Incidental Mutation 'R5825:Or12e7'
ID 450106
Institutional Source Beutler Lab
Gene Symbol Or12e7
Ensembl Gene ENSMUSG00000058194
Gene Name olfactory receptor family 12 subfamily E member 7
Synonyms Olfr1126, MOR264-5, GA_x6K02T2Q125-48959068-48960012
MMRRC Submission 044053-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.140) question?
Stock # R5825 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 87287511-87288455 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 87287794 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 95 (D95G)
Ref Sequence ENSEMBL: ENSMUSP00000150504 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071355] [ENSMUST00000213366]
AlphaFold Q7TR49
Predicted Effect probably benign
Transcript: ENSMUST00000071355
AA Change: D95G

PolyPhen 2 Score 0.222 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000071313
Gene: ENSMUSG00000058194
AA Change: D95G

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 8.6e-52 PFAM
Pfam:7tm_1 47 296 8.9e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213366
AA Change: D95G

PolyPhen 2 Score 0.222 (Sensitivity: 0.91; Specificity: 0.88)
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.1%
  • 10x: 95.3%
  • 20x: 83.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A1bg A T 15: 60,791,976 (GRCm39) Y217* probably null Het
Abca2 A T 2: 25,326,748 (GRCm39) I567F probably benign Het
Acss2 T A 2: 155,391,098 (GRCm39) probably null Het
Atxn7l2 C A 3: 108,112,127 (GRCm39) A320S probably damaging Het
Bfsp1 C T 2: 143,669,379 (GRCm39) G400D probably benign Het
Ces5a G T 8: 94,252,295 (GRCm39) A199D probably damaging Het
Cfhr4 T A 1: 139,702,336 (GRCm39) probably null Het
Chd2 A T 7: 73,134,350 (GRCm39) probably null Het
Crebbp A G 16: 3,905,606 (GRCm39) V1705A probably damaging Het
Cyp2j8 T A 4: 96,395,451 (GRCm39) Q58L probably benign Het
Dlec1 T A 9: 118,972,036 (GRCm39) I1379N probably damaging Het
Dnah9 T C 11: 66,017,427 (GRCm39) H593R probably benign Het
Ep300 T A 15: 81,495,673 (GRCm39) C412S probably benign Het
Fam110a A G 2: 151,811,961 (GRCm39) S270P probably damaging Het
Gcc2 A G 10: 58,130,643 (GRCm39) T1412A probably damaging Het
Helz2 T C 2: 180,874,449 (GRCm39) E2015G probably benign Het
Hormad1 T C 3: 95,469,870 (GRCm39) V39A probably damaging Het
Igf2 G T 7: 142,207,592 (GRCm39) H168Q probably damaging Het
Il18rap A G 1: 40,570,726 (GRCm39) T223A probably benign Het
Itpr2 T C 6: 146,045,647 (GRCm39) E2573G probably damaging Het
Jcad T A 18: 4,674,896 (GRCm39) V886E probably benign Het
Klra1 T C 6: 130,357,592 (GRCm39) R12G probably damaging Het
Lamb1 A G 12: 31,368,613 (GRCm39) I1248V probably benign Het
Lgr6 C T 1: 134,921,748 (GRCm39) A199T probably damaging Het
Mapk7 C T 11: 61,381,207 (GRCm39) R465Q possibly damaging Het
Mogs T C 6: 83,095,193 (GRCm39) V670A possibly damaging Het
Mroh2a C T 1: 88,158,402 (GRCm39) R150* probably null Het
Ninl A T 2: 150,782,644 (GRCm39) I1182N probably damaging Het
Nup160 A G 2: 90,510,114 (GRCm39) probably null Het
Nynrin A G 14: 56,101,683 (GRCm39) R451G probably benign Het
Or5h22 T C 16: 58,895,024 (GRCm39) I140V probably benign Het
Osbp A G 19: 11,948,085 (GRCm39) T131A probably damaging Het
Pcdhga12 A C 18: 37,901,556 (GRCm39) D796A possibly damaging Het
Pcdhgb8 G A 18: 37,895,289 (GRCm39) V120I probably benign Het
Pdgfb A T 15: 79,881,869 (GRCm39) V213E probably benign Het
Phldb2 T C 16: 45,583,460 (GRCm39) M1013V probably benign Het
Pnma8a A G 7: 16,695,020 (GRCm39) S292G probably benign Het
Prrt4 A G 6: 29,177,182 (GRCm39) S196P probably benign Het
Rap1gds1 T C 3: 138,661,136 (GRCm39) M463V possibly damaging Het
Tmprss11g A T 5: 86,646,392 (GRCm39) S58R probably damaging Het
Traf3 C A 12: 111,221,795 (GRCm39) Q319K probably benign Het
Trappc8 C T 18: 21,006,977 (GRCm39) V194M probably damaging Het
Tyw1 A G 5: 130,296,929 (GRCm39) K182R probably damaging Het
Usp48 A G 4: 137,350,689 (GRCm39) T585A probably benign Het
Xkr6 G T 14: 64,056,481 (GRCm39) V387L probably benign Het
Yod1 T C 1: 130,646,743 (GRCm39) W207R probably damaging Het
Zdhhc8 T C 16: 18,046,538 (GRCm39) S63G probably null Het
Zfp827 A G 8: 79,905,645 (GRCm39) E874G probably damaging Het
Zfy1 T A Y: 726,531 (GRCm39) K411N possibly damaging Het
Other mutations in Or12e7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00094:Or12e7 APN 2 87,288,271 (GRCm39) missense probably damaging 1.00
IGL01875:Or12e7 APN 2 87,287,654 (GRCm39) missense probably damaging 0.99
IGL02207:Or12e7 APN 2 87,287,794 (GRCm39) missense probably benign 0.22
R0238:Or12e7 UTSW 2 87,288,381 (GRCm39) missense probably benign 0.00
R0238:Or12e7 UTSW 2 87,288,381 (GRCm39) missense probably benign 0.00
R0239:Or12e7 UTSW 2 87,288,381 (GRCm39) missense probably benign 0.00
R0239:Or12e7 UTSW 2 87,288,381 (GRCm39) missense probably benign 0.00
R0478:Or12e7 UTSW 2 87,288,370 (GRCm39) missense probably damaging 0.99
R1055:Or12e7 UTSW 2 87,287,781 (GRCm39) small deletion probably benign
R1438:Or12e7 UTSW 2 87,288,336 (GRCm39) missense probably benign 0.00
R1625:Or12e7 UTSW 2 87,288,016 (GRCm39) missense probably damaging 1.00
R1912:Or12e7 UTSW 2 87,287,727 (GRCm39) missense probably damaging 1.00
R3052:Or12e7 UTSW 2 87,288,247 (GRCm39) missense probably damaging 1.00
R4638:Or12e7 UTSW 2 87,288,327 (GRCm39) missense possibly damaging 0.60
R5102:Or12e7 UTSW 2 87,288,138 (GRCm39) missense probably benign
R5526:Or12e7 UTSW 2 87,288,109 (GRCm39) missense probably benign 0.01
R5965:Or12e7 UTSW 2 87,288,381 (GRCm39) missense probably benign 0.14
R6505:Or12e7 UTSW 2 87,288,271 (GRCm39) missense probably damaging 1.00
R7494:Or12e7 UTSW 2 87,287,912 (GRCm39) missense probably damaging 0.99
R8081:Or12e7 UTSW 2 87,287,513 (GRCm39) start codon destroyed probably null 0.63
R9228:Or12e7 UTSW 2 87,287,907 (GRCm39) missense possibly damaging 0.87
R9337:Or12e7 UTSW 2 87,287,527 (GRCm39) missense probably benign
R9755:Or12e7 UTSW 2 87,287,719 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TGACAGAGTTTCTCCTCCTGGG -3'
(R):5'- TGCCAGCTGAGTGCACTTTG -3'

Sequencing Primer
(F):5'- TGACCTTCCTAACTTACAAGGG -3'
(R):5'- GCACTTTGTTGGGTTCATGAC -3'
Posted On 2016-12-20