Incidental Mutation 'R5822:Mogat2'
ID 449978
Institutional Source Beutler Lab
Gene Symbol Mogat2
Ensembl Gene ENSMUSG00000052396
Gene Name monoacylglycerol O-acyltransferase 2
Synonyms DGAT2L5, Mgat2
MMRRC Submission 044052-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.104) question?
Stock # R5822 (G1)
Quality Score 83
Status Validated
Chromosome 7
Chromosomal Location 98868291-98887818 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 98869112 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 302 (D302G)
Ref Sequence ENSEMBL: ENSMUSP00000064041 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000064231]
AlphaFold Q80W94
Predicted Effect possibly damaging
Transcript: ENSMUST00000064231
AA Change: D302G

PolyPhen 2 Score 0.824 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000064041
Gene: ENSMUSG00000052396
AA Change: D302G

DomainStartEndE-ValueType
Pfam:DAGAT 39 334 9.1e-120 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208323
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.8%
Validation Efficiency 96% (54/56)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an enzyme that catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. The encoded protein is important in the uptake of dietary fat by the small intestine. This protein forms a complex with diacylglycerol O-acyltransferase 2 in the endoplasmic reticulum, and this complex catalyzes the synthesis of triacylglycerol. [provided by RefSeq, Dec 2015]
PHENOTYPE: Mice homozygous for a null allele exhibit resistance to diet induced obesity, hyperinsulinemia, hyperlipidemia, and steatosis with decreased lipid absorption and increased oxygen consumption when fed a high fat diet. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930553M12Rik T C 4: 88,786,596 (GRCm39) I7M unknown Het
Abca8a C T 11: 109,921,705 (GRCm39) E1450K probably damaging Het
B4galnt2 T C 11: 95,756,985 (GRCm39) Y482C probably damaging Het
Bud23 A G 5: 135,092,775 (GRCm39) F9L probably damaging Het
Cacna1s A T 1: 136,039,816 (GRCm39) E1214V probably damaging Het
Cdh20 T C 1: 104,861,823 (GRCm39) M1T probably null Het
Chkb T C 15: 89,313,715 (GRCm39) E30G probably benign Het
Crp A C 1: 172,525,635 (GRCm39) probably benign Het
Cyp11b1 T C 15: 74,708,670 (GRCm39) R375G probably null Het
Ddx11 C T 17: 66,436,976 (GRCm39) S90L probably benign Het
Flnc A C 6: 29,459,429 (GRCm39) I2510L probably damaging Het
Ftdc1 C A 16: 58,436,075 (GRCm39) probably null Het
Fyb1 T A 15: 6,692,707 (GRCm39) probably benign Het
Gbp3 C T 3: 142,272,239 (GRCm39) P247L probably benign Het
Ggn C T 7: 28,871,981 (GRCm39) P454S probably damaging Het
Herc1 T A 9: 66,352,894 (GRCm39) S2127T probably benign Het
Ipo11 A G 13: 106,984,926 (GRCm39) probably benign Het
Kcnh7 G A 2: 62,546,582 (GRCm39) R1000W probably benign Het
Kdm5b A T 1: 134,516,511 (GRCm39) probably benign Het
Klc3 C T 7: 19,129,724 (GRCm39) probably null Het
Lst1 A T 17: 35,407,359 (GRCm39) M3K unknown Het
Madd C T 2: 90,982,878 (GRCm39) R1355Q probably damaging Het
Map3k10 A G 7: 27,356,159 (GRCm39) L920P probably damaging Het
Mdga2 A G 12: 66,702,109 (GRCm39) V423A probably damaging Het
Nkapl A C 13: 21,652,593 (GRCm39) S7A unknown Het
Npas2 A G 1: 39,386,647 (GRCm39) S639G probably benign Het
Nr1h5 T G 3: 102,856,644 (GRCm39) H260P probably damaging Het
Or2g25 T C 17: 37,971,122 (GRCm39) Y34C probably damaging Het
Or2t49 A T 11: 58,392,464 (GRCm39) L306Q possibly damaging Het
Or4c35 T C 2: 89,808,787 (GRCm39) S222P probably damaging Het
Or7a36 C T 10: 78,820,023 (GRCm39) T133I possibly damaging Het
Or8a1b T C 9: 37,623,087 (GRCm39) M163V probably benign Het
Pan2 T C 10: 128,156,249 (GRCm39) L1142P probably damaging Het
Pdik1l C T 4: 134,014,474 (GRCm39) E11K possibly damaging Het
Ppp1r15a A G 7: 45,172,727 (GRCm39) V555A probably damaging Het
Ppp6c G A 2: 39,090,064 (GRCm39) Q81* probably null Het
Pramel18 A G 4: 101,767,440 (GRCm39) M230V probably damaging Het
Ptprz1 A T 6: 23,001,444 (GRCm39) Y1178F probably benign Het
Relch G A 1: 105,646,581 (GRCm39) V660M probably damaging Het
Rictor G A 15: 6,823,487 (GRCm39) E1555K probably benign Het
Rims2 T A 15: 39,339,886 (GRCm39) L860Q probably damaging Het
Sdr39u1 A G 14: 56,135,196 (GRCm39) V249A probably benign Het
Serhl T C 15: 83,000,528 (GRCm39) V305A probably benign Het
Slc5a11 T C 7: 122,851,654 (GRCm39) I201T probably damaging Het
Stk32a A T 18: 43,446,552 (GRCm39) E334V probably benign Het
Tmem217 A G 17: 29,745,529 (GRCm39) L67P probably damaging Het
Tnnt1 A T 7: 4,519,345 (GRCm39) L12* probably null Het
Trim80 C T 11: 115,338,747 (GRCm39) R526C probably damaging Het
Unc5b A T 10: 60,608,306 (GRCm39) F635I possibly damaging Het
Utp20 T G 10: 88,653,147 (GRCm39) N311T probably benign Het
Zfp276 A G 8: 123,982,457 (GRCm39) T74A probably benign Het
Other mutations in Mogat2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01343:Mogat2 APN 7 98,881,775 (GRCm39) missense possibly damaging 0.60
IGL02052:Mogat2 APN 7 98,887,771 (GRCm39) start codon destroyed probably null 0.99
IGL02153:Mogat2 APN 7 98,872,761 (GRCm39) missense possibly damaging 0.94
R0227:Mogat2 UTSW 7 98,872,339 (GRCm39) missense probably benign 0.02
R0490:Mogat2 UTSW 7 98,872,351 (GRCm39) missense probably benign 0.11
R1331:Mogat2 UTSW 7 98,872,722 (GRCm39) missense possibly damaging 0.66
R1546:Mogat2 UTSW 7 98,881,766 (GRCm39) missense probably damaging 1.00
R2879:Mogat2 UTSW 7 98,871,573 (GRCm39) missense possibly damaging 0.46
R4954:Mogat2 UTSW 7 98,887,724 (GRCm39) missense possibly damaging 0.95
R5040:Mogat2 UTSW 7 98,887,724 (GRCm39) missense possibly damaging 0.95
R5184:Mogat2 UTSW 7 98,872,842 (GRCm39) missense possibly damaging 0.90
R6056:Mogat2 UTSW 7 98,872,720 (GRCm39) missense possibly damaging 0.95
R6256:Mogat2 UTSW 7 98,869,102 (GRCm39) missense probably damaging 1.00
R6500:Mogat2 UTSW 7 98,871,553 (GRCm39) missense probably benign 0.04
R7358:Mogat2 UTSW 7 98,881,673 (GRCm39) missense possibly damaging 0.93
R7375:Mogat2 UTSW 7 98,872,905 (GRCm39) missense probably damaging 1.00
Y5408:Mogat2 UTSW 7 98,872,837 (GRCm39) missense probably damaging 1.00
Z1177:Mogat2 UTSW 7 98,872,836 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATCCCAGGATTAGGAGCTGC -3'
(R):5'- CTTATACACAAACATGGGGTGAGG -3'

Sequencing Primer
(F):5'- ATTAGGAGCTGCCCCCTC -3'
(R):5'- TACACAAACATGGGGTGAGGGAAAG -3'
Posted On 2016-12-20