Incidental Mutation 'R5736:Hs3st4'
ID 451704
Institutional Source Beutler Lab
Gene Symbol Hs3st4
Ensembl Gene ENSMUSG00000078591
Gene Name heparan sulfate (glucosamine) 3-O-sulfotransferase 4
Synonyms Gm6915
MMRRC Submission 043194-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R5736 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 123582092-123998212 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 123996662 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Lysine at position 443 (E443K)
Ref Sequence ENSEMBL: ENSMUSP00000102045 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106437]
AlphaFold D3YVV6
Predicted Effect probably damaging
Transcript: ENSMUST00000106437
AA Change: E443K

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000102045
Gene: ENSMUSG00000078591
AA Change: E443K

DomainStartEndE-ValueType
low complexity region 5 24 N/A INTRINSIC
low complexity region 52 60 N/A INTRINSIC
low complexity region 68 94 N/A INTRINSIC
low complexity region 106 112 N/A INTRINSIC
low complexity region 158 171 N/A INTRINSIC
Pfam:Sulfotransfer_1 190 439 6.4e-46 PFAM
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.2%
  • 10x: 96.5%
  • 20x: 93.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the enzyme heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4. This enzyme generates 3-O-sulfated glucosaminyl residues in heparan sulfate. Cell surface heparan sulfate is used as a receptor by herpes simplex virus type 1 (HSV-1), and expression of this gene is thought to play a role in HSV-1 pathogenesis. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A630095N17Rik G A 1: 75,197,211 (GRCm39) probably benign Het
Akt1 G A 12: 112,623,284 (GRCm39) R367C probably benign Het
Arl8a T A 1: 135,082,458 (GRCm39) S150T probably benign Het
B020004C17Rik A T 14: 57,254,823 (GRCm39) T216S possibly damaging Het
Casz1 G A 4: 149,013,867 (GRCm39) V144I probably benign Het
Cd274 G T 19: 29,359,940 (GRCm39) L248F probably benign Het
Crisp4 T C 1: 18,185,939 (GRCm39) T266A probably benign Het
Dlx6 A T 6: 6,863,660 (GRCm39) H94L probably damaging Het
Exoc1 A G 5: 76,685,615 (GRCm39) N109S possibly damaging Het
Grik2 T C 10: 49,280,506 (GRCm39) E128G probably damaging Het
Ihh T C 1: 74,985,286 (GRCm39) T400A probably benign Het
Lamb1 T A 12: 31,352,664 (GRCm39) C806* probably null Het
Lrrn1 T C 6: 107,544,345 (GRCm39) S48P probably damaging Het
Lsm11 T C 11: 45,835,594 (GRCm39) N49S possibly damaging Het
Map3k11 C T 19: 5,746,739 (GRCm39) A507V probably damaging Het
Mill2 A T 7: 18,592,174 (GRCm39) Q265L probably benign Het
Odad2 T C 18: 7,268,416 (GRCm39) T368A probably benign Het
Or4s2b T C 2: 88,508,985 (GRCm39) M255T probably benign Het
Otx1 C A 11: 21,947,037 (GRCm39) A91S probably damaging Het
Peg10 T A 6: 4,754,423 (GRCm39) L68Q probably benign Het
Phka2 ACC AC X: 159,342,862 (GRCm39) probably null Het
Prkag2 A T 5: 25,083,720 (GRCm39) Y88N probably damaging Het
Prmt5 A C 14: 54,752,297 (GRCm39) D166E probably null Het
Robo4 A T 9: 37,316,093 (GRCm39) T366S possibly damaging Het
Samd3 T C 10: 26,146,070 (GRCm39) I365T probably damaging Het
Sdf2l1 A T 16: 16,949,571 (GRCm39) C92S probably damaging Het
Serpinb6e A G 13: 34,016,753 (GRCm39) F327L probably damaging Het
Slc17a6 G A 7: 51,294,841 (GRCm39) V183I possibly damaging Het
Slc6a11 T C 6: 114,139,123 (GRCm39) S244P probably damaging Het
Slc6a5 A G 7: 49,609,102 (GRCm39) D769G probably benign Het
Slc7a14 A T 3: 31,278,059 (GRCm39) D515E probably benign Het
Slco2a1 A T 9: 102,945,029 (GRCm39) S135C probably benign Het
Spidr A T 16: 15,715,162 (GRCm39) D801E probably damaging Het
Spta1 T C 1: 174,041,821 (GRCm39) probably null Het
Tmem71 C T 15: 66,404,496 (GRCm39) V264I probably benign Het
Zfp563 G T 17: 33,323,960 (GRCm39) R185L possibly damaging Het
Zfp941 G A 7: 140,392,973 (GRCm39) P129S probably benign Het
Other mutations in Hs3st4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01878:Hs3st4 APN 7 123,996,536 (GRCm39) missense probably damaging 1.00
IGL03078:Hs3st4 APN 7 123,996,669 (GRCm39) missense probably damaging 1.00
R0138:Hs3st4 UTSW 7 123,996,416 (GRCm39) missense probably benign 0.01
R1697:Hs3st4 UTSW 7 123,996,080 (GRCm39) missense probably benign
R2063:Hs3st4 UTSW 7 123,996,236 (GRCm39) missense probably benign 0.42
R4891:Hs3st4 UTSW 7 123,996,052 (GRCm39) missense possibly damaging 0.57
R4922:Hs3st4 UTSW 7 123,996,410 (GRCm39) missense probably damaging 1.00
R5084:Hs3st4 UTSW 7 123,996,518 (GRCm39) missense probably damaging 1.00
R5606:Hs3st4 UTSW 7 123,996,365 (GRCm39) missense probably damaging 1.00
R5859:Hs3st4 UTSW 7 123,582,831 (GRCm39) missense probably benign 0.12
R6861:Hs3st4 UTSW 7 123,996,052 (GRCm39) missense possibly damaging 0.57
R7429:Hs3st4 UTSW 7 123,996,605 (GRCm39) missense probably damaging 1.00
R7431:Hs3st4 UTSW 7 123,582,513 (GRCm39) missense probably damaging 0.99
R7472:Hs3st4 UTSW 7 123,996,249 (GRCm39) missense probably damaging 0.99
R9051:Hs3st4 UTSW 7 123,582,680 (GRCm39) missense probably damaging 0.99
R9272:Hs3st4 UTSW 7 123,582,749 (GRCm39) missense probably benign
Z1190:Hs3st4 UTSW 7 123,996,476 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATTTCCTAGGCCTCAAGCGTG -3'
(R):5'- GCCCACGACATTGGATGTAAC -3'

Sequencing Primer
(F):5'- GGTGACTGAGAAGCACTTTTAC -3'
(R):5'- CCACGACATTGGATGTAACCTGATG -3'
Posted On 2017-01-03