Incidental Mutation 'R5734:Nek9'
ID 451602
Institutional Source Beutler Lab
Gene Symbol Nek9
Ensembl Gene ENSMUSG00000034290
Gene Name NIMA (never in mitosis gene a)-related expressed kinase 9
Synonyms C130021H08Rik
MMRRC Submission 043348-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5734 (G1)
Quality Score 225
Status Validated
Chromosome 12
Chromosomal Location 85346288-85386136 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 85350289 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 928 (M928I)
Ref Sequence ENSEMBL: ENSMUSP00000049056 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040992] [ENSMUST00000059341]
AlphaFold Q8K1R7
Predicted Effect probably benign
Transcript: ENSMUST00000040992
AA Change: M928I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000049056
Gene: ENSMUSG00000034290
AA Change: M928I

DomainStartEndE-ValueType
low complexity region 19 49 N/A INTRINSIC
S_TKc 52 308 1.07e-73 SMART
Pfam:RCC1 389 441 1.2e-9 PFAM
Pfam:RCC1_2 428 457 1.5e-8 PFAM
Pfam:RCC1 444 495 3.6e-13 PFAM
Pfam:RCC1_2 482 511 3.6e-11 PFAM
Pfam:RCC1 499 547 7.6e-14 PFAM
Pfam:RCC1 615 665 4.2e-8 PFAM
Pfam:RCC1_2 652 681 4.4e-7 PFAM
low complexity region 752 767 N/A INTRINSIC
low complexity region 889 900 N/A INTRINSIC
low complexity region 910 927 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000059341
SMART Domains Protein: ENSMUSP00000051664
Gene: ENSMUSG00000045064

DomainStartEndE-ValueType
low complexity region 93 106 N/A INTRINSIC
coiled coil region 207 254 N/A INTRINSIC
Pfam:zf-C2HC_2 378 402 3.6e-10 PFAM
low complexity region 433 444 N/A INTRINSIC
Pfam:zf-C2HC_2 489 513 3.1e-11 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.9%
  • 20x: 94.8%
Validation Efficiency 98% (61/62)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein is activated in mitosis and, in turn, activates other family members during mitosis. This protein also mediates cellular processes that are essential for interphase progression. [provided by RefSeq, Jul 2016]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931429L15Rik A G 9: 46,215,303 (GRCm39) probably benign Het
Abcc9 A G 6: 142,571,457 (GRCm39) probably benign Het
Adamts2 G A 11: 50,679,494 (GRCm39) G825R probably damaging Het
Adgre1 A T 17: 57,750,990 (GRCm39) R555W probably benign Het
Apob T A 12: 8,038,781 (GRCm39) V398D probably damaging Het
Arid4b A G 13: 14,334,856 (GRCm39) N355S probably benign Het
Asb3 G T 11: 30,979,021 (GRCm39) D143Y probably damaging Het
Birc6 G A 17: 74,925,419 (GRCm39) probably benign Het
Cacna1a A G 8: 85,310,360 (GRCm39) M1425V probably damaging Het
Capn9 A G 8: 125,332,583 (GRCm39) E474G probably damaging Het
Capza2 T C 6: 17,660,764 (GRCm39) S155P probably damaging Het
Ccdc125 A G 13: 100,823,622 (GRCm39) N202S possibly damaging Het
Ccn1 A G 3: 145,354,023 (GRCm39) C256R probably damaging Het
Chrm5 T A 2: 112,310,445 (GRCm39) T224S probably benign Het
Chtop C T 3: 90,409,422 (GRCm39) probably null Het
Clip1 T C 5: 123,753,217 (GRCm39) probably benign Het
Dbx2 T C 15: 95,552,604 (GRCm39) T14A possibly damaging Het
Dcaf8 T C 1: 172,000,478 (GRCm39) V212A possibly damaging Het
Fam114a1 T C 5: 65,166,389 (GRCm39) M240T probably damaging Het
Fat1 T C 8: 45,504,246 (GRCm39) Y4580H probably damaging Het
Glipr1 G A 10: 111,821,698 (GRCm39) R200* probably null Het
Gm6408 A T 5: 146,419,192 (GRCm39) Y69F probably benign Het
Gpt2 T C 8: 86,249,885 (GRCm39) S456P probably benign Het
Kat8 T C 7: 127,519,751 (GRCm39) F225S probably benign Het
Lactb2 T A 1: 13,730,611 (GRCm39) N22Y probably damaging Het
Lin28a A T 4: 133,735,284 (GRCm39) C67* probably null Het
Mtarc2 T C 1: 184,564,786 (GRCm39) E155G probably benign Het
Myoz3 G A 18: 60,712,543 (GRCm39) T104M possibly damaging Het
Nlrp9a G C 7: 26,270,065 (GRCm39) A831P probably damaging Het
Nop53 T C 7: 15,679,887 (GRCm39) probably null Het
Ofcc1 T A 13: 40,241,325 (GRCm39) T728S probably damaging Het
Pabpc4l T A 3: 46,401,124 (GRCm39) probably null Het
Rbm34 T C 8: 127,696,880 (GRCm39) probably null Het
Relch T C 1: 105,631,608 (GRCm39) probably benign Het
Robo2 C T 16: 74,149,672 (GRCm39) C52Y probably damaging Het
Rpgr G A X: 10,032,511 (GRCm39) P857L probably benign Het
Scn2a A G 2: 65,548,066 (GRCm39) Y57C possibly damaging Het
Selp C T 1: 163,971,460 (GRCm39) probably benign Het
Skp2 T C 15: 9,139,566 (GRCm39) D43G possibly damaging Het
Smad5 T A 13: 56,871,617 (GRCm39) S71T probably damaging Het
Sorcs1 G T 19: 50,171,213 (GRCm39) H892N probably benign Het
Sox6 C T 7: 115,140,856 (GRCm39) probably null Het
St3gal1 A T 15: 66,978,522 (GRCm39) I333N probably damaging Het
Tex15 C A 8: 34,036,364 (GRCm39) Q97K probably benign Het
Tnxb A T 17: 34,917,884 (GRCm39) T2266S possibly damaging Het
Tpbgl C A 7: 99,274,949 (GRCm39) G303C probably damaging Het
Trat1 A T 16: 48,555,304 (GRCm39) S143T possibly damaging Het
Trpm8 T A 1: 88,283,002 (GRCm39) V763E probably benign Het
Ttc21a G A 9: 119,795,732 (GRCm39) D1189N probably benign Het
Usp7 T C 16: 8,519,845 (GRCm39) N178D possibly damaging Het
Zfp217 T C 2: 169,961,064 (GRCm39) D421G possibly damaging Het
Zfp382 T C 7: 29,833,855 (GRCm39) F502S probably damaging Het
Other mutations in Nek9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01431:Nek9 APN 12 85,361,361 (GRCm39) missense probably benign 0.23
IGL01595:Nek9 APN 12 85,361,194 (GRCm39) missense probably damaging 1.00
IGL01603:Nek9 APN 12 85,352,379 (GRCm39) missense probably damaging 1.00
IGL01893:Nek9 APN 12 85,383,174 (GRCm39) missense probably damaging 1.00
IGL02017:Nek9 APN 12 85,376,697 (GRCm39) missense probably damaging 1.00
IGL02197:Nek9 APN 12 85,354,704 (GRCm39) missense probably null
IGL02207:Nek9 APN 12 85,350,257 (GRCm39) nonsense probably null
IGL02749:Nek9 APN 12 85,352,281 (GRCm39) missense probably benign 0.02
IGL02756:Nek9 APN 12 85,358,110 (GRCm39) critical splice donor site probably null
IGL03343:Nek9 APN 12 85,350,383 (GRCm39) missense probably damaging 1.00
Rose_colored UTSW 12 85,350,311 (GRCm39) missense probably damaging 1.00
R0048:Nek9 UTSW 12 85,348,673 (GRCm39) missense probably benign 0.17
R0331:Nek9 UTSW 12 85,374,149 (GRCm39) splice site probably benign
R0499:Nek9 UTSW 12 85,348,657 (GRCm39) missense probably benign 0.09
R1484:Nek9 UTSW 12 85,348,622 (GRCm39) missense probably damaging 1.00
R1760:Nek9 UTSW 12 85,357,184 (GRCm39) missense probably benign 0.00
R1760:Nek9 UTSW 12 85,352,364 (GRCm39) missense possibly damaging 0.71
R1883:Nek9 UTSW 12 85,379,330 (GRCm39) missense probably damaging 1.00
R1884:Nek9 UTSW 12 85,379,330 (GRCm39) missense probably damaging 1.00
R1999:Nek9 UTSW 12 85,376,677 (GRCm39) missense probably damaging 1.00
R2046:Nek9 UTSW 12 85,367,481 (GRCm39) splice site probably benign
R2096:Nek9 UTSW 12 85,361,322 (GRCm39) missense probably benign 0.00
R2150:Nek9 UTSW 12 85,376,677 (GRCm39) missense probably damaging 1.00
R2368:Nek9 UTSW 12 85,376,661 (GRCm39) missense possibly damaging 0.89
R2570:Nek9 UTSW 12 85,379,320 (GRCm39) nonsense probably null
R4381:Nek9 UTSW 12 85,376,632 (GRCm39) missense probably damaging 1.00
R4570:Nek9 UTSW 12 85,367,508 (GRCm39) missense probably damaging 1.00
R4661:Nek9 UTSW 12 85,367,666 (GRCm39) missense possibly damaging 0.78
R4669:Nek9 UTSW 12 85,360,978 (GRCm39) missense probably benign 0.00
R4993:Nek9 UTSW 12 85,357,194 (GRCm39) missense probably damaging 1.00
R5071:Nek9 UTSW 12 85,374,233 (GRCm39) missense possibly damaging 0.70
R5090:Nek9 UTSW 12 85,376,616 (GRCm39) critical splice donor site probably null
R5248:Nek9 UTSW 12 85,355,751 (GRCm39) missense probably damaging 1.00
R5521:Nek9 UTSW 12 85,374,219 (GRCm39) missense probably benign 0.09
R6039:Nek9 UTSW 12 85,359,859 (GRCm39) missense probably benign 0.08
R6039:Nek9 UTSW 12 85,359,859 (GRCm39) missense probably benign 0.08
R6269:Nek9 UTSW 12 85,379,103 (GRCm39) splice site probably null
R6353:Nek9 UTSW 12 85,348,603 (GRCm39) missense probably damaging 0.96
R6406:Nek9 UTSW 12 85,385,946 (GRCm39) missense probably damaging 0.97
R6744:Nek9 UTSW 12 85,376,703 (GRCm39) missense probably benign 0.09
R6922:Nek9 UTSW 12 85,350,311 (GRCm39) missense probably damaging 1.00
R7603:Nek9 UTSW 12 85,350,288 (GRCm39) missense probably benign 0.00
R7686:Nek9 UTSW 12 85,350,433 (GRCm39) missense probably benign 0.01
R7905:Nek9 UTSW 12 85,352,370 (GRCm39) missense probably damaging 1.00
R7964:Nek9 UTSW 12 85,385,787 (GRCm39) missense probably benign 0.02
R8165:Nek9 UTSW 12 85,350,417 (GRCm39) missense probably benign 0.01
R8330:Nek9 UTSW 12 85,376,727 (GRCm39) missense probably damaging 1.00
R8802:Nek9 UTSW 12 85,374,192 (GRCm39) missense probably benign 0.19
R8859:Nek9 UTSW 12 85,353,120 (GRCm39) missense probably damaging 1.00
R8997:Nek9 UTSW 12 85,367,565 (GRCm39) missense probably benign 0.00
R9055:Nek9 UTSW 12 85,348,616 (GRCm39) missense probably damaging 0.99
R9261:Nek9 UTSW 12 85,359,841 (GRCm39) missense probably damaging 1.00
R9661:Nek9 UTSW 12 85,361,253 (GRCm39) missense possibly damaging 0.96
X0052:Nek9 UTSW 12 85,368,801 (GRCm39) critical splice donor site probably null
Z1177:Nek9 UTSW 12 85,380,819 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- GGAATCAAGTTCAAAGTCCCATC -3'
(R):5'- ACTGTTTGTACTGGGGAGCC -3'

Sequencing Primer
(F):5'- GTTCAAAGTCCCATCATTGAGAGAC -3'
(R):5'- ATGGCAGATCCTGTGCATTATC -3'
Posted On 2017-01-03