Incidental Mutation 'R5713:Ing5'
ID 450978
Institutional Source Beutler Lab
Gene Symbol Ing5
Ensembl Gene ENSMUSG00000026283
Gene Name inhibitor of growth family, member 5
Synonyms 1810018M11Rik, 1700027H23Rik
MMRRC Submission 043335-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.350) question?
Stock # R5713 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 93731687-93749823 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 93740452 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 124 (D124E)
Ref Sequence ENSEMBL: ENSMUSP00000140498 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027505] [ENSMUST00000188402] [ENSMUST00000190476]
AlphaFold Q9D8Y8
Predicted Effect probably benign
Transcript: ENSMUST00000027505
AA Change: D151E

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000027505
Gene: ENSMUSG00000026283
AA Change: D151E

DomainStartEndE-ValueType
Pfam:ING 6 107 1.6e-34 PFAM
low complexity region 129 150 N/A INTRINSIC
PHD 188 233 7.34e-12 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000158336
Predicted Effect probably benign
Transcript: ENSMUST00000188402
Predicted Effect probably benign
Transcript: ENSMUST00000190476
AA Change: D124E

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000140498
Gene: ENSMUSG00000026283
AA Change: D124E

DomainStartEndE-ValueType
Pfam:ING 1 80 2.4e-18 PFAM
low complexity region 102 123 N/A INTRINSIC
PHD 161 206 4.7e-14 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.9%
Validation Efficiency 98% (56/57)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a tumor suppressor protein that inhibits cell growth and induces apoptosis. This protein contains a PHD-type zinc finger. It interacts with tumor suppressor p53 and p300, a component of the histone acetyl transferase complex, suggesting a role in transcriptional regulation. Alternative splicing and the use of multiple promoters and 3' terminal exons results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd18 T A 3: 40,889,414 (GRCm39) Y431* probably null Het
Abtb3 A T 10: 85,487,516 (GRCm39) I995F probably damaging Het
Aqp7 G A 4: 41,035,510 (GRCm39) T115I probably benign Het
Arid1b C A 17: 5,387,091 (GRCm39) R1515S probably damaging Het
Atp5mc3 A G 2: 73,739,651 (GRCm39) V63A probably benign Het
Bmp6 C T 13: 38,682,928 (GRCm39) P473S probably damaging Het
Casp3 C A 8: 47,089,349 (GRCm39) T199K probably damaging Het
Ccl3 C T 11: 83,540,066 (GRCm39) C13Y possibly damaging Het
Cdc42bpa T C 1: 179,911,975 (GRCm39) S518P probably benign Het
Clic3 A T 2: 25,348,179 (GRCm39) I109F probably damaging Het
Dnah9 T A 11: 65,916,049 (GRCm39) D2301V possibly damaging Het
Gm26627 A G 6: 29,507,850 (GRCm39) probably benign Het
Gm4887 A T 7: 104,471,000 (GRCm39) noncoding transcript Het
Hc A C 2: 34,903,543 (GRCm39) I1037S probably damaging Het
Il2rb A G 15: 78,376,048 (GRCm39) M1T probably null Het
Jak2 A G 19: 29,248,793 (GRCm39) E90G probably damaging Het
Kalrn A T 16: 33,836,949 (GRCm39) I522N probably benign Het
Lipa A T 19: 34,500,832 (GRCm39) H71Q probably benign Het
Lmnb2 C T 10: 80,741,921 (GRCm39) V57M probably damaging Het
Mllt3 A T 4: 87,759,448 (GRCm39) M200K probably benign Het
Mtpap G A 18: 4,396,280 (GRCm39) S524N probably benign Het
Mup21 C G 4: 62,068,511 (GRCm39) E52Q probably damaging Het
Nasp A G 4: 116,471,558 (GRCm39) F90L probably benign Het
Nr1d1 T C 11: 98,661,237 (GRCm39) D343G probably benign Het
Otop2 T A 11: 115,219,870 (GRCm39) F237I probably damaging Het
Pax4 A G 6: 28,446,184 (GRCm39) I103T probably damaging Het
Pde4a T A 9: 21,114,813 (GRCm39) S430T probably damaging Het
Phf20l1 A G 15: 66,508,669 (GRCm39) N843D possibly damaging Het
Pla2g7 T A 17: 43,905,183 (GRCm39) M37K probably benign Het
Plcb3 T C 19: 6,935,060 (GRCm39) I864V probably damaging Het
Prr16 A G 18: 51,435,910 (GRCm39) T130A probably damaging Het
Rbm24 A G 13: 46,582,780 (GRCm39) D233G probably damaging Het
Rps29 C A 12: 69,205,502 (GRCm39) R32L probably benign Het
Serpind1 A G 16: 17,154,851 (GRCm39) E226G probably damaging Het
Siglecg A T 7: 43,058,226 (GRCm39) I38F probably damaging Het
Slc26a8 T A 17: 28,880,853 (GRCm39) M308L probably benign Het
Supv3l1 A G 10: 62,266,283 (GRCm39) V631A possibly damaging Het
Tcf12 T C 9: 71,792,545 (GRCm39) *58W probably null Het
Trgc2 T A 13: 19,491,515 (GRCm39) probably benign Het
Usp34 T A 11: 23,293,515 (GRCm39) V203E possibly damaging Het
Vmn2r108 A G 17: 20,691,290 (GRCm39) L411P probably damaging Het
Zfp874a A T 13: 67,597,476 (GRCm39) D42E probably benign Het
Other mutations in Ing5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00337:Ing5 APN 1 93,733,816 (GRCm39) start codon destroyed probably null 0.92
IGL02067:Ing5 APN 1 93,739,648 (GRCm39) missense probably damaging 1.00
IGL02699:Ing5 APN 1 93,744,164 (GRCm39) missense possibly damaging 0.81
IGL02744:Ing5 APN 1 93,744,210 (GRCm39) missense probably damaging 0.99
Albion UTSW 1 93,744,166 (GRCm39) missense probably damaging 0.97
cordelia UTSW 1 93,740,154 (GRCm39) missense probably damaging 1.00
Dover UTSW 1 93,740,155 (GRCm39) missense probably damaging 1.00
PIT4458001:Ing5 UTSW 1 93,739,668 (GRCm39) missense possibly damaging 0.64
R0372:Ing5 UTSW 1 93,740,142 (GRCm39) missense probably damaging 0.98
R2903:Ing5 UTSW 1 93,731,710 (GRCm39) unclassified probably benign
R3742:Ing5 UTSW 1 93,740,398 (GRCm39) missense probably damaging 1.00
R7514:Ing5 UTSW 1 93,744,164 (GRCm39) missense possibly damaging 0.81
R7643:Ing5 UTSW 1 93,740,155 (GRCm39) missense probably damaging 1.00
R8104:Ing5 UTSW 1 93,744,166 (GRCm39) missense probably damaging 0.97
R8783:Ing5 UTSW 1 93,740,154 (GRCm39) missense probably damaging 1.00
R9211:Ing5 UTSW 1 93,740,409 (GRCm39) missense possibly damaging 0.93
R9231:Ing5 UTSW 1 93,739,505 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AGCTTTGAGGTCTCGTCTAAATG -3'
(R):5'- ATCAGGACGGTCACTCTACAGC -3'

Sequencing Primer
(F):5'- TCTCGTCTAAATGTGTTAGGGAC -3'
(R):5'- GACGGTCACTCTACAGCTTTTATAAC -3'
Posted On 2017-01-03