Incidental Mutation 'R5844:Dagla'
ID 450617
Institutional Source Beutler Lab
Gene Symbol Dagla
Ensembl Gene ENSMUSG00000035735
Gene Name diacylglycerol lipase, alpha
Synonyms Nsddr
MMRRC Submission 044062-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5844 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 10222629-10282241 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 10248489 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 57 (D57V)
Ref Sequence ENSEMBL: ENSMUSP00000138702 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039327] [ENSMUST00000125567]
AlphaFold Q6WQJ1
Predicted Effect probably damaging
Transcript: ENSMUST00000039327
AA Change: D57V

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000046358
Gene: ENSMUSG00000035735
AA Change: D57V

DomainStartEndE-ValueType
transmembrane domain 21 43 N/A INTRINSIC
transmembrane domain 63 85 N/A INTRINSIC
transmembrane domain 97 119 N/A INTRINSIC
transmembrane domain 134 156 N/A INTRINSIC
Pfam:Lipase_3 394 533 1.3e-12 PFAM
low complexity region 616 625 N/A INTRINSIC
low complexity region 699 717 N/A INTRINSIC
low complexity region 793 810 N/A INTRINSIC
low complexity region 878 896 N/A INTRINSIC
low complexity region 980 1002 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000125567
AA Change: D57V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000138702
Gene: ENSMUSG00000035735
AA Change: D57V

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
transmembrane domain 63 85 N/A INTRINSIC
Meta Mutation Damage Score 0.2607 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 95.9%
Validation Efficiency 98% (55/56)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a diacylglycerol lipase. The encoded enzyme is involved in the biosynthesis of the endocannabinoid 2-arachidonoyl-glycerol.[provided by RefSeq, Nov 2010]
PHENOTYPE: Mice homozygous for null mutations have decreased body weight, adult neuronal proliferation, and nervous system endocannaboid levels and abnormal inhibitory postsynaptic currents. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930407I10Rik A T 15: 81,950,065 (GRCm39) M1321L probably benign Het
Adra1a C T 14: 66,965,183 (GRCm39) T391I probably benign Het
Atf7ip C A 6: 136,583,812 (GRCm39) A1281D probably damaging Het
BC005624 T C 2: 30,866,023 (GRCm39) N141S probably benign Het
Catsperg2 A T 7: 29,397,257 (GRCm39) L1082Q possibly damaging Het
Cavin2 C T 1: 51,328,998 (GRCm39) R152C probably damaging Het
Ccdc33 C T 9: 57,940,489 (GRCm39) probably benign Het
Cfap43 T C 19: 47,784,135 (GRCm39) D466G probably benign Het
Cfap46 C A 7: 139,230,858 (GRCm39) M923I probably damaging Het
Chd1l T A 3: 97,479,883 (GRCm39) K621N probably benign Het
Cnksr1 A G 4: 133,955,575 (GRCm39) probably benign Het
Cym T C 3: 107,127,080 (GRCm39) H25R probably benign Het
Dnah3 TTCCTC TTC 7: 119,550,244 (GRCm39) probably benign Het
Dse T A 10: 34,029,038 (GRCm39) D684V probably damaging Het
Eml2 G A 7: 18,935,088 (GRCm39) V432I probably damaging Het
Fbxo10 A T 4: 45,058,760 (GRCm39) S326T probably benign Het
Galntl5 G T 5: 25,391,091 (GRCm39) probably benign Het
Grm5 A G 7: 87,453,232 (GRCm39) R290G possibly damaging Het
Gtpbp3 A G 8: 71,945,199 (GRCm39) T425A probably benign Het
Hepacam2 A G 6: 3,476,073 (GRCm39) I284T probably damaging Het
Ifi205 A C 1: 173,854,258 (GRCm39) probably null Het
Irs3 T C 5: 137,642,548 (GRCm39) T297A probably benign Het
Kmt2d G A 15: 98,749,990 (GRCm39) probably benign Het
Map4k4 T A 1: 40,039,036 (GRCm39) probably benign Het
Mfsd6 T C 1: 52,697,542 (GRCm39) S782G probably benign Het
Mis18a G A 16: 90,523,969 (GRCm39) silent Het
Mtpn C T 6: 35,489,225 (GRCm39) D100N probably benign Het
Myom2 G A 8: 15,181,182 (GRCm39) probably null Het
Ntaq1 A G 15: 58,017,056 (GRCm39) N157S probably benign Het
Or13a1 A T 6: 116,470,900 (GRCm39) E110V probably damaging Het
Or5g25 A G 2: 85,478,239 (GRCm39) V142A probably benign Het
Pde3b C T 7: 114,108,106 (GRCm39) T568I probably benign Het
Pip4p1 T C 14: 51,166,499 (GRCm39) T160A probably benign Het
Pkhd1 G T 1: 20,451,685 (GRCm39) D2203E probably benign Het
Ppp1r36 A G 12: 76,473,566 (GRCm39) K66E possibly damaging Het
Rfc1 C A 5: 65,451,130 (GRCm39) M319I probably benign Het
Rnd2 C T 11: 101,359,825 (GRCm39) L57F probably damaging Het
Runx1t1 T C 4: 13,881,068 (GRCm39) V456A probably damaging Het
Rxfp2 A G 5: 149,966,589 (GRCm39) K109R probably benign Het
Sgo2a T G 1: 58,055,556 (GRCm39) V580G probably damaging Het
Skint9 T C 4: 112,271,080 (GRCm39) Q110R probably benign Het
Slc38a9 A G 13: 112,868,035 (GRCm39) Y507C probably damaging Het
Smarca4 T A 9: 21,589,238 (GRCm39) probably benign Het
Tmem88 C G 11: 69,288,504 (GRCm39) Q138H probably benign Het
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Tns3 A C 11: 8,384,580 (GRCm39) F1413V probably damaging Het
Trpm8 T C 1: 88,312,433 (GRCm39) *1105Q probably null Het
Zfp853 C T 5: 143,274,424 (GRCm39) V399M unknown Het
Zim1 T C 7: 6,681,115 (GRCm39) R183G probably benign Het
Zmiz1 T C 14: 25,657,354 (GRCm39) S871P probably damaging Het
Other mutations in Dagla
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01484:Dagla APN 19 10,225,884 (GRCm39) missense possibly damaging 0.51
IGL01625:Dagla APN 19 10,228,566 (GRCm39) splice site probably benign
IGL01697:Dagla APN 19 10,248,562 (GRCm39) missense probably benign 0.01
IGL01940:Dagla APN 19 10,229,535 (GRCm39) missense probably benign
IGL02330:Dagla APN 19 10,225,386 (GRCm39) missense probably damaging 1.00
blondie UTSW 19 10,248,465 (GRCm39) missense probably damaging 1.00
dagwood UTSW 19 10,247,079 (GRCm39) critical splice donor site probably null
PIT4480001:Dagla UTSW 19 10,238,022 (GRCm39) missense probably benign 0.02
R0541:Dagla UTSW 19 10,232,170 (GRCm39) critical splice donor site probably null
R0610:Dagla UTSW 19 10,248,922 (GRCm39) missense probably damaging 1.00
R0638:Dagla UTSW 19 10,232,247 (GRCm39) missense probably damaging 0.97
R0653:Dagla UTSW 19 10,225,789 (GRCm39) missense probably damaging 1.00
R1675:Dagla UTSW 19 10,246,687 (GRCm39) missense probably benign 0.00
R1822:Dagla UTSW 19 10,240,550 (GRCm39) missense possibly damaging 0.94
R1830:Dagla UTSW 19 10,248,378 (GRCm39) missense probably benign 0.44
R2303:Dagla UTSW 19 10,229,467 (GRCm39) missense probably damaging 1.00
R2568:Dagla UTSW 19 10,225,516 (GRCm39) missense probably benign
R2879:Dagla UTSW 19 10,248,448 (GRCm39) missense possibly damaging 0.93
R2902:Dagla UTSW 19 10,225,467 (GRCm39) missense probably damaging 0.99
R2939:Dagla UTSW 19 10,233,728 (GRCm39) missense probably damaging 1.00
R3771:Dagla UTSW 19 10,225,831 (GRCm39) missense possibly damaging 0.89
R4176:Dagla UTSW 19 10,240,461 (GRCm39) missense probably damaging 1.00
R4255:Dagla UTSW 19 10,234,316 (GRCm39) nonsense probably null
R4519:Dagla UTSW 19 10,247,096 (GRCm39) missense probably damaging 1.00
R4584:Dagla UTSW 19 10,248,373 (GRCm39) missense probably damaging 1.00
R4586:Dagla UTSW 19 10,248,373 (GRCm39) missense probably damaging 1.00
R4614:Dagla UTSW 19 10,225,641 (GRCm39) missense probably damaging 1.00
R4751:Dagla UTSW 19 10,227,758 (GRCm39) missense probably benign 0.00
R4933:Dagla UTSW 19 10,247,079 (GRCm39) critical splice donor site probably null
R5858:Dagla UTSW 19 10,232,332 (GRCm39) intron probably benign
R5958:Dagla UTSW 19 10,225,788 (GRCm39) missense probably damaging 1.00
R6628:Dagla UTSW 19 10,240,591 (GRCm39) missense probably damaging 1.00
R6799:Dagla UTSW 19 10,234,214 (GRCm39) missense probably damaging 1.00
R7072:Dagla UTSW 19 10,233,659 (GRCm39) critical splice donor site probably null
R7253:Dagla UTSW 19 10,239,945 (GRCm39) splice site probably null
R7451:Dagla UTSW 19 10,230,719 (GRCm39) missense probably damaging 1.00
R7654:Dagla UTSW 19 10,225,570 (GRCm39) missense probably benign 0.01
R7941:Dagla UTSW 19 10,248,867 (GRCm39) missense probably damaging 0.99
R7980:Dagla UTSW 19 10,229,406 (GRCm39) missense possibly damaging 0.82
R8293:Dagla UTSW 19 10,229,401 (GRCm39) critical splice donor site probably null
R8327:Dagla UTSW 19 10,228,451 (GRCm39) missense probably benign 0.11
R8442:Dagla UTSW 19 10,248,883 (GRCm39) missense probably damaging 0.99
R8442:Dagla UTSW 19 10,240,456 (GRCm39) critical splice donor site probably null
R8717:Dagla UTSW 19 10,225,587 (GRCm39) missense probably benign 0.03
R8728:Dagla UTSW 19 10,225,771 (GRCm39) missense probably damaging 1.00
R9053:Dagla UTSW 19 10,246,615 (GRCm39) missense probably damaging 1.00
R9179:Dagla UTSW 19 10,228,525 (GRCm39) missense possibly damaging 0.83
R9275:Dagla UTSW 19 10,232,220 (GRCm39) missense probably damaging 1.00
R9387:Dagla UTSW 19 10,248,465 (GRCm39) missense probably damaging 1.00
R9489:Dagla UTSW 19 10,233,053 (GRCm39) missense probably damaging 1.00
R9498:Dagla UTSW 19 10,232,218 (GRCm39) nonsense probably null
R9539:Dagla UTSW 19 10,228,429 (GRCm39) critical splice donor site probably null
R9605:Dagla UTSW 19 10,233,053 (GRCm39) missense probably damaging 1.00
X0021:Dagla UTSW 19 10,248,528 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TTCAGGGCTGACTCAGTTTG -3'
(R):5'- AGTCGGGCACATCTTGTTG -3'

Sequencing Primer
(F):5'- CTGACTCAGTTTGTGTTTGTAACC -3'
(R):5'- CACATCTTGTTGGGGGAGATATC -3'
Posted On 2016-12-20