Incidental Mutation 'R5701:Rnf145'
ID 450900
Institutional Source Beutler Lab
Gene Symbol Rnf145
Ensembl Gene ENSMUSG00000019189
Gene Name ring finger protein 145
Synonyms 3732413I11Rik
MMRRC Submission 043181-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.206) question?
Stock # R5701 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 44409791-44456347 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 44422120 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 68 (V68M)
Ref Sequence ENSEMBL: ENSMUSP00000098881 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019333] [ENSMUST00000101327]
AlphaFold Q5SWK7
Predicted Effect probably benign
Transcript: ENSMUST00000019333
AA Change: V68M

PolyPhen 2 Score 0.304 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000019333
Gene: ENSMUSG00000019189
AA Change: V68M

DomainStartEndE-ValueType
Pfam:TRC8_N 8 506 2.8e-156 PFAM
RING 537 574 2.12e-8 SMART
low complexity region 590 601 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000101327
AA Change: V68M

PolyPhen 2 Score 0.464 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000098881
Gene: ENSMUSG00000019189
AA Change: V68M

DomainStartEndE-ValueType
Pfam:TRC8_N 7 266 1.2e-70 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124959
Meta Mutation Damage Score 0.2024 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Armc8 A G 9: 99,378,202 (GRCm39) probably null Het
Asxl1 A G 2: 153,241,409 (GRCm39) E653G probably damaging Het
AW551984 G A 9: 39,504,118 (GRCm39) A616V probably benign Het
Birc6 T C 17: 75,004,420 (GRCm39) M4763T possibly damaging Het
Bltp1 T A 3: 36,975,509 (GRCm39) M727K probably benign Het
Cand2 T G 6: 115,774,893 (GRCm39) F1034V probably damaging Het
Ccdc80 T C 16: 44,936,741 (GRCm39) V722A possibly damaging Het
Cd109 CATTTATTTATTTATTTATTTATTTATTTATTTAT CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT 9: 78,619,782 (GRCm39) probably benign Het
Chrnd G A 1: 87,125,380 (GRCm39) V340I possibly damaging Het
Clip1 T C 5: 123,751,366 (GRCm39) probably benign Het
Csmd3 T C 15: 47,513,617 (GRCm39) E1920G probably damaging Het
Csmd3 A T 15: 48,403,729 (GRCm39) F194I probably damaging Het
D930048N14Rik T A 11: 51,544,556 (GRCm39) probably null Het
Defa28 T C 8: 22,073,863 (GRCm39) Y89H probably benign Het
Dnah1 C T 14: 30,996,001 (GRCm39) G2705E probably damaging Het
Eci2 A T 13: 35,174,250 (GRCm39) S104T possibly damaging Het
Ep300 T C 15: 81,485,696 (GRCm39) S228P unknown Het
Gabrb2 T A 11: 42,378,201 (GRCm39) M139K probably damaging Het
Gbp4 T A 5: 105,266,265 (GRCm39) N592I possibly damaging Het
Gpr158 C T 2: 21,751,520 (GRCm39) R480C probably damaging Het
Gps1 A G 11: 120,676,008 (GRCm39) D71G probably benign Het
Hoxc9 T C 15: 102,890,313 (GRCm39) Y77H possibly damaging Het
Il9r T A 11: 32,143,263 (GRCm39) Y231F probably benign Het
Klhl1 A G 14: 96,438,816 (GRCm39) M494T probably benign Het
Kmt2c A G 5: 25,519,015 (GRCm39) V2365A probably benign Het
Kri1 T A 9: 21,192,425 (GRCm39) K241M possibly damaging Het
Macf1 A T 4: 123,397,018 (GRCm39) C928S probably damaging Het
Mcm2 T C 6: 88,870,073 (GRCm39) D32G probably damaging Het
Mex3d T C 10: 80,217,379 (GRCm39) T613A probably benign Het
Mptx2 G A 1: 173,102,414 (GRCm39) L92F probably benign Het
Myh9 T C 15: 77,675,964 (GRCm39) I241V probably benign Het
Myo6 C T 9: 80,165,809 (GRCm39) T398I probably damaging Het
Nckap1l G A 15: 103,381,195 (GRCm39) A366T probably benign Het
Or5m11 A G 2: 85,782,168 (GRCm39) T254A possibly damaging Het
Plscr5 A T 9: 92,087,564 (GRCm39) K178* probably null Het
Rapgef6 T C 11: 54,567,220 (GRCm39) W857R possibly damaging Het
Raxos1 G A 18: 66,071,059 (GRCm39) probably benign Het
Slc66a2 T A 18: 80,315,693 (GRCm39) D118E possibly damaging Het
Synpo2 C G 3: 122,873,879 (GRCm39) G1029A probably damaging Het
Tbc1d5 TTGCTGCTGCTGCTGCTGCTGGTGCTGCTGCTGCTG TTGCTGCTGCTGCTGCTGGTGCTGCTGCTGCTG 17: 51,106,983 (GRCm39) probably benign Het
Vmn2r14 T C 5: 109,367,816 (GRCm39) Y392C probably damaging Het
Vmn2r55 A G 7: 12,404,492 (GRCm39) F304L probably benign Het
Zfp316 C T 5: 143,240,132 (GRCm39) G629D probably benign Het
Other mutations in Rnf145
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00087:Rnf145 APN 11 44,446,039 (GRCm39) missense possibly damaging 0.90
IGL02972:Rnf145 APN 11 44,454,865 (GRCm39) missense probably benign 0.26
IGL03168:Rnf145 APN 11 44,445,985 (GRCm39) missense probably damaging 1.00
IGL03185:Rnf145 APN 11 44,422,157 (GRCm39) missense probably damaging 1.00
IGL02980:Rnf145 UTSW 11 44,452,484 (GRCm39) missense probably benign
R0112:Rnf145 UTSW 11 44,454,978 (GRCm39) missense probably benign
R0346:Rnf145 UTSW 11 44,445,991 (GRCm39) missense probably damaging 1.00
R0415:Rnf145 UTSW 11 44,415,965 (GRCm39) missense probably damaging 0.99
R0452:Rnf145 UTSW 11 44,452,587 (GRCm39) missense probably damaging 1.00
R0487:Rnf145 UTSW 11 44,446,056 (GRCm39) missense probably benign 0.21
R0598:Rnf145 UTSW 11 44,439,770 (GRCm39) missense probably damaging 1.00
R0631:Rnf145 UTSW 11 44,450,851 (GRCm39) missense probably damaging 0.99
R0837:Rnf145 UTSW 11 44,415,815 (GRCm39) missense probably benign 0.00
R1611:Rnf145 UTSW 11 44,442,625 (GRCm39) missense probably damaging 1.00
R1971:Rnf145 UTSW 11 44,439,642 (GRCm39) missense probably damaging 1.00
R1991:Rnf145 UTSW 11 44,452,293 (GRCm39) missense possibly damaging 0.90
R2157:Rnf145 UTSW 11 44,445,997 (GRCm39) missense probably damaging 1.00
R2340:Rnf145 UTSW 11 44,422,205 (GRCm39) missense probably benign 0.04
R3855:Rnf145 UTSW 11 44,422,120 (GRCm39) missense possibly damaging 0.46
R4483:Rnf145 UTSW 11 44,455,104 (GRCm39) missense probably benign 0.10
R4564:Rnf145 UTSW 11 44,439,635 (GRCm39) missense probably benign 0.25
R4922:Rnf145 UTSW 11 44,448,063 (GRCm39) unclassified probably benign
R5633:Rnf145 UTSW 11 44,450,915 (GRCm39) missense probably damaging 1.00
R5672:Rnf145 UTSW 11 44,422,120 (GRCm39) missense possibly damaging 0.46
R5673:Rnf145 UTSW 11 44,422,120 (GRCm39) missense possibly damaging 0.46
R5915:Rnf145 UTSW 11 44,433,549 (GRCm39) critical splice donor site probably null
R6128:Rnf145 UTSW 11 44,446,018 (GRCm39) missense probably damaging 1.00
R6502:Rnf145 UTSW 11 44,415,932 (GRCm39) missense probably damaging 0.98
R6717:Rnf145 UTSW 11 44,452,317 (GRCm39) missense probably benign 0.00
R6963:Rnf145 UTSW 11 44,455,104 (GRCm39) missense probably benign 0.10
R7035:Rnf145 UTSW 11 44,452,583 (GRCm39) missense probably damaging 1.00
R7154:Rnf145 UTSW 11 44,415,822 (GRCm39) missense probably damaging 1.00
R7351:Rnf145 UTSW 11 44,439,623 (GRCm39) missense possibly damaging 0.91
R7639:Rnf145 UTSW 11 44,422,184 (GRCm39) missense probably damaging 1.00
R8074:Rnf145 UTSW 11 44,448,263 (GRCm39) missense probably damaging 0.98
R8536:Rnf145 UTSW 11 44,450,942 (GRCm39) missense probably damaging 1.00
R8861:Rnf145 UTSW 11 44,445,984 (GRCm39) missense probably damaging 1.00
R9123:Rnf145 UTSW 11 44,450,819 (GRCm39) missense probably damaging 1.00
R9125:Rnf145 UTSW 11 44,450,819 (GRCm39) missense probably damaging 1.00
R9172:Rnf145 UTSW 11 44,448,262 (GRCm39) missense possibly damaging 0.95
R9520:Rnf145 UTSW 11 44,452,336 (GRCm39) missense possibly damaging 0.91
R9711:Rnf145 UTSW 11 44,415,830 (GRCm39) nonsense probably null
R9801:Rnf145 UTSW 11 44,448,112 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GTGCTGCAGCTAATTATAAAGCAG -3'
(R):5'- GCAACCTACCTAAGCCTTAACTTTG -3'

Sequencing Primer
(F):5'- CTAATTATAAAGCAGAAAGATGGCGC -3'
(R):5'- ACACTATGTTGACATTAAAAACCAAC -3'
Posted On 2017-01-03