Incidental Mutation 'R0552:Tmprss15'
ID 45260
Institutional Source Beutler Lab
Gene Symbol Tmprss15
Ensembl Gene ENSMUSG00000022857
Gene Name transmembrane protease, serine 15
Synonyms Prss7, enterokinase, enteropeptidase, A130097D21Rik
MMRRC Submission 038744-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0552 (G1)
Quality Score 225
Status Not validated
Chromosome 16
Chromosomal Location 78749896-78887985 bp(-) (GRCm39)
Type of Mutation splice site (5 bp from exon)
DNA Base Change (assembly) C to T at 78821637 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000052034 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023566] [ENSMUST00000060402]
AlphaFold P97435
Predicted Effect probably null
Transcript: ENSMUST00000023566
SMART Domains Protein: ENSMUSP00000023566
Gene: ENSMUSG00000022857

DomainStartEndE-ValueType
transmembrane domain 21 43 N/A INTRINSIC
SEA 52 172 1.62e-22 SMART
LDLa 228 268 1.74e-4 SMART
CUB 270 379 1.54e-11 SMART
MAM 387 549 7.33e-54 SMART
low complexity region 551 567 N/A INTRINSIC
CUB 569 679 1.72e-32 SMART
LDLa 687 724 7.32e-12 SMART
SR 723 813 3.12e-5 SMART
Tryp_SPc 829 1064 1.48e-95 SMART
Predicted Effect probably null
Transcript: ENSMUST00000060402
SMART Domains Protein: ENSMUSP00000052034
Gene: ENSMUSG00000022857

DomainStartEndE-ValueType
transmembrane domain 21 43 N/A INTRINSIC
SEA 52 172 1.62e-22 SMART
LDLa 213 253 1.74e-4 SMART
CUB 255 364 1.54e-11 SMART
MAM 372 534 7.33e-54 SMART
low complexity region 536 552 N/A INTRINSIC
CUB 554 664 1.72e-32 SMART
LDLa 672 709 7.32e-12 SMART
SR 708 798 3.12e-5 SMART
Tryp_SPc 814 1049 1.48e-95 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.1%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes an enzyme that proteolytically activates the pancreatic proenzyme trypsinogen, converting it into trypsin. The encoded protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam9 A T 8: 25,453,026 (GRCm39) N760K probably benign Het
Ahcyl T A 16: 45,974,955 (GRCm39) T141S probably benign Het
Akr1b10 A G 6: 34,369,920 (GRCm39) T216A possibly damaging Het
Arsj A G 3: 126,232,993 (GRCm39) R580G probably benign Het
C9 A T 15: 6,474,918 (GRCm39) I26F probably damaging Het
Cacna2d1 A G 5: 16,533,041 (GRCm39) E578G probably damaging Het
Clca4b C T 3: 144,622,536 (GRCm39) V510I probably benign Het
Dab2 C T 15: 6,464,895 (GRCm39) T561I possibly damaging Het
Golga5 A T 12: 102,450,752 (GRCm39) E12D possibly damaging Het
Hsd17b12 A T 2: 93,874,280 (GRCm39) F208I probably damaging Het
Inf2 A G 12: 112,579,008 (GRCm39) probably benign Het
Kcnh3 T A 15: 99,127,337 (GRCm39) W378R probably damaging Het
Klhdc8b G C 9: 108,326,422 (GRCm39) R158G possibly damaging Het
Klhl41 G A 2: 69,500,554 (GRCm39) R5Q probably benign Het
Lcn3 T C 2: 25,656,421 (GRCm39) probably null Het
Mppe1 A G 18: 67,370,419 (GRCm39) probably null Het
Muc20 G A 16: 32,614,300 (GRCm39) A359V probably damaging Het
Myh14 T C 7: 44,263,105 (GRCm39) D1765G probably damaging Het
Or10j2 T C 1: 173,098,372 (GRCm39) M210T probably benign Het
Or4c10b C T 2: 89,711,235 (GRCm39) Q22* probably null Het
Or5p58 A G 7: 107,693,985 (GRCm39) M264T probably benign Het
Pbrm1 T A 14: 30,757,916 (GRCm39) L182Q probably damaging Het
Pde8a A G 7: 80,967,095 (GRCm39) N412S probably benign Het
Phyh A G 2: 4,940,912 (GRCm39) T271A probably damaging Het
Pkhd1l1 T C 15: 44,352,942 (GRCm39) S258P probably damaging Het
Ptpro T A 6: 137,420,592 (GRCm39) V1007D probably damaging Het
Pyroxd1 A G 6: 142,291,463 (GRCm39) E2G probably benign Het
Ralgapa1 G T 12: 55,723,550 (GRCm39) Q2115K probably benign Het
Rufy3 A G 5: 88,732,129 (GRCm39) E44G possibly damaging Het
Slit2 A T 5: 48,395,721 (GRCm39) N712I probably damaging Het
Sptbn1 A G 11: 30,095,985 (GRCm39) M303T possibly damaging Het
Ssbp4 A G 8: 71,052,509 (GRCm39) I154T probably benign Het
Syne2 A G 12: 75,977,778 (GRCm39) K1409E probably benign Het
Tfap2b T C 1: 19,304,449 (GRCm39) Y420H probably damaging Het
Tlr5 A G 1: 182,803,261 (GRCm39) probably null Het
Tns1 A T 1: 73,959,722 (GRCm39) I418N probably damaging Het
Txlna A T 4: 129,522,984 (GRCm39) V452D probably benign Het
Wdr17 C T 8: 55,146,131 (GRCm39) A90T possibly damaging Het
Zfp563 A T 17: 33,323,659 (GRCm39) S85C possibly damaging Het
Zfp764l1 A T 7: 126,991,504 (GRCm39) I161N possibly damaging Het
Other mutations in Tmprss15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00331:Tmprss15 APN 16 78,782,882 (GRCm39) missense possibly damaging 0.87
IGL00477:Tmprss15 APN 16 78,818,301 (GRCm39) missense probably damaging 1.00
IGL01583:Tmprss15 APN 16 78,868,149 (GRCm39) missense probably benign
IGL01896:Tmprss15 APN 16 78,887,678 (GRCm39) missense probably benign 0.22
IGL02052:Tmprss15 APN 16 78,884,394 (GRCm39) missense probably damaging 1.00
IGL02374:Tmprss15 APN 16 78,832,056 (GRCm39) missense probably benign 0.00
IGL02505:Tmprss15 APN 16 78,784,629 (GRCm39) missense probably benign 0.00
IGL02632:Tmprss15 APN 16 78,782,790 (GRCm39) missense probably damaging 0.98
IGL02674:Tmprss15 APN 16 78,798,682 (GRCm39) missense possibly damaging 0.72
beached UTSW 16 78,821,736 (GRCm39) missense possibly damaging 0.62
Cellulite UTSW 16 78,754,259 (GRCm39) missense probably damaging 1.00
lolling UTSW 16 78,800,298 (GRCm39) missense probably benign 0.26
miniature UTSW 16 78,854,497 (GRCm39) critical splice donor site probably null
PIT1430001:Tmprss15 UTSW 16 78,821,640 (GRCm39) critical splice donor site probably null
R0106:Tmprss15 UTSW 16 78,800,277 (GRCm39) missense probably damaging 0.99
R0106:Tmprss15 UTSW 16 78,800,277 (GRCm39) missense probably damaging 0.99
R0195:Tmprss15 UTSW 16 78,831,222 (GRCm39) missense probably benign 0.05
R0335:Tmprss15 UTSW 16 78,821,630 (GRCm39) splice site probably benign
R0514:Tmprss15 UTSW 16 78,765,155 (GRCm39) missense probably benign 0.05
R0675:Tmprss15 UTSW 16 78,782,838 (GRCm39) missense probably damaging 0.98
R0739:Tmprss15 UTSW 16 78,821,736 (GRCm39) missense possibly damaging 0.62
R1435:Tmprss15 UTSW 16 78,818,342 (GRCm39) missense probably benign 0.03
R1446:Tmprss15 UTSW 16 78,875,846 (GRCm39) missense probably benign 0.01
R1572:Tmprss15 UTSW 16 78,887,717 (GRCm39) missense probably benign 0.00
R1708:Tmprss15 UTSW 16 78,850,958 (GRCm39) missense possibly damaging 0.95
R1893:Tmprss15 UTSW 16 78,868,306 (GRCm39) missense probably benign
R2403:Tmprss15 UTSW 16 78,854,578 (GRCm39) missense probably damaging 1.00
R2866:Tmprss15 UTSW 16 78,832,121 (GRCm39) missense possibly damaging 0.65
R2913:Tmprss15 UTSW 16 78,759,078 (GRCm39) missense probably benign 0.45
R2914:Tmprss15 UTSW 16 78,759,078 (GRCm39) missense probably benign 0.45
R3425:Tmprss15 UTSW 16 78,800,321 (GRCm39) missense possibly damaging 0.83
R3703:Tmprss15 UTSW 16 78,851,030 (GRCm39) critical splice acceptor site probably null
R3916:Tmprss15 UTSW 16 78,782,884 (GRCm39) missense probably damaging 1.00
R3950:Tmprss15 UTSW 16 78,870,074 (GRCm39) missense probably benign 0.04
R4332:Tmprss15 UTSW 16 78,831,222 (GRCm39) missense probably benign 0.15
R4392:Tmprss15 UTSW 16 78,821,326 (GRCm39) missense probably damaging 1.00
R4515:Tmprss15 UTSW 16 78,754,244 (GRCm39) missense probably benign 0.00
R4619:Tmprss15 UTSW 16 78,818,358 (GRCm39) missense probably damaging 1.00
R4620:Tmprss15 UTSW 16 78,818,358 (GRCm39) missense probably damaging 1.00
R4754:Tmprss15 UTSW 16 78,851,012 (GRCm39) missense probably damaging 0.98
R4853:Tmprss15 UTSW 16 78,757,479 (GRCm39) missense probably benign
R5159:Tmprss15 UTSW 16 78,800,298 (GRCm39) missense probably benign 0.26
R5441:Tmprss15 UTSW 16 78,868,335 (GRCm39) critical splice acceptor site probably null
R5824:Tmprss15 UTSW 16 78,831,201 (GRCm39) missense probably damaging 0.99
R5970:Tmprss15 UTSW 16 78,854,547 (GRCm39) missense probably benign 0.00
R6224:Tmprss15 UTSW 16 78,821,266 (GRCm39) missense probably benign 0.08
R6257:Tmprss15 UTSW 16 78,769,113 (GRCm39) missense probably damaging 1.00
R6313:Tmprss15 UTSW 16 78,759,058 (GRCm39) missense probably benign 0.16
R6368:Tmprss15 UTSW 16 78,802,945 (GRCm39) splice site probably null
R6525:Tmprss15 UTSW 16 78,800,266 (GRCm39) missense probably damaging 0.97
R6587:Tmprss15 UTSW 16 78,868,317 (GRCm39) missense probably benign
R6894:Tmprss15 UTSW 16 78,872,702 (GRCm39) nonsense probably null
R7018:Tmprss15 UTSW 16 78,821,741 (GRCm39) missense possibly damaging 0.78
R7180:Tmprss15 UTSW 16 78,764,886 (GRCm39) missense probably damaging 0.97
R7324:Tmprss15 UTSW 16 78,758,907 (GRCm39) missense probably damaging 1.00
R7337:Tmprss15 UTSW 16 78,868,164 (GRCm39) missense probably benign 0.01
R7558:Tmprss15 UTSW 16 78,800,302 (GRCm39) missense possibly damaging 0.55
R7732:Tmprss15 UTSW 16 78,800,308 (GRCm39) missense probably benign 0.11
R7792:Tmprss15 UTSW 16 78,800,275 (GRCm39) missense probably damaging 1.00
R7829:Tmprss15 UTSW 16 78,784,538 (GRCm39) missense probably benign 0.02
R7998:Tmprss15 UTSW 16 78,798,731 (GRCm39) missense possibly damaging 0.79
R8009:Tmprss15 UTSW 16 78,887,751 (GRCm39) missense probably damaging 0.96
R8145:Tmprss15 UTSW 16 78,757,473 (GRCm39) missense probably damaging 1.00
R8183:Tmprss15 UTSW 16 78,884,400 (GRCm39) missense probably benign 0.04
R8221:Tmprss15 UTSW 16 78,821,223 (GRCm39) missense probably damaging 0.99
R8294:Tmprss15 UTSW 16 78,868,176 (GRCm39) missense probably benign
R8537:Tmprss15 UTSW 16 78,884,403 (GRCm39) missense probably damaging 0.99
R8735:Tmprss15 UTSW 16 78,798,702 (GRCm39) missense possibly damaging 0.88
R8858:Tmprss15 UTSW 16 78,854,497 (GRCm39) critical splice donor site probably null
R8869:Tmprss15 UTSW 16 78,750,834 (GRCm39) nonsense probably null
R8884:Tmprss15 UTSW 16 78,821,657 (GRCm39) missense probably benign 0.00
R9014:Tmprss15 UTSW 16 78,872,691 (GRCm39) missense probably benign 0.04
R9075:Tmprss15 UTSW 16 78,754,259 (GRCm39) missense probably damaging 1.00
R9351:Tmprss15 UTSW 16 78,832,086 (GRCm39) missense probably damaging 1.00
R9393:Tmprss15 UTSW 16 78,754,211 (GRCm39) missense probably benign 0.01
R9747:Tmprss15 UTSW 16 78,884,400 (GRCm39) missense probably benign 0.04
R9767:Tmprss15 UTSW 16 78,875,977 (GRCm39) missense probably damaging 1.00
R9783:Tmprss15 UTSW 16 78,887,890 (GRCm39) start gained probably benign
RF005:Tmprss15 UTSW 16 78,750,689 (GRCm39) makesense probably null
Predicted Primers PCR Primer
(F):5'- ACTATCTTGTCTGTGGTTTCAGCACTG -3'
(R):5'- TGGACGCAAGTCTAGTATCTCTTCCAG -3'

Sequencing Primer
(F):5'- CAGCACATGTAATACCTGGTTTGG -3'
(R):5'- CTCTTCCAGTGTGCAAAGAATGC -3'
Posted On 2013-06-11