign 0.03
R8393:Cped1 UTSW 6 22,222,465 (GRCm39) missense possibly damaging 0.80
R8503:Cped1 UTSW 6 22,145,564 (GRCm39) missense probably benign 0.02
R8725:Cped1 UTSW 6 22,059,941 (GRCm39) missense possibly damaging 0.71
R8727:Cped1 UTSW 6 22,059,941 (GRCm39) missense possibly damaging 0.71
R8852:Cped1 UTSW 6 22,215,620 (GRCm39) missense probably damaging 1.00
R8881:Cped1 UTSW 6 22,119,578 (GRCm39) missense possibly damaging 0.58
R8888:Cped1 UTSW 6 22,016,962 (GRCm39) missense possibly damaging 0.51
R8983:Cped1 UTSW 6 22,138,686 (GRCm39) missense probably benign 0.00
R9135:Cped1 UTSW 6 21,987,012 (GRCm39) missense probably damaging 0.98
X0022:Cped1 UTSW 6 21,987,045 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- AGCTTTACTGAGAAATGCTTGTGG -3'
(R):5'- GCCTTAAGATTCCTTGAACCCC -3'

Sequencing Primer
(F):5'- CAGACTAGCTCATTTGTGAACTCCAG -3'
(R):5'- GATTCCTTGAACCCCTAAAAATGAG -3'
Posted On 2016-12-20