Incidental Mutation 'R5708:Tnik'
| ID |
452065 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tnik
|
| Ensembl Gene |
ENSMUSG00000027692 |
| Gene Name |
TRAF2 and NCK interacting kinase |
| Synonyms |
C530008O15Rik, 4831440I19Rik, 1500031A17Rik, C630040K21Rik |
| MMRRC Submission |
043333-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5708 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
28317362-28724734 bp(+) (GRCm39) |
| Type of Mutation |
critical splice donor site (2 bp from exon) |
| DNA Base Change (assembly) |
T to A
at 28666120 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124726
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000159236]
[ENSMUST00000159236]
[ENSMUST00000159308]
[ENSMUST00000159308]
[ENSMUST00000159680]
[ENSMUST00000159680]
[ENSMUST00000160307]
[ENSMUST00000160518]
[ENSMUST00000160518]
[ENSMUST00000160934]
[ENSMUST00000161964]
[ENSMUST00000161964]
[ENSMUST00000162777]
[ENSMUST00000162777]
[ENSMUST00000162485]
[ENSMUST00000162485]
|
| AlphaFold |
P83510 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000159236
|
| SMART Domains |
Protein: ENSMUSP00000124681
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
691 |
726 |
N/A |
INTRINSIC |
|
low complexity region
|
793 |
812 |
N/A |
INTRINSIC |
|
low complexity region
|
951 |
958 |
N/A |
INTRINSIC |
|
CNH
|
1005 |
1303 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000159236
|
| SMART Domains |
Protein: ENSMUSP00000124681
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
691 |
726 |
N/A |
INTRINSIC |
|
low complexity region
|
793 |
812 |
N/A |
INTRINSIC |
|
low complexity region
|
951 |
958 |
N/A |
INTRINSIC |
|
CNH
|
1005 |
1303 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000159308
|
| SMART Domains |
Protein: ENSMUSP00000125466
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
636 |
671 |
N/A |
INTRINSIC |
|
low complexity region
|
746 |
765 |
N/A |
INTRINSIC |
|
low complexity region
|
904 |
911 |
N/A |
INTRINSIC |
|
CNH
|
958 |
1256 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000159308
|
| SMART Domains |
Protein: ENSMUSP00000125466
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
636 |
671 |
N/A |
INTRINSIC |
|
low complexity region
|
746 |
765 |
N/A |
INTRINSIC |
|
low complexity region
|
904 |
911 |
N/A |
INTRINSIC |
|
CNH
|
958 |
1256 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000159680
|
| SMART Domains |
Protein: ENSMUSP00000124876
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
755 |
N/A |
INTRINSIC |
|
low complexity region
|
822 |
841 |
N/A |
INTRINSIC |
|
low complexity region
|
980 |
987 |
N/A |
INTRINSIC |
|
CNH
|
1034 |
1332 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000159680
|
| SMART Domains |
Protein: ENSMUSP00000124876
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
755 |
N/A |
INTRINSIC |
|
low complexity region
|
822 |
841 |
N/A |
INTRINSIC |
|
low complexity region
|
980 |
987 |
N/A |
INTRINSIC |
|
CNH
|
1034 |
1332 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000160307
|
| SMART Domains |
Protein: ENSMUSP00000125081
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
755 |
N/A |
INTRINSIC |
|
low complexity region
|
830 |
849 |
N/A |
INTRINSIC |
|
low complexity region
|
988 |
995 |
N/A |
INTRINSIC |
|
CNH
|
1042 |
1340 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000160518
|
| SMART Domains |
Protein: ENSMUSP00000124011
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
5.9e-99 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
691 |
726 |
N/A |
INTRINSIC |
|
low complexity region
|
801 |
820 |
N/A |
INTRINSIC |
|
low complexity region
|
959 |
966 |
N/A |
INTRINSIC |
|
CNH
|
1013 |
1311 |
9.3e-120 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000160518
|
| SMART Domains |
Protein: ENSMUSP00000124011
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
5.9e-99 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
691 |
726 |
N/A |
INTRINSIC |
|
low complexity region
|
801 |
820 |
N/A |
INTRINSIC |
|
low complexity region
|
959 |
966 |
N/A |
INTRINSIC |
|
CNH
|
1013 |
1311 |
9.3e-120 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160934
|
| SMART Domains |
Protein: ENSMUSP00000123859
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase_Tyr
|
25 |
212 |
2.2e-37 |
PFAM |
|
Pfam:Pkinase
|
25 |
219 |
5.9e-52 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000161964
|
| SMART Domains |
Protein: ENSMUSP00000125411
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
636 |
671 |
N/A |
INTRINSIC |
|
low complexity region
|
738 |
757 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
903 |
N/A |
INTRINSIC |
|
CNH
|
950 |
1248 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000161964
|
| SMART Domains |
Protein: ENSMUSP00000125411
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
636 |
671 |
N/A |
INTRINSIC |
|
low complexity region
|
738 |
757 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
903 |
N/A |
INTRINSIC |
|
CNH
|
950 |
1248 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000162777
|
| SMART Domains |
Protein: ENSMUSP00000124726
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
665 |
700 |
N/A |
INTRINSIC |
|
low complexity region
|
767 |
786 |
N/A |
INTRINSIC |
|
low complexity region
|
925 |
932 |
N/A |
INTRINSIC |
|
CNH
|
979 |
1277 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000162777
|
| SMART Domains |
Protein: ENSMUSP00000124726
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
665 |
700 |
N/A |
INTRINSIC |
|
low complexity region
|
767 |
786 |
N/A |
INTRINSIC |
|
low complexity region
|
925 |
932 |
N/A |
INTRINSIC |
|
CNH
|
979 |
1277 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000162485
|
| SMART Domains |
Protein: ENSMUSP00000124387
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
665 |
700 |
N/A |
INTRINSIC |
|
low complexity region
|
775 |
794 |
N/A |
INTRINSIC |
|
low complexity region
|
933 |
940 |
N/A |
INTRINSIC |
|
CNH
|
987 |
1285 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000162485
|
| SMART Domains |
Protein: ENSMUSP00000124387
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
665 |
700 |
N/A |
INTRINSIC |
|
low complexity region
|
775 |
794 |
N/A |
INTRINSIC |
|
low complexity region
|
933 |
940 |
N/A |
INTRINSIC |
|
CNH
|
987 |
1285 |
1.92e-117 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000162037
|
| Meta Mutation Damage Score |
0.9594 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.2%
|
| Validation Efficiency |
98% (65/66) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired postsynaptic signaling and cognitive function. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 53 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700067K01Rik |
A |
G |
8: 84,729,627 (GRCm39) |
K101R |
probably benign |
Het |
| 4933430I17Rik |
T |
C |
4: 62,444,106 (GRCm39) |
S18P |
probably benign |
Het |
| Adgb |
C |
T |
10: 10,267,501 (GRCm39) |
V940I |
probably damaging |
Het |
| Aox4 |
G |
T |
1: 58,285,032 (GRCm39) |
A595S |
possibly damaging |
Het |
| Asxl2 |
T |
A |
12: 3,550,603 (GRCm39) |
S782T |
possibly damaging |
Het |
| C1s2 |
A |
T |
6: 124,602,702 (GRCm39) |
L503* |
probably null |
Het |
| C7 |
A |
G |
15: 5,044,883 (GRCm39) |
V385A |
possibly damaging |
Het |
| Cdh20 |
T |
C |
1: 104,912,635 (GRCm39) |
F630L |
probably damaging |
Het |
| Cdk14 |
A |
C |
5: 5,316,036 (GRCm39) |
|
probably benign |
Het |
| Cdkl4 |
T |
C |
17: 80,846,951 (GRCm39) |
I239M |
possibly damaging |
Het |
| Cfap299 |
A |
T |
5: 98,885,566 (GRCm39) |
M158L |
probably benign |
Het |
| Col11a1 |
A |
G |
3: 113,890,743 (GRCm39) |
N360S |
unknown |
Het |
| D630003M21Rik |
A |
G |
2: 158,062,312 (GRCm39) |
|
probably null |
Het |
| Dchs1 |
G |
A |
7: 105,422,016 (GRCm39) |
P135S |
probably damaging |
Het |
| Dpysl2 |
A |
G |
14: 67,050,595 (GRCm39) |
S421P |
probably benign |
Het |
| Edn1 |
A |
T |
13: 42,457,143 (GRCm39) |
M59L |
probably benign |
Het |
| EU599041 |
A |
G |
7: 42,875,311 (GRCm39) |
|
noncoding transcript |
Het |
| Furin |
A |
G |
7: 80,047,603 (GRCm39) |
|
probably benign |
Het |
| Gkn2 |
T |
C |
6: 87,354,418 (GRCm39) |
L94P |
probably damaging |
Het |
| Gmeb2 |
A |
T |
2: 180,906,782 (GRCm39) |
C117S |
probably damaging |
Het |
| Greb1 |
T |
A |
12: 16,723,843 (GRCm39) |
I1869F |
probably benign |
Het |
| Heg1 |
A |
G |
16: 33,562,774 (GRCm39) |
E1119G |
probably damaging |
Het |
| Hmgcs2 |
T |
A |
3: 98,198,478 (GRCm39) |
L127Q |
probably damaging |
Het |
| Insyn2a |
C |
A |
7: 134,520,525 (GRCm39) |
V2F |
probably damaging |
Het |
| Kcnh6 |
A |
G |
11: 105,911,082 (GRCm39) |
R493G |
probably benign |
Het |
| Kcnj11 |
C |
T |
7: 45,749,242 (GRCm39) |
R27H |
probably benign |
Het |
| Klra14-ps |
A |
G |
6: 130,134,751 (GRCm39) |
|
noncoding transcript |
Het |
| Lgmn |
A |
T |
12: 102,370,587 (GRCm39) |
N114K |
possibly damaging |
Het |
| Lipg |
C |
T |
18: 75,088,505 (GRCm39) |
M148I |
possibly damaging |
Het |
| Megf8 |
G |
T |
7: 25,034,022 (GRCm39) |
R607L |
probably benign |
Het |
| Mks1 |
A |
G |
11: 87,747,665 (GRCm39) |
T183A |
probably benign |
Het |
| Mllt11 |
A |
G |
3: 95,127,515 (GRCm39) |
V85A |
probably benign |
Het |
| Mpo |
A |
T |
11: 87,692,581 (GRCm39) |
|
probably null |
Het |
| Muc4 |
A |
T |
16: 32,575,515 (GRCm39) |
|
probably benign |
Het |
| Myoz3 |
T |
C |
18: 60,712,104 (GRCm39) |
Y158C |
probably damaging |
Het |
| Or11g25 |
A |
T |
14: 50,723,452 (GRCm39) |
D179V |
probably damaging |
Het |
| Or4k41 |
A |
G |
2: 111,280,354 (GRCm39) |
R290G |
probably damaging |
Het |
| Or5ae1 |
A |
G |
7: 84,565,391 (GRCm39) |
I135V |
possibly damaging |
Het |
| Polq |
T |
A |
16: 36,881,380 (GRCm39) |
S902R |
probably damaging |
Het |
| Rarb |
T |
C |
14: 16,548,545 (GRCm38) |
T93A |
probably damaging |
Het |
| Rgs12 |
A |
G |
5: 35,123,696 (GRCm39) |
D493G |
probably benign |
Het |
| Sec31b |
T |
A |
19: 44,511,583 (GRCm39) |
D606V |
probably damaging |
Het |
| Setd2 |
T |
C |
9: 110,377,891 (GRCm39) |
F569L |
possibly damaging |
Het |
| Sil1 |
T |
C |
18: 35,474,170 (GRCm39) |
E149G |
probably benign |
Het |
| Spata13 |
T |
G |
14: 60,929,452 (GRCm39) |
S337A |
probably damaging |
Het |
| Srfbp1 |
T |
A |
18: 52,622,018 (GRCm39) |
L360M |
probably damaging |
Het |
| Tecta |
A |
T |
9: 42,250,222 (GRCm39) |
C1852S |
probably damaging |
Het |
| Tgfbr3l |
A |
G |
8: 4,300,360 (GRCm39) |
T208A |
probably damaging |
Het |
| Tmem38b |
G |
C |
4: 53,849,051 (GRCm39) |
|
probably null |
Het |
| Tnfrsf11a |
T |
A |
1: 105,741,545 (GRCm39) |
|
probably null |
Het |
| Tsc1 |
A |
T |
2: 28,555,197 (GRCm39) |
|
probably benign |
Het |
| Zfp930 |
T |
C |
8: 69,679,113 (GRCm39) |
V41A |
probably benign |
Het |
| Zscan18 |
A |
T |
7: 12,508,383 (GRCm39) |
D372E |
probably benign |
Het |
|
| Other mutations in Tnik |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00516:Tnik
|
APN |
3 |
28,708,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00726:Tnik
|
APN |
3 |
28,587,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01022:Tnik
|
APN |
3 |
28,679,377 (GRCm39) |
splice site |
probably null |
|
|
IGL01145:Tnik
|
APN |
3 |
28,658,316 (GRCm39) |
intron |
probably benign |
|
|
IGL01664:Tnik
|
APN |
3 |
28,692,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01843:Tnik
|
APN |
3 |
28,625,007 (GRCm39) |
splice site |
probably null |
|
|
IGL02378:Tnik
|
APN |
3 |
28,692,608 (GRCm39) |
nonsense |
probably null |
|
|
IGL02448:Tnik
|
APN |
3 |
28,675,226 (GRCm39) |
missense |
probably null |
0.01 |
|
IGL02756:Tnik
|
APN |
3 |
28,596,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03332:Tnik
|
APN |
3 |
28,720,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
delightful
|
UTSW |
3 |
28,658,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Hottie
|
UTSW |
3 |
28,317,792 (GRCm39) |
start codon destroyed |
probably null |
0.93 |
|
Knockout
|
UTSW |
3 |
28,715,927 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
Looker
|
UTSW |
3 |
28,715,853 (GRCm39) |
nonsense |
probably null |
|
|
Lovely
|
UTSW |
3 |
28,666,119 (GRCm39) |
critical splice donor site |
probably null |
|
|
Usher
|
UTSW |
3 |
28,618,246 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R0135:Tnik
|
UTSW |
3 |
28,661,394 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R0418:Tnik
|
UTSW |
3 |
28,625,029 (GRCm39) |
nonsense |
probably null |
|
|
R0540:Tnik
|
UTSW |
3 |
28,704,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0549:Tnik
|
UTSW |
3 |
28,625,069 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0556:Tnik
|
UTSW |
3 |
28,679,367 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0586:Tnik
|
UTSW |
3 |
28,631,510 (GRCm39) |
splice site |
probably benign |
|
|
R0607:Tnik
|
UTSW |
3 |
28,704,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0842:Tnik
|
UTSW |
3 |
28,648,235 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R1068:Tnik
|
UTSW |
3 |
28,587,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1171:Tnik
|
UTSW |
3 |
28,587,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1597:Tnik
|
UTSW |
3 |
28,658,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1638:Tnik
|
UTSW |
3 |
28,719,889 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1652:Tnik
|
UTSW |
3 |
28,658,442 (GRCm39) |
missense |
probably benign |
0.22 |
|
R1996:Tnik
|
UTSW |
3 |
28,719,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2333:Tnik
|
UTSW |
3 |
28,587,145 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2426:Tnik
|
UTSW |
3 |
28,700,830 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2509:Tnik
|
UTSW |
3 |
28,722,064 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3774:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3775:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4007:Tnik
|
UTSW |
3 |
28,658,430 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4119:Tnik
|
UTSW |
3 |
28,720,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4209:Tnik
|
UTSW |
3 |
28,413,214 (GRCm39) |
splice site |
probably benign |
|
|
R4441:Tnik
|
UTSW |
3 |
28,618,246 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R4611:Tnik
|
UTSW |
3 |
28,596,249 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4714:Tnik
|
UTSW |
3 |
28,648,226 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4772:Tnik
|
UTSW |
3 |
28,661,359 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4829:Tnik
|
UTSW |
3 |
28,593,690 (GRCm39) |
intron |
probably benign |
|
|
R4839:Tnik
|
UTSW |
3 |
28,650,224 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4898:Tnik
|
UTSW |
3 |
28,704,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5029:Tnik
|
UTSW |
3 |
28,719,993 (GRCm39) |
splice site |
probably null |
|
|
R5278:Tnik
|
UTSW |
3 |
28,704,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5307:Tnik
|
UTSW |
3 |
28,596,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5330:Tnik
|
UTSW |
3 |
28,596,167 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5375:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5459:Tnik
|
UTSW |
3 |
28,715,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5749:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5751:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5780:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5837:Tnik
|
UTSW |
3 |
28,722,202 (GRCm39) |
unclassified |
probably benign |
|
|
R5969:Tnik
|
UTSW |
3 |
28,675,097 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6244:Tnik
|
UTSW |
3 |
28,704,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6273:Tnik
|
UTSW |
3 |
28,631,649 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6457:Tnik
|
UTSW |
3 |
28,593,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6464:Tnik
|
UTSW |
3 |
28,666,119 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6473:Tnik
|
UTSW |
3 |
28,317,792 (GRCm39) |
start codon destroyed |
probably null |
0.93 |
|
R6737:Tnik
|
UTSW |
3 |
28,650,235 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7049:Tnik
|
UTSW |
3 |
28,715,853 (GRCm39) |
nonsense |
probably null |
|
|
R7237:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7267:Tnik
|
UTSW |
3 |
28,700,776 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7445:Tnik
|
UTSW |
3 |
28,718,058 (GRCm39) |
splice site |
probably null |
|
|
R7499:Tnik
|
UTSW |
3 |
28,684,743 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7629:Tnik
|
UTSW |
3 |
28,715,877 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7654:Tnik
|
UTSW |
3 |
28,658,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7886:Tnik
|
UTSW |
3 |
28,720,288 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8096:Tnik
|
UTSW |
3 |
28,715,927 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8210:Tnik
|
UTSW |
3 |
28,658,482 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8233:Tnik
|
UTSW |
3 |
28,609,086 (GRCm39) |
missense |
unknown |
|
|
R8386:Tnik
|
UTSW |
3 |
28,317,823 (GRCm39) |
missense |
unknown |
|
|
R8399:Tnik
|
UTSW |
3 |
28,548,159 (GRCm39) |
missense |
unknown |
|
|
R8490:Tnik
|
UTSW |
3 |
28,650,321 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8539:Tnik
|
UTSW |
3 |
28,596,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8751:Tnik
|
UTSW |
3 |
28,666,057 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8804:Tnik
|
UTSW |
3 |
28,648,202 (GRCm39) |
missense |
unknown |
|
|
R8966:Tnik
|
UTSW |
3 |
28,587,044 (GRCm39) |
missense |
unknown |
|
|
R8998:Tnik
|
UTSW |
3 |
28,719,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8999:Tnik
|
UTSW |
3 |
28,719,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9016:Tnik
|
UTSW |
3 |
28,692,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9154:Tnik
|
UTSW |
3 |
28,704,235 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9284:Tnik
|
UTSW |
3 |
28,593,570 (GRCm39) |
missense |
unknown |
|
|
R9290:Tnik
|
UTSW |
3 |
28,675,124 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9411:Tnik
|
UTSW |
3 |
28,684,754 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9484:Tnik
|
UTSW |
3 |
28,649,093 (GRCm39) |
missense |
unknown |
|
|
X0022:Tnik
|
UTSW |
3 |
28,722,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Tnik
|
UTSW |
3 |
28,661,477 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1176:Tnik
|
UTSW |
3 |
28,658,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTTTCATGGACGAGGCACTG -3'
(R):5'- CGCAACTGTGTCTGTGTTTC -3'
Sequencing Primer
(F):5'- GAGGCACTGTCTGTAACTTGTAACC -3'
(R):5'- TGTGTTTCCAAGTTTTTACCCAG -3'
|
| Posted On |
2017-01-03 |
Incidental Mutation