Incidental Mutation 'R5716:Or6c8'
ID 451185
Institutional Source Beutler Lab
Gene Symbol Or6c8
Ensembl Gene ENSMUSG00000059762
Gene Name olfactory receptor family 6 subfamily C member 8
Synonyms Olfr767, MOR115-1, GA_x6K02T2PULF-10765431-10764502
MMRRC Submission 043187-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R5716 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 128914901-128915830 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 128915424 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Isoleucine at position 136 (N136I)
Ref Sequence ENSEMBL: ENSMUSP00000150151 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000082131] [ENSMUST00000213579]
AlphaFold Q8VG33
Predicted Effect probably benign
Transcript: ENSMUST00000082131
AA Change: N136I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000080775
Gene: ENSMUSG00000059762
AA Change: N136I

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.9e-49 PFAM
Pfam:7tm_1 39 288 3.6e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213579
AA Change: N136I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810065E05Rik T C 11: 58,312,594 (GRCm39) V24A possibly damaging Het
Abca14 G A 7: 119,846,217 (GRCm39) probably null Het
Acad12 A G 5: 121,748,046 (GRCm39) V124A probably benign Het
Alg1 A T 16: 5,057,820 (GRCm39) D238V probably damaging Het
Bcar3 A G 3: 122,306,564 (GRCm39) E179G probably damaging Het
Brf2 A G 8: 27,616,074 (GRCm39) S104P probably benign Het
Coq8a A T 1: 180,006,825 (GRCm39) Y21N possibly damaging Het
Cramp1 A G 17: 25,193,709 (GRCm39) F924L probably damaging Het
Dpyd G T 3: 118,692,828 (GRCm39) C324F probably damaging Het
Eif4b T C 15: 101,990,494 (GRCm39) Y33H probably benign Het
Fry C T 5: 150,293,686 (GRCm39) Q460* probably null Het
Fryl T C 5: 73,257,808 (GRCm39) I665V probably benign Het
Gpank1 A G 17: 35,342,229 (GRCm39) K90E probably damaging Het
Hexd A G 11: 121,112,388 (GRCm39) I482V probably benign Het
Hmcn2 G A 2: 31,226,579 (GRCm39) E185K probably damaging Het
Hmcn2 A G 2: 31,348,750 (GRCm39) E4922G possibly damaging Het
Ino80d A T 1: 63,097,856 (GRCm39) D679E probably benign Het
Kalrn A T 16: 33,807,546 (GRCm39) C2608S probably benign Het
Kars1 T A 8: 112,730,074 (GRCm39) probably null Het
Lcn2 A G 2: 32,275,825 (GRCm39) V211A possibly damaging Het
Lsmem1 A T 12: 40,230,692 (GRCm39) V70E possibly damaging Het
Med12l T C 3: 59,208,798 (GRCm39) probably null Het
Megf11 T C 9: 64,413,392 (GRCm39) F60L possibly damaging Het
Muc21 A C 17: 35,931,675 (GRCm39) probably benign Het
Neb T A 2: 52,100,596 (GRCm39) H4438L probably benign Het
Nuf2 C A 1: 169,349,958 (GRCm39) V107F probably benign Het
Or14j6 A T 17: 38,214,719 (GRCm39) Y94F probably benign Het
Or9i2 C T 19: 13,816,003 (GRCm39) C178Y probably damaging Het
Pabpn1l A G 8: 123,347,160 (GRCm39) V215A probably damaging Het
Pnn A G 12: 59,118,658 (GRCm39) I414V probably benign Het
Rab11fip3 A G 17: 26,255,638 (GRCm39) Y539H probably damaging Het
Rassf4 A G 6: 116,638,828 (GRCm39) V13A probably benign Het
Sephs1 T C 2: 4,889,389 (GRCm39) F56L probably benign Het
Sh3rf3 C T 10: 58,967,105 (GRCm39) P816S probably benign Het
Skint10 A G 4: 112,568,844 (GRCm39) L291P probably damaging Het
Thsd7a T A 6: 12,343,147 (GRCm39) I1157L probably benign Het
Tmem184c T C 8: 78,333,036 (GRCm39) H85R possibly damaging Het
Tmem94 T C 11: 115,683,254 (GRCm39) V679A probably benign Het
Tpcn2 A C 7: 144,811,550 (GRCm39) F566V possibly damaging Het
Uqcrc1 A G 9: 108,776,473 (GRCm39) N298D probably benign Het
Other mutations in Or6c8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01784:Or6c8 APN 10 128,915,224 (GRCm39) missense probably benign 0.13
IGL01945:Or6c8 APN 10 128,915,172 (GRCm39) missense probably damaging 1.00
IGL02341:Or6c8 APN 10 128,915,330 (GRCm39) nonsense probably null
IGL02389:Or6c8 APN 10 128,915,099 (GRCm39) missense probably damaging 0.97
IGL02516:Or6c8 APN 10 128,915,662 (GRCm39) missense possibly damaging 0.95
IGL02755:Or6c8 APN 10 128,915,065 (GRCm39) missense probably benign 0.00
R0145:Or6c8 UTSW 10 128,915,232 (GRCm39) missense probably damaging 0.97
R0453:Or6c8 UTSW 10 128,915,640 (GRCm39) missense probably damaging 0.97
R0578:Or6c8 UTSW 10 128,915,062 (GRCm39) missense probably damaging 1.00
R1034:Or6c8 UTSW 10 128,915,830 (GRCm39) start codon destroyed probably benign 0.43
R1494:Or6c8 UTSW 10 128,915,484 (GRCm39) missense probably damaging 1.00
R1941:Or6c8 UTSW 10 128,915,823 (GRCm39) missense probably damaging 0.99
R3707:Or6c8 UTSW 10 128,915,254 (GRCm39) missense probably benign 0.31
R5405:Or6c8 UTSW 10 128,915,265 (GRCm39) missense probably damaging 0.99
R8224:Or6c8 UTSW 10 128,915,304 (GRCm39) missense possibly damaging 0.90
R9680:Or6c8 UTSW 10 128,915,358 (GRCm39) missense probably benign 0.02
Z1177:Or6c8 UTSW 10 128,915,921 (GRCm39) critical splice acceptor site probably benign
Predicted Primers PCR Primer
(F):5'- TTACCAGCATTAGAGTCACCAC -3'
(R):5'- CTGGTCAGCATTACAACGGG -3'

Sequencing Primer
(F):5'- GCATTAGAGTCACCACCAGGG -3'
(R):5'- GAAACAAGAGTATTAGCTTTGCTGGC -3'
Posted On 2017-01-03