Incidental Mutation 'R0551:Or5b102'
ID 45207
Institutional Source Beutler Lab
Gene Symbol Or5b102
Ensembl Gene ENSMUSG00000094986
Gene Name olfactory receptor family 5 subfamily B member 102
Synonyms MOR202-14, GA_x6K02T2RE5P-3390804-3391727, Olfr1454
MMRRC Submission 038743-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R0551 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 13040777-13041700 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 13041658 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 294 (D294E)
Ref Sequence ENSEMBL: ENSMUSP00000148859 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073732] [ENSMUST00000213806] [ENSMUST00000214695] [ENSMUST00000217568]
AlphaFold Q8VFW2
Predicted Effect probably benign
Transcript: ENSMUST00000073732
AA Change: D294E

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000073409
Gene: ENSMUSG00000094986
AA Change: D294E

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.1e-50 PFAM
Pfam:7tm_1 39 288 2.7e-18 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208608
Predicted Effect probably benign
Transcript: ENSMUST00000213806
AA Change: D294E

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
Predicted Effect probably benign
Transcript: ENSMUST00000214695
AA Change: D294E

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
Predicted Effect probably benign
Transcript: ENSMUST00000217568
AA Change: D294E

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.1%
  • 20x: 95.1%
Validation Efficiency 99% (77/78)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik T A 14: 32,384,598 (GRCm39) T456S probably benign Het
Acmsd A T 1: 127,694,070 (GRCm39) K333N probably benign Het
Adcy2 T A 13: 68,944,658 (GRCm39) K241N probably damaging Het
Aebp1 A G 11: 5,817,955 (GRCm39) I77V probably benign Het
Albfm1 C T 5: 90,720,578 (GRCm39) P250S probably damaging Het
Ankrd35 A G 3: 96,591,276 (GRCm39) T521A probably benign Het
Arap2 C T 5: 62,798,666 (GRCm39) probably null Het
Arfgap3 A T 15: 83,227,338 (GRCm39) C25S probably damaging Het
Arhgap20 T A 9: 51,737,125 (GRCm39) probably benign Het
Arhgap39 C T 15: 76,619,086 (GRCm39) D833N probably damaging Het
Auts2 T C 5: 131,469,307 (GRCm39) E446G possibly damaging Het
Brwd1 C T 16: 95,837,174 (GRCm39) R886H probably damaging Het
Carm1 G A 9: 21,491,787 (GRCm39) probably null Het
Cdc5l G A 17: 45,726,610 (GRCm39) R321W probably damaging Het
Cfap54 A T 10: 92,860,984 (GRCm39) M841K probably benign Het
Clca4b T A 3: 144,634,387 (GRCm39) T69S probably damaging Het
Cpox A G 16: 58,495,753 (GRCm39) I357V probably benign Het
Diaph3 C A 14: 87,147,536 (GRCm39) V711L probably benign Het
Fabp3-ps1 T C 10: 86,567,904 (GRCm39) probably benign Het
Fam120b A T 17: 15,651,905 (GRCm39) probably benign Het
Fcho1 A G 8: 72,164,818 (GRCm39) S488P probably benign Het
Flcn A G 11: 59,686,574 (GRCm39) probably null Het
Flt3l A G 7: 44,781,690 (GRCm39) W234R probably damaging Het
Fzd7 G T 1: 59,522,443 (GRCm39) V109L probably damaging Het
G3bp1 A G 11: 55,379,969 (GRCm39) N101S probably benign Het
Gadd45g A G 13: 52,001,963 (GRCm39) E143G probably damaging Het
Ganab T G 19: 8,884,644 (GRCm39) I149S probably benign Het
Garnl3 A G 2: 32,906,750 (GRCm39) S413P probably damaging Het
Glis1 C T 4: 107,425,316 (GRCm39) probably null Het
Gm11563 A G 11: 99,549,539 (GRCm39) S72P unknown Het
Gpd1 T G 15: 99,618,510 (GRCm39) I188S possibly damaging Het
Gria2 A G 3: 80,639,333 (GRCm39) probably benign Het
Hpcal4 G T 4: 123,082,848 (GRCm39) A65S possibly damaging Het
Igsf10 G A 3: 59,236,089 (GRCm39) T1364I probably benign Het
Kdm4a T C 4: 117,995,428 (GRCm39) *1065W probably null Het
Klkb1 A G 8: 45,731,003 (GRCm39) probably null Het
Lipo3 T C 19: 33,557,951 (GRCm39) D147G probably damaging Het
Lrp1 A G 10: 127,407,827 (GRCm39) S1821P probably benign Het
Macroh2a2 A G 10: 61,576,945 (GRCm39) S308P probably damaging Het
Manba T C 3: 135,223,734 (GRCm39) I207T probably damaging Het
Mark3 T A 12: 111,600,068 (GRCm39) S428T probably benign Het
Mfsd4a G A 1: 131,969,657 (GRCm39) T348I probably damaging Het
Mybbp1a A G 11: 72,339,202 (GRCm39) M880V probably benign Het
N4bp2 T A 5: 65,977,684 (GRCm39) probably null Het
Nrdc T G 4: 108,904,905 (GRCm39) I712S probably damaging Het
Nup210 G A 6: 90,998,466 (GRCm39) R774C possibly damaging Het
Obscn G A 11: 58,998,688 (GRCm39) R1395* probably null Het
Pcdh7 T C 5: 57,879,336 (GRCm39) Y964H probably damaging Het
Pgap6 C A 17: 26,339,576 (GRCm39) Q605K probably damaging Het
Plin4 T C 17: 56,413,756 (GRCm39) T290A probably benign Het
Ppara T C 15: 85,671,306 (GRCm39) probably benign Het
Psg21 T G 7: 18,386,565 (GRCm39) probably null Het
Ptar1 C A 19: 23,697,704 (GRCm39) N405K probably benign Het
Ralgps2 A G 1: 156,660,233 (GRCm39) probably null Het
Rnf6 T A 5: 146,148,205 (GRCm39) N271I possibly damaging Het
Sis T C 3: 72,832,740 (GRCm39) D1019G possibly damaging Het
Slc37a3 A G 6: 39,329,688 (GRCm39) probably benign Het
Slc49a3 A G 5: 108,592,331 (GRCm39) probably benign Het
Slc6a12 G A 6: 121,333,877 (GRCm39) V238I probably damaging Het
Sntg1 C A 1: 8,624,960 (GRCm39) V279L possibly damaging Het
Sorbs1 T A 19: 40,300,260 (GRCm39) E567D probably damaging Het
Sp110 C A 1: 85,516,821 (GRCm39) probably benign Het
Ssu2 A G 6: 112,357,515 (GRCm39) V175A possibly damaging Het
Stk36 G A 1: 74,655,780 (GRCm39) E428K probably benign Het
Teddm1b A T 1: 153,751,090 (GRCm39) I300F possibly damaging Het
Thy1 T C 9: 43,958,645 (GRCm39) V129A probably damaging Het
Tiam2 T A 17: 3,479,229 (GRCm39) M654K probably damaging Het
Tmem69 T C 4: 116,410,470 (GRCm39) S167G probably benign Het
Tmem81 C G 1: 132,435,567 (GRCm39) I124M probably damaging Het
Tspan10 A G 11: 120,335,244 (GRCm39) D118G probably damaging Het
Tspo2 A G 17: 48,755,841 (GRCm39) probably benign Het
Ttn G A 2: 76,738,672 (GRCm39) Q4002* probably null Het
Tyro3 G A 2: 119,647,385 (GRCm39) R834Q probably damaging Het
Ugt2b1 T C 5: 87,073,943 (GRCm39) K139E probably benign Het
Vmn1r9 A T 6: 57,048,524 (GRCm39) I200F probably benign Het
Other mutations in Or5b102
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01598:Or5b102 APN 19 13,041,513 (GRCm39) missense probably damaging 1.00
IGL02942:Or5b102 APN 19 13,041,552 (GRCm39) missense probably benign 0.45
IGL03331:Or5b102 APN 19 13,041,231 (GRCm39) missense probably damaging 1.00
R0738:Or5b102 UTSW 19 13,041,102 (GRCm39) missense probably damaging 1.00
R1532:Or5b102 UTSW 19 13,041,639 (GRCm39) missense probably damaging 1.00
R2072:Or5b102 UTSW 19 13,041,044 (GRCm39) missense probably benign 0.00
R2092:Or5b102 UTSW 19 13,041,166 (GRCm39) nonsense probably null
R2656:Or5b102 UTSW 19 13,041,348 (GRCm39) missense probably benign 0.05
R2850:Or5b102 UTSW 19 13,040,934 (GRCm39) missense probably damaging 1.00
R4212:Or5b102 UTSW 19 13,041,123 (GRCm39) missense probably damaging 0.98
R5303:Or5b102 UTSW 19 13,041,139 (GRCm39) nonsense probably null
R6362:Or5b102 UTSW 19 13,040,709 (GRCm39) start gained probably benign
R6928:Or5b102 UTSW 19 13,041,348 (GRCm39) missense probably benign 0.05
R7183:Or5b102 UTSW 19 13,041,680 (GRCm39) missense probably benign 0.00
R7701:Or5b102 UTSW 19 13,041,445 (GRCm39) missense probably damaging 1.00
R7741:Or5b102 UTSW 19 13,041,423 (GRCm39) missense probably damaging 0.98
R8057:Or5b102 UTSW 19 13,040,638 (GRCm39) start gained probably benign
R8272:Or5b102 UTSW 19 13,040,795 (GRCm39) missense possibly damaging 0.47
R8534:Or5b102 UTSW 19 13,041,432 (GRCm39) missense probably damaging 1.00
R8769:Or5b102 UTSW 19 13,041,307 (GRCm39) nonsense probably null
R9400:Or5b102 UTSW 19 13,041,139 (GRCm39) nonsense probably null
R9511:Or5b102 UTSW 19 13,041,119 (GRCm39) missense probably damaging 0.99
R9651:Or5b102 UTSW 19 13,041,256 (GRCm39) missense probably benign 0.01
Z1176:Or5b102 UTSW 19 13,041,010 (GRCm39) missense probably benign 0.15
Predicted Primers PCR Primer
(F):5'- TGTAAGCCCCTACATTATGCTACCACC -3'
(R):5'- TGAGGGCACCACTTCACAATCTTG -3'

Sequencing Primer
(F):5'- TGTGAGTCCAATGTAGTCCATC -3'
(R):5'- CACAATCTTGAATTTGGTACAGGGTG -3'
Posted On 2013-06-11