Incidental Mutation 'R5698:Ccnt2'
ID 450761
Institutional Source Beutler Lab
Gene Symbol Ccnt2
Ensembl Gene ENSMUSG00000026349
Gene Name cyclin T2
Synonyms 2900041I18Rik, CycT2
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R5698 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 127701901-127732574 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 127730965 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Arginine at position 614 (K614R)
Ref Sequence ENSEMBL: ENSMUSP00000108189 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027587] [ENSMUST00000112570]
AlphaFold Q7TQK0
Predicted Effect probably benign
Transcript: ENSMUST00000027587
AA Change: K614R

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000027587
Gene: ENSMUSG00000026349
AA Change: K614R

DomainStartEndE-ValueType
CYCLIN 42 141 4.27e-14 SMART
CYCLIN 154 242 4.51e0 SMART
low complexity region 531 543 N/A INTRINSIC
low complexity region 621 653 N/A INTRINSIC
low complexity region 658 664 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000112570
AA Change: K614R

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000108189
Gene: ENSMUSG00000026349
AA Change: K614R

DomainStartEndE-ValueType
CYCLIN 42 141 4.27e-14 SMART
CYCLIN 154 242 4.51e0 SMART
low complexity region 531 543 N/A INTRINSIC
low complexity region 621 634 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143513
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153359
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
PHENOTYPE: Mice homozygous for a gene trap allele die prior to the 4-cell stage. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930556J24Rik A G 11: 3,926,366 (GRCm39) K334E possibly damaging Het
Ache G A 5: 137,288,821 (GRCm39) V176M probably damaging Het
Acss3 T C 10: 106,784,605 (GRCm39) D539G probably damaging Het
Adam6b T A 12: 113,455,083 (GRCm39) D633E probably benign Het
Aldh16a1 G A 7: 44,803,831 (GRCm39) probably benign Het
Amigo2 G A 15: 97,143,607 (GRCm39) Q272* probably null Het
Aoc1l1 A G 6: 48,953,256 (GRCm39) T394A possibly damaging Het
Appbp2 A T 11: 85,100,925 (GRCm39) H171Q probably damaging Het
Arhgef18 A G 8: 3,489,499 (GRCm39) D277G probably damaging Het
Armc8 A G 9: 99,417,873 (GRCm39) V95A probably benign Het
Atp6v0a4 C T 6: 38,027,442 (GRCm39) probably null Het
Atp8a1 A T 5: 67,924,496 (GRCm39) N289K probably benign Het
Cand2 C T 6: 115,768,704 (GRCm39) L505F probably damaging Het
Col25a1 A G 3: 130,272,632 (GRCm39) probably null Het
Copa T A 1: 171,946,511 (GRCm39) L976* probably null Het
Ddx39b T C 17: 35,470,287 (GRCm39) V267A probably benign Het
Dpp4 T A 2: 62,164,655 (GRCm39) Q709L probably damaging Het
Eno4 A G 19: 58,956,904 (GRCm39) probably null Het
Exoc3 A G 13: 74,322,134 (GRCm39) L647P probably benign Het
Eya4 T C 10: 23,015,975 (GRCm39) S308G possibly damaging Het
Fbxo41 T C 6: 85,454,638 (GRCm39) T693A possibly damaging Het
Fcgbp A G 7: 27,791,447 (GRCm39) T903A possibly damaging Het
Fkbp10 G T 11: 100,314,352 (GRCm39) W384L probably damaging Het
Frem2 A G 3: 53,559,926 (GRCm39) I1527T possibly damaging Het
H13 T A 2: 152,530,875 (GRCm39) I220N probably damaging Het
Has2 T C 15: 56,531,312 (GRCm39) R468G probably damaging Het
Ighmbp2 A G 19: 3,324,538 (GRCm39) S243P probably damaging Het
Irs1 T C 1: 82,266,455 (GRCm39) H587R probably benign Het
Kcnk1 C T 8: 126,752,144 (GRCm39) T250M probably damaging Het
Kif9 T C 9: 110,339,532 (GRCm39) V458A probably benign Het
Krt14 T C 11: 100,096,451 (GRCm39) T208A probably benign Het
Mybpc3 C A 2: 90,955,194 (GRCm39) H349Q possibly damaging Het
Neurl3 T A 1: 36,305,587 (GRCm39) T207S possibly damaging Het
Nol9 T C 4: 152,135,031 (GRCm39) V388A probably damaging Het
Notch3 T C 17: 32,376,961 (GRCm39) N315D probably damaging Het
Oas1h G T 5: 121,009,045 (GRCm39) A252S probably damaging Het
Or13c7b C A 4: 43,821,183 (GRCm39) M59I probably damaging Het
Pcbp1 G A 6: 86,502,134 (GRCm39) T255M possibly damaging Het
Plec A G 15: 76,083,808 (GRCm39) V18A probably benign Het
Ppp1r17 A T 6: 56,003,529 (GRCm39) E114V probably damaging Het
Scamp5 A T 9: 57,352,716 (GRCm39) M151K possibly damaging Het
Sestd1 T C 2: 77,048,512 (GRCm39) Y135C possibly damaging Het
Slc22a21 T G 11: 53,842,175 (GRCm39) K534N probably benign Het
Slc25a12 T C 2: 71,112,917 (GRCm39) E448G probably damaging Het
Slco3a1 A G 7: 73,996,566 (GRCm39) L280P probably damaging Het
Sppl2b C A 10: 80,701,879 (GRCm39) probably null Het
Srd5a2 T C 17: 74,334,014 (GRCm39) E135G possibly damaging Het
Tfg A T 16: 56,521,467 (GRCm39) M183K probably damaging Het
Ticrr G A 7: 79,328,881 (GRCm39) M673I probably benign Het
Tm4sf20 T G 1: 82,745,958 (GRCm39) M61L probably benign Het
Ttll8 A T 15: 88,823,209 (GRCm39) S85T possibly damaging Het
Uggt2 G A 14: 119,280,138 (GRCm39) S780F probably damaging Het
Uroc1 T C 6: 90,324,302 (GRCm39) L442P probably damaging Het
Zfp1005 C T 2: 150,111,394 (GRCm39) H695Y possibly damaging Het
Znrf3 A G 11: 5,239,006 (GRCm39) probably benign Het
Zswim2 C A 2: 83,755,527 (GRCm39) D125Y possibly damaging Het
Other mutations in Ccnt2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00807:Ccnt2 APN 1 127,725,628 (GRCm39) splice site probably benign
IGL01370:Ccnt2 APN 1 127,731,250 (GRCm39) missense possibly damaging 0.49
IGL02055:Ccnt2 APN 1 127,719,447 (GRCm39) missense possibly damaging 0.46
IGL02169:Ccnt2 APN 1 127,702,126 (GRCm39) splice site probably benign
R0526:Ccnt2 UTSW 1 127,727,182 (GRCm39) missense probably damaging 1.00
R0538:Ccnt2 UTSW 1 127,730,902 (GRCm39) missense probably damaging 0.98
R0744:Ccnt2 UTSW 1 127,730,131 (GRCm39) missense probably benign 0.42
R0833:Ccnt2 UTSW 1 127,730,131 (GRCm39) missense probably benign 0.42
R0836:Ccnt2 UTSW 1 127,730,131 (GRCm39) missense probably benign 0.42
R1763:Ccnt2 UTSW 1 127,727,143 (GRCm39) missense possibly damaging 0.94
R2037:Ccnt2 UTSW 1 127,731,136 (GRCm39) missense probably damaging 1.00
R2159:Ccnt2 UTSW 1 127,702,891 (GRCm39) missense probably benign 0.00
R4585:Ccnt2 UTSW 1 127,730,766 (GRCm39) missense probably damaging 0.99
R5342:Ccnt2 UTSW 1 127,719,470 (GRCm39) splice site silent
R5527:Ccnt2 UTSW 1 127,730,401 (GRCm39) missense probably benign 0.00
R6606:Ccnt2 UTSW 1 127,730,978 (GRCm39) missense probably benign 0.00
R6821:Ccnt2 UTSW 1 127,731,072 (GRCm39) missense probably damaging 0.99
R6979:Ccnt2 UTSW 1 127,702,873 (GRCm39) missense probably damaging 0.97
R7512:Ccnt2 UTSW 1 127,730,031 (GRCm39) missense possibly damaging 0.85
R8743:Ccnt2 UTSW 1 127,702,020 (GRCm39) missense probably damaging 1.00
R9334:Ccnt2 UTSW 1 127,723,046 (GRCm39) missense probably damaging 0.99
R9722:Ccnt2 UTSW 1 127,729,925 (GRCm39) missense probably damaging 1.00
X0019:Ccnt2 UTSW 1 127,702,877 (GRCm39) missense probably damaging 1.00
X0027:Ccnt2 UTSW 1 127,702,025 (GRCm39) missense probably damaging 0.98
Z1177:Ccnt2 UTSW 1 127,730,795 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCGGAAAGACACAGCTCTTC -3'
(R):5'- TAGCCCACCTGGTATGTGAC -3'

Sequencing Primer
(F):5'- TCGGAAAGACACAGCTCTTCTGATG -3'
(R):5'- CACCTGGTATGTGACAGGGG -3'
Posted On 2017-01-03