Incidental Mutation 'R5728:Wnt8b'
ID 452631
Institutional Source Beutler Lab
Gene Symbol Wnt8b
Ensembl Gene ENSMUSG00000036961
Gene Name wingless-type MMTV integration site family, member 8B
Synonyms
MMRRC Submission 043345-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5728 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 44481912-44502712 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 44499757 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 169 (T169A)
Ref Sequence ENSEMBL: ENSMUSP00000042867 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041163]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000041163
AA Change: T169A

PolyPhen 2 Score 0.692 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000042867
Gene: ENSMUSG00000036961
AA Change: T169A

DomainStartEndE-ValueType
WNT1 38 351 1.02e-185 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 95%, 86% and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele are viable and healthy with no evidence of hippocampal or hypothalamic defects and normal cell proliferation in the neurogenic region of the adult dentate gyrus. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A930018P22Rik T A 2: 103,953,213 (GRCm39) M13K possibly damaging Het
Abca13 T A 11: 9,520,576 (GRCm39) V4493D probably damaging Het
Ank1 A G 8: 23,612,783 (GRCm39) probably null Het
B4galnt4 A G 7: 140,650,488 (GRCm39) D785G probably benign Het
Chtop C T 3: 90,407,399 (GRCm39) G187D probably damaging Het
Cnih1 A G 14: 47,017,648 (GRCm39) F78S probably damaging Het
Cybb C G X: 9,316,989 (GRCm39) D246H probably benign Het
Dcun1d4 T C 5: 73,677,491 (GRCm39) F57L possibly damaging Het
Dgkz A G 2: 91,776,132 (GRCm39) S44P possibly damaging Het
Dhps A G 8: 85,799,964 (GRCm39) D138G probably damaging Het
Elp2 A G 18: 24,750,509 (GRCm39) E282G probably damaging Het
Exoc6b T C 6: 84,837,173 (GRCm39) Y342C probably damaging Het
Fasn A C 11: 120,704,339 (GRCm39) S1386A probably benign Het
Foxj3 A T 4: 119,430,959 (GRCm39) N111Y probably damaging Het
Gm5431 T C 11: 48,779,440 (GRCm39) E772G probably damaging Het
Gpbar1 A G 1: 74,318,216 (GRCm39) N153S probably damaging Het
Hspg2 T C 4: 137,270,077 (GRCm39) I2345T possibly damaging Het
Igkv6-29 C A 6: 70,115,584 (GRCm39) G70V possibly damaging Het
Lce1f A G 3: 92,626,652 (GRCm39) S2P unknown Het
Lrrk2 A G 15: 91,659,177 (GRCm39) D1863G probably benign Het
Lurap1 T C 4: 116,001,585 (GRCm39) E36G possibly damaging Het
Lysmd3 A G 13: 81,817,380 (GRCm39) E119G probably damaging Het
Map9 G A 3: 82,270,642 (GRCm39) V69I probably benign Het
Mfsd4b2 A C 10: 39,799,791 (GRCm39) F37C possibly damaging Het
Moxd1 A T 10: 24,099,581 (GRCm39) H27L possibly damaging Het
Myo15a A T 11: 60,379,722 (GRCm39) K1476N probably damaging Het
Mzf1 A G 7: 12,777,985 (GRCm39) I552T probably benign Het
Nfatc2 A G 2: 168,322,169 (GRCm39) V910A probably benign Het
Or52n2 C T 7: 104,542,436 (GRCm39) R133Q possibly damaging Het
Prss2 T C 6: 41,500,851 (GRCm39) V88A probably benign Het
Rhbdf1 A G 11: 32,159,901 (GRCm39) probably null Het
Slc10a4 A T 5: 73,169,677 (GRCm39) Q434L probably damaging Het
Slc4a3 A G 1: 75,526,484 (GRCm39) T2A probably benign Het
Sqor A G 2: 122,651,320 (GRCm39) *194W probably null Het
Stx16 G A 2: 173,935,292 (GRCm39) G156R probably damaging Het
Tagap1 A G 17: 7,224,420 (GRCm39) V92A probably benign Het
Tiam2 A G 17: 3,465,231 (GRCm39) Y320C probably damaging Het
Toporsl T C 4: 52,611,469 (GRCm39) I454T probably benign Het
Ttc23l G T 15: 10,551,636 (GRCm39) T30K possibly damaging Het
Ubap1l T C 9: 65,276,570 (GRCm39) V24A probably benign Het
Unc13c A T 9: 73,466,238 (GRCm39) S1810T probably benign Het
Vmn1r56 A T 7: 5,199,122 (GRCm39) I165K probably benign Het
Wrap73 T C 4: 154,239,099 (GRCm39) probably null Het
Wwc2 A G 8: 48,317,096 (GRCm39) I703T unknown Het
Zfp354a T A 11: 50,961,432 (GRCm39) C546S probably damaging Het
Other mutations in Wnt8b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01647:Wnt8b APN 19 44,499,704 (GRCm39) missense probably damaging 1.00
Manorborne UTSW 19 44,500,396 (GRCm39) missense probably damaging 1.00
Prospero UTSW 19 44,500,280 (GRCm39) missense probably damaging 1.00
R0601:Wnt8b UTSW 19 44,482,106 (GRCm39) missense probably benign 0.01
R0948:Wnt8b UTSW 19 44,498,968 (GRCm39) missense possibly damaging 0.69
R1315:Wnt8b UTSW 19 44,500,462 (GRCm39) missense probably damaging 1.00
R1672:Wnt8b UTSW 19 44,499,715 (GRCm39) missense probably damaging 1.00
R1864:Wnt8b UTSW 19 44,482,029 (GRCm39) missense probably benign 0.08
R6180:Wnt8b UTSW 19 44,500,082 (GRCm39) missense probably benign 0.01
R6997:Wnt8b UTSW 19 44,500,280 (GRCm39) missense probably damaging 1.00
R7187:Wnt8b UTSW 19 44,500,121 (GRCm39) missense probably benign 0.04
R7216:Wnt8b UTSW 19 44,500,511 (GRCm39) missense probably benign
R7469:Wnt8b UTSW 19 44,500,001 (GRCm39) missense possibly damaging 0.83
R7673:Wnt8b UTSW 19 44,500,127 (GRCm39) missense possibly damaging 0.73
R8003:Wnt8b UTSW 19 44,500,396 (GRCm39) missense probably damaging 1.00
R8055:Wnt8b UTSW 19 44,481,952 (GRCm39) start gained probably benign
Predicted Primers PCR Primer
(F):5'- CTCAGACTGAAAGAGGGCAC -3'
(R):5'- CGTTTCATGGTGCCCTTGAC -3'

Sequencing Primer
(F):5'- TGGCAAAAACAAGATTGAAACCAATC -3'
(R):5'- AGCTGGAGCAGTTGCCAG -3'
Posted On 2017-01-03