Incidental Mutation 'R5716:Uqcrc1'
ID |
451183 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Uqcrc1
|
Ensembl Gene |
ENSMUSG00000025651 |
Gene Name |
ubiquinol-cytochrome c reductase core protein 1 |
Synonyms |
1110032G10Rik |
MMRRC Submission |
043187-MU
|
Accession Numbers |
|
Essential gene? |
Probably essential
(E-score: 0.957)
|
Stock # |
R5716 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
9 |
Chromosomal Location |
108765701-108778691 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 108776473 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Asparagine to Aspartic acid
at position 298
(N298D)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000026743
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000026743]
[ENSMUST00000194047]
[ENSMUST00000194469]
[ENSMUST00000195738]
|
AlphaFold |
Q9CZ13 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000026743
AA Change: N298D
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000026743 Gene: ENSMUSG00000025651 AA Change: N298D
Domain | Start | End | E-Value | Type |
low complexity region
|
17 |
37 |
N/A |
INTRINSIC |
Pfam:Peptidase_M16
|
58 |
205 |
2.1e-54 |
PFAM |
Pfam:Peptidase_M16_C
|
210 |
395 |
3.4e-34 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000192305
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000192918
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000193332
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000193607
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000194047
|
SMART Domains |
Protein: ENSMUSP00000141435 Gene: ENSMUSG00000025651
Domain | Start | End | E-Value | Type |
Pfam:Peptidase_M16
|
41 |
188 |
7.7e-53 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000194469
|
SMART Domains |
Protein: ENSMUSP00000141743 Gene: ENSMUSG00000025651
Domain | Start | End | E-Value | Type |
Pfam:Peptidase_M16_C
|
1 |
94 |
5.4e-9 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000195387
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000195738
|
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.2%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 40 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1810065E05Rik |
T |
C |
11: 58,312,594 (GRCm39) |
V24A |
possibly damaging |
Het |
Abca14 |
G |
A |
7: 119,846,217 (GRCm39) |
|
probably null |
Het |
Acad12 |
A |
G |
5: 121,748,046 (GRCm39) |
V124A |
probably benign |
Het |
Alg1 |
A |
T |
16: 5,057,820 (GRCm39) |
D238V |
probably damaging |
Het |
Bcar3 |
A |
G |
3: 122,306,564 (GRCm39) |
E179G |
probably damaging |
Het |
Brf2 |
A |
G |
8: 27,616,074 (GRCm39) |
S104P |
probably benign |
Het |
Coq8a |
A |
T |
1: 180,006,825 (GRCm39) |
Y21N |
possibly damaging |
Het |
Cramp1 |
A |
G |
17: 25,193,709 (GRCm39) |
F924L |
probably damaging |
Het |
Dpyd |
G |
T |
3: 118,692,828 (GRCm39) |
C324F |
probably damaging |
Het |
Eif4b |
T |
C |
15: 101,990,494 (GRCm39) |
Y33H |
probably benign |
Het |
Fry |
C |
T |
5: 150,293,686 (GRCm39) |
Q460* |
probably null |
Het |
Fryl |
T |
C |
5: 73,257,808 (GRCm39) |
I665V |
probably benign |
Het |
Gpank1 |
A |
G |
17: 35,342,229 (GRCm39) |
K90E |
probably damaging |
Het |
Hexd |
A |
G |
11: 121,112,388 (GRCm39) |
I482V |
probably benign |
Het |
Hmcn2 |
G |
A |
2: 31,226,579 (GRCm39) |
E185K |
probably damaging |
Het |
Hmcn2 |
A |
G |
2: 31,348,750 (GRCm39) |
E4922G |
possibly damaging |
Het |
Ino80d |
A |
T |
1: 63,097,856 (GRCm39) |
D679E |
probably benign |
Het |
Kalrn |
A |
T |
16: 33,807,546 (GRCm39) |
C2608S |
probably benign |
Het |
Kars1 |
T |
A |
8: 112,730,074 (GRCm39) |
|
probably null |
Het |
Lcn2 |
A |
G |
2: 32,275,825 (GRCm39) |
V211A |
possibly damaging |
Het |
Lsmem1 |
A |
T |
12: 40,230,692 (GRCm39) |
V70E |
possibly damaging |
Het |
Med12l |
T |
C |
3: 59,208,798 (GRCm39) |
|
probably null |
Het |
Megf11 |
T |
C |
9: 64,413,392 (GRCm39) |
F60L |
possibly damaging |
Het |
Muc21 |
A |
C |
17: 35,931,675 (GRCm39) |
|
probably benign |
Het |
Neb |
T |
A |
2: 52,100,596 (GRCm39) |
H4438L |
probably benign |
Het |
Nuf2 |
C |
A |
1: 169,349,958 (GRCm39) |
V107F |
probably benign |
Het |
Or14j6 |
A |
T |
17: 38,214,719 (GRCm39) |
Y94F |
probably benign |
Het |
Or6c8 |
T |
A |
10: 128,915,424 (GRCm39) |
N136I |
probably benign |
Het |
Or9i2 |
C |
T |
19: 13,816,003 (GRCm39) |
C178Y |
probably damaging |
Het |
Pabpn1l |
A |
G |
8: 123,347,160 (GRCm39) |
V215A |
probably damaging |
Het |
Pnn |
A |
G |
12: 59,118,658 (GRCm39) |
I414V |
probably benign |
Het |
Rab11fip3 |
A |
G |
17: 26,255,638 (GRCm39) |
Y539H |
probably damaging |
Het |
Rassf4 |
A |
G |
6: 116,638,828 (GRCm39) |
V13A |
probably benign |
Het |
Sephs1 |
T |
C |
2: 4,889,389 (GRCm39) |
F56L |
probably benign |
Het |
Sh3rf3 |
C |
T |
10: 58,967,105 (GRCm39) |
P816S |
probably benign |
Het |
Skint10 |
A |
G |
4: 112,568,844 (GRCm39) |
L291P |
probably damaging |
Het |
Thsd7a |
T |
A |
6: 12,343,147 (GRCm39) |
I1157L |
probably benign |
Het |
Tmem184c |
T |
C |
8: 78,333,036 (GRCm39) |
H85R |
possibly damaging |
Het |
Tmem94 |
T |
C |
11: 115,683,254 (GRCm39) |
V679A |
probably benign |
Het |
Tpcn2 |
A |
C |
7: 144,811,550 (GRCm39) |
F566V |
possibly damaging |
Het |
|
Other mutations in Uqcrc1 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01309:Uqcrc1
|
APN |
9 |
108,778,026 (GRCm39) |
missense |
possibly damaging |
0.62 |
IGL02332:Uqcrc1
|
APN |
9 |
108,776,937 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02698:Uqcrc1
|
APN |
9 |
108,777,011 (GRCm39) |
critical splice donor site |
probably null |
|
R0313:Uqcrc1
|
UTSW |
9 |
108,777,642 (GRCm39) |
missense |
possibly damaging |
0.69 |
R0743:Uqcrc1
|
UTSW |
9 |
108,773,773 (GRCm39) |
nonsense |
probably null |
|
R2027:Uqcrc1
|
UTSW |
9 |
108,776,083 (GRCm39) |
missense |
probably benign |
0.06 |
R2513:Uqcrc1
|
UTSW |
9 |
108,765,836 (GRCm39) |
missense |
probably damaging |
1.00 |
R4680:Uqcrc1
|
UTSW |
9 |
108,776,929 (GRCm39) |
missense |
probably damaging |
1.00 |
R4993:Uqcrc1
|
UTSW |
9 |
108,773,878 (GRCm39) |
missense |
probably damaging |
1.00 |
R5223:Uqcrc1
|
UTSW |
9 |
108,771,224 (GRCm39) |
missense |
probably damaging |
1.00 |
R5941:Uqcrc1
|
UTSW |
9 |
108,776,554 (GRCm39) |
unclassified |
probably benign |
|
R6274:Uqcrc1
|
UTSW |
9 |
108,771,224 (GRCm39) |
missense |
probably damaging |
1.00 |
R6598:Uqcrc1
|
UTSW |
9 |
108,776,690 (GRCm39) |
missense |
possibly damaging |
0.93 |
R7132:Uqcrc1
|
UTSW |
9 |
108,778,536 (GRCm39) |
missense |
probably damaging |
0.98 |
R7150:Uqcrc1
|
UTSW |
9 |
108,776,926 (GRCm39) |
missense |
probably benign |
0.02 |
R7524:Uqcrc1
|
UTSW |
9 |
108,765,827 (GRCm39) |
missense |
possibly damaging |
0.48 |
R8708:Uqcrc1
|
UTSW |
9 |
108,776,108 (GRCm39) |
missense |
probably damaging |
0.97 |
R8889:Uqcrc1
|
UTSW |
9 |
108,766,186 (GRCm39) |
missense |
probably damaging |
1.00 |
R8892:Uqcrc1
|
UTSW |
9 |
108,766,186 (GRCm39) |
missense |
probably damaging |
1.00 |
R8975:Uqcrc1
|
UTSW |
9 |
108,776,721 (GRCm39) |
missense |
probably damaging |
1.00 |
R9136:Uqcrc1
|
UTSW |
9 |
108,776,973 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
Predicted Primers |
PCR Primer
(F):5'- TTCTGTTTTCCCAGGAGGCC -3'
(R):5'- TCTGTGGCACATATCCTAAGC -3'
Sequencing Primer
(F):5'- AGCCCTGCCATGTGTTG -3'
(R):5'- GTGGCACATATCCTAAGCTCCATAAC -3'
|
Posted On |
2017-01-03 |