Incidental Mutation 'R5696:Fbxl5'
ID |
450652 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Fbxl5
|
Ensembl Gene |
ENSMUSG00000039753 |
Gene Name |
F-box and leucine-rich repeat protein 5 |
Synonyms |
Fbl4, Fir4 |
Accession Numbers |
|
Essential gene? |
Essential
(E-score: 1.000)
|
Stock # |
R5696 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
5 |
Chromosomal Location |
43901958-43939529 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 43916182 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Valine to Aspartic acid
at position 367
(V367D)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000112444
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047857]
[ENSMUST00000087465]
[ENSMUST00000114047]
[ENSMUST00000119523]
[ENSMUST00000121736]
[ENSMUST00000124610]
[ENSMUST00000196483]
|
AlphaFold |
Q8C2S5 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000047857
AA Change: V410D
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000045792 Gene: ENSMUSG00000039753 AA Change: V410D
Domain | Start | End | E-Value | Type |
Pfam:Hemerythrin
|
6 |
138 |
1.3e-10 |
PFAM |
FBOX
|
208 |
248 |
2.31e-9 |
SMART |
low complexity region
|
289 |
310 |
N/A |
INTRINSIC |
LRR
|
355 |
379 |
2.43e2 |
SMART |
LRR
|
382 |
407 |
4.87e-4 |
SMART |
low complexity region
|
481 |
492 |
N/A |
INTRINSIC |
LRR
|
596 |
621 |
2.45e0 |
SMART |
LRR
|
624 |
649 |
4.65e-1 |
SMART |
Blast:LRR
|
650 |
681 |
2e-13 |
BLAST |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000087465
AA Change: V410D
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000084733 Gene: ENSMUSG00000039753 AA Change: V410D
Domain | Start | End | E-Value | Type |
Pfam:Hemerythrin
|
6 |
138 |
4.3e-15 |
PFAM |
FBOX
|
208 |
248 |
2.31e-9 |
SMART |
low complexity region
|
289 |
310 |
N/A |
INTRINSIC |
LRR
|
355 |
379 |
2.43e2 |
SMART |
LRR
|
382 |
407 |
4.87e-4 |
SMART |
low complexity region
|
481 |
492 |
N/A |
INTRINSIC |
LRR
|
596 |
621 |
1.23e2 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000114047
AA Change: V404D
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000109681 Gene: ENSMUSG00000039753 AA Change: V404D
Domain | Start | End | E-Value | Type |
Pfam:Hemerythrin
|
19 |
132 |
4.4e-11 |
PFAM |
FBOX
|
202 |
242 |
2.31e-9 |
SMART |
low complexity region
|
283 |
304 |
N/A |
INTRINSIC |
LRR
|
349 |
373 |
2.43e2 |
SMART |
LRR
|
376 |
401 |
4.87e-4 |
SMART |
low complexity region
|
475 |
486 |
N/A |
INTRINSIC |
LRR
|
590 |
615 |
2.45e0 |
SMART |
LRR
|
618 |
643 |
4.65e-1 |
SMART |
Blast:LRR
|
644 |
675 |
2e-13 |
BLAST |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000119523
AA Change: V393D
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000113557 Gene: ENSMUSG00000039753 AA Change: V393D
Domain | Start | End | E-Value | Type |
Pfam:Hemerythrin
|
6 |
121 |
2.2e-9 |
PFAM |
FBOX
|
191 |
231 |
2.31e-9 |
SMART |
low complexity region
|
272 |
293 |
N/A |
INTRINSIC |
LRR
|
338 |
362 |
2.43e2 |
SMART |
LRR
|
365 |
390 |
4.87e-4 |
SMART |
low complexity region
|
464 |
475 |
N/A |
INTRINSIC |
LRR
|
579 |
604 |
2.45e0 |
SMART |
LRR
|
607 |
632 |
4.65e-1 |
SMART |
Blast:LRR
|
633 |
664 |
2e-13 |
BLAST |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000121736
AA Change: V367D
PolyPhen 2
Score 0.934 (Sensitivity: 0.80; Specificity: 0.94)
|
SMART Domains |
Protein: ENSMUSP00000112444 Gene: ENSMUSG00000039753 AA Change: V367D
Domain | Start | End | E-Value | Type |
PDB:3V5Z|B
|
1 |
118 |
2e-71 |
PDB |
FBOX
|
165 |
205 |
2.31e-9 |
SMART |
low complexity region
|
246 |
267 |
N/A |
INTRINSIC |
LRR
|
312 |
336 |
2.43e2 |
SMART |
LRR
|
339 |
364 |
4.87e-4 |
SMART |
low complexity region
|
438 |
449 |
N/A |
INTRINSIC |
LRR
|
553 |
578 |
1.23e2 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000124421
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000140469
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000124610
AA Change: V410D
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000116720 Gene: ENSMUSG00000039753 AA Change: V410D
Domain | Start | End | E-Value | Type |
Pfam:Hemerythrin
|
6 |
138 |
5.7e-12 |
PFAM |
FBOX
|
208 |
248 |
1.5e-11 |
SMART |
low complexity region
|
289 |
310 |
N/A |
INTRINSIC |
LRR
|
355 |
379 |
1e0 |
SMART |
LRR
|
382 |
407 |
2e-6 |
SMART |
low complexity region
|
481 |
492 |
N/A |
INTRINSIC |
LRR
|
596 |
621 |
1e-2 |
SMART |
LRR
|
624 |
649 |
1.9e-3 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000196483
AA Change: V409D
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000143703 Gene: ENSMUSG00000039753 AA Change: V409D
Domain | Start | End | E-Value | Type |
Pfam:Hemerythrin
|
6 |
138 |
1.3e-10 |
PFAM |
FBOX
|
208 |
248 |
2.31e-9 |
SMART |
low complexity region
|
289 |
309 |
N/A |
INTRINSIC |
LRR
|
354 |
378 |
2.43e2 |
SMART |
LRR
|
381 |
406 |
4.87e-4 |
SMART |
low complexity region
|
480 |
491 |
N/A |
INTRINSIC |
LRR
|
595 |
620 |
2.45e0 |
SMART |
LRR
|
623 |
648 |
4.65e-1 |
SMART |
Blast:LRR
|
649 |
680 |
2e-13 |
BLAST |
|
Predicted Effect |
unknown
Transcript: ENSMUST00000141902
AA Change: V330D
|
SMART Domains |
Protein: ENSMUSP00000120338 Gene: ENSMUSG00000039753 AA Change: V330D
Domain | Start | End | E-Value | Type |
PDB:3V5Z|B
|
2 |
82 |
3e-43 |
PDB |
FBOX
|
129 |
169 |
2.31e-9 |
SMART |
low complexity region
|
210 |
231 |
N/A |
INTRINSIC |
LRR
|
276 |
300 |
2.43e2 |
SMART |
LRR
|
303 |
328 |
4.87e-4 |
SMART |
low complexity region
|
402 |
413 |
N/A |
INTRINSIC |
LRR
|
517 |
542 |
2.45e0 |
SMART |
LRR
|
545 |
570 |
4.65e-1 |
SMART |
Blast:LRR
|
571 |
602 |
3e-13 |
BLAST |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000143316
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000196543
|
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.6%
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2010] PHENOTYPE: Mice homozygous for a null mutation display embryonic lethality before turning of the embryo with iron overload, growth retardation, and hemorrhage. Mice heterozygous for a knock-out allele exhibit abnormal iron homeostasis when fed a low iron diet. [provided by MGI curators]
|
Allele List at MGI |
All alleles(10) : Gene trapped(10)
|
Other mutations in this stock |
Total: 73 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Adam8 |
G |
A |
7: 139,569,159 (GRCm39) |
R186W |
probably benign |
Het |
Afg3l2 |
A |
G |
18: 67,540,529 (GRCm39) |
I660T |
probably damaging |
Het |
Amtn |
T |
A |
5: 88,532,944 (GRCm39) |
Y186* |
probably null |
Het |
Atosa |
A |
G |
9: 74,917,399 (GRCm39) |
E666G |
probably benign |
Het |
Atrip |
A |
G |
9: 108,894,569 (GRCm39) |
S453P |
possibly damaging |
Het |
Bahcc1 |
T |
C |
11: 120,164,813 (GRCm39) |
L840P |
probably damaging |
Het |
Capn2 |
T |
C |
1: 182,306,165 (GRCm39) |
E527G |
possibly damaging |
Het |
Caprin2 |
A |
T |
6: 148,779,316 (GRCm39) |
Y164N |
possibly damaging |
Het |
Ccnh |
T |
A |
13: 85,344,446 (GRCm39) |
|
probably null |
Het |
Cdon |
G |
T |
9: 35,403,162 (GRCm39) |
V1091F |
possibly damaging |
Het |
Ceacam14 |
A |
G |
7: 17,548,267 (GRCm39) |
Y119C |
probably damaging |
Het |
Ces2h |
A |
G |
8: 105,745,611 (GRCm39) |
K445E |
possibly damaging |
Het |
Cfap46 |
A |
G |
7: 139,191,947 (GRCm39) |
S2357P |
probably damaging |
Het |
Commd4 |
A |
T |
9: 57,063,499 (GRCm39) |
S86R |
possibly damaging |
Het |
Cpsf6 |
A |
T |
10: 117,196,934 (GRCm39) |
|
probably benign |
Het |
Dag1 |
A |
T |
9: 108,086,646 (GRCm39) |
V165E |
probably benign |
Het |
Dmxl1 |
A |
T |
18: 50,065,008 (GRCm39) |
K2618* |
probably null |
Het |
Dnah17 |
A |
G |
11: 117,991,882 (GRCm39) |
Y1229H |
probably benign |
Het |
Endov |
T |
A |
11: 119,382,625 (GRCm39) |
L24Q |
probably damaging |
Het |
Fap |
C |
T |
2: 62,332,803 (GRCm39) |
V717M |
probably damaging |
Het |
Fbxl2 |
A |
G |
9: 113,815,546 (GRCm39) |
L239P |
probably damaging |
Het |
Fkbp10 |
G |
T |
11: 100,314,352 (GRCm39) |
W384L |
probably damaging |
Het |
Gbp8 |
C |
T |
5: 105,166,682 (GRCm39) |
V216I |
possibly damaging |
Het |
Gclm |
G |
A |
3: 122,059,936 (GRCm39) |
A239T |
probably benign |
Het |
Gm11569 |
C |
T |
11: 99,689,556 (GRCm39) |
|
probably benign |
Het |
Gnas |
C |
A |
2: 174,141,468 (GRCm39) |
|
probably benign |
Het |
Grb10 |
T |
A |
11: 11,883,566 (GRCm39) |
N508I |
probably benign |
Het |
Gykl1 |
T |
G |
18: 52,827,267 (GRCm39) |
I158M |
probably benign |
Het |
Ide |
G |
A |
19: 37,295,420 (GRCm39) |
T214M |
unknown |
Het |
Il12rb2 |
T |
A |
6: 67,272,262 (GRCm39) |
Q341H |
possibly damaging |
Het |
Ints1 |
T |
C |
5: 139,740,744 (GRCm39) |
E1946G |
probably benign |
Het |
Kdelr3 |
T |
C |
15: 79,410,100 (GRCm39) |
|
probably null |
Het |
Kif1b |
A |
C |
4: 149,358,306 (GRCm39) |
|
probably null |
Het |
Kri1 |
A |
G |
9: 21,191,533 (GRCm39) |
I320T |
probably damaging |
Het |
Krt9 |
TCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCC |
TCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCC |
11: 100,079,903 (GRCm39) |
|
probably benign |
Het |
Lin9 |
T |
C |
1: 180,486,646 (GRCm39) |
S111P |
probably benign |
Het |
Lpcat2b |
C |
A |
5: 107,580,773 (GRCm39) |
P34Q |
probably damaging |
Het |
Ltk |
T |
A |
2: 119,590,080 (GRCm39) |
T49S |
probably benign |
Het |
Map3k9 |
A |
T |
12: 81,780,896 (GRCm39) |
H421Q |
probably benign |
Het |
Mapkbp1 |
T |
A |
2: 119,852,201 (GRCm39) |
|
probably null |
Het |
Mcm4 |
A |
G |
16: 15,443,434 (GRCm39) |
S830P |
probably damaging |
Het |
Nek10 |
T |
A |
14: 14,860,736 (GRCm38) |
|
probably null |
Het |
Nlrp9b |
A |
T |
7: 19,758,417 (GRCm39) |
R551S |
probably benign |
Het |
Nol4l |
T |
C |
2: 153,260,026 (GRCm39) |
T143A |
probably damaging |
Het |
Or1r1 |
T |
C |
11: 73,875,362 (GRCm39) |
H24R |
possibly damaging |
Het |
Or51g1 |
T |
A |
7: 102,633,748 (GRCm39) |
T208S |
probably benign |
Het |
Or6z5 |
T |
C |
7: 6,477,742 (GRCm39) |
|
probably null |
Het |
Or7a39 |
A |
T |
10: 78,715,919 (GRCm39) |
R304S |
probably benign |
Het |
Pde4dip |
G |
T |
3: 97,616,806 (GRCm39) |
A1812D |
probably damaging |
Het |
Plekhb1 |
C |
A |
7: 100,305,960 (GRCm39) |
G26C |
probably damaging |
Het |
Polr1a |
T |
A |
6: 71,906,410 (GRCm39) |
F409I |
probably benign |
Het |
Ptpn13 |
T |
A |
5: 103,702,625 (GRCm39) |
M1197K |
probably benign |
Het |
Qrich2 |
T |
C |
11: 116,335,828 (GRCm39) |
I2114V |
probably damaging |
Het |
Rbm27 |
T |
C |
18: 42,450,731 (GRCm39) |
Y449H |
probably damaging |
Het |
Rp1l1 |
A |
G |
14: 64,267,195 (GRCm39) |
D927G |
probably damaging |
Het |
Secisbp2 |
C |
A |
13: 51,833,857 (GRCm39) |
Q666K |
probably damaging |
Het |
Slc45a2 |
T |
C |
15: 11,001,219 (GRCm39) |
I106T |
probably damaging |
Het |
Slx4 |
G |
T |
16: 3,797,831 (GRCm39) |
Q1518K |
probably damaging |
Het |
Smim10l1 |
T |
C |
6: 133,082,489 (GRCm39) |
F12S |
probably damaging |
Het |
Son |
T |
C |
16: 91,468,301 (GRCm39) |
V306A |
possibly damaging |
Het |
Stab1 |
A |
G |
14: 30,882,178 (GRCm39) |
S506P |
probably benign |
Het |
Syne2 |
A |
C |
12: 76,040,919 (GRCm39) |
D3859A |
probably benign |
Het |
Tab1 |
T |
A |
15: 80,032,930 (GRCm39) |
Y71* |
probably null |
Het |
Tarbp1 |
A |
C |
8: 127,174,079 (GRCm39) |
M909R |
probably damaging |
Het |
Tex15 |
T |
G |
8: 34,063,220 (GRCm39) |
S1157R |
probably benign |
Het |
Tnni3 |
G |
A |
7: 4,523,453 (GRCm39) |
T120I |
probably benign |
Het |
Ttn |
T |
C |
2: 76,747,888 (GRCm39) |
E4387G |
probably benign |
Het |
Ugt3a1 |
G |
A |
15: 9,361,534 (GRCm39) |
|
silent |
Het |
Unc5d |
T |
C |
8: 29,156,870 (GRCm39) |
I783V |
probably benign |
Het |
Usp40 |
T |
C |
1: 87,923,474 (GRCm39) |
T266A |
probably benign |
Het |
Vmn2r59 |
C |
T |
7: 41,695,468 (GRCm39) |
V315I |
probably benign |
Het |
Zbtb48 |
G |
T |
4: 152,105,067 (GRCm39) |
H532N |
probably damaging |
Het |
Zfp1005 |
C |
T |
2: 150,111,394 (GRCm39) |
H695Y |
possibly damaging |
Het |
|
Other mutations in Fbxl5 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00236:Fbxl5
|
APN |
5 |
43,922,678 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL00797:Fbxl5
|
APN |
5 |
43,915,743 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL00811:Fbxl5
|
APN |
5 |
43,915,567 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01065:Fbxl5
|
APN |
5 |
43,902,676 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01626:Fbxl5
|
APN |
5 |
43,916,047 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02285:Fbxl5
|
APN |
5 |
43,922,690 (GRCm39) |
missense |
possibly damaging |
0.88 |
D3080:Fbxl5
|
UTSW |
5 |
43,915,708 (GRCm39) |
missense |
probably benign |
0.00 |
PIT4498001:Fbxl5
|
UTSW |
5 |
43,908,323 (GRCm39) |
missense |
possibly damaging |
0.73 |
R0195:Fbxl5
|
UTSW |
5 |
43,928,140 (GRCm39) |
missense |
probably damaging |
1.00 |
R0647:Fbxl5
|
UTSW |
5 |
43,925,411 (GRCm39) |
missense |
probably damaging |
0.98 |
R1540:Fbxl5
|
UTSW |
5 |
43,915,978 (GRCm39) |
missense |
possibly damaging |
0.92 |
R1545:Fbxl5
|
UTSW |
5 |
43,928,140 (GRCm39) |
missense |
probably damaging |
1.00 |
R1569:Fbxl5
|
UTSW |
5 |
43,922,803 (GRCm39) |
missense |
probably damaging |
1.00 |
R1921:Fbxl5
|
UTSW |
5 |
43,922,832 (GRCm39) |
missense |
probably benign |
0.16 |
R3081:Fbxl5
|
UTSW |
5 |
43,908,222 (GRCm39) |
missense |
probably damaging |
1.00 |
R3776:Fbxl5
|
UTSW |
5 |
43,915,618 (GRCm39) |
missense |
possibly damaging |
0.57 |
R4096:Fbxl5
|
UTSW |
5 |
43,915,583 (GRCm39) |
missense |
probably benign |
0.19 |
R4275:Fbxl5
|
UTSW |
5 |
43,920,114 (GRCm39) |
intron |
probably benign |
|
R4383:Fbxl5
|
UTSW |
5 |
43,920,305 (GRCm39) |
intron |
probably benign |
|
R4469:Fbxl5
|
UTSW |
5 |
43,925,528 (GRCm39) |
missense |
probably damaging |
1.00 |
R4654:Fbxl5
|
UTSW |
5 |
43,922,771 (GRCm39) |
missense |
probably damaging |
0.99 |
R5067:Fbxl5
|
UTSW |
5 |
43,916,114 (GRCm39) |
missense |
probably benign |
0.00 |
R5093:Fbxl5
|
UTSW |
5 |
43,930,896 (GRCm39) |
missense |
probably damaging |
1.00 |
R5738:Fbxl5
|
UTSW |
5 |
43,920,170 (GRCm39) |
missense |
probably benign |
0.30 |
R6029:Fbxl5
|
UTSW |
5 |
43,922,746 (GRCm39) |
missense |
probably damaging |
0.96 |
R6185:Fbxl5
|
UTSW |
5 |
43,978,894 (GRCm39) |
missense |
probably benign |
0.02 |
R6842:Fbxl5
|
UTSW |
5 |
43,930,928 (GRCm39) |
missense |
probably damaging |
1.00 |
R7234:Fbxl5
|
UTSW |
5 |
43,915,562 (GRCm39) |
missense |
probably benign |
0.08 |
R7563:Fbxl5
|
UTSW |
5 |
43,978,891 (GRCm39) |
missense |
probably benign |
0.00 |
R7653:Fbxl5
|
UTSW |
5 |
43,916,116 (GRCm39) |
missense |
probably benign |
|
R7842:Fbxl5
|
UTSW |
5 |
43,915,945 (GRCm39) |
missense |
probably damaging |
1.00 |
R7860:Fbxl5
|
UTSW |
5 |
43,916,018 (GRCm39) |
missense |
probably benign |
0.00 |
R8139:Fbxl5
|
UTSW |
5 |
43,916,087 (GRCm39) |
nonsense |
probably null |
|
R8393:Fbxl5
|
UTSW |
5 |
43,925,433 (GRCm39) |
missense |
possibly damaging |
0.94 |
R8727:Fbxl5
|
UTSW |
5 |
43,908,362 (GRCm39) |
splice site |
probably benign |
|
R9616:Fbxl5
|
UTSW |
5 |
43,916,159 (GRCm39) |
missense |
probably benign |
|
RF012:Fbxl5
|
UTSW |
5 |
43,930,847 (GRCm39) |
missense |
probably damaging |
1.00 |
X0065:Fbxl5
|
UTSW |
5 |
43,918,140 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- GCCAAATCTTCAGCATCTAGC -3'
(R):5'- ACAGTAATGCTCTTACCCATCTATCTG -3'
Sequencing Primer
(F):5'- CTTTCAGAAGACACAGGTTCAGTC -3'
(R):5'- CTTCGGCATCTTGATCTG -3'
|
Posted On |
2017-01-03 |